E-Pub Articles Ahead of Print ::: Anti-Cancer Agents in Medicinal Chemistry

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 17, 14 Issues, 2017


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
ICCF-CNRS UMR 6296
Université Clermont Auvergne
Clermont-Ferrand
France


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Articles Ahead of Print

Synthesis, Cytotoxicity and Antimicrobial Activity of New Enmein-type Kauranoid Diterpenoid Derivatives


Dahong Li, Tong Han, Xu Hu, Kangtao Tian, Shengtao Xu, Tingting Zhou, Keguang Cheng, Zhanlin Li, Huiming Hua and Jinyi Xu.


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Nano-encapsulation of Dietary Phytoconstituent Capsaicin on Emulsome: Evaluation of Anticancer Activity Through the Measurement of Liver Oxidative Stress in Rats


Tapan Kumar Giri, Kaustav Pramanik, Tapan Kumar Barman and Subhasis Maity.


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Antioxidant Properties of Fractions for Unripe Fruits of Capsicum annuum L. var. Conoides


Chung-Yi Chen, Ching-Yu Yen, Gao-Mai Shen, Tzu-Jung Yu, Yi-Shin Liao, Ru-In Jian, Sheng-Chieh Wang, Jen-Yang Tang and H-W Chang.


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Apicidin Inhibited Proliferation and Invasion and Induced Apoptosis via Mitochondrial Pathway in Non-small Cell Lung Cancer GLC-82 Cells


Jianye Zhang, Zhenzhu Lai, Wenjing Huang, Huiping Ling, Minting Lin, Sili Tang, Yun Liu and Yiwen Tao.


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Evaluation of the in vitro Chemosensitivity and Correlation with Clinical Outcomes in Lung Cancer using the ATP-TCA


Zhiyao Chen, Shichao Zhang, Sheng Ma, Chang Li, Chun Xu, Yinfang Shen, Jun Zhao and Liyan Miao.


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Synthesis of Novel Benzothiazole-Piperazine Derivatives and Their Biological Evaluation as Acetylcholinesterase Inhibitors and Cytotoxic Agents


Enise Ece Gurdal, Bengisu Turgutalp, Hayrettin Ozan Gulcan, Tugba Erçetin, Mustafa Fethi Sahin, Irem Durmaz, Rengul Cetin Atalay, Quoc Dat Nguyen, Wolfgang Sippl and Mine Yarim.


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Synthesis and Evaluation of Some Dibromoquinazoline-sulphonamide Hybrids and some Schiff´s Base Analogs for their Cytotoxic Activity


Marwa F. Ahmed and Radwan El-Haggar.


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The Evolutionary Tale and Future Directions of Aromatase Inhibitors in Breast Carcinoma


Dipanjan Bhattacharjee, Meena K. Kumari , S. Avin and Mohan V Babu Amberkar.


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Pharmacogenetics of Aromatase Inhibitors in Endocrine Responsive Breast Cancer: Lessons Learnt from Tamoxifen and CYP2D6 Genotyping


Karin Jeanne Baatjes, Magda Conradie, Justus Paul Apffelstaedt and Maritha Kotze.


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The Oxime Derivatives of 1-R-1H-Naphtho[2.3-d][1.2.3]triazole-4.9-dione 2-oxides: Synthesis and Properties


Alexander A. Shtil, Leonid M. Gornostaev, Vladimir B. Tsvetkov, Alina A. Markova, Tatyana I. Lavrikova, Yulia G. Khalyavina, Anastasia S. Kuznetsova, Dmitry N. Kaluzhny, Alexei V. Shunayev, Maria V. Tsvetkova, Valeria A. Glazunova and Vladimir V Chernyshev.


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Antitumor Activity of Copper (I)–Nicotinate Complex and Autophagy Modulation in HCC1806 Breast Cancer Cells


Mohamed A. Abdel-Mohsen, Eman S. El-Shafey, Camelia A Abdel Malak and Morsy M Abou-Yossef.


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1,3,4-Oxadiazoles as Telomerase Inhibitor: Potential Anticancer Agents


Shalini Bajaj, Partha Pratim Roy and Jagadish Singh.


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Anti-cancer Effect of Cyanidin-3-glucoside from Mulberry via Caspase-3 Cleavage and DNA Fragmentation in vitro and in vivo


Eugene Cho, Eun Yong Chung, Hye-Yeon Jang, On-Yu Hong, Hee Suk Chae, Young-Ju Jeong, Sun-Young Kim, Byeong-Soo Kim, Jong-Suk Kim and Kwang-Hyun Park.


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Enhancement of the Effect of Methyl Pyropheophorbide-a-Mediated Photodynamic Therapy was Achieved by Increasing ROS through Inhibition of Nrf2-HO-1 or Nrf2- ABCG2 Signaling


Si Tian, Min Yong, Jiang Zhu, Li Zhang, Li Pan, Qing Chen, Kai-Ting Li, Yu-Han Kong , Yuan Jiang, Ting-He Yu, Le-Hua Yu and Ding-Qun Bai.


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Synthesis of Novel Imine Stilbene Analogs Exhibiting Potent Anticancer Activity


Raju Naini, Ravikumar Eslavath , Singh S Surya, Rama Krishna Kancha, Venkateswara Rao Khareedu and Dashavantha Reddy Vudem.


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Eco-friendly Synthesis of Pyrido[2,3-d]pyrimidine Analogs and Their Anticancer and Tyrosine Kinase Inhibition Activities


Abeer. M. El-Naggar, Ali Khalil, Hala Zeidan and Wael M El-Sayed.


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Polo-Like Kinase 1 Pharmacological Inhibition as Monotherapy or in Combination: Comparative Effects of Polo-Like Kinase 1 Inhibition in Medulloblastoma Cells


Julia Alejandra Pezuk, Maria Sol Brassesco, Priscila Maria Manzini Ramos, Carlos Alberto Scrideli and Luiz Gonzaga Tone.


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β-lactam Structured, 4-(4-(Methylsulfonyl)phenyl)-1-pentyl-3-phenoxyazetidin-2-one: Selectively Targets Cancerous B Lymphocyte Mitochondria


Nahal Pirahmadi, Afshin Zarghi, Ahmad Salimi, Hadi Arefi and Jalal Pourahmad.


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Apoptotic Effects of Some Tetrahydronaphthalene Derivatives on K562 Human Chronic Myelogenous Leukemia Cell Line


Aslı Koç, Tulin Ozkan, Yalda Hekmatshoar, Ayse Selen Gurkan-Alp, Fugen Aktan, Zeliha Buyukbingol, Asuman Sunguroglu, Erdem Buyukbingol and Arzu Zeynep Karabay.


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Post-Transcriptional and Post-Translational Regulation of Central Carbon Metabolic Enzymes in Cancer


Yunqian Wang, Yingxuan Chen and Jingyuan Fang.


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Fluorescent Immortalized Human Adipose Derived Stromal Cells (hASCs-TS/GFP+) for Studying Cell Drug Delivery Mediated by Microvesicles


Valentina Coccè, Luigi Balducci, Maria Laura Falchetti, Luisa Pascucci, Emilio Ciusani, Anna Teresa Brini, Francesca Sisto, Giovanna Piovani, Giulio Alessandri, Eugenio Parati, Laura Cabeza and Augusto Pessina.


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Myc Decoy Oligodeoxynucleotide Inhibits Growth and Modulates Differentiation of Mouse Embryonic Stem Cells as a Model of Cancer Stem Cells


Behrooz Johari, Mina Ebrahimi-Rad, Faezeh Maghsood, Majid Lotfinia, Zohreh Saltanatpouri, Ladan Teimoori-Toolabi, Zahra Sharifzadeh, Morteza Karimipoor and Mehdi Kadivar.


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Design, Synthesis, and Biological Evaluation of Betulinic Acid Derivatives as New Antitumor Agents for Leukemia


Fernanda Waechter, Gloria Santos Silva, Julia Willig, Cristiane Bernardes de Oliveira, Bruna Domingues Vieira, Daniela Barreto Trivella, Aline Rigon Zimmer, Andréia Buffon, Diogo André Pilger and Simone Gnoatto.


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Progress of CDK4/6 Inhibitor Palbociclib in the Treatment of Cancer


Fengquan Chen, Jian Zhang, Wenfang Xu and Yingjie Zhang.


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Inhibitory Effects of Novel SphK2 Inhibitors on Migration of Cancer Cells


Euiyeon Lee, Junghyun Jung, Deokho Jung, Chang Soo Mok, Hyunjin Jeon, Chang Seo Park, Wonhee Jang and Youngeun Kwon.


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Synthesis and Cytotoxic Activities of Difluoro-Dimethoxy Chalcones


Cem Yamali, Halise Inci Gul, Dilan Ozmen Ozgun, Sakagami Sakagam Hiroshi, Naoki Umemura, Cavit Kazaz and Mustafa Gul.


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Novel Thiourea Derivatives Bearing Sulfonamide Moiety as Anticancer Agents Through COX-2 Inhibition


Mostafa M. Ghorab, Mohamed S.A. El-Gaby, Mansour S. Alsaid, Yaseen A.M.M. Elshaier, Aiten M. Soliman , Fardous F. El-Senduny and Farid A Badria.


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ECPIRM, a Potential Therapeutic Agent for Cutaneous T-Cell Lymphoma, Inhibits Cell Proliferation and Promotes Apoptosis via a JAK/STAT Pathway


Hua Yang, Pengcheng Ma, Yuping Cao, Mengli Zhang, Lingjun Li, Jun Wei, Lei Tao and Kun Qian.


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Evaluation of the Anticancer Activities of the Plant Alkaloids Sanguinarine and Chelerythrine in Human Breast Adenocarcinoma Cells


Igor Vivian Almeida, Liliane Menezes Fernandes, Bruna Isabela Biazi and Veronica Elisa Pimenta Vicentini.


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Pathological and Therapeutic Aspects of Long noncoding RNAs in osteosarcoma


Kaixiu Wang, Wei Jiang, Chao Cheng, Yusheng Li and Min Tu.


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May Adjuvant Therapy Play A Role for the Management of Renal Cell Carcinoma? A Review of Literature and Ongoing Trials


Carlo Messina, Elisa Zanardi and Francesco Boccardo.


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Ferulenol, a Sesquiterpene Coumarin, Induce Apoptosis via Mitochondrial Dysregulation in Lung Cancer Induced by Benzo[a]pyrene: Involvement of Bcl2 Protein


Nesrine Lariche, Mesbah Lahouel, Lamia Benguedouar and Amar Zellagui.


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Current Progresses in Metal-based Anticancer Complexes as Mammalian TrxR Inhibitors


Yizhe Cheng and Yan Qi.


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A Preliminary Study of the Action of Virtosomes from Non-dividing Cells on Tumour Cell Replication in vitro and in vivo


Mariano Garcia-Arranz, Damian Garcia-Olmo, Luz Vega-Clemente and Maurice Stroun.


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Colon Cancer and Specific Ways to Deliver Drugs to the Large Intestine


Hossein Derakhshankhah, Zhila Izadi, Alireza Lotfabadi, Loghman Alaei, Ali Akbar Saboury, Rassoul Dinarvand, Adeleh Divsalar, Arefeh Seyedarabi, Ebrahim Barzegari and Mina Evini.


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Topical Ingenol Mebutate: A New Treatment Modality for Multiple Actinic Keratoses and Field Cancerization


Kresimir Kostovic, Sandra Jerkovic Gulin, Zrinka Bukvic Mokos and Romana Ceovic.


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Fine Tuning Antibody Conjugation Methods using SNAP-tag Technology


Karinna Chouman, Mira Woitok, Radoslav Mladenov, Claudia Kessler, Elmar Weinhold, Gisela Hanz, Rainer Fischer, Ivo Meinhold-Heerlein, Andreas Bleilevens, Gerrit Gresch, Anka Maria Haugg, Felix Zeppernick, Dirk Bauerschlag, Nicolai Maass, Elmar Stickeler, Katharina Kolberg and Ahmad Fawzi Hussain.


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Improving the Hsp90 Inhibitors Containing 4-(2,4-Dihydroxyphenyl)-1,2,3- thiadiazole Scaffold: Synthesis, Affinity and Effect on Cancer Cells


Egidijus Kazlauskas, Algirdas Brukštus, Herkus Petrikas, Vilma Petrikaitė, Inga Čikotienė and Daumantas Matulis.


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The Effects of Nanoencapsulated Curcumin-Fe3O4 on Proliferation and hTERT Gene Expression in Lung Cancer Cells


Hadi Sadeghzadeh, Younes Pilehvar-Soltanahmadi, Abolfazl Akbarzadeh, Hassan Dariushnejad, Forough Sanjarian and Nosratollah Zarghami.


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Synthesis and Characterization of Two New Thiophene Acetyl Salicylic Acid Esters and their ortho- and para-effect on Anticancer Activity


Hakan Ünver and Zerrin Canturk.


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Synthesis and Characterization of Water-soluble Conjugates of Cabazitaxel Hemiesters-Dextran


Elahehnaz Parhizkar, Fatemeh Ahmadi, Saeid Daneshamouz, Soliman Mohammadi-Samani, Amirhossein Sakhteman and Golnaz Parhizgar.


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Tocilizumab Labeling with 99mTechnetium via HYNIC as a Molecular Diagnostic Agent for Multiple Myeloma


Ximena Camacho, Camila Longo Machado, Maria Fernanda García, Marcelo Fernández, Natalia Oddone, Juan Benech, Juan Pablo Gambini, Hugo Cerecetto, Roger Chammas, Pablo Cabral and Eloisa Riva.


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Congenital Malformations Attributed to Prenatal Exposure to Cyclophosphamide


Padmanabhan Rengasamy.


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Synthesis, EGFR Inhibition and Anti-cancer Activity of New 3,6-dimethyl-1-phenyl- 4-(substituted-methoxy)pyrazolo[3,4-d]pyrimidine Derivatives


Rania B. Bakr, Ahmed B. M. Mehany and Khaled R A Abdellatif.


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C-glycosyl Flavone from Urginea indica Inhibits Growth and Dissemination of Ehrlich Ascites Carcinoma Cells in Mice


Ganesh Babu Bevara, A.D Naveen Kumar, K Koteswramma Laxmi, Anil Kumar Badana, Seema Kumari, Nagendra Sastry Yarla and Rama Rao Malla.


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In Vitro Anticancer Evaluation of Platinum(II/IV) Complexes with Diisoamyl Ester of (S,S)-ethylenediamine-N,N’-di-2-propanoic Acid


Bojana B. Zmejkovski, Nebojša Pantelić, Lana Filipović, Sandra Aranđelović, Siniša Radulović, Tibor J. Sabo and Goran N Kaluđerović.


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Inhibition of Epithelial-mesenchymal Transition in Response to Treatment with Metformin and Y27632 in Breast Cancer Cell Lines


Camila Leonel, Lívia Carvalho Ferreira, Thaiz Ferraz Borin, Marina Gobbe Moschetta, Gabriela Scavacini Freitas, Michel Raineri Haddad, João Antonio de Camargos Pinto Robles and Debora Aparecida Pires de Campos Zuccari.


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Anticancer Activities of New N-hetaryl-2-cyanoacetamide Derivatives Incorporating 4,5,6,7-Tetrahydrobenzo[b]thiophene Moiety


Magda F. Mohamed, Yasmin M Attia, Samia A. Shouman and Ismail A Abdelhamid.


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Personalized Nanoparticles for Cancer Therapy: A Call for Greater Precision


Nare Sahakyan, Amir Haddad, Shye Richardson, Valery Forcha-Etieundem, Lee Christopher, Hanan Alharbi and Robert Campbell.


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Immune Checkpoints Aberrations and Malignant Mesothelioma: Assessment of Prognostic Value and Evaluation of Therapeutic Potentials


Hadeer Mohamed, Mostafa Eltobgy and Omar Abdel-Rahman.


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Inhibition of TGF-β Signaling in Tumor Cells by Small Molecule Src Family Kinase Inhibitors


Tobias Bartscht, Benjamin Rosien, Dirk Rades, Roland Kaufmann, Harald Biersack, Hendrik Lehnerta and Hendrik Ungefroren.


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Cytokine Status of Serum in Ovarian Cancer Patients with Different Tumor Neoadjuvant Chemotherapy Response


Inna I. Antoneeva, Tatyana V. Abakumova, Dinara R. Dolgova, Tatyana P. Gening, Sabina S. Pirmamedova, Dinara F. Myasnikova and Snezhanna O Gening.


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Targeting Leptin as a Therapeutic Strategy against Ovarian Cancer Peritoneal Metastasis


Xiao Wei, Yi Liu, Cheng Gong, Teng Ji, Xiaoshui Zhou, Taoran Zhang, Dongyi Wan, Sen Xu, Ping Jin, Xin Yang, Xiaoting Li, Ding Ma, Zongyuan Yang and Qinglei Gao.


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Design, Synthesis and Biological Evaluation of a Phenyl Butyric Acid Derivative, N-(4-chlorophenyl)-4-phenylbutanamide: A HDAC6 Inhibitor with Anti-proliferative Activity on Cervix Cancer and Leukemia Cells


Rodríguez-Fonseca Rolando Alberto, Sixto-López Yudibeth, Fragoso-Vázquez M. Jonathan, Flores-Mejía Raúl, Cabrera-Pérez Laura Cristina, Vázquez-Moctezuma Ismael, Rosales-Hernández Martha Cecilia, Bello Martiniano, M. Martínez-Archundia, Trujillo-Ferrara José Guadalupe, Becerra-Martínez Elvia and Correa-Basurto José.


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Cytotoxic, Antiproliferative and Apoptotic Effects of Perillyl Alcohol and Its Biotransformation Metabolite on A549 and HepG2 Cancer Cell Lines


Ceren E. Oturanel, İsmail Kıran, Özge Özşen, Gülşen A. Çiftçi and Özlem Atlı.


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Nano-Delivery in Pediatric Tumors: Looking Back, Moving Forward


Marta Colletti, Virginia Di Paolo, Angela Galardi, Giuseppe Maria Milano, Angela Mastronuzzi, Franco Locatelli and Angela Di Giannatale.


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Double Edge Sword Behavior of Carbendazim: A Potent Fungicide With Anti-Cancer Therapeutic Properties


Karan Goyal, Ajay Sharma, Ridhima Arya, Rohit Sharma, Girish K. Gupta and Anil K Sharma.


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The Effect of A Hexanoic Acid Linker Insertion on the Pharmacokinetics and Tumor Targeting Properties of the Melanoma Imaging Agent 99mTc-HYNIC-cycMSH


Vania Teixeira, Marcelo Fernández, Natalia Oddone, Xiuli Zhang, Fabio Gallazzi, Hugo Cerecetto, Juan Pablo Gambini, Williams Porcal, Pablo Cabral and Thomas P Quinn.


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Major Highlights of the CAR-TCR Summit, Boston, 2016


Vita Golubovskaya, Robert Berahovich, Shirley Xu, Hizkia Harto and Lijun Wu.


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Role of Azoles in Cancer Prevention and Treatment: Present and Future Perspectives


Khurshid Ahmad, Mohd Kalim A. Khan, Mohammad Hassan Baig, Mohd Imran and Girish Kumar Gupta.


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Novel Hybrid Molecules on the Basis of Steroids and (5Z,9Z)-Tetradeca-5,9-dienoic Acid: Synthesis, Anti-Cancer Studies and Human Topoisomerase I Inhibitory Activity


Vladimir A. D`yakonov, Lilya U. Dzhemileva, Regina A. Tuktarova, Svetlana R. Ishmukhametova, Milyausha M. Yunusbaeva, Ilfir R. Ramazanova and Usein M Dzhemilev.


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Anti-cancer Agents in Medicinal Chemistry Ring A-modified Derivatives from the Natural Triterpene 3-O-acetyl-11-keto-β-boswellic Acid and their Cytotoxic Activity


Tao Li, Peihong Fan, Yaqing Ye, Qian Luo and Hongxiang Lou.


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Novel [1,2,4] Triazol [4,3-a] pyridine Derivatives as Potential Selective c-Met Inhibitors with Improved Pharmacokinetic Properties


Junjun Zhao, Shaohua Gou, Xiaobing Zhang, Yan Liang and Lei Fang.


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FLT3 Inhibitors in the Management of Acute Myeloid Leukemia


Elisabetta Zappone, Marzia Defina, Lara Aprile, Alessandro Gozzetti, Giulia Bartalucci and Monica Bocchia.


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Recent Advancements In 1, 4-Disubstituted 1H-1,2,3-Triazoles As Potential Anticancer Agents


Kashmiri Lal and Pinki Yadav.


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Bruton Kinase Inhibitors in Chronic Lymphocytic Leukemia


Alessandro Gozzetti, Veronica Candi, Corrado Zuanelli Brambilla, Giulia Papini, Alberto Fabbri and Monica Bocchia.


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Preclinical Toxicity Evaluation of Paclitaxel Biopolymer Formulation


Nadezhda Pavlovna Ermakova, Anton Pavlovich Bonartsev, Anton Lavrentievich Zernov, Olga Ivanovna Konyaeva, Natalia Yurievna Kulbachevskaya, Irina Borisovna Merkulova, Tatiana Vladimirovna Abramovac, Vera Andreevna Chaley, Sergey Georgievich Yakovlev, Garina Alexandrovna Bonartseva, Konstantin Valdemarovich Shaitan and Vladimir Mikhailovich Bukhman.


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Retinoic acid Signaling in P19 Stem Cell Differentiation


Jyotshna Kanungo.


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The use of Azoles Containing Natural Products in Cancer Prevention and Treatment: An Overview


Nasimudeen R. Jabir, Chelapram K. Firoz, Ashish Bhushan, Shams Tabrez and Mohammad A Kamal.


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1, 3, 6-Trihydroxy-7-methyl-9, 10-anthracenedione isolated from genus Lindera with anti-cancer activity


Guoqing Wei, Hui Chen, Fangyuan Nie, Xiaofeng Ma and Hezhong Jiang.


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15,16-dihydrotanshinone I induces apoptosis and inhibits the proliferation, migration of human osteosarcoma cell line 143B in vitro


Xuepeng Chen, Qihong Li, Yan He, Hongjiang Du, Zhajun Zhan, Hong zhao, Jiejun Shi, Qingsong Ye and Ji'an Hu.


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Research Progress on the Antitumor Effects of Rhein: Literature Review


Chao Wu, Hongyan Cao, Hua Zhou, Lin Sun, Jingui Xue, Jianyuan Li, Yanqin Bian, Runfei Sun, Shu Dong, Ping Liu and Mingyu Sun.


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Synthesis and Anticancer Study of novel 4H-Chromen Derivatives


Xiaolin Lu, Gaochao Dong, Ying Zheng, Chao Zhang, Yang Qiu, Tao Lu and Xiang Zhou.


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Regulatory Approaches to Non-clinical Reproductive Toxicity Testing of Anti-Cancer Drugs.


Georg Schmitt and Paul Barrow.


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Histamine and Histaminergic Receptors in Colorectal Cancer: From Basic Science to Evidence-based Medicine


Giuseppe Losurdo, Mariabeatrice Principi, Bruna Girardi, Maria Pricci, Michele Barone, Enzo Ierardi and Alfredo Di Leo.


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Effects of Anticancer Drugs in Reproductive Parameters of Juvenile Male Animals and Role of Protective Agents


Juliana Elaine Perobelli.


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