E-Pub Articles Ahead of Print ::: Current Pharmaceutical Design

ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)

Volume 21, 42 Issues, 2015

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Current Pharmaceutical Design

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E-Pub Articles Ahead of Print

The Current Role and Therapeutic Targets of Vitamin D in Gastrointestinal Inflammation and Cancer
Gan Hui Cai, Ming Xing Li, Lan Lu, Ruby Lok Yi Chan, Jian Hao Wang and Chi Hin Cho
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The Genetic Landscapes of Inflammation-Driven Gastrointestinal Tract cancers
Yubing Wang, Mingfei Yan, Penelope Mei-Yu Or and Andrew Man-Lok Chan
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Targeting Epithelial-Mesenchymal Transition Phenotype for Gastro-Intestinal Cancer
Hueng-Chuen Fan, Shinn-Zong Lin and Horng-Jyh Harn
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PPARδ Signaling Regulates Colorectal Cancer
Mengli You, Shuping Yuan, Juanjuan Shi and Yongzhong Hou
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Chronic Inflammation and Colorectal Cancer: The Role of Vascular Endothelial Growth Factor
Tao Hu, Long Fei Li, Jing Shen, Lin Zhang and Chi Hin Cho
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Inflammatory and non-inflammatory roles for Toll-like receptors in gastrointestinal cancer
Alison C. West and Brendan J. Jenkins
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Beyond Cox-Inhibition: ‘Side-Effects’ of Ibuprofen on Neoplastic Development and Progression
Paulo Matos and Peter Jordan
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New Molecules as Drug Candidates for the Treatment of Upper and Lower GI Tract Ulcers
Sandor Szabo and Ganna Tolstanova
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Regulatory Mechanism of the Gastric Hyperemic Response Following Barrier Disruption: Roles of Cyclooxygenase-1, the Prostaglandin E2/EP1 Receptor and Sensory Neurons
Koji Takeuchi, Masanori Takeeda, Kikuko Amagase and Masato Nakashima
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Hydrogen Sulfide-Based Anti-Inflammatory and Chemopreventive Therapies: An Experimental Approach
Kyle L. Flannigan and John L. Wallace
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The regulation of miRNAs in inflammation-related carcinogenesis
Yiming Ma, Wenxiao Han, Lan Yang, Longmei He and Hongying Wang
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Inflammation Fuels Tumor Progress and Metastasis
Jingyi Liu, Pengnian Charles Lin and Binhua P. Zhou
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Editorial: The Pathogenesis of Inflammation and Cancer in the Gastrointestinal Tract: From Basic Science to Translational Medicine
C.H. Cho and H.Y. Wang
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Efficacy of Andolast in Mild to Moderate Asthma: A Randomized, Controlled, Double-Blind Multicenter Study (The Andast Trial)
Mario Malerba, Massimo D`Amato, Alessandro Radaeli, Giampaolo Giacovelli, Lucio Rovati, Sayed H. Arshad and Stephen T. Holgate
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Editorial: Breaking the Skin Barrier: Achievements and the Future
Yasser Shahzad
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Atrial Fibrillation and Gastro-Oesophageal Reflux Disease - Controversies and Challenges
Mariana Floria, Oana Bărboi, Ciprian Rezuș, Valentin Ambărus, Cristina Cijevschi-Prelipcean, Gheorghe Balan and Vasile Liviu Drug
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MicroRNAs in Esophageal Adenocarcinoma: Functional Significance and Potential for the Development of New Molecular Disease Markers
Yuri V. Bobryshev, Alexander N. Orekhov and Dmitry A. Chistiakov
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Predicting the Druggability of Protein-Protein Interactions Based on Sequence and Structure features of active pockets
X u Dai, Run Yu Jing, Yanzhi Guo, Yong Cheng Dong, Yue Long Wang, Yuan Liu, Xue Mei Pu and Menglong Li
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Anti-VEGF Drugs in Eye Diseases: Local Therapy with Potential Systemic Effects
Markus van der Giet, Cornelia Henkel, Mirjam Schuchardt and Markus Tölle
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The Potential Effect of Fluorinated Compounds in the Treatment of Alzheimer’s Disease
Bárbara Gomes, Joana A. Loureiro, Manuel A.N. Coelho and Maria do Carmo Pereira
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Anticancer Advances of Matrine and Its Derivatives
Jianping Yong, Xiaoyuan Wu and Canzhong Lu
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Skeletal Muscle Cell Behavior After Physical Agent Treatments
Michela Battistelli, Sara Salucci, Michele Guescini, Davide Curzi, Vilberto Stocchi and Elisabetta Falcieri
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Analysis of Edg-Like LPA Receptor-Ligand Interactions
Balazs Balogh, Tamas Pazmany and Peter Matyus
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Multiple Roles of Fibroblast Growth Factor 21 in Metabolism
Li Li and Liling Tang
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Evaluation of the In Vivo Safety Profiles of Rictor Inhibition Using a Zebrafish Model
Yang Cao, Lijun Jiang, Lei Zhao, Xiaoxi Zhou, Na Wang, Peilin Zhang, Yuting Tang and Jianfeng Zhou
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Applications of Important Polysaccharides in Drug Delivery
Gangliang Huang, Xinya Mei, Feng Xiao, Xin Chen, Qilin Tang and Daquan Peng
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The Molecular Mechanisms of TRAIL Resistance in Cancer Cells: Help in Designing New Drugs
Feng Wang, Junsheng Lin and Ruian Xu
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Editorial: Mitochondrial Biogenesis: Pharmacological Approaches
Teresa Valero
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Mechanisms of Inflammatory Response and Organ Dysfunction: Organ-Protective Strategy by Anesthetics
Noboru Hatakeyama and Naoyuki Matsuda
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VEGF and Colon Cancer Growth Beyond Angiogenesis: Does VEGF Directly Mediate Colon Cancer Growth Via a Non-angiogenic Mechanism?
Amrita Ahluwalia, Michael K. Jones, Tamara Matysiak-Budnik and Andrzej S. Tarnawski
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The Impact of Computational Structure-Based Methods on Drug Discovery
Charles H. Reynolds
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Anti-miRNA-23a Oligonucleotide Suppresses Glioma Cells Growth by Targeting Apoptotic Protease Activating Factor-1
Shizhong Lian, Ruyi Shi, Tao Bai, Yang Liu, Wang Miao, Hongqin Wang, Xiaodong Liu and Yimin Fan
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Editorial: The SNAP-tag Technology – A Versatile Tool with many Applications
Stefan Barth
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Gender Based Differences in Stress-induced Gastric Ulcer Formation and its Regulation by Nitric Oxide (NO): An Experimental Study
Kavita Gulati, Ayanabha Chakraborti and Arunabha Ray
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Differential Influences of Gastric Bypass and Sleeve Gastrectomy on Plasma Nesfatin-1 and Obestatin Levels in Patients with Type 2 Diabetes Mellitus
Wei-Jei Lee, Chih-Yen Chen, Kong-Han Ser, Keong Chong, Shu-Chun Chen, Pui-Ching Lee, You-Di Liao and Shou-Dong Lee
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Probiotics for the Prevention and Treatment of Allergies, with an Emphasis on Mode of Delivery and Mechanism of Action
Satya Prakash, Catherine Tomaro-Duchesneau, Shyamali Saha, Laetitia Rodes, Imen Kahouli and Meenakshi Malhotra
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Consumption of Mixed Fruit-juice Drink and Vitamin C Reduces Postprandial Stress Induced by a High Fat Meal in Healthy Overweight Subjects
Ilaria Peluso, Debora V. Villano, Susan A. Roberts, Eleonora Cesqui, Anna Raguzzini, Gina Borges, Alan Crozier, Giovina Catasta, Elisabetta Toti and Mauro Serafini
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Immunomodulating and Anti-allergic Effects of Negroamaro and Koshu Vitis vinifera Fermented Grape Marc (FGM)
Giuseppe Marzulli, Thea Magrone, Luisa Vonghia, Masahiro Kaneko, Hiroaki Takimoto, Yoshio Kumazawa and Emilio Jirillo
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Potential Use of Dietary Natural Products, Especially Polyphenols, for Improving Type-1 Allergic Symptoms
Kumazawa Y, Takimoto H, Matsumoto T and Kawaguchi K
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Omega-6 and Omega-3 Polyunsaturated Fatty Acids and Allergic Diseases in Infancy and Childhood
Elizabeth A. Miles and Philip C. Calder
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Factors Affecting Residual Platelet Aggregation in Prasugrel Treated Patients
Dimitrios Alexopoulos, Ioanna Xanthopoulou, Angelos Perperis, Argyro Siapika, Katerina Stavrou, Evropi Tsoni, Periklis Davlouros and George Hahalis
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What Fans the Fire: Insights into Mechanisms of Leptin in Metabolic Syndrome- Associated Heart Diseases
Maolong Dong and Jun Ren
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Transactivation of ErbB Receptors by Leptin in the Cardiovascular System: Mechanisms, Consequences and Target for Therapy
Jerzy Bełtowski and Anna Jazmroz-Wiśniewska
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Structural Insights into Chitinolytic Enzymes and Inhibition Mechanisms of Selective Inhibitors
Tian Liu, Lei Chen, Qiang Ma, Xu Shen and Qing Yang
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Structure-based Design of Conformationally Flexible Reverse Transcriptase Inhibitors to Combat Resistant HIV
Ge-Fei Hao, Sheng-Gang Yang and Guang-Fu Yang
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Structural Basis of Resistance to Anti-Cytochrome bc1 Complex Inhibitors: Implication for Drug Improvement
Lothar Esser, Chang-An Yu and Di Xia
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ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development
Young Hee Choi, Ai-Ming Yu and Ai-Ming Yu
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Structure-Based Drug Design to Overcome Drug Resistance: Challenges and Opportunities
Rafaela S. Ferreira1, Adriano D. Andricopulo and Adriano D. Andricopulo
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Novel Next-Generation Sequencing and Networks-Based Therapeutic Targets: Realistic and More Effective Drug Design and Discovery
Dimitrios H. Roukos, Giannis G. Baltogiannis, Christos S. Katsouras, Aris Bechlioulis, Katerina K. Naka, Charalambos Batsis, Theodore Liakakos and Lampros K. Michalis
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Endothelial Dysfunction and the Effects of TNF Inhibitors on the Endothelium in Psoriasis and Psoriatic Arthritis: A Systematic Review
Elizabeth A. Brezinski, Matthew R. Follansbee, Ehrin J. Armstrong and April W. Armstrong
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Effects of Biologic Agents and Other Disease-Modifying Antirheumatic Drugs on Cardiovascular Outcomes in Psoriasis and Psoriatic Arthritis: A Systematic Review
April W. Armstrong, Elizabeth A. Brezinski, Matthew R. Follansbee and Ehrin J. Armstrong
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Ultrasound-Based Multimodal Molecular Imaging and Functional Ultrasound Contrast Agents
Yan Lin, Zhi-Yi Chen and Feng Yang
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Long-term Etanercept Therapy Favors Weight Gain and Ameliorates Cachexia in Rheumatoid Arthritis Patients: Roles of Gut Hormones and Leptin
Chih-Yen Chen, Chang-Youh Tsai, Pui-Ching Lee and Shou-Dong Lee
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The Effect of First-in-Class Small Molecule RhoA Inhibitor, HL07, on the Phenylephrine-induced Artery Contraction
Yan Zhang, Jing Deng, Sheng Ma, Lin Xue, Jin Zhu, Wei-liang Zhu, Hua-liang Jiang, Jian Li and Li-yan Miao
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Non-Systemic Drugs: A Critical Review
Dominique Charmot
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Advancement of Targeted Ultrasound Contrast Agents and their Applications in Molecular Imaging and Targeted Therapy
Feng Yang, Zhi-Yi Chen and Yan Lin
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Atorvastatin Sensitises Vascular Smooth Muscle Cells, but not Endothelial Cells, to TNF-α-induced Cell Death
Arturo Giordano, Simona Romano, Giovanna Nappo, Stefano Messina, Michele Polimeno, Nicola Corcione, Gaetano Calì, Paolo Ferraro, Mario Monaco, Nicola Zambrano and Maria Fiammetta Romano
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Carotenoids and Cardiovascular Risk
Paola Giordano, Pietro Scicchitano, Manuela Locorotondo, Cosimo Mandurino, Gabriella Ricci, Santa Carbonara, Michele Gesualdo, Annapaola Zito, Annamaria Dachille, Paola Caputo, Roberta Riccardi, Giulia Frasso, Giuseppe Lassandro, Antonio Di Mauro and Marco Matteo Ciccone
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A Computational Study of the Oligosaccharide Binding Sites in the Lectin-Like Domain of Tumor Necrosis Factor and the TNF-derived TIP Peptide
Alexander Dulebo, Rüdiger Ettrich, Rudolf Lucas and David Kaftan
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Target-based Anti-angiogenic Therapy in Breast Cancer
Markus Wehland, Johann Bauer, Manfred Infanger and Daniela Grimm
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Preclinical Safety and Pharmacokinetic Profile of 3K3A-APC, a Novel, Modified Activated Protein C for Ischemic Stroke
Patricia D. Williams, Berislav V. Zlokovic, John H. Griffin, Kent E. Pryor and Thomas P. Davis
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