E-Pub Articles Ahead of Print ::: Current Pharmaceutical Design

ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 21, 42 Issues, 2015


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Current Pharmaceutical Design

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William A. Banks
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E-Pub Articles Ahead of Print

Borderline Personality Disorder and Oxytocin: Review of Clinical Trials and Future Directions
Ali Amad, Pierre Thomas and M. Mercedes Perez-Rodriguez
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Off-Label Use of Medications for Treatment of Benzodiazepine Use Disorder
Pamela Sabioni, Jonathan Bertram and Bernard Le Foll
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Sense and Sensibility when Prescribing ‘Off-Label’ to Psychiatric Patients
David S Baldwin, Nupur Tiwari and Robert Gordon
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Current Issues in the Use of fMRI-Based Neurofeedback to Relieve Psychiatric Symptoms
Thomas FOVET, Renaud JARDRI and David LINDEN
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Novel Indications for Benzodiazepine Antagonist Flumazenil in GABA Mediated Pathological Conditions of the Central Nervous System
Gary Hulse, Erin Kelty, Sean Hood, Amanda Norman, Maria Rita Basso and Albert Stuart Reece
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Off-Label Prescribing of Antipsychotics in Adults, Children and Elderly Individuals: A Systematic Review of Recent Prescription Trends
Louise CARTON, Olivier COTTENCIN, Maryse LAPEYRE-MESTRE, Pierre A. GEOFFROY, Jonathan FAVRE and Nicolas SIMON
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Emerging Drugs and Indications for Cardio-Metabolic Disorders in People with Severe Mental Illness
Youssef Kouidrat, Ali Amad and Marc De Hert
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Methylphenidate in Adults with Attention Deficit Hyperactivity Disorder and Substance Use Disorders
Nicolas SIMON, Benjamin ROLLAND and Laurent KARILA
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Melatonin and Melatonin Agonists as Adjunctive Treatments in Bipolar Disorders
Pierre Alexis GEOFFROY, Bruno ETAIN, Jean-Arthur MICOULAUD FRANCHI, Frank BELLIVIER and Philipp RITTER
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Transcranial Direct Current Stimulation for the Treatment of Refractory Symptoms of Schizophrenia. Current Evidence and Future Directions
Marine MONDINO, Jerome BRUNELIN, Ulrich PALM, Andre R. BRUNONI, Emmanuel POULET and Shirley FECTEAU
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Is There a Place for Off-Label Pharmacotherapy in Cannabis Use Disorder? A Review on Efficacy and Safety
Vincent Laprevote, Raymund Schwan, Thomas Schwitzer, Benjamin Rolland and Johannes Thome
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GABAB agonists for the treatment of Alcohol Use Disorder
A. Mirijello, F. Caputo, G. Vassallo, B. Rolland, C. Tarli, A. Gasbarrini and G. Addolorato
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Off-Label Trazodone Prescription: Evidence, Benefits and Risks
Bossini Letizia, Coluccia Anna, Casolaro Ilaria, Benbow Jim, Giovanni Amodeo, Riccardo De Giorgi and Andrea Fagiolini
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When is a Proof-of-Concept (POC) not a POC? Pomaglumetad (LY2140023) as a Case Study for Antipsychotic Efficacy
Gerard J. Marek
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5-HT6 Receptor Antagonists: Potential Efficacy for the Treatment of Cognitive Impairment in Schizophrenia
Natasja M.W.J. de Bruin and Chris G. Kruse
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Bone Recuperation after rhBMP-2 Insertion in Alcoholic Animals-Experimental Study
Bruna Gabriela dos Santos Kotake, Leda Maria Pescinini Salzedas, Edilson Ervolino, Ricardo Alexandre, Junqueira Calzzani, Walter Sebald and João Paulo Mardegan Issa
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Treatment of Cognitive Impairment in Schizophrenia: Potential Value of Phosphodiesterase Inhibitors in Prefrontal Dysfunction
Van Duinen MA, Reneerkens OAH, Lambrecht L, Sambeth A, Rutten BPF, Van Os J, Blokland A and Prickaerts J
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Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker
Kenji Hashimoto
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Recent Development of New DNA Origami Nanostructures for Drug Delivery
Juan Yan, Chongya Hu, Xunwei Liu, Jian Zhong, Gang Sun and Dannong He
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Hydrophilic Polymers for Modified-Release Nanoparticles: A Review of Mathematical Modelling for Pharmacokinetic Analysis
Andreani T., Fangueiro J.F., Jose S., Santini A., Silva A.M. and Souto E.B.
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Multifunctional Delivery Systems for Advanced oral Uptake of Peptide/Protein Drugs
Jin Woo Park, Sun Jin Kim, Dong Sup Kwag, Sol Kim, Jeyoung Park, Yu Seok Youn, You Han Bae and Eun Seong Lee
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Emerging Use of Nanotechnology in the Treatment of Neurological Disorders
Resham Chhabra, Giovanni Tosi and Andreas M Grabrucker
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Crystallization Methods for Preparation of Nanocrystals for Drug Delivery System
Yuan Gao, Jingkang Wang, Yongli Wang, Qiuxiang Yin, Brian Glennon, Jian Zhong, Jinbo Ouyang, Xin Huang and Hongxun Hao
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Lipid-Based Nanocarriers for RNA Delivery
Hui Yi Xue, Pengbo Guo, Wu-Cheng Wen and Ho Lun Wong
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Formulation and Stability Aspects of Nanosized Solid Drug Delivery Systems
Peter Szabo and Romana Zelko
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Nanoparticle-Based Combination Therapy for Cancer Treatment
Ji Young Yhee, Sejin Son, Hyukjin Lee and Kwangmeyung Kim
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Functionalized Nanocarriers for Enhanced Bioactive Delivery to Squamous Cell Carcinomas: Targeting Approaches and Related Biopharmaceutical Aspects
Adeyemi S. Adebowale, Yahya E. Choonara, Pradeep Kumar, Lisa C. du Toit and Viness Pillay
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Application of Carbon Nanomaterials in Gene Delivery for Endogenous RNA Interference In Vitro and In Vivo
Lanying Li, Yanli Wen, Qin Xu, Li Xu, Dong Liu and Gang Liu
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Zein-based Nanofibres for Drug Delivery: Classes and Current Applications
Yong Zhang, Lili Cui, Yan Chen, Heng Zhang, Jian Zhong, Yanan Sun, Nianqiu Shi, Chunlei Li and Wei Kong
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Intratumoral Pharmacokinetics: Challenges to Nanobiomaterials
Ahmed M. Al-Abd, Fahad A. Al-Abbasi and Vladimir P. Torchilin
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Graphene Oxide-Based Nanocarriers for Cancer Imaging and Drug Delivery
Peihong You, Yang Yang, Mingwei Wang, Xiaoyu Huang and Xiao Huang
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Multidimensional Ophthalmic Nanosystems for Molecular Detection and Therapy of Eye Disorders
Swati Vyas, Pratik Kakade, Manasi Chogale, John Disouza and Vandana Patravale
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EHDA Spraying: A Multi-Material Nano-Engineering Route
R Haj-Ahmad, M Rasekh, K Nazari, Y Li, Y Fu, B Li, Q Zhang, Z Xia, H Liu, T Gu, G Wang, I Kucuk, H Khan, MS Arshad, X Li and Z Ahmad
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Generation of Targeted Adeno-Associated Virus (AAV) Vectors for Human Gene Therapy
Yarong Liu, Natnaree Siriwon, Jennifer A. Rohrs and Pin Wang
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Contribution of Nanotechnology to Improved Treatment of Periodontal Disease
Spela Zupancic, Petra Kocbek, Sasa Baumgartner and Julijana Kristl
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Editorial: Nanotechnology for Drug Delivery: Part I
Jian Zhong
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Editorial: The Pathogenesis of Inflammation and Cancer in the Gastrointestinal Tract: From Basic Science to Translational Medicine
C.H. Cho and H.Y. Wang
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Efficacy of Andolast in Mild to Moderate Asthma: A Randomized, Controlled, Double-Blind Multicenter Study (The Andast Trial)
Mario Malerba, Massimo D`Amato, Alessandro Radaeli, Giampaolo Giacovelli, Lucio Rovati, Sayed H. Arshad and Stephen T. Holgate
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Editorial: Breaking the Skin Barrier: Achievements and the Future
Yasser Shahzad
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Atrial Fibrillation and Gastro-Oesophageal Reflux Disease - Controversies and Challenges
Mariana Floria, Oana Bărboi, Ciprian Rezuș, Valentin Ambărus, Cristina Cijevschi-Prelipcean, Gheorghe Balan and Vasile Liviu Drug
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MicroRNAs in Esophageal Adenocarcinoma: Functional Significance and Potential for the Development of New Molecular Disease Markers
Yuri V. Bobryshev, Alexander N. Orekhov and Dmitry A. Chistiakov
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Anti-VEGF Drugs in Eye Diseases: Local Therapy with Potential Systemic Effects
Markus van der Giet, Cornelia Henkel, Mirjam Schuchardt and Markus Tölle
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The Potential Effect of Fluorinated Compounds in the Treatment of Alzheimer’s Disease
Bárbara Gomes, Joana A. Loureiro, Manuel A.N. Coelho and Maria do Carmo Pereira
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Anticancer Advances of Matrine and Its Derivatives
Jianping Yong, Xiaoyuan Wu and Canzhong Lu
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Skeletal Muscle Cell Behavior After Physical Agent Treatments
Michela Battistelli, Sara Salucci, Michele Guescini, Davide Curzi, Vilberto Stocchi and Elisabetta Falcieri
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Analysis of Edg-Like LPA Receptor-Ligand Interactions
Balazs Balogh, Tamas Pazmany and Peter Matyus
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Evaluation of the In Vivo Safety Profiles of Rictor Inhibition Using a Zebrafish Model
Yang Cao, Lijun Jiang, Lei Zhao, Xiaoxi Zhou, Na Wang, Peilin Zhang, Yuting Tang and Jianfeng Zhou
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Applications of Important Polysaccharides in Drug Delivery
Gangliang Huang, Xinya Mei, Feng Xiao, Xin Chen, Qilin Tang and Daquan Peng
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The Molecular Mechanisms of TRAIL Resistance in Cancer Cells: Help in Designing New Drugs
Feng Wang, Junsheng Lin and Ruian Xu
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Editorial: Mitochondrial Biogenesis: Pharmacological Approaches
Teresa Valero
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Mechanisms of Inflammatory Response and Organ Dysfunction: Organ-Protective Strategy by Anesthetics
Noboru Hatakeyama and Naoyuki Matsuda
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VEGF and Colon Cancer Growth Beyond Angiogenesis: Does VEGF Directly Mediate Colon Cancer Growth Via a Non-angiogenic Mechanism?
Amrita Ahluwalia, Michael K. Jones, Tamara Matysiak-Budnik and Andrzej S. Tarnawski
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The Impact of Computational Structure-Based Methods on Drug Discovery
Charles H. Reynolds
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Anti-miRNA-23a Oligonucleotide Suppresses Glioma Cells Growth by Targeting Apoptotic Protease Activating Factor-1
Shizhong Lian, Ruyi Shi, Tao Bai, Yang Liu, Wang Miao, Hongqin Wang, Xiaodong Liu and Yimin Fan
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Editorial: The SNAP-tag Technology – A Versatile Tool with many Applications
Stefan Barth
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Gender Based Differences in Stress-induced Gastric Ulcer Formation and its Regulation by Nitric Oxide (NO): An Experimental Study
Kavita Gulati, Ayanabha Chakraborti and Arunabha Ray
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Differential Influences of Gastric Bypass and Sleeve Gastrectomy on Plasma Nesfatin-1 and Obestatin Levels in Patients with Type 2 Diabetes Mellitus
Wei-Jei Lee, Chih-Yen Chen, Kong-Han Ser, Keong Chong, Shu-Chun Chen, Pui-Ching Lee, You-Di Liao and Shou-Dong Lee
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Probiotics for the Prevention and Treatment of Allergies, with an Emphasis on Mode of Delivery and Mechanism of Action
Satya Prakash, Catherine Tomaro-Duchesneau, Shyamali Saha, Laetitia Rodes, Imen Kahouli and Meenakshi Malhotra
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Consumption of Mixed Fruit-juice Drink and Vitamin C Reduces Postprandial Stress Induced by a High Fat Meal in Healthy Overweight Subjects
Ilaria Peluso, Debora V. Villano, Susan A. Roberts, Eleonora Cesqui, Anna Raguzzini, Gina Borges, Alan Crozier, Giovina Catasta, Elisabetta Toti and Mauro Serafini
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Immunomodulating and Anti-allergic Effects of Negroamaro and Koshu Vitis vinifera Fermented Grape Marc (FGM)
Giuseppe Marzulli, Thea Magrone, Luisa Vonghia, Masahiro Kaneko, Hiroaki Takimoto, Yoshio Kumazawa and Emilio Jirillo
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Potential Use of Dietary Natural Products, Especially Polyphenols, for Improving Type-1 Allergic Symptoms
Kumazawa Y, Takimoto H, Matsumoto T and Kawaguchi K
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Omega-6 and Omega-3 Polyunsaturated Fatty Acids and Allergic Diseases in Infancy and Childhood
Elizabeth A. Miles and Philip C. Calder
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Factors Affecting Residual Platelet Aggregation in Prasugrel Treated Patients
Dimitrios Alexopoulos, Ioanna Xanthopoulou, Angelos Perperis, Argyro Siapika, Katerina Stavrou, Evropi Tsoni, Periklis Davlouros and George Hahalis
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What Fans the Fire: Insights into Mechanisms of Leptin in Metabolic Syndrome- Associated Heart Diseases
Maolong Dong and Jun Ren
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Transactivation of ErbB Receptors by Leptin in the Cardiovascular System: Mechanisms, Consequences and Target for Therapy
Jerzy Bełtowski and Anna Jazmroz-Wiśniewska
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Structural Insights into Chitinolytic Enzymes and Inhibition Mechanisms of Selective Inhibitors
Tian Liu, Lei Chen, Qiang Ma, Xu Shen and Qing Yang
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Structure-based Design of Conformationally Flexible Reverse Transcriptase Inhibitors to Combat Resistant HIV
Ge-Fei Hao, Sheng-Gang Yang and Guang-Fu Yang
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Structural Basis of Resistance to Anti-Cytochrome bc1 Complex Inhibitors: Implication for Drug Improvement
Lothar Esser, Chang-An Yu and Di Xia
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ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development
Young Hee Choi, Ai-Ming Yu and Ai-Ming Yu
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Structure-Based Drug Design to Overcome Drug Resistance: Challenges and Opportunities
Rafaela S. Ferreira1, Adriano D. Andricopulo and Adriano D. Andricopulo
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Novel Next-Generation Sequencing and Networks-Based Therapeutic Targets: Realistic and More Effective Drug Design and Discovery
Dimitrios H. Roukos, Giannis G. Baltogiannis, Christos S. Katsouras, Aris Bechlioulis, Katerina K. Naka, Charalambos Batsis, Theodore Liakakos and Lampros K. Michalis
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Endothelial Dysfunction and the Effects of TNF Inhibitors on the Endothelium in Psoriasis and Psoriatic Arthritis: A Systematic Review
Elizabeth A. Brezinski, Matthew R. Follansbee, Ehrin J. Armstrong and April W. Armstrong
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Effects of Biologic Agents and Other Disease-Modifying Antirheumatic Drugs on Cardiovascular Outcomes in Psoriasis and Psoriatic Arthritis: A Systematic Review
April W. Armstrong, Elizabeth A. Brezinski, Matthew R. Follansbee and Ehrin J. Armstrong
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Ultrasound-Based Multimodal Molecular Imaging and Functional Ultrasound Contrast Agents
Yan Lin, Zhi-Yi Chen and Feng Yang
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Long-term Etanercept Therapy Favors Weight Gain and Ameliorates Cachexia in Rheumatoid Arthritis Patients: Roles of Gut Hormones and Leptin
Chih-Yen Chen, Chang-Youh Tsai, Pui-Ching Lee and Shou-Dong Lee
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The Effect of First-in-Class Small Molecule RhoA Inhibitor, HL07, on the Phenylephrine-induced Artery Contraction
Yan Zhang, Jing Deng, Sheng Ma, Lin Xue, Jin Zhu, Wei-liang Zhu, Hua-liang Jiang, Jian Li and Li-yan Miao
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Non-Systemic Drugs: A Critical Review
Dominique Charmot
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Advancement of Targeted Ultrasound Contrast Agents and their Applications in Molecular Imaging and Targeted Therapy
Feng Yang, Zhi-Yi Chen and Yan Lin
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Atorvastatin Sensitises Vascular Smooth Muscle Cells, but not Endothelial Cells, to TNF-α-induced Cell Death
Arturo Giordano, Simona Romano, Giovanna Nappo, Stefano Messina, Michele Polimeno, Nicola Corcione, Gaetano Calì, Paolo Ferraro, Mario Monaco, Nicola Zambrano and Maria Fiammetta Romano
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Carotenoids and Cardiovascular Risk
Paola Giordano, Pietro Scicchitano, Manuela Locorotondo, Cosimo Mandurino, Gabriella Ricci, Santa Carbonara, Michele Gesualdo, Annapaola Zito, Annamaria Dachille, Paola Caputo, Roberta Riccardi, Giulia Frasso, Giuseppe Lassandro, Antonio Di Mauro and Marco Matteo Ciccone
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A Computational Study of the Oligosaccharide Binding Sites in the Lectin-Like Domain of Tumor Necrosis Factor and the TNF-derived TIP Peptide
Alexander Dulebo, Rüdiger Ettrich, Rudolf Lucas and David Kaftan
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Target-based Anti-angiogenic Therapy in Breast Cancer
Markus Wehland, Johann Bauer, Manfred Infanger and Daniela Grimm
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Preclinical Safety and Pharmacokinetic Profile of 3K3A-APC, a Novel, Modified Activated Protein C for Ischemic Stroke
Patricia D. Williams, Berislav V. Zlokovic, John H. Griffin, Kent E. Pryor and Thomas P. Davis
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