E-Pub Articles Ahead of Print ::: Letters in Drug Design & Discovery

ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)


Volume 12, 10 Issues, 2015


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Letters in Drug Design & Discovery

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Editor-in-Chief:
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: lddd@benthamscience.org

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E-Pub Articles Ahead of Print

Virtual Screening of NCI Diversity Set IILead to New Cyclin-Dependent Kinases 5Inhibitors Using AutoDock


Siripit Pitchuanchom, Chavi Yenjai, Chantana Boonyarat, Stefano Forli and Arthur J Olson.


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Assembly of Quinoline, Triazole and Oxime Ether in a Single Molecular Entity: A Greener and One-pot Synthesis of Novel Oximes as Potential Cytotoxic Agents


Koduru Sri Shanthi Praveena, Edupuganti Veera Venkat Shivaji Ramarao, Yedia Poornachandra, Chityala Ganesh Kumar, Nallapati Sureshbabu, Nandula Yadagiri Sreenivasa Murthy and Sarbani Pal.


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Peptide Drugs QSAR Modeling Based on a New Descriptor of Amino Acids- SVGT


Jianbo Tong, Lingxiao Li, Shuling Liu and Jia Chang.


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Substituted 1,2,4-oxodiazoles as Potent Inhibitors of Human 11β - hydroxysteroid Dehydrogenase Type 1 (11β-HSD1): Virtual Screening and Docking Results


Dmitry V. Ziolkovskiy, Victoria V. Lipson, Anastasia D. Nikitina and Valentin A Chebanov.


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Synthesis and Evaluation of Certain Symmetrical Schiff Bases as Inhibitors of MDA-MB-241 Human Breast Cancer Cell Proliferation


Smaail Radi, Said Tighadouini, Olivier Feron, Olivier Riant and Yahia N Mabkhot.


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Discovery of Potential Dual Inhibitors Against Lipases Rv0183 and Rv3802c for Tuberculosis Therapeutics


Parameswaran Saravanan and Sanjukta Patra.


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Synthesis and Properties of Brassinosteroid Biosynthesis Inhibitor Fluorescent Probe with Dansyl Moiety


Tomoki Hoshi, Yuko Yoshizawa and Keimei Oh.


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Privileged 1,2,4-Oxadiazoles in Anticancer Drug Design: Novel 5- Aryloxymethyl-1,2,4-oxadiazole Leads for Prostate Cancer Therapy


Alexey Lukin, Ruben Karapetian, Yan Ivanenkov and Mikhail Krasavin.


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Synthesis and Antifungal Activity Evaluation of New 1,2,4-Triazole Derivatives Bearing Salicylidene Hydrazide Moiety


Seref Demirayak, Ismail Kayagil, Leyla Yurttas and Sevda Er.


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In Silico Modeling of Antimalarial Protein Kinase Inhibitors


Rahul Balasaheb Aher and Kunal Roy.


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Accumulation Effects of 3-N-Benzyloxycarbonyl-β-Aminobutyric Salicylate on the Alkaloids in Catharanthusroseus Cells


Er-Bing Yang, Yong Wang, Hong-Jun Zang, Zheng-Ming Li and Xing-Hai Liu.


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Prediction of Caco-2 Cell Permeability Using Bilinear Indices and Multiple Linear Regression


Huong Le-Thi-Thu, Yudith Canizares-Carmenate, Yovani Marrero-Ponce, Francisco Torrens and Juan A Castillo-Garit.


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Curcumin: the Yellow Molecule with Pleiotropic Biological Effects


Prabhakar Singh, Kanti Bhooshan Pandey and Syed Ibrahim Rizvi.


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Application of Sustained-release Carrier of NanoAg-Epidermal Growth Factor in Promoting Refractory Diabetic Wound Healing


Ning-ning Tang, Feng Hu, Jin-yan Liu, Can Liu, Chao-qi Yin, Yong Chen and Jian-da Zhou.


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Synthesis of 4-Phenylthieno[2,3-e][1,2,4]triazolo[4,3-a]pyrimidine-5(4H)-one Derivatives and Evaluation of Their Anti-inflammatory Activity


Fu-Jun Pan, Shi-Ben Wang, Da-Chuan Liu, Guo-Hua Gong and Zhe-Shan Quan.


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Design and Synthesis of Novel Spiro-Piperidinyl Pyrazolone Derivatives and Their Potential Antiviral Activity


Rajagopalan Srinivasan, Badiadka Narayana, Balladka Kunhanna Sarojini, Veerakyathappa Bhanuprakash and Chenna Govindaraju Darshan Raj.


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Molecular Simulation of HDAC1/3 Inhibitor: Insights into the Structural Basis of Selectivity


Lei Zhang and Lihui Zhang.


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Novel Aminopeptidase N Inhibitors with Improved Antitumor Activities


Qiang Wang, Qiao Shi and Lu Huang.


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Studies on the IC50 of Trisubstituted Thiazoles as Cdc7 Kinase Inhibitors


Huazhen Yang, Xun Liu, Zhiling Ye, Fucheng Song, Lianhua Cui, Zhuang Yu, Hongzong Si and Honglin Zhai.


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Design, Synthesis and Biological Evaluation of4-(Imidazolylmethyl)-2-Aryl-Quinoline Derivatives as Aromatase Inhibitors and Anti-Breast Cancer Agents


Razieh Ghodsi, Ebrahim Azizi, Maria Grazia Ferlin, Vincenzo Pezzi and Afshin Zarghi.


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Development of Energy-Based Pharmacophore Model and Stepwise Virtual Screening of LRRK2 Inhibitors Through Molecular Dynamics and Mechanics


Sagar S. Bhayye, Kunal Roy and Achintya Saha.


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Synthesis, Biological Evaluation and Molecular Docking Studies of 4H-Benzo-[h]Chromenes, 7H-Benzo[h]Chromeno[2,3-d]Pyrimidines as Antitumor Agents


Ahmed H. Halawa, Ahmed M. Fouda, Al-Anood M. Al-Dies and Ahmed M El-Agrody.


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Evaluation of Serine Protease Inhibitors as Potent FVIIa-sTF Inhibitors in the Blood Coagulation Cascade


Andrea Roxanne J. Anas and Ken-ichi Harada.


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A Series of 2, 4(1H, 3H)-Quinazolinedione Derivatives: Synthesis and Biological Evaluation as Potential Anticancer Agents


Hulya Akgun, Demet Us Yilmaz, Rengul Cetin Atalay and Damla Gozen.


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Novel Derivatives of Benfluron and Dimefluron: Synthesis and Anticancer Activity


Lenka Sucha, Marek Kolenic, Jiri Kratochvil, Milan Pour, Milan Nobilis, Eva Cermakova, Martina Rezacova and Pavel Tomsik.


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Computational Docking Studies of Novel Heterocyclic Carboxamides as Potential PI3Kα Inhibitors


Kamal Sweidan, Dima A. Sabbah, Jorn Engelmann, Heba Abdel-Halim and Ghassan Abu Sheikha.


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Recent Developments in the Synthesis and Applications of Anticancer Amonafide Derivatives a Mini Review


Gary Gellerman.


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Effect of Acute Administration of 8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine Hydrochloride (TC-2153) on Biogenic Amines Metabolism in Mouse Brain


Elizabeth A. Kulikova, Ekaterina Y. Bazhenova, Nina K. Popova, Tatyana M. Khomenko, Konstantin P. Volcho, Nariman F. Salakhutdinov and Alexander V Kulikov.


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Discovery of New Inhibitors of Urease Enzyme: A Study Using STD-NMR Spectroscopy


Jalaluddin A. J. Awllia, Ayesha Sara, Atia-tul- Wahab, Maryam AL-Ghamdi, Saima Rasheed, Etimad Huwait and M Iqbal Choudhary.


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3D-QSAR and Molecular Docking Studies of Flavonoid Derivatives as Potent Acetylcholinesterase Inhibitors


An Zhou, Zeyu Wu, Ailing Hui, Bin Wang, Xianchun Duan, Haixiang Wang and Jian Pan.


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Syntheses and Activity of Carbohydrate-Containing Chitinase Inhibitors


Gangliang Huang, Xinya Mei, Xin Chen and Feng Xiao.


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Synthesis, Cytoprotective and Anti-Tumor Activities of Isatin Schiff Bases


Gang Chen, Mei Meng, Yu Zhang, Xiaojiang Hao, Ye Wang and Shuzhen Mu.


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Design, Synthesis and Evaluation of Novel 9-substituted Carbazole Derivatives as Potential Anticancer Agents


Nitin Kumar and Devender Pathak.


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In Silico Molecular Interaction Studies of Chiral Heterocyclic Analogs of SAHA as Selective Histone Deacetylase 8 Inhibitors


Appavoo Umamaheswari, Navabshan Irfan and Ayarivan Puratchikody.


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An Insight into Patents of Fluoroquinolone Derivatives


Prabodh Chander Sharma, Mona Piplani and Harish Rajak.


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Psychoemotional Background of Temporomandibular Joint Dysfunction and Possible drug Therapy


Pihut Malgorzata, Gierowski Krzysztof, Ceranowicz Piotr and Ferendiuk Ewa.


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Synthesis and Cytotoxicities of 2-[4-Hydroxy-(3, 5-Bis-Aminomethyl)-Benzylidene]-Indan-1-ones


Mehtap Tugrak, Halise Inci Gul and Hiroshi Sakagami.


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A Review on Recent Robotic and Analytic Technologies in High Throughput Screening and Synthesis for Drug Discovery


Min Zhu.


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QSAR Studies on the Bioactivity of Plasmodium Falciparum Glucose-6-Phosphate Dehydrogenase Inhibitors


Xiaoli Hou, Yue Kong, Maolin Wang and Aixia Yan.


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HIF Inhibitors: New Hope for Cancer Therapy


Mayur Poddar, Tejraj M. Aminabhavi and Malleshappa N Noolvi.


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Oxime Carbamates as Potential Insecticidal Agents: Design, Synthesis and Biological Evaluation


Shaoyong Ke, Ziwen Yang, Liqiao Shi, Manli Liu, Ying Liang, Kaimei Wang, Aibing Jiang and Zhigang Zhang.


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Application of Agents Against Interferon-Gamma-Dependent Chemokines in Immunotherapy


Poupak Fallahi, Silvia Martina Ferrari, Dilia Giuggioli, Clodoveo Ferri and Alessandro Antonelli.


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Exploring Structure-Based Drug Design for the Development of Multi-Target Antihypertensives


Estella G. da Mota, Elaine F. F. da Cunha and Matheus P Freitas.


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Synthesis and Anticancer Activity of 1, 3, 5-Triaryl-1H-Pyrazole


Sajad Ghadbegi, Seyed Nasser Ostad, Abbas Shafiee and Mohsen Amini.


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Preparation and Characterization of CS/(β-CD)/PAA Composite Hydrogels for Controlled Drug Delivery


Jie Ren, Xiaoci Yang, Mengqi Yao, Jinfen Gu, Xiaohua Tang and Wu Yang.


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Synthesis, Antitumor of New Pyrimidineand Caffeine Derivatives


Ameen Ali Abu-Hashem and Hoda Abdel Raouf Hussein.


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Design, Synthesis and AntitumorActivities of Bis-arylureas and Bisarylamides Based on 1H-benzo[d]imidazole Moiety as Novel BRaf V600E/VEGFR2 Dual Inhibitors


Weimin Yang, Yadong Chen, Yanmin Zhang, Sanzhi Tang, Hongli Chen, Weifang Tang and Tao Lu.


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Synthesis and Biological Activity of Thiazole Dithiocarbamate Derivatives


Nalan Gundogdu-Karaburun.


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Synthesis and Anticancer Activity of Some 2-[3/4-(2-Substituted Phenyl-2- oxoethoxy)benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one Derivatives


Nalan Gundogdu-Karaburun, Ahmet Cagri Karaburun, Seref Demirayak, Ismail Kayagil and Leyla Yurttas.


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Synthesis and Biological Evaluation of New Tubulin Inhibitors: Shikonin Thio-glycoside Derivatives


Xiao-Ming Wang, Hong-Yan Lin, Jin-Liang Qi, Li-Fei Bai and Yong-Hua Yang.


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Fat-Soluble Vitamins Release Based on Clinoptilolite Zeolite as an Oral Drug Delivery System


Mehdi Rahimi, Hamid Mobedi, Aliasghar Behnamghader, Alireza Nateghi Baygi, Houri Mivehchi and Esmaeil Biazar.


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Synthesis and Biological Evaluations of 3-Benzothiazol-2-yl Coumarin Derivatives as MEK1 Inhibitors


Chao Wang, Fengrong Xu, Yan Niu, Yun Wu, Jing Sun, Yihong Peng, Lei Liang and Ping Xu.


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Synthesis and Biological Evaluation of Arylthiourea Derivatives with Antitubercular Activity


Rusong Luo, Tuomo Laitinen, Liyan Teng, Tapio Nevalainen, Maija Lahtela-Kakkonen, Baofu Zheng, Honghai Wang, Antti Poso and Xuelian Zhang.


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Synthesis and Antiproliferative Evaluation of Hybrids of Indolin-2-one and Quinazoline-4(3H)-one Linked via Imine Bond


Wei-Yao Wu, Sheng-Li Cao, Bei-Bei Mao, Ji Liao, Zhong-Feng Li, Hao-Bin Song and Xingzhi Xu.


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Construction and High Expression of a Recombinant Amino-Proximal HSV-2 Glycoprotein B Polypeptide with Immunogenicity in Escherichia coli


Xu Ning, Tu Jingjing, Wang Xian Yan and Xu Fang.


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Synthesis and Study of Antitumor Activity of Artimisinin Glucoside


Yanrong Ren and Guoping Chen.


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Synthesis and Biological Activity of New 2,3-dihydro-1H-cyclopenta[b]- quinoline Derivatives as Acetylcholinesterase Inhibitors


Pawel Szymanski, Magdalena Markowicz, Marek Bajda, Barbara Malawska and Elzbieta Mikiciuk-Olasik.


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Novel Aminoalcohol Derivatives Bearing 4-Phenylphenol as Antischistosomal Drugs


Li-Ping Duan, Jian Xue, Yi Tao and Hao-Bing Zhang.


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Deformable Surfactant Vesicles Loading Ammonium Glycyrrhizinate: Characterization and In Vitro Permeation Studies


Luisa Di Marzio, Carlotta Marianecci, Federica Rinaldi, Sara Esposito and Maria Carafa.


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