ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)

Volume 16, 14 Issues, 2015

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Current Drug Targets

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  • 52nd of 254 in Pharmacology & Pharmacy

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Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556

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Upcoming Articles (E-Pub Abstracts ahead of Print)

T cell-activated signaling pathways and locally produced cytokines as potential targets in celiac disease
Aleksandra Piechota-Polańczyk, Maciej Sałaga and Ihor Huk
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Motility disorders, functional gastrointestinal disorders, inflammatory bowel disease and cardiac rhythm disturbances — is there a link? Review of literature
Michał Żorniak, Marek Walug and Marek Hartle
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Immunomodulatory Drugs: IMiDs in Acute Myeloid Leukemia (AML)
Joshua F. Zeidner and Matthew C. Foster
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Hemoglobin degradation pathway of Plasmodium falciparum as antimalarial drug target
Tabish Qidwai
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Do we need full donor chimerism? How alloreactive cell therapies without substantial engraftment might treat hematologic cancers
Elizabeth F. Krakow, Hui-Sheng Ai, Brian Shaffer, Jean-Sébastien Delisle, Kai-Xun Hu and Anthony D. Sung
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Nitroso-Redox Balance and Modulation of Basal Myocardial Function: an Update from the Italian Society of Cardiovascular Research (SIRC)
Carlo G Tocchetti, Marilisa Molinaro, Tommaso Angelone, Vincenzo Lionetti, Rosalinda Madonna, Fabio Mangiacapra, Francesco Moccia, Claudia Penna, Laura Sartiani, Federico Quaini and Pasquale Pagliaro
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Metformin for prevention and treatment of colon cancer: a reappraisal of experimental and clinical data
Vladimir N. Anisimov
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The Impact of Combination Therapy with a-Blockers and 5ARIs on the Progression of BPH
Petros Sountoulides
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Targeting the Multifaceted HuR Protein, Benefits and Caveats
Chiara Zucal, Vito D’Agostino, Rosa Loffredo, Barbara Mantelli, Natthakan Thongon, Preet Lal, Elisa Latorre and Alessandro Provenzani
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Primary Cilia in Tumor Biology: The Primary Cilium as a Therapeutic Target in Cholangiocarcinoma
Sergio A Gradilone, María J Lorenzo Pisarellob and Nicholas F LaRussob
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How to Manage Infections Caused by Antibiotic Resistant Gram-negative Bacteria - EBMT Educational Meeting from the Severe Aplastic Anaemia and Infectious Diseases Working Parties, Naples, Italy, 2014
Małgorzata Mikulska
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Docetaxel/2-Hydroxypropyl β-Cyclodextrin Inclusion Complex Increases Docetaxel Solubility and Release from a Nanochannel Drug Delivery System
Silvia Ferrati, Eugenia Nicolov, Shyam Bansal, Sharath Hosali, Melissa Landis and Alessandro Grattoni
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Molecular Bases Of Chemoresistance In Cholangiocarcinoma
J JG Marin, E Lozano, O Briz, R Al-Abdulla, M A Serrano and R IR Macias
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Discovery of Novel Anti-Diabetic Drugs by Targeting Lipid Metabolism
Xiu Zhou, Jun Xu, Yuguang Shi and Ye Ji-Ming
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Novel Antigen Targets for Immunotherapy of Acute Myeloid Leukemia
Meghali Goswami and Christopher S. Hourigan
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TNF Superfamily Protein–Protein Interactions: Feasibility of Small-Molecule Modulation
Yun Song and Peter Buchwald
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The Epidemiological, Mechanistic and Potential Clinical Role of AR in Urothelial Carcinoma
Maria T Bourlon, Thomas W Flaig, Division of Medical Oncology University of Colorado Cancer Center MS 8117, 12801 E. 17th Avenue, Room 8117 , Aurora and CO 80045
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Stem Cell Transplant from Unrelated Donor in Patients with Severe Aplastic Anemia: Indications, Donor Selection, Conditioning, GVHD Prophylaxis
Anna Paola Iori, Emilia Scalzulli, Laura Lombardi, Giovanni Fernando Torelli and Walter Barberi
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MicroRNAs in breast cancer: one More Turn in Regulation
P Eroles, E Tormo, B Pineda, E Espin and A Lluch
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Steps and Routes of HCV Infection: the Great Promise of new Anti-Viral Targets
Annalisa Crema, Antonio Ponzetto, Massimo Clementi and Guido Carloni
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The Genetic Basis of New Treatment Modalities in Melanoma
Manfred Kunz
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Predictive Diagnostic Pathology in the Target Therapy Era in Breast Cancer
Caterina Marchiò, Davide Balmativola, Roberta Castiglione, Laura Annaratone and Anna Sapino
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Multiscale Imaging of Nanoparticle Drug Delivery
Lawrence W. Dobrucki, Dipanjan Pan and Andrew M. Smith
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Antimicrobial and Antioxidant Properties of Satureja Montana L. and S. Subspicata Vis. (Lamiaceae)
Dario Kremer, Iztok Jože Košir, Marijana Zovko Končić, Andreja Čerenak, Tanja Potočnik, Siniša Srečec, Marko Randić and Ivan Kosalec
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Cardiovascular Complications In Inflammatory Bowel Disease
Rudolf Schicho, Gunther Marsche and Martin Storr
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Roles of Apoptosis and Cellular Senescence in Cancer and Aging
Claudia Cerella, Cindy Grandjenette, Mario Dicato and Marc Diederich
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"Penile Rehabilitation After Radical Prostatectomy"
David Jacques Cohen and Sidney Glina
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Aplastic Anemia: Alternative Immunosuppressive Treatments and Eltrombopag. A report from the 2014 EBMT Educational Meeting from the Severe Aplastic Anaemia and Infectious Diseases Working Parties
Antonio M Risitano
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The Role of JNK Signalling in Responses to Oxidative DNA Damage
Zeeshan Shaukat, Dawei Liu, Rashid Hussain, Mahwish Khan and Stephen L. Gregory
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Cardioprotection by Targeting the Pool of Resident and Extracardiac Progenitors
Konrad Urbanek, Caterina Frati, Gallia Graiani, Denise Madeddu, Angela Falco, Stefano Cavalli, Bruno Lorusso, Andrea Gervasi, Lucia Prezioso, Monia Savi, Francesca Ferraro, Federica Galaverna, Pietro Rossetti, Costanza Annamaria Lagrasta, R e Fancesca, Eugenio Quaini, Francesco Rossi, Antonella De Angelis and Federico Quaini
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(1→3)-α-D-Glucans from Aspergillus spp.: Structural Characterization and Biological Study on Their Carboxymethylated Derivatives
Adrian Wiater, Roman Paduch, Adam Choma, Stączek Sylwia, Małgorzata Pleszczyńska, Michał Tomczyk, Marcello Locatelli and Szczodrak Janusz
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The Impact of the Emerging Genomics Data on the Management of Age-Related Phenotypes in the Context of Cellular Senescence
Alberto Montesanto, Silvana Geracitano, Sabrina Garasto, Sergio Fusco, Fabrizia Lattanzio, Giuseppe Passarino and Andrea Corsonello
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Architectural Clones in Aplastic Anaemia- Lessons Learned from High Throughput Sequencing
Austin G Kulasekararaj and Judith C W Marsh
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Platelet Activity in the Pathophysiology of Inflammatory Bowel Diseases
Chunqiu Chen, Yongyu Li, Zhen Yu, Zhanju Liu, Yanhong Shi, Urszula Lewandowska, Marta Sobczak, Jakub Fichna and Martin Kreis
View Abstract
Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors
Cristina Campestre, Mariangela Agamennone, Marilena Tauro and Paolo Tortorella
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Ischemic Colitis: Current Diagnosis and Treatment
Paula Mosińska and Jakub Fichna
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Hyaluronic Acid as a Protein Polymeric Carrier: an Overview and a Report on Human Growth Hormone
Anna Mero, Monica Campisi, Michele Caputo, Christian Cuppari, Antonio Rosato, Oddone Schiavon and Gianfranco Pasut
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Protective Effect of Aronia Melanocarpa Polyphenols on Cadmium Accumulation in the Body: a Study in a Rat Model of Human Exposure to this Metal
Malgorzata M. Brzóska, Malgorzata Galażyn-Sidorczuk, Maria Jurczuk and Michal Tomczyk
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OPA1 in Cardiovascular Health and Disease
N Burke, A R Hall and D J Hausenloy
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Recent Advances in Optical Molecular Imaging and its Applications in Targeted Drug Delivery
Xibo Ma, Hui Hui, Wenting Shang, Xiaohua Jia and Jie Tian
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Matched Sibling Donor Hematopoietic Stem Cell Transplant in Patients with Acquired Aplastic Anemia
André Tichelli and Jakob R. Passweg
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Indoxyl Sulfate: a Candidate Target for the Prevention and Treatment of Cardiovascular Disease in Chronic Kidney Disease
Chiara Barisione, Giorgio Ghigliotti, Marco Canepa, Manrico Balbi, Claudio Brunelli and Pietro Ameri
View Abstract
Molecular Imaging of Therapeutic Potential of Reporter Probes
Bhushan Thakur, Subhoshree Chatterjee, Smrita Chaudhury and Pritha Ray
View Abstract
Intracellular Ca2+ Signals to Reconstruct a Broken Heart: Still a Theoretical Approach?
Francesco Moccia, Federico Alessandro Ruffinatti and Estella Zuccolo
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Aquaporin-1 and Sodium-Hydrogen Exchangers as Pharmacological Targets in Diabetic Atherosclerosis
Rosalinda Madonna and Raffaele De Caterina
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Micrornas As Tools And Effectors For Patient Treatment In Gastrointestinal Carcinogenesis
Edoardo D`Angelo, Caterina Vicentini, Marco Agostini, Andras Kiss, Raffaele Baffa, Aldo Scarpa and Matteo Fassan
View Abstract
Image Guidance in Stem Cell Therapeutics: Unfolding the Blindfold
Amirali B. Bukhari, Shruti Dutta and Abhijit De
View Abstract
Aqueous Extracts of Selected Potentilla Species Modulate Biological Activity of Human Normal Colon Cells
Roman Paduch, Adrian Wiater, Marcello Locatelli, Małgorzata Pleszczyńska and Michał Tomczyk
View Abstract
Stem cell aging and age-related cardiovascular disease: Perspectives of treatment by ex-vivo stem cell rejuvenation
Madonna Rosalinda, Engel B. Felix, M Davidson Sean, Ferdinandy Péter, Görbe Anikó, P.G. Sluijter Joost and W Van Laake Linda
View Abstract
Immobilization and Detection Strategies for Multifunctional Glycochips
Gangliang Huang, Qilin Tang and Xin Chen
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The Activated Endocannabinoid System in Atherosclerosis: Driving Force or Protective Mechanism?
Sabine Steffens and Pál Pacher
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Personalized Drug Therapy in Cystic Fibrosis: From Fiction to Reality
Fernando Augusto de Lima Marson, Carmen Silvia Bertuzzo and Jose Dirceu Ribeiro
View Abstract
Hedgehog signaling and urological cancers
Katsumi Shigemura and Masato Fujisawa
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Auto-antibodies as possible markers and mediators of ischemic, dilated, and rhythmic cardiopathies.
Nathalie Satta and Nicolas Vuilleumier
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Biomedical Imaging in Implantable Drug Delivery Systems
Haoyan Zhou, Christopher Hernandez, Monika Goss, Anna Gawlik and Agata A. Exner
View Abstract
Bioactive Food Components as Dietary Intervention for Cystic Fibrosis
Nualpun Sirinupong and Zhe Yang
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Polymeric Aggregates in Ionic Liquids: the Green Future of the Delivery Systems
Guido Angelini and Carla Gasbarri
View Abstract
Molecular Pathophysiology of Priapism: Emerging Targets
Uzoma A. Anele, Belinda F. Morrison and Arthur L. Burnett
View Abstract
The role of adipocytokines in atherogenesis and atheroprogression
Federico Carbone, François Mach and Fabrizio Montecucco
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Prevention and therapeutic strategies of thromboembolic events in patients with inflammatory bowel diseases: a report of three cases
Marcin Włodarczyk, Aleksandra Sobolewska, Jakub Fichna and Maria Wiśniewska-Jarosińska
View Abstract
Proteomic profiling of a biomimetic drug delivery platform
Claudia Corbo, Alessandro Parodi, Michael Evangelopoulos, David A. Engler, Risë K. Matsunami, Anthony C. Engler, Roberto Molinaro, Shilpa Scaria, Francesco Salvatore and Ennio Tasciotti
View Abstract
CYLD-Mediated Signaling and Diseases
Bryan J. Mathis, Yimu Lai, Chen Qu, Joseph S. Janicki and Taixing Cui
View Abstract
Preparation of Multifunctional Nanoprobes for Tumor-Targeted Fluorescent Imaging and Therapy
Mi Zhou, Xiao Xiao, Adnan A. Kadi, Hoong-kun Fun, Jinbo Li and Yan Zhang
View Abstract
Multistage Nanovectors Enhance the Delivery of Free and Encapsulated Drugs
Jonathan O. Martinez, Michael Evangelopoulos, Rohan Bhavane, Stefania Acciardo, Francesco Salvatore, Xuewu Liu, Mauro Ferrari and Ennio Tasciotti
View Abstract
Systemic Delivery of Free Chitosan Accelerates Femur Fracture Healing in Rats
Peng Shao, Yongzhong Wei, Crispin R. Dass, Guoying Zhang and Zhisheng Wu
View Abstract
Image-Guided Drug Delivery with Single-Photon Emission Computed Tomography: A Review of Literature
Rubel Chakravarty, Hao Hong and Weibo Cai
View Abstract
Silencing of Tumor Necrosis Factor Receptor-1 in Human Lung Microvascular Endothelial Cells using Particle Platforms for siRNA Delivery
Litao Bai, Helen A. Andersson, Kellie McConnell, Diana Chan, Michael Hernandez, Javier Gonzalez, Xuewu Liu, Saverio La Francesca, Jason Sakamoto and Rita E. Serda
View Abstract
Penetration Enhancer-Containing Vesicles: Does the Penetration Enhancer Structure Affect Topical Drug Delivery?
Anna Maria Fadda
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Supramolecular Nanomedicine - An Overview
Bhupinder Singh Sekhon
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αIIbβ3-Integrin Ligands: Abciximab and Eptifibatide as Proapoptotic Factors in MCF-7 Human Breast Cancer Cells
Joanna Kononczuk, Arkadiusz Surazynski, Urszula Czyzewska, Izabela Prokop, Michal Tomczyk, Jerzy Palka and Wojciech Miltyk
View Abstract
Safety of Nanoparticles in Medicine
Joy Wolfram, Motao Zhu, Yong Yang, Jianliang Shen, Emanuela Gentile, Donatella Paolino, Massimo Fresta, Guangjun Nie, Chunying Chen, Haifa Shen, Mauro Ferrari and Yuliang Zhao
View Abstract
Non-small Cell Lung Carcinoma: An Overview on Targeted Therapy
Ana Vanessa Nascimento, Hassan Bousbaa, Domingos Ferreira and Bruno Sarmento
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Genomic identification of potential targets unique to Candida albicans for the discovery of antifungal agent
Himanshu Tripathi, Suaib Luqman, Abha Meena and Feroz Khan
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A Review on Skin Targeted Delivery of Bioactives as 2 Ultradeformable Vesicles: Overcoming the Penetration Problem
Priyanka Karunanidhi and Singh Sanjay
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Editorial:Mirnas as Legitimate Targets for Cancer Therapy
Wang Z
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