ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)


Volume 12, 8 Issues, 2016


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Medicinal Chemistry

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Editor-in-Chief:
Atta-ur-Rahman
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: mc@benthamscience.org

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Upcoming Articles (E-Pub Abstracts ahead of Print)

Antimicrobial Activity of Synthesized 2-Methylthiobenzo[g][1,2,4]-triazolo[1,5-a]quinazoline Derivatives


Rashad Al-Salahi, Hatem A. Abuelizz, Mahasin Wadi, Rabab A. El Dib and Mohamed Marzouk.


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THREE ARACHIDONOYLAMIDE DERIVATIVES INHIBIT PRO-INFLAMMATORY GENES EXPRESSION BY MODULATING NF-κB AND AP1 ACTIVITIES


Alex Gregorelli, Anna Sgarbossa, Shahbaz Khan, Annunziata Soriente, Margherita De Rosa, Carmela Saturnino and Marta Menegazzi.


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Synthesis and Biological Evaluations of Cytotoxic and Antiangiogenic Triterpenoids-Jacaranone Conjugates


Hua Sun, Partick Y. K. Yue, Shao-Rong Wang, Lihong Huo, Ying Zhao, Songbo Xie, Jens Vindahl Kringelum, Ole Lund, Olivier Taboureau, Jun Zhou, Ricky N. S. Wong and Wei-Shuo Fang.


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New hopes in cancer battle - a review of new molecules and treatment strategies


Marika Turek, Magdalena Krzyczmonik and Piotr Bałczewski.


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Microwave Assisted Organic Synthesis of Heterocycles in Aqueous Media: Recent Advances in Medicinal Chemistry


Francesco Frecentese, Irene Saccone, Giuseppe Caliendo, Angela Corvino, Ferdinando Fiorino, Elisa Magli, Elisa Perissutti, Beatrice Severino and Vincenzo Santagada.


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Synthesis, Anticlotting and Antiplatelet Effects of 1,2,3-Triazoles Derivatives


Laura de Andrade Moura, Ana Carolina Marqui de Almeida, Andreza Vieira da Silva, Vivian Rodrigues de Souza, Vitor Francisco Ferreira, Michel Vieira Menezes, Carlos Roland Kaiser, Sabrina Baptista Ferreira and André Lopes Fuly.


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Synthesis of 1,4-disubstituted 1,2,3-triazole Derivatives Using Click Chemistry and their Src Kinase Activities


Alexandre Lebeau, Cyril Abrioux, David Bénimèlis, Zohra Benfodda and Patrick Meffre.


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Synergistic Effect of the Combination of Novel Suberoylanilide Hydroxamic Acid Derivatives with Cisplatin on Anti-proliferation of Human Cancer Cells


Rui Xie, Jinghua Shi, Chunhui Cheng, Fan Yun, Xia Liu, Pingwah Tang, Xinying Wu, Ming Yang and Qipeng Yuan.


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Synthesis and Biological Evaluation of N-Aryl-N’-(5-(2-hydroxybenzoyl)pyrimidin-2-yl)guanidines as Toll-Like Receptor 4 Antagonists Synthesis of Guanidine-Based TLR4 Antagonists


Matej Sova, Kaja Rožman, Urban Švajger, Primož Rožman and Stanislav Gobec.


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Integrated In Silico-In Vitro Discovery of Lung Cancer-related Tumor Pyruvate Kinase M2 (PKM2) Inhibitors


Xiangyun Ye, Yinjia Sun, Yunhua Xu, Zhiwei Chen and Shun Lu.


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Synthesis of cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) and evaluation of their antifungal potential


Dorimar Stiz, Rogério Corrêa, Felicia Diodata D'Auria, Giovanna Simonetti and Valdir Cechinel-Filho.


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An Evaluation on Different Machine Learning Algorithms for Classification and Prediction of Antifungal Peptides


Maryam Mousavizadegan and Hassan Mohabatkar.


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Cell-based Assays for Assessing Toxicity: A Basic Guide


Raveen Parboosing, Gugulethu Mzobe, Louis Chonco and Indres Moodley.


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Synthesis and Biological Activities of Lanthanide (III) Nitrate Complexes with N-(2-hydroxynaphthalen-1-yl) methylene) Nicotinohydrazide Schiff Base


Ahmed K. Hijazi, Ziyad A. Taha, Abdulaziz M. Ajlouni, Waleed M. Al-Momani, Idris M. Idris and Eman Abu Hamra.


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Synthesis and evaluation of phenyliminoindolin-containing phenylacetamide derivatives with the antidepressant and anticonvulsant effects


Li-Ping Guan, Bing-Yu Liu, Ying-Chun Quan, Li-Ye Yang, Xing-Hua Zhen and Si-Hong Wang.


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Synthesis, Antibacterial Activity, Interaction with Nucleobase and Molecular Docking Studies of 4-Formylbenzoic Acid Based Thiazoles


Krzysztof Z. Łączkowski, Anna Biernasiuk, Angelika Baranowska-Łączkowska, Konrad Misiura, Anna Malm, Tomasz Plech and Agata Paneth.


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Ether and carbamate derivatives of 3-quinuclidinol and 3-hydroxymethylquinuclidine: synthesis and evaluation as nicotinic ligands


Sivakumar Annadurai, Min Zhang, Jerome L. Gabriel, Merouane Bencheriff and Daniel J Canney.


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In-Vitro Anticancer Evaluation and Docking Study of Novel benzo[g] quinazoline-sulfonamide Derivatives


Mostafa M. Ghorab, Mansour S. Alsaid, Mohamed S. Al-Dosary and Marwa G El-Gazzar.


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Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives incorporating benzisoselenazolone scaffold as potential antitumor agents


Xiaoyun Fu, Sha Li, Fen Jing, Xuefeng Wang, Baolin Li, Jijun Zhao, Yuming Liu and Baoquan Chen.


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Efficient Synthesis and Discovery of Schiff Bases as Potent Cholinesterase Inhibitors


Basma M. Abd Razik, Hasnah Osman, Mohammed Oday Ezzat, Alireza Basiri, Abdussalam Salhin, Yalda Kia and Vikneswaran Murugaiyah.


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Nitazoxanide Analogues as Antimicrobial Agents against Nosocomial Pathogens


Jia-Suey Gau, Wen-Pao Lin, Li-Ching Kuo and Ming-Kuan Hu.


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Synthesis, in vivo anticoagulant evaluation and molecular docking studies of bicoumarins obtained from furocoumarin peucedanin


Alla V. Lipeeva, Mikhail V. Khvostov, Dmitry S. Baev, Makhmut M. Shakirov, Tatijana G. Tolstikova and Elvira E Shults.


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Biologically Active New N, N', N''-Tri-Substituted Ferrocenyl Phenylguanidines and their Characterization


Rukhsana Gul, Ataf Ali Altaf, Azim Khan, Amin Badshah, Afzal Shah, Zia ur Rehman, Rabia Naz, Muhammad Nawaz Tahir and Asif Junaid.


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Preliminary Studies on the Activity of Mixed Polyphenol-Heterocyclic systems against B16-F10 Melanoma Cancer Cells


Duc Duy Vo, Isabelle Rouaud, Francoise Le Devehat, Fabien Gautier, Sophie Barillé-Nion, Philippe Juin, Nicolas Levoin, Joël Boustie and René Grée.


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Competitive Interaction Between Plasma Omega-3 Fatty Acids and Arachidonic Acid is Related to Down-Regulation of A Signaling Mediator


Kunio Yui, George Imataka and Yohei Kawasaki.


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Synthesis, Biological Evaluation and Pharmacokinetic Studies of Mefenamic Acid - N-Hydroxymethylsuccinimide Ester Prodrug as Safer NSAID


Asif Husain, Priyanka Ahuja, Aftab Ahmad and Shah Alam Khan.


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Design, Synthesis and Antiproliferative Activity of Novel Benzothiazole Derivatives Conjugated with Semicarbazone Scaffold


Guanglong Bao, Baoquan Du, Yuxiu Ma, Meng Zhao, Ping Gong and Xin Zhai.


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Facing Chagas’ disease: trypanocidal properties of new coumarin-chalcone scaffolds


Saleta Vazquez-Rodriguez, Roberto Figueroa Guíñez, Maria João Matos, Claudio Olea-Azar, Juan Diego Maya, Eugenio Uriarte and Lourdes Santana.


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Identification of New Inhibitors for Human SIRT1: An in-silico Approach


Balasundaram Padmanabhan, Manjula Ramu, Sruti Mathur, Sruthi Unni and Saravanamuthu Thiyagarajan.


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The current use of mass spectrometry in combination with other separation techniques in drug discovery arena


Piotr Kawczak and Tomasz Bączek.


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Design, Synthesis, and Cytotoxicity of Novel 2,4,6-Trisubstituted 1,3,5-triazines Bearing Aryl Hydrazone Moiety as Potent Antitumor Agent


Limei Wang, Sijia Zhao, Guanglong Bao, Yu Zhang, Shuancheng Xi, Guolin Zhou, Xin Zhai and Ping Gong.


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Antiplasmodial Limonoids from Trichilia rubescens (Meliaceae)


Tsamo Tontsa Armelle, Nangmo Kemda Pamela, Mkounga Pierre, Ingrid B. Müller, Kirk Marat, Gabriele Sass and Nkengfack Augustin Ephrem.


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Discovery and optimization of 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-(amino)pyridin-3-yl)ureas as novel KDR kinase inhibitors


Yu Jiao, Fei Huang, Pengfei Xu, Yanmin Zhang, Shangyan Yang, Danfeng Zhang, Tao Lu and Weifang Tang.


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Antimicrobial and Anti-Biofilm Activity of Thiourea Derivatives Bearing 3-Amino-1H-1, 2, 4-Triazole Scaffold


Joanna Stefanska, Karolina Stepien, Anna Bielenica, Daniel Szulczyk, Barbara Miroslaw, Anna E Koziol, Giuseppina Sanna, Filippo Iuliano, Silvia Madeddu, Michal Jozwiak and Marta Struga.


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Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach


Engi A. Hassaan, Sara C. Sigler, Tamer M. Ibrahim, Kevin J. Lee, Lauren K. Cichon, Bernard D. Gary, Joshua C. Canzoneri, Gary A. Piazza and Ashraf HAbadi.


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Chemosensitization of prostate carcinoma cells with a receptor-directed Smac conjugate


Alexander Sturzu, Sumbla Sheikh, Hartmut Echner, Martin Deeg, Thomas Nägele, Christopher Weidenmaier, Christian Schwentner, Marius Horger, Ulrike Ernemann and Stefan Heckl.


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Synthesis, structural characterization of a novel ferrocene derivative and preliminarily anticancer activity


Jianping Yong, Xiaoyuan Wu, Jianzhen Liao, Canzhong Lu and Xiaolong Liu.


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Synthesis, Molecular Docking Study, and Cytotoxic Activity of 3,4-diaryl-5-(4-pyridinyl)-1,2,4-oxadiazole


Bita Zareian, Sajad Ghadbeighi, Amirali Amirhamzeh, Seyed Nasser Ostad, Abbas Shafiee and Mohsen Amini.


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DNA Hybridization on Chitosan-Functionalized Silicon Substrate


Amina Omar, El-Sayed M. El-Sayed, Mona S. Talaat and Medhat Ibrahim.


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Design, Synthesis and Structure-Activity Relationship Studies of Novel 4-(1-adamantyl) Phenyl Analogues as HIF-1α Inhibitors


Yan Xia, Qiong Duan, Bao-Hua Zhao, Dong-Feng Li and Rui-Bin Hou.


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Robust Modeling and Scaffold Hopping: Case Study based on HIV Reverse Transcriptase Inhibitors Type-1 Data


Girinath G. Pillai, Laznier Mederos, Chandramukhi S. Panda, Amber Gronski, Peeter Burk, C. Dennis Hall, Alan R. Katritzky, Kaido Tämm and Mati Karelson.


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The Brain Protective Effect of rTMS (Repetitive Transcranial Magnetic Stimulation) in Depression: A Mini-Review in Animal Studies


Burak Yulug, Lütfü Hanoglu, Ahmet Mithat Tavli, Nesrin Helvacı Yılmaz and Ertugrul Kılıc.


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Cytotoxic Effects of Salvinorin A, A Major Constituent of Salvia divinorum


Ana Martinho, Sara M. Silva and Eugenia Gallardo.


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QSRR and QSAR Studies of Antitumor Drugs In View of their Biological Activity Prediction


Paulina Szatkowska-Wandas, Marcin Koba, Grzegorz Smoliński and Jacek Wandas.


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Pharmacophore and QSAR Modeling of Neuronal Nitric Oxide Synthase Ligands and Subsequent Validation and In Silico Search for New Scaffolds


Ghadeer Suaifan, Mayadah Shehadeh, Hebah Al-Ijel, Khuloud Al-Jamal and Mutasem Taha.


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Monooxime Bispyridinium Reactivators Bearing Xylene Linker – Synthesis and In Vitro Evaluation on Model of Organophosphate-Inhibited Acetylcholinesterase


Kamil Musilek, Jan Hambalek, Ondrej Holas, Vlastimil Dohnal and Kamil Kuca.


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Synthesis and Anti-Thyroid Cancer Effect of Iodo-Chrysin Derivatives


Yun Wei, Qutong Zheng, Guotao Tang, Chen Song, Guan Wang, Yinxiang Zhang, Yan Xiao, Xianliang Zeng, Zongbao Wang, Jichang Xiao and Xing Zheng.


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Synthesis, in Vitro Biological Screening and Molecular Docking Studies of Novel Camphor Based Thiazoles


Krzysztof Z. Łączkowski, Konrad Misiura, Anna Biernasiuk, Anna Malm, Agata Siwek, Tomasz Plech, Emilia Ciok-Pater, Krzysztof Skowron and Eugenia Gospodarek.


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