E-Pub Articles Ahead of Print ::: Medicinal Chemistry

ISSN: 1875-6638 (Online)
ISSN: 1573-4064 (Print)


Volume 12, 8 Issues, 2016


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Medicinal Chemistry

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E-Pub Articles Ahead of Print

Synthesis, Cytotoxic Activity on Leukemia Cell Lines and Quantitative Structure-Activity Relationships (QSAR) Studies of Morita-Baylis-Hillman Adducts


Claudio G. Lima–Junior, Gláucia V. Faheina–Martins, Caio C. B. Bomfim, Everton P. Silva, Demetrius A. M. de Araújo, Edilson B. Alencar Filho and Mário L A A Vasconcellos.


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Design, Synthesis and Qualitative Structure Activity Relationship Evaluations of Quinoline-Based Bisarylimidazoles as Antibacterial Motifs


Raed Abu Odeh, Raed A. Al-Qawasmeh, Mutasem O. Sinnokrot, Mohammad H. Semreen, Musa H. Abu-Zarga, Basil Bani Huthail, Hamadeh Tarazi, Imad Abu Yousef and Taleb H Al-Tel.


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Synthesis of 1,4-disubstituted 1,2,3-triazole Derivatives Using Click Chemistry and their Src Kinase Activities


Alexandre Lebeau, Cyril Abrioux, David Bénimèlis, Zohra Benfodda and Patrick Meffre.


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Synthesis and Biological Evaluation of N-Aryl-N’-(5-(2-hydroxybenzoyl)pyrimidin-2-yl)guanidines as Toll-Like Receptor 4 Antagonists Synthesis of Guanidine-Based TLR4 Antagonists


Matej Sova, Kaja Rožman, Urban Švajger, Primož Rožman and Stanislav Gobec.


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Design, Synthesis and Antiproliferative Activity of Novel Benzothiazole Derivatives Conjugated with Semicarbazone Scaffold


Guanglong Bao, Baoquan Du, Yuxiu Ma, Meng Zhao, Ping Gong and Xin Zhai.


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Facing Chagas’ Disease: Trypanocidal Properties of New Coumarinchalcone Scaffolds


Saleta Vazquez-Rodriguez, Roberto Figueroa Guíñez, Maria João Matos, Claudio Olea-Azar, Juan Diego Maya, Eugenio Uriarte and Lourdes Santana.


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Nitazoxanide Analogues as Antimicrobial Agents Against Nosocomial Pathogens


Jia-Suey Gau, Wen-Pao Lin, Li-Ching Kuo and Ming-Kuan Hu.


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Synthesis, in vivo Anticoagulant Evaluation and Molecular Docking Studies of Bicoumarins Obtained from Furocoumarin Peucedanin


Alla V. Lipeeva, Mikhail V. Khvostov, Dmitry S. Baev, Makhmut M. Shakirov, Tatijana G. Tolstikova and Elvira E Shults.


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Biologically Active New N, N', N''-Tri-Substituted Ferrocenyl Phenylguanidines and their Characterization


Rukhsana Gul, Ataf Ali Altaf, Azim Khan, Amin Badshah, Afzal Shah, Zia ur Rehman, Rabia Naz, Muhammad Nawaz Tahir and Asif Junaid.


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Preliminary Studies on the Activity of Mixed Polyphenol-Heterocyclic Systems Against B16-F10 Melanoma Cancer Cells


Duc Duy Vo, Isabelle Rouaud, Francoise Le Devehat, Fabien Gautier, Sophie Barillé-Nion, Philippe Juin, Nicolas Levoin, Joël Boustie and René Grée.


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Synthesis and Evaluation of Phenyliminoindolin-Containing Phenylacetamide Derivatives with the Antidepressant and Anticonvulsant Effects


Li-Ping Guan, Bing-Yu Liu, Ying-Chun Quan, Li-Ye Yang, Xing-Hua Zhen and Si-Hong Wang.


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Synthesis, Antibacterial Activity, Interaction with Nucleobase and Molecular Docking Studies of 4-Formylbenzoic Acid Based Thiazoles


Krzysztof Z. Łączkowski, Anna Biernasiuk, Angelika Baranowska-Łączkowska, Konrad Misiura, Anna Malm, Tomasz Plech and Agata Paneth.


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Ether and Carbamate Derivatives of 3-quinuclidinol and 3- hydroxymethylquinuclidine: Synthesis and Evaluation as Nicotinic Ligands


Sivakumar Annadurai, Min Zhang, Jerome L. Gabriel, Merouane Bencheriff and Daniel J Canney.


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In-Vitro Anticancer Evaluation and Docking Study of Novel benzo[g] quinazoline-sulfonamide Derivatives


Mostafa M. Ghorab, Mansour S. Alsaid, Mohamed S. Al-Dosary and Marwa G El-Gazzar.


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Efficient Synthesis and Discovery of Schiff Bases as Potent Cholinesterase Inhibitors


Basma M. Abd Razik, Hasnah Osman, Mohammed Oday Ezzat, Alireza Basiri, Abdussalam Salhin, Yalda Kia and Vikneswaran Murugaiyah.


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Cell-based Assays for Assessing Toxicity: A Basic Guide


Raveen Parboosing, Gugulethu Mzobe, Louis Chonco and Indres Moodley.


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Fluorescein-labeled Bacitracin and Daptomycin Conjugates: Synthesis, Fluorescence Imaging and Evaluation


Sumbla Sheikh, Alexander Sturzu, Hubert Kalbacher, Thomas Nägele, Christopher Weidenmaier, Marius Horger, Christian Schwentner, Ulrike Ernemann and Stefan Heckl.


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Antiplasmodial Limonoids from Trichilia rubescens (Meliaceae)


Tsamo Tontsa Armelle, Nangmo Kemda Pamela, Mkounga Pierre, Ingrid B. Müller, Kirk Marat, Gabriele Sass and Nkengfack Augustin Ephrem.


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Design, Synthesis, and Cytotoxicity of Novel 2,4,6-Trisubstituted 1,3,5- triazines Bearing Aryl Hydrazone Moiety as Potent Antitumor Agent


Limei Wang, Sijia Zhao, Guanglong Bao, Yu Zhang, Shuancheng Xi, Guolin Zhou, Xin Zhai and Ping Gong.


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The Current Use of Mass Spectrometry in Combination with Other Separation Techniques in Drug Discovery Arena


Piotr Kawczak and Tomasz Bączek.


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Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach


Engi A. Hassaan, Sara C. Sigler, Tamer M. Ibrahim, Kevin J. Lee, Lauren K. Cichon, Bernard D. Gary, Joshua C. Canzoneri, Gary A. Piazza and Ashraf HAbadi.


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Antimicrobial and Anti-biofilm Activity of Thiourea Derivatives Bearing 3-amino-1H-1,2,4-triazole Scaffold


Joanna Stefanska, Karolina Stepien, Anna Bielenica, Daniel Szulczyk, Barbara Miroslaw, Anna E Koziol, Giuseppina Sanna, Filippo Iuliano, Silvia Madeddu, Michal Jozwiak and Marta Struga.


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Synthesis, Biological Evaluation and Pharmacokinetic Studies of Mefenamic Acid - N-Hydroxymethylsuccinimide Ester Prodrug as Safer NSAID


Asif Husain, Priyanka Ahuja, Aftab Ahmad and Shah Alam Khan.


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Synthesis, Structural Characterization of a Novel Ferrocene Derivative and Preliminarily Anticancer Activity


Jianping Yong, Xiaoyuan Wu, Jianzhen Liao, Canzhong Lu and Xiaolong Liu.


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Chemosensitization of Prostate Carcinoma Cells with a Receptor-directed Smac Conjugate


Alexander Sturzu, Sumbla Sheikh, Hartmut Echner, Martin Deeg, Thomas Nägele, Christopher Weidenmaier, Christian Schwentner, Marius Horger, Ulrike Ernemann and Stefan Heckl.


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Chemical Composition and Inhibitory Effects of Hypericum brasiliense and H. connatum on Prolyl oligopeptidase and Acetylcholinesterase Activities


Maura Z. dos Santos, Ionara I. Dalcol, Luciana Adolpho, Meritxell Teixidó, Teresa Tarragó, Ademir Morel and Ernest Giralt.


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Cytotoxic Effects of Salvinorin A, A Major Constituent of Salvia divinorum


Ana Martinho, Sara M. Silva and Eugenia Gallardo.


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Robust Modeling and Scaffold Hopping: Case Study Based on HIV Reverse Transcriptase Inhibitors Type-1 Data


Girinath G. Pillai, Laznier Mederos, Chandramukhi S. Panda, Amber Gronski, Peeter Burk, C. Dennis Hall, Alan R. Katritzky, Kaido Tämm and Mati Karelson.


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The Brain Protective Effect of rTMS (Repetitive Transcranial Magnetic Stimulation) in Depression: A Mini-Review in Animal Studies


Burak Yulug, Lütfü Hanoglu, Ahmet Mithat Tavli, Nesrin Helvacı Yılmaz and Ertugrul Kılıc.


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QSRR and QSAR Studies of Antitumor Drugs in View of their Biological Activity Prediction


Paulina Szatkowska-Wandas, Marcin Koba, Grzegorz Smoliński and Jacek Wandas.


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Synthesis and Anti-thyroid Cancer Effect of Iodo-chrysin Derivatives


Yun Wei, Qutong Zheng, Guotao Tang, Chen Song, Guan Wang, Yinxiang Zhang, Yan Xiao, Xianliang Zeng, Zongbao Wang, Jichang Xiao and Xing Zheng.


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DNA Hybridization on Chitosan-Functionalized Silicon Substrate


Amina Omar, El-Sayed M. El-Sayed, Mona S. Talaat and Medhat Ibrahim.


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Synthesis and Biological Evaluation of Novel 1,3,4-thiadiazole Derivatives Incorporating Benzisoselenazolone Scaffold as Potential Antitumor Agents


Xiaoyun Fu, Sha Li, Fen Jing, Xuefeng Wang, Baolin Li, Jijun Zhao, Yuming Liu and Baoquan Chen.


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Understanding the Structural Basis of ALDH-2 Inhibition by Molecular Docking


Thayssa T. S. C. Ferreira and Carlos Alberto Manssour Fraga.


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Current medical treatment of early breast cancer


Franco Lumachi.


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