ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)


Volume 16, 14 Issues, 2015


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Current Drug Targets

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  • 77th of 254 in Pharmacology & Pharmacy

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Editor-in-Chief:
Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA


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Current: 3.021
5 - Year: 3.260

Upcoming Articles (E-Pub Abstracts ahead of Print)

Targeting the Eph-ephrin system with protein-protein interaction (PPI) inhibitors


Massimiliano Tognolini and Alessio Lodola.


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Targeting α7 nicotinic acetylcholine receptor to combat inflammation in cardio-cerebral-vascular diseases


Hui Fu, Min Ni, Ji-Kuai Chen, Ting Zhao, Ya-Ping Deng, Dong-Jie Li, Guo-Jun Jiang and Fu-Ming Shen.


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HIV gp120: a target for therapeutics and vaccine design.


C Cicala, F Nawaz, K Jelicic, J Arthos and Fauci AS.


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CD6 as a cell surface receptor and as a target for regulating immune responses.


Marion H Brown.


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PLK1 INHIBITION: PROSPECTIVE ROLE FOR THE TREATMENT OF PEDIATRIC TUMORS


Julia Alejandra Pezuk, Elvis Terci Valera and María Sol Brassesco.


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Structure-Function Relationships of Class D Carbapenemases


Jean-Denis Docquier and Stefano Mangani.


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Renin-Angiotensin-Aldosterone System: A Current Drug Target for the Management of Neuropathic Pain


Arunachalam Muthuraman and Parneet Kaur.


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Human Immunodeficiency Virus-1 Cell-To-Cell Transmission And Antiviral Strategies: An Overview.


Nicoletta Casartelli.


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Potential Role of (-)-epigallocatechin-3-gallate (EGCG) in the Secondary Prevention of Alzheimer Disease


Laura Xicota, Jose Rodríguez-Morató, Mara Dierssen and Rafael de la Torre.


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Molecular Mechanisms of Cholangiocarcinogenesis: New Potential Targets For Therapy


Oihane Erice, Maite Merino-Azpitarte, Ander Arbelaiz, María Gutierrez-Larranaga, Raúl Jiménez-Agüero, María J. Perugorria, Luis Bujanda and Jesús M Banales.


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The key role of canonical Wnt/β-catenin signaling in cartilage chondrocytes


Xiaoliang Yuan, Haiqing Liu, Hao Huang, Hai Liu, Linfu Li, Jianqiong Yang, Weimei Shi, Weiyou Liu and Longhuo Wu.


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Treatment of HCV-related mixed cryoglobulinemia


Dilia Giuggioli, Marco Sebastiani, Michele Colaci, Poupak Fallahi, Laura Gragnani, Anna Linda Zignego, Alessandro Antonelli and Clodoveo Ferri.


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DOCKING STUDIES FOR MULTI-TARGET DRUGS


L. Scotti, F.J.B. Mendonça Júnior, H. Ishiki, F.F. Ribeiro, Singla Rajeev K, J.M. Barbosa Filho, M.S. Da Silva and MT Scotti.


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Identifying Novel Targets for Treatment of Liver Fibrosis: What Can We Learn from Injured Tissues which Heal Without a Scar?


Michele T. Pritchard and Jennifer M McCracken.


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Direct-acting antivirals for hepatitis C virus (HCV): The progress continues


Jordan J Feld.


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HIV-1 matrix protein p17 and its receptors


Francesca Caccuri, Stefania Marsico, Simona Fiorentini, Arnaldo Caruso and Cinzia Giagulli.


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HIV-1 TAT and IMMUNE DYSREGULATION in AIDS PATHOGENESIS: a THERAPEUTIC TARGET


Chiara Chiozzini and Elena Toschi.


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Innate and Adaptive Immune Responses in Chronic HCV infection


Lynn B Dustin.


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NEW PERSPECTIVES IN THE PHARMACOLOGICAL TREATMENT OF NON-MELANOMA SKIN CANCER


Paola Savoia, Ottavio Cremona and Paolo Fava.


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How Current Direct-Acting Antiviral and Novel Cell Culture Systems for HCV are Shaping Therapy and Molecular Diagnosis of Chronic HCV Infection


Fabrizio Maggi, Daniele Focosi and Mauro Pistello.


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The current indications and the benefits of combining a β3-agonist with an anticholinergic for the treatment of OAB


Cosimo De Nunzio, Fabrizio Presicce, Luisella Pirozzi, Castellan Pietro, Luigi Schips, Luca Cindolo, Riccardo Lombardo and Andrea Tubaro.


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New antimicrobial approaches: reuse of old drugs.


Dianella Savoia.


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Is Intake of Flavonoid-based Food Supplements during Pregnancy Safe for the Developing Child? A Literature Review.


Marta Barenys, Stefan Masjosthusmann and Ellen Fritsche.


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Molecular Pharmacology of Malignant Pleural Mesothelioma: Challenges and Perspectives from Preclinical and Clinical Studies


Stefano Thellung, Roberto E. Favoni, Roberto Wurth, Mario Nizzari, Alessandra Pattarozzi, Antonio Daga, Tullio Florio and Federica Barbieri.


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Targeting interferon regulatory factor for cardiometabolic diseases: opportunities and challenges


Zhang Yaxing, Zhang Xiao-Jing and Li Hongliang.


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Nano-based Anti-tubercular Drug Delivery and Therapeutic Interventions in Tuberculosis


Rohit Sharma, Amanpreet Kaur, A.K. Sharma, Neeraj Dilbaghi and Anil K Sharma.


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Chemokines in the pathogenesis and as therapeutical markers and targets of HCV chronic infection, and HCV extrahepatic manifestations


Poupak Fallahi, Silvia Martina Ferrari, Dilia Giuggioli, Marco Sebastiani, Michele Colaci, Clodoveo Ferri and Alessandro Antonelli.


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Impairment of Liver Glycogen Storage in the db/db Animal Model of Type 2 Diabetes: a Potential Target for Future Therapeutics?


Mitchell A. Sullivan, Brooke E. Harcourt, Ping Xu, Josephine M. Forbes and Robert G Gilbert.


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Phospholipase A2 Isoforms as Novel Targets for Prevention and Treatment of Inflammatory and Oncologic Diseases


Nagendra Sastry Yarla, Anupam Bishayee, Lakshmipathi Vadlakonda, Ramakrishna Chintala, Govinda Rao Duddukuri, Pallu Reddanna and DSVGK Kaladhar.


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Targeting the Eph System with Peptides and Peptide Conjugates


Stefan J. Riedl and Elena B Pasquale.


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HDL as a Target for Glycemic Control


Boris Waldman, Alicia J. Jenkins, David Sullivan, Martin K.C. Ng and Anthony C Keech.


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ALDH2---the Genetic Polymorphism and Enzymatic Activity Regulation: Their Epidemiologic and Clinical Implications


Rui Zhang, Jiali Wang, Mengyang Xue, Feng Xu and Yuguo Chen.


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VIRTUAL SCREENING FOR THE DEVELOPMENT OF DUAL-INHIBITORS TARGETING TOPOISOMERASE IB AND TYROSYL-DNA PHOSPHODIESTERASE 1


Francesca Cardamone, Simone Pizzi, Federico Iacovelli, Mattia Falconi and Alessandro Desideri.


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Nanocarriers based anticancer drugs: current scenario and future perceptions Rakesh Raj٭, Pooja Mongia, Suresh Kumar Sahu and Alpana Ram


Rakesh Raj, Pooja Mongia, Suresh Kumar Sahu and Alpana Ram.


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Can Targeting the Incretin Pathway Dampen RAGE-Mediated Events In Diabetic Nephropathy?


Karly C. Sourris, Henry Yao, George Jerums, Mark E. Cooper, Elif I. Ekinci and Melinda T Coughlan.


View Abstract


THE USE OF MESENCHYMAL STEM CELLS FOR THE TREATMENT OF AUTOIMMUNITY: FROM ANIMALS MODELS TO HUMAN DISEASE


Alessandra Fierabracci, Andrea Del Fattore, Marta Muraca, Domenico Vittorio Delfino and Maurizio Muraca.


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Silencing of tumor necrosis factor receptor-1 in human lung microvascular endothelial cells using particle platforms for siRNA delivery


Litao Bai, Helen A. Andersson, Kellie McConnell, Diana Chan, Michael Hernandez, Javier Gonzalez, Xuewu Liu, Saverio La Francesca, Jason Sakamoto and Rita E Serda.


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CXCL8 as a Potential Therapeutic Target for HIV-Associated Neurocognitive Disorders


Manmeet K. Mamik and Anuja Ghorpade.


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Wnt Signaling in Rhabdomyosarcoma – a Potential Targeted Therapy Option


Eleanor Chen.


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SIRT1 as a promising novel therapeutic target for myocardial ischemia reperfusion injury and cardiometabolic disease


Dong Han, Jinda Wang, Sai Ma, Yundai Chen and Feng Cao.


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Release of Soluble Ligands for the Activating NKG2D Receptor: One More Immune Evasion Strategy Evolved by HIV-1 ?


Erica Giuliani, Lia Vassena, Cristina Cerboni and Margherita Doria.


View Abstract


Targeting TNF-alpha in HIV-1 infection


Amit Kumar, Laurie Coquard and Georges Herbein.


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Structural and Functional Aspects of Extended-Spectrum AmpC cephalosporinases


Rachel A Powers.


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HIV-1 Tat-mediated calcium dysregulation and neuronal dysfunction in vulnerable brain regions


Xiu-Ti Hu.


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Antioxidant and antimicrobial properties of Veronica spicata L. (Plantaginaceae)


Valerija Dunkić, Ivan Kosalec, Iztok Joze Kosir, Tanja Potocnik, Andreja Cerenak, Marijana Zovko Koncic, Dubravka Vitali, Ivna Dragojevic Muller, Martina Kopricanec, Nada Bezic, Sinisa Srecec and Dario Kremer.


View Abstract


Microscopies at the nanoscale for nano-scale drug delivery systems


Luciana Dini, Elisa Panzarini, Stefania Mariano, Daniele Passeri, Melania Reggente, Marco Rossi and Cristian Vergallo.


View Abstract


Natural Products on Nonalcoholic Fatty Liver Disease


Jiao-Ya Xu, Li Zhang, Zhong-Ping Li and Guang Ji.


View Abstract


Eph receptors as drug targets: single-chain antibodies and beyond


Urpo Lamminmäki, Dimitar Nikolov and Juha Himanen.


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Tuning T cell activation: the function of CD6 at the immunological synapse and in T cell responses


Rita F. Santos, Liliana Oliveira and Alexandre M Carmo.


View Abstract


Chronic exposure to low-level cadmium in diabetes: role of oxidative stress and comparison with polychlorinated biphenyls.


Adeline Jacquet, Faycal Ounnas, Marine Lenon, Josiane Arnaud, Christine Demeilliers and Jean-Marc Moulis.


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Perspectives on membrane-associated progesterone receptors as prospective therapeutic targets


Sae Hasegawa, Mayu Kasubuchi, Kazuya Terasawa and Ikuo Kimura.


View Abstract


ISCHEMIRs: Finding a way through the obstructed cerebral arteries


Sreekala S. Nampoothiri, Hari Vinayak Menon, Debashish Das and Rajanikant G K.


View Abstract


Antimuscarinics in the treatment of OAB: is there a first-line and a second-line choice?


Apostolos Apostolidis.


View Abstract


Endogenous retroelements in cellular senescence and related pathogenic processes: promising drug targets in age-related diseases.


Maurizio Cardelli, Robertina Giacconi, Marco Malavolta and Mauro Provinciali.


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An integrative review on role and mechanisms of ghrelin in stress, anxiety and depression


Anjana Bali and Amteshwar Singh Jaggi.


View Abstract


Antioxidants as a Potential Preventive and Therapeutic Strategy for Cadmium


Malgorzata M. Brzóska, Sylwia Borowska and Michal Tomczyk.


View Abstract


Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth The Anticarcinogenic Mechanisms of Regeneration


An-Sofie Stevens, Nicky Pirotte, Annelies Wouters, Andromeda Van Roten, Frank Van Belleghem, Maxime Willems, Ann Cuypers, Tom Artois and Karen Smeets.


View Abstract


Gastric Carcinoma at the Era of Targeted Therapies


Johann DREANIC, Marion DHOOGE, Elena SION, Catherine BREZAULT, Stanislas CHAUSSADE and Romain CORIAT.


View Abstract


Current Perspectives on Novel Drug Delivery Systems and Approaches for Management of Cervical Cancer: A Comprehensive Review


Umme Hani, Riyaz Ali M Osmani, Rohit R Bhosale, Parthasarathi K. Kulkarni and Hosakote G Shivakumar.


View Abstract


Interfering with Hedgehog Pathway: New Avenues for Targeted Therapy in Rhabdomyosarcoma


Gabriele Manzella and Beat W Schäfer.


View Abstract


A Review of Pharmacological Treatment Options for Lung Cancer: Emphasis on Novel Nanotherapeutics and Associated Toxicity


Christopher G. England, Chin F. Ng, Victor van Berkel and Hermann B Frieboes.


View Abstract


Antioxidant Mechanisms in Nonalcoholic Fatty Liver Disease


Liu Wensheng, Susan S Baker, Robert D Baker and Lixin Zhu.


View Abstract


New advances in the molecular mechanisms driving biliary fibrosis and emerging molecular targets


A Santos-Laso, P Munoz-Garrido, M Felipe-Agirre, L Bujanda, J M Banales and M J Perugorria.


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Nanoparticles-Based Treatment for Bone Metastasis


Rossana Saracino, Rosa Luciano, Giulia Battafarano, Antonio Perrotta, Maurizio Muraca and Andrea Del Fattore.


View Abstract


Targeted drug delivery for cardiovascular and cerebrovascular diseases


Jingjing Luan and Guangxi Zhai.


View Abstract


Doxorubicin action on mitochondria: relevance to osteosarcoma therapy?


Jo Armstrong and Crispin R Dass.


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Endoplasmic Reticulum Stress, Calcium Dysregulation and Altered Protein Translation: Intersection of Processes that Contribute to Cancer Cachexia Induced Skeletal Muscle Wasting


S. T. Isaac, T. C. Tan and P Polly.


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Cancellers - Exploring the Possibility of Receptor Decoy Traps as a Superior Anti-Retroviral Strategy


Sundararaj Stanley Jeremiah, Kenji Ohba and Naoki Yamamoto.


View Abstract


Pharmacological interference with protein-protein interactions of A-kinase anchoring proteins as a strategy for the treatment of disease


Veronika A. Deak and Enno Klussmann.


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Bridging the Gap: The Potential Role of Corticosteroid Binding Globulin in Cardiac Steroid Facilitation


Hans Hendrik Schäfer, Thomas Dieterle, Aaron Trachsler, Mikael Gencay and Edelgard Anna Kaiser.


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Identification of Lipid Species Linked to the Progression of Non-alcoholic Fatty Liver Disease


Yuki Kawano, Shin Nishiumi, Masaya Saito, Yoshihiko Yano, Takeshi Azuma and Masaru Yoshida.


View Abstract


ABC transporter inhibitors in reversing multidrug resistance to chemotherapy


Haigang Cui, Anna J. Zhang, Mingwei Chen and Johnson J Liu.


View Abstract


Lipophilic statins as anticancer agents: molecular targeted actions and proposal in advanced gynaecological malignancies.


Salvatore Gizzo, M.D, Michela Quaranta, M.D, Giovanni Battista Nardelli, M.D. & Marco Noventa and MD.


View Abstract


A Comprehensive Review on miR-200c, a Promising Cancer Biomarker with Therapeutic Potential


Suresh Kumar, Alo Nag and Chandi C Mandal.


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MicroRNAs and the Response of Prostate Cancer to Anti-Cancer Drugs


Marzia Pennati, Marco Folini, Paolo Gandellini and Nadia Zaffaroni.


View Abstract


Nano Traditional Chinese Medicine: Current Progresses and Future Challenges


Songqing Liu, Y i Huang, Fang Liu and Yinglan Zhao.


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Dormant Circulating Tumor Cells In Prostate Cancer: Biological, Clinical And Therapeutic Implications


M. J. Alvarez-Cubero, F Vázquez-Alonso, I Puche-Sanz, F. G. Ortega, M. Martin-Prieto, J L Garcia-Puche, M. Pascual-Geler, J A. Lorente, J. M. Cozar-Olmo and M J Serrano-Fernández.


View Abstract


Mini Review: Pathophysiology of Erectile Dysfunction


Hotaka Matsui, Nikolai A. Sopko, Johanna L. Hannan and Trinity J Bivalacqua.


View Abstract


Hemoglobin degradation pathway of Plasmodium falciparum as antimalarial drug target


Tabish Qidwai.


View Abstract


Do we need full donor chimerism? How alloreactive cell therapies without substantial engraftment might treat hematologic cancers


Elizabeth F. Krakow, Hui-Sheng Ai, Brian Shaffer, Jean-Sébastien Delisle, Kai-Xun Hu and Anthony D Sung.


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The Impact of Combination Therapy with a-Blockers and 5ARIs on the Progression of BPH


Petros Sountoulides.


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Primary Cilia in Tumor Biology: The Primary Cilium as a Therapeutic Target in Cholangiocarcinoma


Sergio A Gradilone, María J Lorenzo Pisarellob and Nicholas F LaRussob.


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Docetaxel/2-Hydroxypropyl β-Cyclodextrin Inclusion Complex Increases Docetaxel Solubility and Release from a Nanochannel Drug Delivery System


Silvia Ferrati, Eugenia Nicolov, Shyam Bansal, Sharath Hosali, Melissa Landis and Alessandro Grattoni.


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Molecular Bases Of Chemoresistance In Cholangiocarcinoma


J JG Marin, E Lozano, O Briz, R Al-Abdulla, M A Serrano and R IR Macias.


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MicroRNAs in breast cancer: one More Turn in Regulation


P Eroles, E Tormo, B Pineda, E Espin and A Lluch.


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Antimicrobial and Antioxidant Properties of Satureja Montana L. and S. Subspicata Vis. (Lamiaceae)


Dario Kremer, Iztok Jože Košir, Marijana Zovko Končić, Andreja Čerenak, Tanja Potočnik, Siniša Srečec, Marko Randić and Ivan Kosalec.


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Roles of Apoptosis and Cellular Senescence in Cancer and Aging


Claudia Cerella, Cindy Grandjenette, Mario Dicato and Marc Diederich.


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The Role of JNK Signalling in Responses to Oxidative DNA Damage


Zeeshan Shaukat, Dawei Liu, Rashid Hussain, Mahwish Khan and Stephen L Gregory.


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(1→3)-α-D-Glucans from Aspergillus spp.: Structural Characterization and Biological Study on Their Carboxymethylated Derivatives


Adrian Wiater, Roman Paduch, Adam Choma, Stączek Sylwia, Małgorzata Pleszczyńska, Michał Tomczyk, Marcello Locatelli and Szczodrak Janusz.


View Abstract


The Impact of the Emerging Genomics Data on the Management of Age-Related Phenotypes in the Context of Cellular Senescence


Alberto Montesanto, Silvana Geracitano, Sabrina Garasto, Sergio Fusco, Fabrizia Lattanzio, Giuseppe Passarino and Andrea Corsonello.


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Architectural Clones in Aplastic Anaemia- Lessons Learned from High Throughput Sequencing


Austin G Kulasekararaj and Judith C W Marsh.


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Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors


Cristina Campestre, Mariangela Agamennone, Marilena Tauro and Paolo Tortorella.


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Hyaluronic Acid as a Protein Polymeric Carrier: an Overview and a Report on Human Growth Hormone


Anna Mero, Monica Campisi, Michele Caputo, Christian Cuppari, Antonio Rosato, Oddone Schiavon and Gianfranco Pasut.


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Protective Effect of Aronia Melanocarpa Polyphenols on Cadmium Accumulation in the Body: a Study in a Rat Model of Human Exposure to this Metal


Malgorzata M. Brzóska, Malgorzata Galażyn-Sidorczuk, Maria Jurczuk and Michal Tomczyk.


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Matched Sibling Donor Hematopoietic Stem Cell Transplant in Patients with Acquired Aplastic Anemia


André Tichelli and Jakob R Passweg.


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Aqueous Extracts of Selected Potentilla Species Modulate Biological Activity of Human Normal Colon Cells


Roman Paduch, Adrian Wiater, Marcello Locatelli, Małgorzata Pleszczyńska and Michał Tomczyk.


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Polymeric Aggregates in Ionic Liquids: the Green Future of the Delivery Systems


Guido Angelini and Carla Gasbarri.


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Proteomic profiling of a biomimetic drug delivery platform


Claudia Corbo, Alessandro Parodi, Michael Evangelopoulos, David A. Engler, Risë K. Matsunami, Anthony C. Engler, Roberto Molinaro, Shilpa Scaria, Francesco Salvatore and Ennio Tasciotti.


View Abstract


Multistage Nanovectors Enhance the Delivery of Free and Encapsulated Drugs


Jonathan O. Martinez, Michael Evangelopoulos, Rohan Bhavane, Stefania Acciardo, Francesco Salvatore, Xuewu Liu, Mauro Ferrari and Ennio Tasciotti.


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Systemic Delivery of Free Chitosan Accelerates Femur Fracture Healing in Rats


Peng Shao, Yongzhong Wei, Crispin R. Dass, Guoying Zhang and Zhisheng Wu.


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Silencing of Tumor Necrosis Factor Receptor-1 in Human Lung Microvascular Endothelial Cells using Particle Platforms for siRNA Delivery


Litao Bai, Helen A. Andersson, Kellie McConnell, Diana Chan, Michael Hernandez, Javier Gonzalez, Xuewu Liu, Saverio La Francesca, Jason Sakamoto and Rita E Serda.


View Abstract


Penetration Enhancer-Containing Vesicles: Does the Penetration Enhancer Structure Affect Topical Drug Delivery?


Anna Maria Fadda.


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Supramolecular Nanomedicine - An Overview


Bhupinder Singh Sekhon.


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αIIbβ3-Integrin Ligands: Abciximab and Eptifibatide as Proapoptotic Factors in MCF-7 Human Breast Cancer Cells


Joanna Kononczuk, Arkadiusz Surazynski, Urszula Czyzewska, Izabela Prokop, Michal Tomczyk, Jerzy Palka and Wojciech Miltyk.


View Abstract


Safety of Nanoparticles in Medicine


Joy Wolfram, Motao Zhu, Yong Yang, Jianliang Shen, Emanuela Gentile, Donatella Paolino, Massimo Fresta, Guangjun Nie, Chunying Chen, Haifa Shen, Mauro Ferrari and Yuliang Zhao.


View Abstract


Non-small Cell Lung Carcinoma: An Overview on Targeted Therapy


Ana Vanessa Nascimento, Hassan Bousbaa, Domingos Ferreira and Bruno Sarmento.


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Genomic identification of potential targets unique to Candida albicans for the discovery of antifungal agent


Himanshu Tripathi, Suaib Luqman, Abha Meena and Feroz Khan.


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A Review on Skin Targeted Delivery of Bioactives as 2 Ultradeformable Vesicles: Overcoming the Penetration Problem


Priyanka Karunanidhi and Singh Sanjay.


View Abstract


Editorial:Mirnas as Legitimate Targets for Cancer Therapy


Wang Z.


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