ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

Aims & ScopeAbstracted/Indexed in

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  • 29th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Current: 2.469
5 - Year: 2.974

Upcoming Articles (E-Pub Abstracts ahead of Print)

Naphthoflavones as antiproliferative agents : Design, synthesis and Biological evaluation


Dinesh Kumara, Kunal Nepalia, PMS Bedia, Arem Qayumb, Shashank Singhb and Subheet K Jaina.


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Juglone exerts cytotoxic, anti-proliferative and anti-invasive effects on Glioblastoma multiforme in a cell culture model


Dziugas Meskelevicius, Kastytis Sidlauskas, Ruta Bagdonaviciute, Julius Liobikas and Daiva Majiene.


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Peroxisome Proliferator-activated Receptors and their ligands in cancer drug resistance: opportunity or challenge


Bahman Yousefi, Nosratollah Zarghami, Nasser Samadi and Maryam Majidinia.


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8-bromo-7-methoxychrysin reversed M2 polarization of tumor-associated macrophages induced by liver cancer stem-like cells


Shuwen Sun, Yinghong Cui, Kaiqun Ren, Meifang Quan, Zhenwei Song, Hui Zou, Duo Li, Yu Zheng and Jianguo Cao.


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Fibroblast Growth Factor Receptor (FGFR): A new target for non-small cell lung cancer therapy


Federica Biello, Giovanni Burrafato, Erika Rijavec, Carlo Genova, Giulia Barletta, Anna Truini, Simona Coco, Maria Giovanna Dal Bello, Angela Alama, Francesco Boccardo and Francesco Grossi.


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Synthesis of Combretastatin A-4 analogs and their biological activity


Agnieszka Głowacka, Monika Gensicka, Grzegorz Cholewinski and Krystyna Dzierzbicka.


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Synthesis of New Benzimidazole and Benzothiazole Disulfide Metal Complexes as G-quadruplex Binding Ligands


Kawkab Saour and Dunya Lafta.


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Synthesis of arylamino-1,3,5-triazines functionalized with alkylating 2-chloroethylamine fragment and studies of their cytotoxicity on the breast cancer MCF-7 cell line


Justyna Fraczyk, Beata Kolesinska, Monika Swiontek, Wojciech Lipinski, Danuta Drozdowska and Zbigniew Jerzy Kaminski.


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Docking studies of glutamine valproic acid derivative (S)-5-amino-2-(heptan-4-ylamino)-5-oxopentanoic acid (Gln-VPA) on HDAC8 with biological evaluation in HeLa cells


F Martínez-Ramos, GR Luna-Palencia, I Vásquez-Moctezuma, D Méndez-Luna, MJ Fragoso-Vázquez, J Trujillo-Ferrara, MA Meraz-Ríos, JE Mendieta-Wejebe and J Correa-Basurto.


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Synthesis and Cytotoxicity of Two Active Metabolites of Larotaxel


Jianwei Li, Anping Li, Minghua Li, Yufeng Qiao and Hui Zhang.


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Synthesis of 4-piperidone based curcuminoids with anti-inflammatory and anti-proliferation potential in human cancer cell lines


Amit Anthwal, Kundan Singh, M.S.M. Rawat, Amit K. Tyagi, Ashanul Haque, Imran Ali and Diwan S Rawat.


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Role of carboxypeptidase N invasion and migration in breast cancer


Ranliang Cui, Peng Zhang and Yueguo Li.


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The utility of chemotherapy in the treatment of metastatic prostate cancer


Kanika Gupta, Jacob Elkon, Ehab El-Bahesh and Jeanny B Aragon-Ching.


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Natural Product-Derived Spirooxindole Fragments Serve as Privileged Substructures for Discovery of New Anticancer Agents


Bin Yu, Yi-Chao Zheng, Xiao-Jing Shi, Ping-Ping Qi and Hong-Min Liu.


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Lgr5 contributes to intestinal metaplasia during gastric carcinogenesis: a meta-analysis


Ye Han, Hugang Shen, Xiaofeng Xue, Bin Yuan, Yuting Kuang, Qiaoming Zhi and Hong Zhao.


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miR-203 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting oncogene ADAM9 and oncogenic long non-coding RNA HULC


Daiwei Wan, Shunli Shen, Shunjun Fu, Chenglong Shen, Jian Wu, Sutong Wang, Wenxuan Xie, Bin Chen, Liya A, Yixing Guo, Dingcheng Zheng, Qiaoming Zhi and Baogang Peng.


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The prognostic value of serum LDH levels in patients with hepatocellualr carcinoma after hepatic resection


Wen-Jie Hu, Shun-Jun Fu, Jing-Fang Diao, Dai-Wei Wan, Zhi-Jian Tan, Qiao-Ming Zhi and Jun-Ming He.


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CYTOTOXICITY, ANTIOXIDANT AND APOPTOSIS STUDIES OF QUERCETIN-3-O GLUCOSIDE AND 4-(β-D-GLUCOPYRANOSYL-1→4-α-L-RHAMNOPYRANOSYLOXY)-BENZYL ISOTHIOCYANATE FROM MORINGA OLEIFERA


F. Maiyo, R. Moodley and M Singh.


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Recent Developments on 1,2,4-Triazole Nucleus in Anticancer Compounds: A Review


Ramandeep Kaur, Ashish Ranjan Dwivedi, Bhupinder Kumar and Vinod Kumar.


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Synthesis of Methotrexate Loaded Chitosan nanoparticles and in vitro evaluation of the potential in treatment of prostate cancer


Selvi Gunel Nur, Ozel Buket, Kipcak Sezgi, Aktan Cagdas, Akgun Cansu, Ak Guliz, Yilmaz Habibe, Biray Avci Cigir, Dodurga Yavuz and Hamarat Sanlier Senay.


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Guaraná a richest caffeine food increase oxaliplatin sensitivity of colorectal HT-29 cells by apoptosis pathway modulation


Francine Carla Cadoná, Alencar Kolinski Machado, Verônica Farina Azzolin, Fernanda Barbisan, Eduardo Bortoluzzi Dornelles, Werner Glanzner, Paulo Bayard Dias Gonçalves, Charles Elias Assmann, Euler Esteves Ribeiro and Ivana Beatrice Mânica da Cruz.


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New Pyrano[2,3-d:6,5-d']dipyrimidine Derivatives - Synthesis, in vitro Cytotoxicity Activity and Computational Studies


Suresh Maddila, Sreekantha B Jonnalagadda, Kovashnee Naicker, Sridevi Gorle, Surjyakant Rana, Kotaiah Yalagala, Surya N. Maddila, Moganavelli Singh and Parvesh Singh.


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A Novel Method to Synthesize 4-Aryl-1H-1,2,3-Triazoles and their Anti-hepatoma Activity


Xiaolong Li, Yun He, Li Hai, Tao Zhang and Yong Wu.


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Metal Containing Cytostatics and Their Interaction with Cellular Thiol Compounds Causing Chemoresistance


Jan Hrabeta, Vojtech Adam, Tomas Eckschlager, Eva Frei, Marie Stiborova and Rene Kizek.


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A review of the recent developments in synthetic anti-breast cancer agents


Parvesh Singh, Nomandla Ngcoya and Vipan Kumar.


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Blood-Brain Barrier and Breast Cancer Resistance Protein: a limit to the therapy of CNS tumors and neurodegenerative diseases


Anna Lisa Iorio, Martina da Ros, Ornella Fantappiè, Maurizio Lucchesi, Ludovica Facchini, Alessia Stival, Sabrina Becciani, Milena Guidi, Claudio Favre, Maurizio de Martino, Lorenzo Genitori and Iacopo Sardi.


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Yin and yang of polyphenols in cancer prevention. A short review.


Jolie Kiemlian Kwee.


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Long noncoding RNA C21orF96 promotes the migration, invasion and lymph node metastasis in gastric cancer


Ziguo Yang, Qiaoming Zhi, Dan Wang, Li Zhang, Yuting Kuang, Ruizhen Miao, Yulong Shi and Xiaobo Guo.


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Determination of the Antiproliferative Activity of New Theobromine Derivatives and Evaluation of Their In Vitro Hepatotoxic Effects


Maya Georgieva, Magdalena Kondeva-Burdina, Javor Mitkov, Virginia Tzankova, Georgi Momekov and Alexander Zlatkov.


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Chemical Structure Characteristics and Bioactivity of Small Molecule FAK Inhibitors


Fang-Yuan CAO, Xiao-Ping ZHOU, Jing SU, Xiao-Hong YANG, Feng-Hui MU, Jia-Yi SHEN and Wei SUN.


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Nanoliposome is a promising carrier of protein and peptide biomolecule for the treatment of cancer


Tapan Kumar Giri, Ayan Giri, Tapan Kumar Barman and Subhasis Maity.


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Synthesis and pharmacological evaluation of maleopimaric N-arylimides: Identification of novel proapoptotic agents


Guiyang Yao, Manyi Ye, Yongtao Zhu, Zhixin Liao and Hengshan Wang.


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Tannic Acid Inhibits Proliferation, Migration, Invasion of Prostate Cancer and Modulates Drug Metabolizing and Antioxidant Enzymes


SERDAR KARAKURT and ORHAN ADALI.


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Recent Progress of Allicin on Cell Growth Inhibition and Apoptosis in Gastric Cancer Cells


Runlan Luo, Dengyang Fang, Hongdong Hang and Zeyao Tang.


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Leuckart synthesis and pharmacological assessment of novel acetamide derivatives


Priyanka Rani, Dilipkumar Pal, Rahul Rama Hegde and Syed Riaz Hashim.


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Hepato and Cardiotoxicity of Chemotherapeutic Treatment Evaluated by Means of Small Animal Imaging.


Fiorella Carla Tesán, Mariano Portillo, Diego Martinel-Lamas, Vanina Araceli Medina, María Jimena Salgueiro and Marcela Zubillaga.


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Nano-Hydroxyapatite Doped with Ho-166 as Drug Delivery System for Bone Cancer Therapy


Franciana Maria Rosa da Silva, Julio Cezar de Almeida Junior, Elizabeth Eugênio de Mello Oliveira, Marta de Souza Albernaz, Alexandre Malta Rossi and Ralph Santos-Oliveira.


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PERSPECTIVES OF BENZIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS IN THE NEW ERA


Snehlata Yadav, Balasubramanian Narasimhan and Harmeet kaur.


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Biological Potential of Halfsandwich Ruthenium(II) and Iridium(III) Complexes


Gerd Ludwig, Marija Mojić, Mirna Z. Bulatović, Sanja Mijatović, Danijela Maksimović-Ivanić, Dirk Steinborn and Goran N Kaluđerović.


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A review on novel breast cancer therapies: Photodynamic therapy and plant derived agent induced cell death mechanisms


Blassan Plackal Adimuriyil George and Heidi Abrahamse.


View Abstract


15,16-dihydrotanshinone I induces apoptosis and inhibits the proliferation, migration of human osteosarcoma cell line 143B in vitro


Xuepeng Chen, Qihong Li, Yan He, Hongjiang Du, Zhajun Zhan, Hong zhao, Jiejun Shi, Qingsong Ye and Ji'an Hu.


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A Curcumin Analog, GO-Y078, Effectively Inhibits Angiogenesis through Actin Disorganization


Shunsuke Sugiyama, Yuki Yoshino, Sei Kuriyama, Masahiro Inoue, Keigo Komine, Kazunori Otsuka, Aki Kohyama, Hiroyuki Yamakoshi, Chikashi Ishioka, Masamitsu Tanaka, Yoshiharu Iwabuchi and Hiroyuki Shibata.


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Indole-3-ethylsulfamoylphenylacrylamides with Potent Anti-proliferative and Anti-angiogenic Activities


Samir Mehndiratta, Shiow-Lin Pan, Sunil Kumar and Jing-Ping Liou.


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Synthesis of 9-O-3-(1-piperazinyl/morpholinyl/piperidinyl)pentyl-berberines as potential antioxidant and cytotoxic agents


Bhupendra M. Mistry, Rahul V. Patel, Young-Soo Keum and Doo Hwan Kim.


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Flavonoids with Therapeutic Potential in Prostate Cancer


Bao Vue, Sheng Zhang and Qiao-Hong Chen.


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Anticancer Activity of Organogallium(III) Complexes in Colon Cancer Cells


Milena R. Kaluderovic, Marija Mojić, Santiago Gómez-Ruiz, Sanja Mijatović and Danijela Maksimović-Ivanić.


View Abstract


Design and Synthesis of Novel Schiff base-benzothiazole hybrids as potential Epidermal Growth Factor Receptor (EGFR) Inhibitors


Meenakshi Singh, Sudhir K. Singh, Bhushan Thakur, Pritha Ray and Sushil K Singh.


View Abstract


Research Progress on the Antitumor Effects of Rhein: Literature Review


Chao Wu, Hongyan Cao, Hua Zhou, Lin Sun, Jingui Xue, Jianyuan Li, Yanqin Bian, Runfei Sun, Shu Dong, Ping Liu and Mingyu Sun.


View Abstract


Interactions of Non-Phosphorous Glycerolipids with DNA: Energetics, Molecular Docking and Topoisomerase I Attenuation


Valery Y. Grinberg, Vladimir B. Tsvetkov, Alina A. Markova, Lyubov G. Dezhenkova, Tatiana V. Burova, Natalia V. Grinberg, Alexander S. Dubovik, Natalia V. Plyavnik and Alexander A Shtil.


View Abstract


Synthesis and Biological Evaluation of Scutellaria flavone cyclane-aminol Mannich base derivatives as Novel CDK1 Inhibitors


Lisha Ha, Yuan Qian, Shixuan Zhang, Xiulan Ju, Shiyou Sun, Hongmin Guo, Qianru Wang, Kangjian Li, Qingyu Fan, Yang Zheng and Hailiang Li.


View Abstract


Expeditious Entry to Functionalized Pseudo-peptidic Organoselenide Redox Modulators via Sequential Ugi/SN Methodology


Saad Shaaban, Amr Negm, Mohamed A. Sobh and Ludger A Wessjohann.


View Abstract


Recent Advances in Anticancer Chemotherapeutics based upon Azepine Scaffold


Sarbjit Singh, Jail Goo, Veeraswamy Gajulapati, Tong-Shin Chang, Kyeong Lee and Yongseok Choi.


View Abstract


1, 3, 6-Trihydroxy-7-methyl-9, 10-anthracenedione isolated from genus Lindera with anti-cancer activity


Guoqing Wei, Hui Chen, Fangyuan Nie, Xiaofeng Ma and Hezhong Jiang.


View Abstract


O-6-methylguanine-DNA Methyltransferase Inhibits Gastric Carcinoma Cell Migration and Invasion by Downregulation of Matrix Metalloproteinase 2


Chenglong Li, Li Deng, Qiaoming Zhi, Qingyou Meng, Aimin Qian, Hongfei Sang, Jiazeng Xia and Xiaoqiang Li.


View Abstract


MicroRNA-183 Functions As an Oncogene by Regulating PDCD4 in Gastric Cancer


Chenglong Li, Li Deng, Qiaoming Zhi, Qingyou Meng, Aimin Qian, Hongfei Sang, Xiaoqiang Li and Jiazeng Xia.


View Abstract


ANTITUBULINIC EFFECT OF NEW FLUORAZONE DERIVATIVES ON MELANOMA CELLS


Claudia Sticozzi, Francesca Aiello, Rita Bassi Andreasi, Ximena Maria Muresan, Giuseppe Belmonte, Franco Cervellati, Emilia Maellaro, Emanuela Maioli and Giuseppe Valacchi.


View Abstract


Oleanolic acid A-lactams inhibit the growth of HeLa, KB, MCF-7 and Hep-G2 cancer cell lines at micromolar concentrations


Barbara Bednarczyk-Cwynar, Piotr Ruszkowski, Teresa Bobkiewicz-Kozlowska and Lucjusz Zaprutko.


View Abstract


Combination of DC Vaccine and Conventional Chemotherapeutics


Wei Dong, Ran Wei, Hongchang Shen, Yang Ni, Long Meng and Jiajun Du.


View Abstract


Cryptotanshinone induces pro-death autophagy through JNK signaling mediated by reactive oxygen species generation in lung cancer cells


Wenhui Hao, Xuenong Zhang, Wenwen Zhao, Hong Zhu, Zhao-Yang Liu, Jinjian Lu and Xiuping Chen.


View Abstract


Isolation, purification and characterization of a novel steroidal saponin cholestanol glucoside from Lasiodiplodia theobromae that induces apoptosis in A549 cells.


Jinu Mathew Valayil, Gini C Kuriakose and Jayabaskaran C.


View Abstract


Synthesis of Diflunisal thiazolidinones as anticancer agents


Sevil Şenkardeş, Özlem Bingöl Özakpınar, Derya Özsavcı, Azize Şener, Özge Çevik and ŞGüniz Küçükgüzel.


View Abstract


Multiple pharmacological properties of a novel parthenin analog P16 as evident by its cytostatic and antiangiogenic potential against pancreatic adenocarcinoma PANC-1 cells


Akshra Goswami, Bhahwal Ali Shah, Navneet Batra, Ajay Kumar, Santosh Kumar Guru, Shashi Bhushan, Fayaz Ahmed Malik, Amit Joshi and Jagtar Singh.


View Abstract


MicroRNA-31 inhibits lung adenocarcinoma stem-like cells via down-regulation of MET-PI3K-Akt signaling pathway


Chunying Hou, Bo Sun, Yao Jiang, Ji Zheng, Nan Yang, Chao Ji, Zhen Liang, Jiaojiao Shi, Rui Zhang, Yanyong Liu, Caiying Ye and Pingping Zuo.


View Abstract


Differential Gene Expression of BRCA1,ERBB2 and TP53 biomarkers between Human Breast Tissue and Peripheral Blood Samples of Breast Cancer


Abdulrazzaq Neamah Zghair, Deepak Kumar Sinha, Arkan Kassim, Mohmmad Alfaham and Anil K Sharma.


View Abstract


Exploring a novel target treatment on breast cancer: aloe-emodin mediated photodynamic therapy induced cell apoptosis and inhibited cell metastasis


Qing Chena, Si Tiana, Jing Zhub, Kai-Ting Lia, Ting-He Yuc, Le-Hua Yub and Ding-Qun Bai.


View Abstract


Sodium Selenite Decreased HDAC Activity, Cell Proliferation and Induced Apoptosis in Three Human Glioblastoma Cells.


Florence Hazane-Puch, Josiane Arnaud, Candice Trocmé, Patrice Faure, François Laporte and Pierre Champelovier.


View Abstract


Novel dibenzo[b,d]furan–1H-1,2,4-triazole derivatives: Synthesis and antitumor activity


Xing Chen, Yi-Min Shi, Chao Huang, Sha Xia, Li-Juan Yang and Xiao-Dong Yang.


View Abstract


Evaluating Intestinal Permeability by Measuring Plasma Endotoxin and Diamine Oxidase in Children with Acute Lymphoblastic Leukemia Treated with High-dose Methotrexate


Ye Meng, Ying Zhang, Mei Liu, Yong Kun Huang, Jun Zhang, Qin Yao, Ya Ling Zhao and Jing Jing Xiong.


View Abstract


A Novel Platinum-based Compound with Preferential Cytotoxic Activity against a Panel of Cancer Cell Lines


Farhad Shahsavar, Mahmood Bozorgmehr, Ebrahim Mirzadegan, Anita Abedi, Zohreh Mehri Lighvan, Fereshteh Mohammadi, Nasser Safari, Vahid Amani and Amir-Hassan Zarnani.


View Abstract


Paclitaxel Loaded Nanoliposomes in Thermosensitive Hydrogel: A Dual Approach for Sustained and Localized Delivery


Mohit Mahajan, Puneet Utreja and Subheet Kumar Jain.


View Abstract


MECHANISMS OF RESISTANCE TO CHEMOTHERAPY IN GASTRIC CANCER


Marin J.J.G., Al-Abdulla R., Lozano E., Briz O., Bujanda L., Banales J.M. and Macias RIR.


View Abstract


Design, synthesis and biological evaluation of thiohydantoin derivatives as novel anti-prostate cancer agents


Jianzhen Liu, Bo Liu, Yongkui Jing and Guisen Zhao.


View Abstract


Based on Nucleotides Analysis of Tumor Cell Lines to Construct and Validate a Prediction Model of Mechanisms of Chemotherapeutics


Cuichai Liu, Fang Wang, Xi Liu, Min Liu, Zheng Liu and Lixin Sun.


View Abstract


Role of genetics and epigenetics in mucosal, uveal, and cutaneous melanomagenesis


Mario Venza, Maria Visalli, Concetta Beninati, Carmelo Biondo and Diana Teti.


View Abstract


Up-regulated circulating miR-106a by DNA methylation promised a potential diagnostic and prognostic marker for gastric cancer


Renshun Yuan, Gang Wang, Qiaoming Zhi, Huabin Chen, Ye Han, Bin Wang, Zhongyang Kou, Hao Hu, Zhaoji Guo, Xiaofeng Xue and Hong Zhao.


View Abstract


Clinical Significance of miR-1826 as a Novel Prognostic Biomarker in Colorectal Cancer


You Hu, Bin Yi, Songbing He, Pengfei Liu, Lei Wang, Jing Yu, Daiwei Wan, Jin Zhou, Xinguo Zhu and Qiaoming Zhi.


View Abstract


Melatonin Regulates Angiogenic Factors under Hypoxia in Breast Cancer Cell Lines


Bruna V. Jardim-Perassi, Mateus R. Lourenco, Gabriel M. Doho, Ingrid H. Grigolo, Gabriela B. Gelaleti, Livia C. Ferreira, Thaiz F. Borin, Marina G. Moschetta and Debora AP de Campos Zuccari.


View Abstract


Pseudogene PTENP1 Suppresses Gastric Cancer Progression by Modulating PTEN


Xiaoqiang Guo, Li Deng, Kaiyuan Deng, Hao Wang, Ting Shan, Hong Zhou, Zheng Liang, Jiazeng Xia and Chenglong Li.


View Abstract


miRNA-101 Suppresses Epithelial-to-Mesenchymal Transition by Targeting HMGA2 in Pancreatic Cancer Cells


Wenli Jiang, Wen Gu, Ronglin Qiu, Chenglong Shen, Yaohao Wu, Jie Zhang, Jiajia Zhou, Yixing Guo, Zhixi Li, Jiemin Deng, Lexiang Zeng, Jin Tang, Qiaoming Zhi and Xiaogeng Deng.


View Abstract


SCYL1-BP1 affects cell cycle arrest in human hepatocellular carcinoma cells via Cyclin F and RRM2


Yang Wang, Qiaoming Zhi, Qin Ye, Chengyuan Zhou, Lei Zhang, Wei Yan, Qun Wu, Di Zhang, Pu Li and Keke Huo.


View Abstract


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