E-Pub Articles Ahead of Print ::: Medicinal Chemistry

ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)


Volume 13, 8 Issues, 2017


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Medicinal Chemistry

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Editor-in-Chief:
Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece


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Articles Ahead of Print

The Role of Vitamin D in Multiple Sclerosis: Biology & Biochemistry, Epidemiology and Potential Roles in Treatment


Steve Simpson Jr, Ingrid van der Mei and Bruce Taylor


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Scaffold Hopping Strategy for the Design, Synthesis and Biological Activity Evaluation of Novel Hexacyclic Scutellarein Derivatives with a 1,3-Oxazine Ring Fused at A-ring


Yue Zhong , Yu-Ting Lu, Ying Sun, Nian-Guang Li, Ting Gu, Wen-Yu Wu, Shao-Peng Yu and Zhi-Hao Shi


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An Update on the Role of Matrix Metalloproteinases in the Pathogenesis of Multiple Sclerosis


Marina Boziki and Nikolaos Grigoriadis


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Myelin Oligodendrocyte Glycoprotein and Multiple Sclerosis


Maria-Eleni Androutsou, Anthi Tapeinou, Alexios Vlamis-Gardikas and Theodore Tselios


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Is There a Link between Vitamin B and Multiple Sclerosis?


Natalie Nemazannikova, Kathleen Mikkelsen, Lily Stojanovska, Gregory L. Blatch and Vasso Apostolopoulos


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Managing Neuropathic Pain in Multiple Sclerosis: Pharmacological Interventions


Samuel S. Duffy, Justin G. Lees, Chamini J. Perera and Gila Moalem-Taylor


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IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages


Alfonso López-Vázquez, Jesús Garcia-Bañuelos, Angélica González-Garibay, Pedro Urzúa-Lozano, Susana Del Toro-Arreola, Miriam Bueno-Topete, Sergio . Sánchez-Enríquez, José Muñoz-Valle, Luis Jave-Suárez, Juan Armendáriz-Borunda and Vlanca Bastidas-Ramírez


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Therapeutic Monoclonal Antibodies and Multiple Sclerosis: The Essentials


Ioannis Heliopoulos and Athanasia Patousi


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Identification of 1-Aryl-1H-1,2,3-triazoles as Potential New Antiretroviral Agents


Daniel T.G. Gonzaga, Thiago M.L. Souza, Viviane M.M. Andrade, Vitor F. Ferreira and Fernando de C. da Silva


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In vitro α-Glucosidase Inhibition by Non-sugar based Triazoles of Dibenzoazepine, their Structure-Activity Relationship, and Molecular Docking


Maria A. Khan, Kulsoom Javaid, Abdul Wadood, Alam Jamal, Farhana Batool, Saba Fazal-ur-Rehman, Fatima Z. Basha and M. Iqbal Choudhary


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Drug Design, Synthesis and in vitro Evaluation of Substituted Benzofurans as Hsp90 Inhibitors


Sundeep Kadasi, Thadeu E. M.M. Costa, Neha Arukala, Mallika Toshakani, Chaitanya Duggineti, Sreekanth Thota, Sayan Dutta Gupta, Shiva Raj, Carmen Penido, Maria G Henriques and Nulgumnalli Manjunathaiah Raghavendra


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Design, Synthesis, and Biological Evaluation of C-2 Substituted 3Hthieno[ 2,3-d]pyrimidin-4-one Derivatives as Novel FGFR1 Inhibitors


Ping Guo, Faqing Ye , Zixin Xie, Huan Zhang, Zaikui Zhang , Chao Han , Donghua Cheng, Dan Lin, Yuan Zhang, Xuebao Wang and Xin Guo


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1,1'-Carbonyldiimidazole (CDI) Mediated Facile Synthesis, Structural Characterization, Antimicrobial Activity, and in-silico Studies of Coumarin- 3-carboxamide Derivatives


Uzma Salar, Khalid Mohammed Khan, Muhammad Imran Fakhri, Shafqat Hussain, Saima Tauseef, Shagufta Ameer, Abdul Wadood, Huma Khan and Shahnaz Perveen


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iRNA-2methyl: Identify RNA 2′-O-methylation Sites by Incorporating Sequence-Coupled Effects into General PseKNC and Ensemble Classifier


Wang-Ren Qiu, Shi-Yu Jiang , Bi-Qian Sun, Xuan Xiao, Xiang Cheng and Kuo-Chen Chou


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Biology-Oriented Synthesis (BIOS) of Piperine Derivatives and their Comparative Analgesic and Antiinflammatory Activities


Ammar Yasir, Saiqa Ishtiaq, Muhammad Jahangir, Muhammad Ajaib, Uzma Salar and Khalid Mohammed Khan


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Synthesis and Antimalarial Activity of New Enantiopure Aminoalcoholpyrrolo[ 1,2-a]quinoxalines


Alexia Jonet, Jean Guillon, Catherine Mullié, Anita Cohen, Guillaume Bentzinger, Jérémy Schneider, Nicolas Taudon, Sebastien Hutter, Nadine Azas, Stephane Moreau, Solene Savrimoutou, Patrice Agnamey, Alexandra Dassonville-Klimpt and Pascal Sonnet


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Cell Cycle Arrest and Apoptosis Induction Activity of Nitidine Chloride on Acute Myeloid Leukemia Cells


Peng Li, Shuxin Yan, Xin Dong, Zhao Li, Yu Qiu, Chunyan Ji, Jingru Zhang, Min Ji, Wei Li, Hongchun Wang, Zhi Liu, Xing Li Wang, Jingjing Ye and Daoxin Ma


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Evaluation of 1,3-benzoxathiol-2-one Derivatives as Potential Antifungal Agents


Luciana Terra, Eliza de L. Chazin, Paola de S. Sanches, Max Saito, Marcus V.N. de Souza, Claudia R.B. Gomes, James L. Wardell, Solange M.S.V. Wardell, Plínio C. Sathler, Gabriela C.C. Silva, Viviane O. Lione, Marcos Kalil, Ana Joffily, Helena C. Castro and Thatyana R.A. Vasconcelos


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Synthesis, Structural Characterization and Antinociceptive Activities of New Arylated Quinolines via Suzuki-Miyaura Cross Coupling Reaction


Malik Aman Ullah, Muhammad Adeel, Muhammad N. Tahir, Abdur Rauf, Muhammad Akram, Taibi Ben Hadda, Yahia N. Mabkhot, Naveed Muhammad, Fehmida Naseer and Mohammad S. Mubarak


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Rapid Access to Oxazine Fused Furocoumarins and in vivo and in silico Studies of Theirs Biological Activity


Alla V. Lipeeva, Dmitry S. Baev, Margarita P. Dolgikh, Tatijana G. Tolstikova and Elvira E. Shults


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Effect on Acetylcholinesterase and Anti-oxidant Activity of Synthetic Chalcones having a Good Predicted Pharmacokinetic Profile


Renata Parruca Sakata, Micheli Figueiro, Daniel Fabio Kawano and Wanda Pereira Almeida


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Synthesis and Analgesic Activity of Amines Combining Diazaadamantane and Monoterpene Fragments


Konstantin Ponomarev, Ekaterina Morozova, Alla Pavlova, Evgeniy Suslov, Dina Korchagina, Andrej Nefedov, Tat`yana Tolstikova, Konstantin Volcho and Nariman Salakhutdinov


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Quinolinic Carboxylic Acid Derivatives as Potential Multi-target Compounds for Neurodegeneration: Monoamine Oxidase and Cholinesterase Inhibition


Nehal Afreen Khan, Imtiaz Khan, Syed Mobasher Ali Abid, Sumera Zaib, Aliya Ibrar, Hina Andleeb, Shahid Hameed and Jamshed Iqbal


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Isolation of Chlorogenic Acid from Soil Borne Fungi Screlotium rolfsii, their Reversal of Multidrug Resistance and anti-proliferative in Mouse Lymphoma Cells


Bashir Ahmad, Muhammad Rizwan, Abdur Rauf , Muslim Raza, Shumaila Bashir , Joseph Molnáre, Ákos Csonka, Diána Szabó, Mohammad S. Mubarak, Mah Noor and Bina S. Siddiqui


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The Role of QSAR and Virtual Screening Studies in Type 2 Diabetes Drug Discovery


Simone Q. Pantaleão, Drielli G.V. Fujii, Vinícius G. Maltarollo, Danielle da C. Silva, Gustavo H.G. Trossini, Karen C. Weber, Luis P.B. Scott and Kathia M. Honorio


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Synthesis and Biological Evaluation of Curcumin-Nitroxide-Based Molecular Hybrids as Antioxidant and Anti-Proliferative Agents


Balázs Bognár, Muthulakshmi Kuppusamy, Esha Madan, Tamás Kálai, Mária Balog, József Jekő, Periannan Kuppusamy and Kálmán Hideg


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Better Predictive Value of Cancer Antigen125 (CA125) as Biomarker in Ovary and Breast Tumors and its Correlation with the Histopathological Type/Grade of the Disease


Aarifa Nazmeen, Smarajit Maiti, Kusumita Mandal, Samir K. Roy, Tamal Kanti Ghosh, Nirmalya K. Sinha and Kamalika Mandal


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Synthesis of New Arylidene 2,5-Diketopiperazines and Evaluation of Their Anti-Acetylcholinesterase, Anti-xanthine Oxidase, Anti-diabetic and Cytotoxic Activities


Mohamed Amine Belkacem, Hichem Ben Jannet, Hicham Ferhout, Laila Mzali and Jalloul Bouajila


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Identification of Novel 5,6-dimethoxyindan-1-one Derivatives as Antiviral Agents


Siddappa A. Patil, Vikrant Patil, Renukadevi Patil, Kenneth Beaman and Shivaputra A. Patil


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In vitro and in silico Studies of Mangiferin from Aphloia theiformis on Key Enzymes Linked to Diabetes Type 2 and Associated Complications


Marie C.N Picot, Gokhan Zengin, Adriano Mollica, Azzurra Stefanucci, Simone Carradori and Mohamad F. Mahomoodally


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Synthesis and Preliminary Cytotoxicity Studies of 1-[1-(4,5-Dihydrooxazol- 2-yl)-1H-indazol-3-yl]-3-phenylurea and 3-phenylthiourea Derivatives


Anita Kornicka, Franciszek Sączewski, Patrick J. Bednarski, Martyna Korcz, Piotr Szumlas, Ewa Romejko, Aneta Sakowicz, Łukasz Sitek and Monika Wojciechowska


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Synthesis, Characterization and Cholinesterase Inhibition Studies of New Arylidene Aminothiazolylethanone Derivatives


Jamshed Iqbal, Ghulam Shabir, Fayaz A. Larik, Shafi Ullah Khan, Aamer Saeed, Muhammad S. Shah and Pervaiz A. Channar


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Additive Effect of MCP in Combination with Cefotaxime Against Staphylococcus aureus


Elias Dahdouh, Salah El-Khatib, Elias Baydoun and Roula M. Abdel-Massih


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A Simple Method to Predict Blood-Brain Barrier Permeability of Drug- Like Compounds Using Classification Trees


Juan A. Castillo-Garit, Gerardo M. Casañola-Martin, Huong Le-Thi-Thu, Hai Pham-The and Stephen J. Barigye


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A Concise Update on the Relevance of Secretory Phospholipase A2 Group IIA and Its Inhibitors to Cancer


Juan Chen, Long Ye, Yu Sun and Yoshikazhu Takada


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Bioactive Constituents from an Endophytic Fungus, Penicillium polonicum NFW9, Associated with Taxus fauna


Nighat Fatima, Tawanun Sripisut, Ui Joung Youn, Safia Ahmed, Ihsan Ul-Haq, Ulyana Muñoz-Acuña, Charles J. Simmons, Muneer Ahmed Qazi, Muniba Jadoon, Ghee Teng Tan, Esperanza J. Carcache de Blanco and Leng Chee Chang


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A New Anti-Aging Lysophosphatidic Acid from Arabidopsis thaliana


Yujuan Sun, Yanhui Wang, Guangfa Wang, Lan Xiang and Jianhua Qi


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Synthesis of Adamantane Aminoethers with Antitubercular Potential


Angeliki-Sofia Foscolos, Ioannis Papanastasiou, Andrew Tsotinis, Nicolas Kolocouris, George B. Foscolos, Anthony Vocat and Stewart T. Cole


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