E-Pub Articles Ahead of Print ::: Letters in Drug Design & Discovery

ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)


Volume 14, 12 Issues, 2017


Download PDF Flyer




Letters in Drug Design & Discovery

This journal supports open access

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
G. Perry
University of Texas
San Antonio, TX
USA


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 0.974
5 - Year: 2.25

E-Pub Articles Ahead of Print

A Brief Overview on Chemistry and Biology of Benzoxepine


Naveen Kuntala, Jhonsee R. Telu, Jaya S. Anireddy and Sarbani Pal.


View Abstract Purchase Online


Synthesis and antioxidant activity of indole derivatives containing 4-substituted piperazine moieties


Tuncagül Altuntaş, Nilüfer Yilmaz, Tülay Çoban, Zühal Kilic-Kurt and Sureyya Olgen.


View Abstract Purchase Online


The Decisive Role of Mutual Arrangement of Hydroxy and Methoxy Groups in (3(4)-hydroxy-4(3)-methoxyphenyl)-4,7-dimethyl-3,4,4a,5,8,8ahexahydro- 2H-chromene-4,8-diols in their Biological Activity


Alla Pavlova, Oksana Patrusheva, Irina Il'ina, Konstantin Volcho, Tat'yana Tolstikova and Nariman Salakhutdinov.


View Abstract Purchase Online


Antitubercular and Antimicrobial Activity of NH4VO3 Promoted 1,4- Dihydropyridine Incorporated 1,3,4-trisubstituted Pyrazole


Harikrishna Nandam, Arun M. Isloor, Ananda Kulal, Tanya Parish, Joazaizulfazli Jamalis, Hazem A. Ghabbour and Hoong-Kun Fun.


View Abstract Purchase Online


Synthesis and Evaluation of Anti-Tuberculosis and Anti-Cancer Activities of Hydrazones and N-Acylhydrazones by Using Sonochemistry, a New General Procedure


Ligia Souza da Silveira Pinto, Marcus Vinicius Nora De Souza and Carlos Roland Kaiser.


View Abstract Purchase Online


Molecular Docking, 3D-QSAR and Structural Optimization of Indole Biphenylcarboxylic Acids as PPARγ Antagonists


Xin Liu, Zhi Jing, Wenqing Jia, Shuqing Wang, Weiren Xu and Xian-Chao Cheng.


View Abstract Purchase Online


Copper Complexes of 8-Aminoquinoline and Uracils as Novel Aromatase Inhibitors


Nujarin Sinthupoom, Veda Prachayasittikul, Ratchanok Pingaew, Apilak Worachartcheewan, Supaluk Prachayasittikul, Somsak Ruchirawat and Virapong Prachayasittikul.


View Abstract Purchase Online


Withania somnifera Phytochemicals Confer Neuroprotection by Inhibition of the Catalytic Domain of Human Matrix Metalloproteinase-9


Gaurav Kumar, Pankaj Paliwal and Ranjana Patnaik.


View Abstract Purchase Online


Novel Chromeno[2,3-d]pyrimidines - Design, Synthesis and Antioxidant Activity


Kotiah Yalagala, Sreekantha B. Jonnalagadda, Suresh Maddila, Surjyakanta Rana and Surya Narayana Maddila.


View Abstract Purchase Online


Development of Xanthine Based Inhibitors Targeting Phosphodiesterase 9A


Nivedita Singh, Parameswaran Saravanan, M.S. Thakur and Sanjukta Patra.


View Abstract Purchase Online


Molecular Docking and Structure Activity Relationship Studies of NSAIDs. What do they Reveal About IC50?


Chrysoula Mikra, Georgios Rossos, Sotirios K Hadjikakou and Nikolaos Kourkoumelis.


View Abstract Purchase Online


Chronobiotic Hormone Melatonin: Comparative in vitro Release Studies from Matrix Tablets and Liposomal Formulations


Androniki Zampakola, Angeliki Siamidi, Natassa Pippa, Costas Demetzos and Marilena Vlachou.


View Abstract Purchase Online


NF-κB Inhibitors in Head and Neck Cancer


Siddavaram Nagini, Kranthi Kiran Kishore Tanagala and Indranil Chattopadhyay.


View Abstract Purchase Online


Synthesis and Evaluation of New Thiazolyl Hydrazone Derivatives as Potential Anticancer Agents


Zafer Asim Kaplancikli, Belgin Sever, Mehlika Dilek Altıntop, Özlem Atlı, Merve Baysal and Ahmet Özdemir.


View Abstract Purchase Online


Synthesis, Antiproliferative, and Antiangiogenic Activities of Benzochromene and Benzoquinoline Derivatives on Prostate Cancer in vitro


Gricelda Mata, Juan Rodrigues, Neira Gamboa, Katiuska Charris, Gricela Lobo, Melina Monasterios, Milagros Avendaño, Michael Lein, Klaus Jung Claudia Abramjuk and Jaime Charris.


View Abstract Purchase Online


Pharmacokinetic Evaluation of Callistemon viminalis Derived Natural Compounds as Targeted Inhibitors Against δ -Opioid Receptor and Farnesyl Transferase


kamal ahmad, Abdul Roof Bhat and Fareeda Athar.


View Abstract Purchase Online


Nano Conjugated PLGA-Chlorambucil: Synthesis In Vitro Anti Non- Hodgkin's Lymphoma Cellular Assay


Fatemeh Monnavari, Artin Assadi, Hossein Heidari, Rahimeh Rasouli, Mostafa Saffari, Seyed Ataollah Sadat Shandiz, Mohammad Reza Aghasadeghi, Peyman Keyhanvar, Farnoor Davachi Omoomi, Mohammad saffari, Seyed Esmaeil Sadat Ebrahimi, Morteza Pirali Hamedani and Mehdi Shafiee Ardestani.


View Abstract Purchase Online


Synthesis of Mannich Bases by Two Different Methods and Evaluation of their Acetylcholine Esterase and Carbonic Anhydrase Inhibitory Activities


Halise Inci Gul, Alkan Demirtas, Gokbay Ucar, Parham Taslimi and İlhami Gulcin.


View Abstract Purchase Online


Homology Modeling of Human Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 2: Insights into Isoenzyme-Specific Differences Using Molecular Docking Simulatons


Gokcen Eren.


View Abstract Purchase Online


Synthesis, Anti-inflammatory and Molecular Docking Study of Schiff Bases Containing Methanesulphonyl Pharmacophore


Khaled R. A. Abdellatif, Mohammed T. Elsaady, Salah A. Abdel-Aziz and Ahmed H A Abu Sabah.


View Abstract Purchase Online


Benzopentathiepine Derivative, 8-(Trifluoromethyl)-1,2,3,4,5-Benzopentathiepin- 6-Amine Hydrochloride (TC-2153), As a Promising Antidepressant of New Generation


Elizabeth A. Kulikova, Konstantin Volcho, Nariman Salakhutdinov and Alexander V Kulikov.


View Abstract Purchase Online


3D-QSAR and Molecular Docking Studies of Pyrazole Derivatives as Inhibitors of Enoyl Acyl Carrier Protein Reductase from Mycobacterium tuberculosis


Sheshagiri R. Dixit, Shrinivas D. Joshi, V. H. Kulkarni and Tejraj M Aminabhavi.


View Abstract Purchase Online


3D-QSAR, Molecular Docking and Molecular Dynamics Studies of 2,4- Diarylaminopyrimidine Analogues (DAAP Analogues) as Potent ALK Inhibitors


Fu long Wu, Qian qian Lv, Zhong hua Wang, Dan dan Li, Peng Peng, Yan Yin, Si heng Cui and Fan hong Wu.


View Abstract Purchase Online


Design, Synthesis and Insecticidal Activity of Diamides with Oxydibenzene or Diphenylamine Subunits


Ye Liu, Xusheng Shao, Xinfei Chen, Xiaoyong Xu, Zhong Li and Jiagao Cheng.


View Abstract Purchase Online


Improved Anti-inflammatory Activity and Potential Cytoprotective Properties of Tolfenamic Acid, Naproxen and Indomethacin Derivatives


Panagiotis Theodosis-Nobelos, Theodora C. Politou, Chrysoula Athanasekou and Eleni A Rekka.


View Abstract Purchase Online


Synthesis and Nematocidal Activity of Novel Pyrazole Carboxamide Derivatives Against Meloidogyne incognita


Wen Zhao, Zhong-Hua Shen, Jia-Hua Xing, Tian-Ming Xu, Wei-Li Peng and Xing-Hai Liu.


View Abstract Purchase Online


Synthesis and Antiproliferative Activities of Novel O-Benzyl Salicylamide Derivatives


Jan Dušek, Aleš Imramovský, Karel Pauk, Radek Jorda, Eva Řezníčková and Vladimír Kryštof.


View Abstract Purchase Online


Possible Binding Mode Analysis of Pyrazolo-triazole Hybrids as Potential Anticancer Agents through Validated Molecular Docking and 3D-QSAR Modeling Approaches


Sk. Abdul Amin, Nilanjan Adhikari, Ramkishore Agrawal, Tarun Jha and Shovanlal Gayen.


View Abstract Purchase Online


Design, Synthesis and Evaluation of Novel Derivatives of Orotic Acid Amide as Potent Glucokinase Activators


Leilei Zhang, Shengquan Hu, Lei Lei, Yuliang Zhang, Lijing Zhang, Hongrui Song, Zhufang Shen and Zhiqiang Feng.


View Abstract Purchase Online


3D-QSAR Studies of HDAC6 Inhibitors Using Docking-Based Alignment


Chunqi Hu, Liang Hong, Jun Li and Wenting Du.


View Abstract Purchase Online


Structure-Based Hybridization, Conventional and Microwave Irradiated Synthesis, Biological Evaluation and Molecular Docking Studies of New Compounds Derived from Thiomorpholin


Serpil Demirci, Fatma Aksakal, Nesrin Colak, Serdar Ulker, Ahmet Demirbas and Neslihan DEMİRBAS.


View Abstract Purchase Online


Novel Indole-Isoxazole Hybrids: Synthesis and In Vitro Anti-cholinesterase Activity


Fahimeh Vafadarnejad, Mina Saeedi, Mohammad Mahdavi, Ali Rafinejad, Elahe Karimpour-Razkenari, Bilqees Sameem, Mahnaz Khanavi and Tahmineh Akbarzadeh.


View Abstract Purchase Online


Design, Synthesis, Antioxidant and Anticancer Activity of New Coumarin Derivatives Linked with Thiazole, Isoxazole or Pyrazole Moiety


Khaled Abdellatif, Mohamed Abdelgawad, Heba Elshemy, Nesma Kahk and Dalia M El Amir.


View Abstract Purchase Online


Fe3+-Tryptophan-3-Hydroxy-2-Methyl or ethyl pyridinones towards Novel Molecular Tumor Nuclear Resonance Imaging Agents


Ali Khalaj, Shadi Hosseini, Rahimeh Rasouli, Artin Assadi, Seyedeh Ghoreishi and Mehdi Shafiee Ardestani.


View Abstract Purchase Online


Synthesis of Phosphorylated Derivatives of 2′, 3′-O-Isopropylidene Adenosine and their In Ovo Antiviral Activity


S. Rasheed, C. Naga Raju, G. Madhava, Ch. Subramanyam, S.K. Thaslim Basha, A. Jannardhan and G Narasimha.


View Abstract Purchase Online


Design, Synthesis and Antidepressant and Anticonvulsant Effect of 1-Alkoxy-1H-Benzo[d]-1,2,3-Triazole Derivatives


Yu Sun and Qing-Hao Jin.


View Abstract Purchase Online


Anti-biofilm and Antibacterial Effects of Novel Metal-coordinated Sulfamethoxazole Against Escherichia coli


Caren Rigon Mizdal, Sílvio Terra Stefanello, Pauline Cordenonsi Bonez, Vanessa Albertina Agertt, Vanessa da Costa Flores, Grazielle Guidolin Rossi, Fallon dos Santos Siqueira, Lenice de Lourenço Marques and Marli Matiko Anraku Campos.


View Abstract Purchase Online


Quorum Sensing Inhibitor Activities of Celecoxib Derivatives in Pseudomonas aeruginosa


Seyhan Ulusoy, Sevil Aydın, İnci Coşkun, Gülgün Boşgelmez-Tınaz, Laurent Soulere, Yves Queneau and Ş Güniz Küçükgüzel.


View Abstract Purchase Online


Synthesis, Antibacterial, Antifungal, Antimycobacterial Activity Evaluation of Novel 1,2,4-triazole Derivatives Bearing 4-aminophenyl Moiety Biological Evaluation of New Triazole Derivatives


Betül Kaya, Leyla Yurttas, Meral Yılmaz Cankılıç and Zafer Asım Kaplancıklı.


View Abstract Purchase Online


Polyphenolic Compound from Vitis vinifera L. Have Potential for the Alzheimer Disease Treatment


Soukup Ondrej, Stralkova Radomira, Mistova Tereza, Popov Marek, Hejtmankova Alena, Lachman Jaromir, Klimova Blanka and Kuca Kamil.


View Abstract Purchase Online


A Facile Synthesis and Drug Design of Some New Heterocyclic Compounds Incorporating Pyridine Moiety and Their Antimicrobial Evaluation


Sobhi M. Gomha, Fathy M. Abdelrazek, Aly H. Abdelrahman, Peter Metz and Mohsen A Sayed.


View Abstract Purchase Online


A Two QSAR Way for Antidiabetic Agents Targeting Using α-Amylase and α-Glucosidase Inhibitors: Model Parameters Settings in Artificial Intelligence Techniques


Karel Diéguez-Santana, Hai Pham-The, Oscar Miguel Rivera-Borroto, Amilkar Puris, Huong Le-Thi-Thu and Gerardo M Casañola-Martin.


View Abstract Purchase Online


Synthesis, Enzyme Assays and Molecular Docking Studies of Fluorinated Bioisosteres of Santacruzamate A as Potential HDAC Tracers


Muneer Ahamed, Koen Vermeulen, Michael Schnekenburger, Lise Román Moltzau, Finn Olav Levy, János Marton, Mathy Froeyen, Dag Erlend Olberg, Marc Diederich and Guy Bormans.


View Abstract Purchase Online


Computational Analysis of Pyridopyrimidine-based Polo Like Kinase 2 (PLK2) Inhibitors: Examining the Structural Basis for Anticancer Activity


Anand Balupuri, Pavithra K. Balasubramanian and Seung Joo Cho.


View Abstract Purchase Online


Quinoline Derivatives as Novel Depigmenting and Antioxidant Agents


Rebeca Mól Lima, Jordana de Abreu Lazzarini, Isabela Oliveira Souza, Adilson David Silva, Nádia Rezende Barbosa Raposo and Kauana Cristina de Souza.


View Abstract Purchase Online


Pentoxifylline Alleviates Proteinuria in Fructose Model of Metabolic Syndrome


Hany M. El-Bassossy, Basma Eid and Ahmad Azhar.


View Abstract Purchase Online


Synthesis of Novel 4-(Dimethylaminoalkyl)piperazine-1-carbodithioate Derivatives as Cholinesterase Inhibitors


Ulviye Acar, Serkan Levent, Begüm Nurpelin Sağlık, Yusuf Özkay and Zafer Asım Kaplancıklı.


View Abstract Purchase Online


Caffeic Acid Phenethyl Ester Restores Adipocyte Function Following Lipopolysaccharide treatment


Ignazio Barbagallo, Giovanni Li Volti, Valeria Sorrenti, Claudia Di Giacomo, Rosaria Acquaviva, Marco Raffaele, Fabio Galvano and Luca Vanella.


View Abstract Purchase Online


Novel Second Generation HIV Integrase Inhibitor- DOLUTEGRAVIR : an emerging weapon against HIV


Vivek Jain, Diksha Gupta, Ashutosh Pareek and Yashumati Ratan Bhardwaj.


View Abstract Purchase Online


Sequential Therapy For Helicobacter Pylori In Elderly Patients: Effectiveness, Safety And Predictors Of Success


Giuseppe Losurdo, Andrea Iannone, Floriana Giorgio, Michele Barone, Mariabeatrice Principi, Enzo Ierardi and Alfredo Di Leo.


View Abstract Purchase Online


3D-QSAR studies of novel cytotoxic bufadienolides via CoMFA and CoMSIA approaches


Jian Jie, Hui Lin, Kangjia Liu, Yushui Han, Jialiang Guo, Longxin Lin, Yiqun Chang, Gaokeng Xiao, Weimin Chen and Pinghua Sun.


View Abstract Purchase Online


In Vivo Antimalarial and In Vitro Antileishmanial Activity of 4-Aminoquinoline Derivatives Hybridized to Isoniazid or Sulfa or Hydrazine Groups


Clarice Abramo, Roberta R. Soares, Luciana MR Antinarelli, Isabela de Oliveira Souza, Fernanda V. Lopes, Kézia Katiani Gorza Scopel and Adilson D da Silva.


View Abstract Purchase Online


In silico Modeling for the Design of 2-substitted Benzimidazole Derivatives, and Prediction of Activity as Procaspase-3 Activators and Apoptosis Inducer


Vivek K. Vyas, Manjunath Ghate and Prajakta Kulkarni.


View Abstract Purchase Online


Cytotoxic, Apoptotic and DNA Synthesis Inhibitory Effects of Some Thiazole Derivatives


Gülşen Akalın Çiftçi, Mehlika Dilek Altıntop, Halide Edip Temel, Ahmet Özdemir and Zafer Asım Kaplancıklı.


View Abstract View on PubMed Purchase Online


Synthesis, Molecular Docking and Pharmacological Study of Pyrimidothiadiazinones and its bis-derivatives


Sobhi M. Gomha, Ikhlass Abbas, Mohamed Elneairy, Mahmoud Elaasser and bazada khamis.


View Abstract Purchase Online


Molecular Docking, Molecular Dynamics, and In Silico Prediction of the Toxic Potential of Primaquine Thiazolidinone Derivatives


Andre Silva Pimentel and Erika Murce.


View Abstract Purchase Online


Field Based 3D-QSAR model of KATP channel activation by 4, 6 disubstituted Benzopyran Derivatives


Kamlesh Asotra, yaseen gigani, Andrew Lynn and Swati Gupta.


View Abstract Purchase Online


Synthesis, Docking and Antidiabetic Activity of Some Newer Benzamide Derivatives as Glucokinase Activators


Rohit Singh, Viney Lather, Deepti Pandita, Vikramjeet Judge, Karthikeyan N. Arumugam and Ajmer Singh Grewal.


View Abstract Purchase Online


Structural studies of aminopeptidase P from Plasmodium falciparum: a novel target against malaria


P Snigdha, P Lakshmana Rao, N Prakash Prabhu and Insaf Ahmed Qureshi.


View Abstract Purchase Online


The Summation of Atomic Contributions is an Overly Simplified Characterization of the Holistic Molecular Behavior


Yoan Martínez-López, Yovani Marrero-Ponce, Gustavo Echeverri Jaramillo and Stephen J Barigye.


View Abstract Purchase Online


Design, Synthesis and Biological Evaluation of Novel Tetrahydroquinoline Based Propanehydrazides as Antitubercular Agents


Subhash Chander, Penta Ashok, Bidart de Macedo Maira, Cappoen Davie and Sankaranarayanan Murugesan.


View Abstract Purchase Online


Model for Classification of ChEMBL Dataset of Anti-breast cancer Compounds According to Multiple Pharmacological Parameters, Biological Assays, and Receptors


Francisco J. Prado-Prado, Angel G. Arguello-Chan, Coraima I. Estrada-Domínguez, Alejandra Aguirre-Crespo, Francisco J. Aguirre-Crespo and Xerardo García-Mera.


View Abstract Purchase Online


Preparation and Characterization of CS/(β-CD)/PAA Composite Hydrogels for Controlled Drug Delivery


Jie Ren, Xiaoci Yang, Mengqi Yao, Jinfen Gu, Xiaohua Tang and Wu Yang.


View Abstract Purchase Online


Advertisement

Related Journals




Related eBooks


Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science