E-Pub Articles Ahead of Print ::: Current Pharmaceutical Design

ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 23, 46 Issues, 2017


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Current Pharmaceutical Design

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Articles Ahead of Print

Cytokines Induced During Influenza Virus Infection


Tatiana Betáková, Anna Kostrabova, Veronika Lachova and Lucia Turianova.


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Hypertension - Current Natural Strategies to Lower Blood Pressure


Jacek Rysz, Beata Franczyk, Maciej Banach and Anna Gluba-Brzózka.


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Curcumin and Endothelial Function: Evidence and Mechanisms of Protective Effects


Maryam Saberi Karimian, Matteo Pirro, Thomas P. Johnston, Muhammed Majeed and Amirhossein Sahebkar.


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Nanoscale Delivery Systems: Actual and Potential Applications in the Natural Products Industry


Antal Diana Simona, Ardelean Florina, Chis Aimée Rodica, Ollivier Evelyne and Serban Maria-Corina.


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Medicinal Plants Targeting Cardiovascular Diseases in View of Avicenna


Zahra Sobhani, Saeed Reza Nami, Seyed Ahmad Emami, Amirhossein Sahebkar and Behjat Javadi.


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The Use of Plant Sterols and Stanols as Lipid-Lowering Agents in Cardiovascular Disease


Jacek Rysz, Beata Franczyk, Robert Olszewski, Maciej Banach and Anna Gluba-Brzózka.


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Effects of Tea and Coffee Consumption on Cardiovascular Diseases and Relative Risk Factors: An Update


Arianna Di Lorenzo, Valeria Curti, Gian Carlo Tenore, Seyed Mohammed Nabavi and Maria Daglia.


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Effects of Carotenoids on Health: Are All the Same? Results from Clinical Trials


Arrigo F.G. Cicero and Alessandro Colletti.


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Angiogenesis and Oxidative Stress in Metastatic Tumor Progression: Pathogenesis and Novel Therapeutic Approach of Colon Cancer


Kathy K. Auyeung and Joshua K Ko.


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Peripheral Corticotropin Releasing Factor Signaling Inhibits Gastric Emptying: Mechanisms of Action and Role in Stress-related Gastric Alterations of Motor Function


József Czimmer and Yvette Taché.


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A Rat Model of Ischemic Enteritis: Pathogenic Importance of Enterobacteria, iNOS/NO, and COX-2/PGE2


Koji Takeuchi, Yoshino Komatsu, Yuka Nakamori and Tohru Kotani.


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Stress in Gastrointestinal Tract and Stable Gastric Pentadecapeptide BPC 157. Finally, do we have a Solution?


Predrag Sikiric, Sven Seiwerth, Rudolf Rucman, Domagoj Drmic, Mirjana Stupnisek, Antonio Kokot, Marko Sever, Ivan Zoricic, Zoran Zoricic, Lovorka Batelja, Tihomil Ziger, Josipa Vlainic, Zarko Rasic and Martina Lovric Bencic.


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Congenital Hypothyroidism: Facts, Facets & Therapy


Yedukondalu Kollati, Ranga Rao Ambati, Prakash Narayana Reddy, N. Satya Sampath Kumar, Rajesh K. Patel and Vijaya R Dirisala.


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Recent Approaches to Platinum(IV) Prodrugs: A Variety of Strategies for Enhanced Delivery and Efficacy


Anas Najjar, Naeema Rajabi and Rafik Karaman.


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Momordicacharantia: A New Strategic Vision to Improve the Therapy of Endoplasmic Reticulum Stress


Wai Chin Chong, Rohit Gundamaraju, Ravichandra Vemuri, Marcus T Scotti and Luciana Scotti.


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The Role of Epidermal Growth Factor Receptor in the Management of Gastrointestinal Carcinomas: Present Status and Future Perspectives


Malik Quasir Mahmood, Shakti Dhar Shukla, Kamal Dua and Madhur D Shastri.


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Zinc and Gastrointestinal Disorders: A Role for the Zinc Transporters Zips and ZnTs


Stephen Myers, Madhur D. Shastri, John Adulcikas, Sukhwinder Singh Sohal and Shaghayegh Norouzi.


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Antidiabetic Drugs and the Kidney


Moses Elisaf, Eleftheria Tzavela, Nikolaos Karanatsis and Vasilis Tsimichodimos.


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The Role of Stress in Inflammatory Bowel Diseases


Sgambato Dolores, Miranda Agnese, Ranaldo Rocco, Federico Alessandro and Romano Marco.


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The Roles of Endoplasmic Reticulum Stress in the Pathophysiological Development of Cartilage and Chondrocytes


Xiaoliang Yuan, Haiqing Liu, Linfu Li, Hai Liu, Jianqiong Yang, Weimei Shi, Yuan Feng, Hao Huang and Longhuo Wu.


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Lenticulostriate Artery and Lenticulostriate-artery Neural Complex: New Concept for Intracerebral Hemorrhage


Rong Hu and Hua Feng.


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Recent Advances in the Gastric Mucosal Protection Against Stress-induced Gastric Lesions. Importance of Renin-angiotensin Vasoactive Metabolites, Gaseous Mediators and Appetite Peptides


Tomasz Brzozowski, Katarzyna Magierowska, Marcin Magierowski, Agata Ptak-Belowska, Robert Pajdo, Slawomir Kwiecien, Rafal Olszanecki and Ryszard Korbut.


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Editorial: Spinal Locomotor Systems


Pierre A Guertin.





Gastroprotective Effect of Stress Preconditioning: Involvement of Glucocorticoids


Ludmila Filaretova.


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Iron Chelators Dictate Immune Cells Inflammatory Ability: Potential Adjuvant Therapy for IBD


Marcello Chieppa, Vanessa Galleggiante, Grazia Serino, Monica Massaro and Angelo Santino.


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Stress and Salivary Glands


Beáta Kerémi, Anita Beck, Tibor Károly Fábián, Gábor Fábián, Géza Szabó, Ákos Nagy and Gábor Varga.


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Flavonoids Active Against Osteosarcoma: A Review of the Molecular Mechanisms Involved


Hui Liu, Yutong Gao, Yonghui Dong, Peng Cheng, Anmin Chen and Hui Huang.


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Selective Inhibition of Phosphodiesterases 4A, B, C and D Isoforms in Chronic Respiratory Diseases: Current and Future Evidences


Sonia Contreras, Javier Milara, Esteban Morcillo and Julio Cortijo.


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Role of Lactic Acid Probiotic Bacteria in IBD


Ravichandra Vemuri, Rohit Gundamaraju and Rajaraman Eri.


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Effective Strategies and Applications of Dendrimers in the Treatment of Ovarian Cancer


Akila Kesavan, Pakala Suresh Babu, Rayala Suresh Kumar and Ganesh Venkatraman.


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Neuroprotective Effect of Atremorine in an Experimental Model of Parkinson’s Disease


Ivan Carrera, Lucia Fernandez-Novoa, Carolina Sampedro and Ramon Cacabelos.


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Novel Caffeic Acid Phenethyl Ester (Cape) Analogues as Inducers of Heme Oxygenase-1


Valeria Pittalà, Luca Vanella, Loredana Salerno, Claudia Di Giacomo, Rosaria Acquaviva, Marco Raffaele, Giuseppe Romeo, Maria N. Modica, Orazio Prezzavento and Valeria Sorrenti.


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Cyclodextrins as Encapsulation Agents to Improve the Anti-inflammatory Drugs Profile: a Systematic Review and Meta-Analysis


Priscila L. Santos, Renan G. Brito, Jullyana S.S. Quintans, Adriano A.S. Araújo, Irwin R.A. Menezes, Nicole K. Brogden and Lucindo J Quintans-Júnior.


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Discovery and Optimization of NAD+-Dependent DNA Ligase Inhibitors as Novel Antibacterial Compounds


Fangchao Bi, Ruixin Ma and Shutao Ma.


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Editorial: Review on Intracerebral Haemorrhage: Multidisciplinary Approaches to the Injury Mechanism Analysis and Therapeutic Strategies


Bochu Wang and Shilei Hao.





MicroRNAs as Big Regulators of Neural Stem/Progenitor Cell Proliferation, Differentiation and Migration: A Potential Treatment for Stroke


Qian Zhang, Kaiyuan Zhang, Chao Zhang, Hongfei Ge, Yi Yin, Hua Feng and Rong Hu.


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Vascular Remodelling in Well-controlled Hypertensive Patients: The Challenge of Residual Risk Management


Massimo Puato, Chiara Nardin, Marta Zanon, Paolo Palatini, Paolo Pauletto and Marcello Rattazzi.


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Food as Pharma? The Case of Glucosinolates


Edoardo Capuano, Matthijs Dekker, Ruud Verkerk and Teresa Oliviero.


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The Role of MicroRNAs in Diagnosis, Prognosis, Metastasis and Resistant Cases in Breast Cancer


Srijit Das and Teoh Seong Lin.


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Current Status and Perspectives Regarding the Therapeutic Potential of Targeting EGFR Pathway by Curcumin in Lung Cancer


Mojtaba Shafiee, Elham Mohamadzade, Soudabeh ShahidSales, Samaneh Khakpouri, Mina Maftouh, Seyed Alireza Parizadeh, Seyed Mahdi Hasanian and Amir Avan.


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A New Vaccine Delivery Vehicle and Adjuvant Candidate: Bordetella Pertussis Inactivated Whole Cells Entrapped in Alginate Microspheres


Naser Mohammadpour Dounighia, Fereshteh Shahcheraghi, Mehdi Razzaghi-Abyaneh, Mojtaba Nofeli and Hossein Zolfagharian.


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Development of Poly(lactide-co-glicolide) Nanoparticles Incorporating Morphine Hydrochloride to Prolong its Circulation in Blood


Victoria Gómez-Murcia, Mercedes García Montalbán, Juan Carmelo Gómez-Fernández and Pilar Almela.


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Bioengineered 3D Scaffolds in Cancer Research: Focus on Epithelial to Mesenchymal Transition and Drug Screening


XiaoLi Xu and LiLing Tang.


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The Role of PPARs in Pathological Cardiac Hypertrophy and Heart Failure


Hai-Han Liao, Xu-Hui Jia, Huang-Jun Liu, Yang Zheng and Tang Qizhu.


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Editorial: (Pharmaco)metabolomics in Drug Discovery and Individualisation of Treatment


Theodora Katsila and George P Patrinos.





In Vitro Screening of an FDA-Approved Library Against ESKAPE Pathogens


Waleed Younis, Ahmed AbdelKhalek, Abdelrahman S. Mayhoub and Mohamed N Seleem.


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PI3K/Akt Pathway: A Potential Therapeutic Target for Chronic Pain


Shu-Ping Chen, Ya-Qun Zhou, Dai-Qiang Liu, Wen Zhang, Anne Manyande, Xue-Hai Guan, Yu-ke Tian, Da-Wei Ye and Deeq Mohamed Omar.


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CYP4Z1 – A Human Cytochrome P450 Enzyme that Might Hold the Key to Curing Breast Cancer


Xu Yang, Michael Hutter, Wilson Wen Bin Goh and Matthias Bureik.


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GABAergic System in Action: Connection to Gastrointestinal Stress-related Disorders


Maja Jazvinšćak Jembrek, Michelangelo Auteri, Rosa Serio and Josipa Vlainić.


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Significance of Cholinergic and Peptidergic Nerves in Stress-Induced Ulcer and MALT Lymphoma Formation


Masahiko Nakamura, Anders Øverby, Akina Uehara, Masaya Oda, Shinichi Takahashi, Somay Y. Murayama and Hidenori Matsui.


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Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress


Akinori Yanaka.


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In vivo Phenotyping Methods: Cytochrome P450 Probes with Emphasis on the Cocktail Approach


Guillermo Alberto Keller, María Laura Ferreirós Gago, Roberto Alejandro Diez and Guillermo Di Girolamo.


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Novel Drugs for Hypertension and Heart Failure: Struggling for a Place Under the Sun


Charles Faselis, Chrysoula Boutari, Michael Doumas, Konstantinos Imprialos, Konstantinos Stavropoulos and Peter Kokkinos.


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Regulation of Na+/K+-ATPase by Estradiol and IGF-1 in Cardio-Metabolic Diseases


Milan Obradovic, Julijana Stanimirovic, Anastasija Panic, Nikola Bogdanovic, Emina Sudar-Milovanovic, Desanka Cenic-Milosevic and Esma R Isenovic.


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Sex Differences in Type-2 Diabetes: Implications for Cardiovascular Risk Management


Valeria Raparelli, Susanna Morano, Flavia Franconi, Andrea Lenzi and Stefania Basili.


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Metabolic and Cardiovascular Actions of Nesfatin-1: Implications in Health and Disease


Naresh Ramesh, Kavishankar Gawli, Venkatakiran Pasupulleti and Suraj Unniappan.


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Metabolomics in the Diagnosis and Pharmacotherapy of Lung Diseases


Philippe Devillier, Hélène Salvator, Emmanuel Naline, Louis-Jean Couderc and Stanislas Grassin-Delyle.


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Proteoglycans and Diabetes


Linda M Hiebert.


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Hormonal Regulation of Nitric Oxide (NO) in Cardio-Metabolic Diseases


Emina Sudar-Milovanovic, Sonja Zafirovic, Aleksandra Jovanovic, Jovana Trebaljevac, Milan Obradovic, Desanka Cenic-Milosevic and Esma R Isenovic.


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Potential Role for Dendritic Cells in Endothelial Dysfunction, Diabetes and Cardiovascular Disease


Astrid Parenti, Laura Pala, Sara Paccosi and Carlo Maria Rotella.


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Synergistic Interaction Between Heme Oxygenase (HO) and Nuclear-Factor E2- Related Factor-2 (Nrf2) Against Oxidative Stress in Cardiovascular Related Diseases


Joseph Fomusi Ndisang.


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Exosome-Encapsulated microRNAs as Potential Circulating Biomarkers in Colon Cancer


Mina Hosseini, Sara Khatamianfar, Seyed Mahdi Hassanian, Reza Nedaeinia, Mojtaba Shafiee, Mina Maftouh, Majid Ghayour-Mobarhan, Soudabeh Shahid Sales and Amir Avan.


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The Importance of Wireless Capsule Endoscopy for Research into the Intestinal Absorption Window of 5-Aminosalicylic Acid in Experimental Pigs


Jaroslav Kvetina, Ilja Tacheci, Milan Nobilis, Marcela Kopacova, Martin Kunes and Jan Bures.


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Levamisole: A Positive Allosteric Modulator for the α3β4 Nicotinic Acetylcholine Receptors Prevents Weight Gain in the CD-1 Mice on a High Fat Diet


Jeanne A. Lewis, Jerrel L. Yakel and Anshul A Pandya.


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Development of a Novel Human scFv Against EGFR L2 Domain by Phage Display Technology


Leila Rahbarnia, Safar Farajnia, Hossein Babaei, Jafar Majidi, Kamal Veisi, Shiva Ahdi Khosroshahi and Asghar Tanomand.


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Gut Microbiota Modulation and Anti-Inflammatory Properties of Dietary Polyphenols in IBD: New and Consolidated Perspectives


Angelo Santino, Aurelia Scarano, Stefania De Santis, Maria De Benedictis, Giovanna Giovinazzo and Marcello Chieppa.


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Pharmacogenetics and Metabolism from Science to Implementation in Clinical Practice: The Example of Dihydropyrimidine Dehydrogenase


Marzia Del Re, Giuliana Restante, Antonello Di Paolo, Stefania Crucitta, Eleonora Rofi and Romano Danesi.


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Tonic and Rhythmic Spinal Activity Underlying Locomotion


Yury P. Ivanenko, Victor S. Gurfinkel, Victor A. Selionov, Irina A. Solopova, Francesca Sylos-Labini, Pierre A Guertin and Francesco Lacquaniti.


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Muscle Coordination and Locomotion in Humans


Francesca Sylos-Labini, Myrka Zago, Pierre A Guertin, Francesco Lacquaniti and Yury P Ivanenko.


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Neuromodulation of Spinal Locomotor Networks in Rodents


Manuel Díaz-Ríos, Pierre A. Guertin and Marla Rivera-Oliver.


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Locomotor Training and Factors Associated with Blood Glucose Regulation After Spinal Cord Injury


Philip D. Chilibeck and Pierre A Guertin.


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The Role of Proprotein Convertase Subtilisin-Kexin Type 9 Inhibitors in the Management of Dyslipidemia


Konstantinos Tziomalos.


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NLRP3 Inhibitors as Potential Therapeutic Agents for Treatment of Inflammatory Bowel Disease


Agampodi Promoda Perera, Dale Kunde and Rajaraman Eri.


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Biofilm-mediated Antibiotic-resistant Oral Bacterial Infections: Mechanism and Combat Strategies


Indu Lata Kanwar, Abhishek Kumar Sah and Preeti K Suresh.


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Multifunctional Superparamagnetic Nanoparticles: From Synthesis to siRNA Delivery


Sanam Arami, Majid Mahdavi, Mohammad Reza Rashidi, Marziyeh Fathi, Mohammad Saeid Hejazi and Nasser Samadi.


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Introduction for Design of Nanoparticle Based Drug Delivery Systems


Jun Yan Chan Edgar and Hui Wang.


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Role of the Autonomic Nervous System in the Tumor Micro-Environment and its Therapeutic Potential


Zhifang Xu, Seiji Shioda, Masahisa Jinushi, Yutaka Kawakami, Hirokazu Ohtaki, Shenjun Wang, Xue Zhao, Yangyang Liu, Dan Zhou and Yi Guo.


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Editorial: Antiplatelet and Anticoagulation Treatment in Special Populations


Manolis Vavuranakis, Dimitrios A. Vrachatis and Dimitrios Tousoulis.





Editorial: Conventional, Traditional and Alternative Therapies for Cardiovascular Disorders. Part 3: Alternative Therapy


Alexander N. Orekhov and Ekaterina A Ivanova.





Editorial: Conventional, Traditional and Alternative Therapies for Cardiovascular Disorders. Part 2: Traditional Therapy


Alexander N. Orekhov and Ekaterina A Ivanova.





Editorial: Targeting the Brain with Nanomedicine: Diagnostics, Prevention and Treatment


Luis J Cruz.





Editorial: Frontier Views in Designing Therapeutic Candidates for Management of Diverse Diseases


Mohammad A. Kamal and Nigel H Greig.





Anti-PCSK9 Antibodies: A New Era in the Treatment of Dyslipidemia


Joel Schmitz and Ioanna Gouni-Berthold.


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Platelet Function Testing: A Role for Personalised Therapy in Coronary Disease


Mohamed Farag and Diana A Gorog.


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Progranulin, a New Adipokine at the Crossroads of Metabolic Syndrome, Diabetes, Dyslipidemia and Hypertension


Agnieszka Korolczuk and Jerzy Bełtowski.


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Role of Proinflammatory Cytokines in Dopaminergic System Disturbances, Implications for Anhedonic Features of MDD


Zihang Pan, Joshua D. Rosenblat, Walter Swardfager and Roger S McIntyre.


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Effect of Green Tea Phytochemicals on Mood and Cognition


Christina Dietz and Matthijs Dekker.


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A Review on SIRtuins in Diabetes


R. Aditya, A. Ravi Kiran, D. Sai Varma, Ravichandra Vemuri and Rohit Gundamaraju.


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Apolipoprotein(a) Antisense Oligonucleotides: A New Treatment Option for Lowering Elevated Lipoprotein(a)?


Julia Schreml and Ioanna Gouni-Berthold.


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The Effect of Proprotein Convertase Subtilisin-Kexin Type 9 and its Inhibition on Glucose Metabolism and Cardiovascular Risk. We Should do Better the Second Time After Statins


Vasilios G. Athyros, Konstantinos Tziomalos, Michael Doumas, George Sfikas and Asterios Karagiannis.


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SGLT-2 Inhibitors and Cardiovascular Risk in Diabetes Mellitus: A Comprehensive and Critical Review of the Literature


Konstantinos Imprialos, Charles Faselis, Chrysoula Boutari, Konstantinos Stavropoulos, Vasilios Athyros, Asterios Karagiannis and Michael Doumas.


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Antiplatelet Agents and Anticoagulants: From Pharmacology to Clinical Practice


Maria E. Tsoumani and Alexandros D Tselepis.


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Bile Salt Stabilized Vesicles (bilosomes): A Novel Nano-Pharmaceutical Design for Oral Delivery of Proteins and Peptides


Javed Ahmad, Madhur Singhal, Saima Amin, Md. Rizwanullah, Sohail Akhter, Mohammad Amjad Kamal, Nafis Haider, Patrick Midoux and Chantal Pichon.


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Nutraceuticals and Dietary Supplements to Improve Quality of Life and Outcomes in Heart Failure Patients


Arrigo FG. Cicero and Alessandro Colletti.


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Mass Spectrometry Imaging in Nanomedicine: Unraveling the Potential of MSI for the Detection of Nanoparticles in Neuroscience


Florian PY. Barré, Ron MA. Heeren and Nina Ogrinc Potočnik.


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Metal Nanoparticles for the Treatment and Diagnosis of Neurodegenerative Brain Diseases


Valentina Vio, María José Marchant, Eyleen Araya and Marcelo J Kogan.


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Nano-Medicine Improving the Bioavailability of Small Molecules for the Prevention of Neurodegenerative Diseases


Piera Di Martino, Roberta Censi, Maria Rosa Gigliobianco, Luana Zerrillo, Federico Magnoni, Dimitrios Agas, Wilma Quaglia and Giulio Lupidi.


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Antiplatelet and Anticoagulation Treatment in Patients with Thrombocytopenia


Nuccia Morici, Silvia Cantoni, Paola Vallerio, Marco Cattaneo and Stefano Savonitto.


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Sodium-glucose Cotransporter 2 Inhibitors (SGLT2i): Their Role in Cardiometabolic Risk Management


Niki Katsiki, Dimitri P Mikhailidis and Michael J Theodorakis.


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Targeted Nanoparticles for the Treatment of Alzheimer’s Disease


Rafael Martín-Rapún, Laura De Matteis, Alfredo Ambrosone, Sonia García-Embid, Lucía Gutiérrez and Jesús M de la Fuente.


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Traumatic Brain Injury: Preclinical Imaging Diagnostic(s) and Therapeutic Approaches


Eric L. Kaijzel, Ermond R. van Beek, Marieke A. Stammes, Ivo Que, Alan B. Chan, Clemens W.G.M. Löwik and Luis J Cruz.


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Blood Serum Atherogenicity: Cellular Test for the Development of Anti- Atherosclerotic Therapy


Veronika A. Myasoedova, Galina A. Ivashinnikova, Igor A. Sobenin, Ekaterina A. Ivanova and Alexander N Orekhov.


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Inflammation: A Novel Therapeutic Target/Direction in Atherosclerosis


Bin Li, Weihong Li, Xiaoli Li and Hong Zhou.


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Effective Agents Targeting the Mitochondria and Apoptosis to Protect the Heart


Eltyeb Abdelwahid, Aurimas Stulpinas and Audrone Kalvelyte.


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Perspectives of In Vivo Bioluminescence Imaging: Application to Basic and Translational Neuroscience


Stefanie Vogel, Franziska Collmann and Mathias Hoehn.


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Genetics in the Clinical Decision of Antiplatelet Treatment


Gerasimos Siasos, Marina Zaromitidou, Evangelos Oikonomou, Manolis Vavuranakis, Vicky Tsigkou, Nikolaos Papageorgiou, Dimitrios Chaniotis, Dimitrios A. Vrachatis, Christodoulos Stefanadis, Athanasios G. Papavassiliou and Dimitrios Tousoulis.


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Targeting Nanomedicine to Brain Tumors: Latest Progress and Achievements


Moniek van `t Root, Clemens Löwik and Laura Mezzanotte.


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The Potential of Nano-Vehicle Mediated Therapy in Vasculitis and Multiple Sclerosis


Ruben V. Huis in `t Veld, Candido G. da Silva, Eric L. Kaijzel, Alan B. Chan and Luis J Cruz.


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Targeting the Brain with Nanomedicine


Felix Rueda and Luis J Cruz.


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Endothelial Progenitor Cells as a Therapeutic Approach for Intracerebral Hemorrhage


Juan Pías-Peleteiro, Francisco Campos, María Pérez-Mato, Esteban López-Arias, Manuel Rodríguez-Yáñez, José Castillo and Tomás Sobrino.


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Probing the Human Spinal Locomotor Circuits by Phasic Step-Induced Feedback and by Tonic Electrical and Pharmacological Neuromodulation


Ursula S. Hofstoetter, Maria Knikou, Pierre A. Guertin and Karen Minassian.


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Multilevel Analysis of Locomotion in Immature Preparations Suggests Innovative Strategies to Reactivate Stepping after Spinal Cord Injury


Michele R. Brumley, Pierre A. Guertin and Giuliano Taccola.


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The Utility of Interappendicular Connections in Bipedal Locomotion


David McMillan, Ray de Leon, Pierre A. Guertin and Dy Christine.


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Rationale for Assessing Safety and Efficacy of Drug Candidates Alone and in Combination with Medical Devices: The Case Study of Spinalon™


Pierre A Guertin.


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Neural Circuits Underlying Fly Larval Locomotion


Hiroshi Kohsaka, Pierre A. Guertin and Akinao Nose.


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Antithrombotic Treatment Management in Patients with Intracerebral Hemorrhage: Reversal and Restart


Dimitrios Giakoumettis, George A. Alexiou, Dimitrios A. Vrachatis, Kostas Themistoklis, Pantelis Stathis, Manolis Vavuranakis and Marios S Themistocleous.


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Antiplatelet Agents and Anticoagulants in Patients with Chronic Kidney Disease – from Pathophysiology to Clinical Practice


Jens Lutz and Kerstin Jurk.


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The Role of Antiplatelet Therapy in Primary Prevention. A Review


Lauge Østergaard, Emil L Fosbøl and Matthew T Roe.


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Peri-procedural Anticoagulation in Catheter Ablation for Atrial Fibrillation: A Review


Dimitrios A. Vrachatis, Georgios Giannopoulos, Charalambos Kossyvakis, Vasiliki Panagopoulou, Manolis Vavuranakis, Theodore G. Papaioannou, Stamatina Pagoni, Vlasios N. Pyrgakis, Michael W. Cleman and Spyridon G Deftereos.


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Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach Towards the Discovery of Novel Intestinal Antiseptic Drug Candidates


Ulviye Acar Çevik, Begüm Nurpelin Sağlık, Yusuf Özkay, Zerrin Cantürk, Juan Bueno, Fatih Demirci and Ali Savaş Koparal.


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Oral Antiplatelet and Anticoagulant Agents in the Prevention and Management of Ischemic Stroke


Shreya Shrestha, Shannon Coy and Kimon Bekelis.


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Double-Blind, Placebo-Controlled, Randomized Phase I/IIa Study (Safety and Efficacy) with Buspirone/Levodopa/Carbidopa (SpinalonTM) in Subjects with Complete AIS A or Motor-Complete AIS B Spinal Cord Injury


Mohan Radhakrishna, Inge Steuer, François Prince, Mary Roberts, David Mongeon, Maryam Kia, Sasha Dyck, Gilbert Matte, Mario Vaillancourt and Pierre A Guertin.


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Recombinant Activated Factor VII (Eptacog Alfa Activated, NovoSeven®) in Patients with Rare Congenital Bleeding Disorders. A Systematic Review on its Use in Surgical Procedures


Matteo Nicola Dario Di Minno, Pasquale Ambrosino, Veronika A. Myasoedova, Manuela Amato, Itala Ventre, Elena Tremoli and Alessandro Di Minno.


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Antiplatelet and Anticoagulation Therapy in Structural Heart Disease Interventions Beyond TAVI


Manolis Vavuranakis, Konstantinos Dean Boudoulas, Ourania Katsarou, Dimitrios A. Vrachatis, Konstantinos I. Kalogeras, Theodore G. Papaioannou, Gerasimos Siasos, Evangelos Oikonomou, George Lazaros, Michael-Andreas Vavuranakis, Spyridon Deftereos and Dimitrios Tousoulis.


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Antiplatelets and Antithrombotics in Patients with Liver Insufficiency: From Pathophysiology to Clinical Practice


Melanie Deutsch and John Koskinas.


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Theories About Blood Coagulation in the Writings of Ancient Greek Medico-philosophers


Gregory Tsoucalas, Marianna Karamanou, Theodoros G. Papaioannou and Markos Sgantzos.


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Natural Approaches in Diabetes Management: A Review of Diet, Exercise, and Natural Products


William M. Schultz, Tina Varghese, Robert E. Hein, Devinder S. Dhindsa, Elliot N. Mahlof, Hannah C. Cai, Geoffrey Southmayd, Pratik B. Sandesaraa, Danny J. Eapen and Laurence S Sperling.


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Perspectives on Strategies Using Swellable Polymers in Solid Dispersions for Controlled Drug Release


Thao TD Tran and Phuong HL Tran.


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Is Metformin a Perfect Drug? Updates in Pharmacokinetics and Pharmacodynamics


Magdalena Markowicz-Piasecka, Kristiina Maria Huttunen, Łukasz Mateusiak, Elżbieta Mikiciuk-Olasik and Joanna Sikora.


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Traditional and Alternative Therapies for Refractory Angina


Duygu Kocyigit, Kadri Murat Gurses, Muhammed Ulvi Yalcin and Lale Tokgozoglu.


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The Role of Chinese Herbal Medicines and Bioactive Ingredients Targeting Myocardial KCa and KATP Channels in Cardiovascular Diseases


Yan Dong, Pengqian Wang, Xue Feng, Bing Li, Zhong Wang and Haixia Li.


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Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Agonists as Therapeutic Agents for Cardiovascular Disorders: Focus on Atherosclerosis


Ekaterina A. Ivanova, Veronika A. Myasoedova, Alexandra A. Melnichenko and Alexander N Orekhov.


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DARPins Bioengineering and its Theranostic Approaches: Emerging Trends in Protein Engineering


Mahmood Rasool, Arif Malik, Mubashir Hussain, Kalsoom A. Haq, Kiran Butt, Abdul Basit, Muhammad Imran Naseer, Muhammad Asif, Rozena Shaikh, Mohammad Zahid Mustafa, Qamre Alam, Ghulam Rasool, Waseem Ahmad, Absarul l Haque and Mohammad Amjad Kamal.


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Antihypertensive Treatments In Patients Affected By Aortic Valve Stenosis


Paolo Poggio, Gianluca Folesani, Giuseppe M. Raffa, Paola Songia, Vincenzo Valenti, Veronika Myasoedova and Alessandro Parolari.


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MtDNA Damage Associated with Mitochondrial Cytopathies


Anastasia I. Ryzhkova, Margarita A. Sazonova, Vasily V. Sinyov, Elena V. Galitsyna, Mariуa M. Chicheva, Alexandra A. Melnichenko, Zukhra B. Khasanova, Andrey V. Zhelankin, Konstantin Y. Mitrofanov, Anton Yu. Postnov, Alexander N. Orekhov and Igor A Sobenin.


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Cybrid Models of Pathological Cell Processes in Different Diseases


Margarita A. Sazonova, Vasily V. Sinyov, Anastasia I. Ryzhkova, Elena V. Galitsyna, Tatiana P. Shkurat, Alexandra A. Melnichenko, Natalya A. Demakova, Anton Yu. Postnov, Igor A. Sobenin and Alexander N Orekhov.


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Reversal Agents for Oral Antiplatelet and Anticoagulant Treatment During Bleeding Events: Current Strategies


Peter Raimondi, Elaine M. Hylek and Konstantinos N Aronis.


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Therapeutic Potential of Drugs Targeting Pathophysiology of Intracerebral Hemorrhage: From Animal Models to Clinical Applications


Kuo-Hsing Liao, Chih-Wei Sung, Ya-Ni Huang, Wei-Jiun Li, Po-Chuan Yu and Jia-Yi Wang.


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Natural Products with Antiplatelet Action


Gabriela Elisa Hirsch, Paulo Ricardo Nazário Viecili, Amanda Spring de Almeida, Sabrina Nascimento, Fernando Garcez Porto, Juliana Otero, Aline Schmidt, Brenda da Silva, Mariana Migliorini Parisi and Jonatas Zeni Klafke.


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Therapeutic Suppression of Nonsense Mutation: An Emerging Target in Multiple Diseases and Thrombotic Disorders


Md. Asiful Islam, Fahmida Alam, Mohammad Amjad Kamal, Siew Hua Gan, Kah Keng Wong and Teguh Haryo Sasongko.


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PI3K/Akt/mTOR Intracellular Pathway and Breast Cancer: Factors, Mechanism and Regulation


Var Ruchi Sharma, Girish Kumar Gupta, A.K. Sharma, Navneet Batra, Daljit K. Sharma, Amit Joshi and Anil K Sharma.


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Gymnema sylvestre for Diabetes: From Traditional Herb to Future’s Therapeutic


Pragya Tiwari, Khurshid Ahmad and Mohammad Hassan Baig.


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The Underestimated Role of Mechanical Stimuli in Brain Diseases and the Related In Vitro Models


Tingwang Guo, Peng Ren, Shilei Hao and Bochu Wang.


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A Review on Injury Mechanism of Intracerebral Hemorrhage in Vehicle Accidents


Fan Li, Honggeng Li, Zhi Xiao, Ronggui Lu, Zhiteng Zhang, Haiyun Zhu and Lihai Ren.


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Epidemiology, Prognosis and Prevention of Non-Traumatic Intracerebral Hemorrhage


Christian Weimar and Julian Kleine-Borgmann.


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Targeting Vascular Neural Network in Intracerebral Hemorrhage


Yi Yin, Hongfei Ge, John H. Zhang and Hua Feng.


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Brain Drug Delivery Systems for the Stroke Intervention and Recovery


Tiantian Luo, Ju Wang, Shilei Hao, Tingwang Guo, Peng Ren, Zhongjun Cheng, Feiyan Gao, Yuhua Gong and Bochu Wang.


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Targeting the Nrf2-Heme Oxygenase-1 Axis after Intracerebral Hemorrhage


Jing Chen-Roetling and Raymond F Regan.


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Cell-Free Circulating Epigenomic Signatures: Non-Invasive Biomarker for Cardiovascular and Other Age-Related Chronic Diseases


Arpit Bhargava, Naveen Kumar Khare, Neha Bunkar, Koel Chaudhury, Kailash Chand Pandey, Subodh Kumar Jain and Pradyumna Kumar Mishra.


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HDL-Targeting Therapeutics: Past, Present and Future


Emile Zakiev, Ma Feng, Vasily Sukhorukov and Anatol Kontush.


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Editorial: Discovery and Validation of Drug Targets Through Human Genetics and Epigenetics


Karmen Stankov.





2


María José Torres.





Editorial: Towards the Integration of Quantitative and Systems Pharmacology into Drug Discovery: a Systems Level Understanding of Therapeutic and Toxic Effects of Drugs


Violeta I Pérez Nueno.





Medicinal Plants with Multiple Effects on Cardiovascular Diseases: A Systematic Review


Hojjat Rouhi-Boroujeni, Esfandiar Heidarian, Hamid Rouhi-Boroujeni, Fatemeh Deris and Mahmoud Rafieian-Kopaei.


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An Umbrella Review of Nuts Intake and Risk of Cardiovascualr Disease


Lukas Schwingshackl, Georg Hoffmann, Benjamin Missbach, Marta Stelmach-Mardas and Heiner Boeing.


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Complementary Role of Herbal Medicine and Exercise in Cardiovascular Disease Prevention and Management: A Review of Evidence


Sundar Kumar Veluswamy, Abraham Samuel Babu and Lakshmi Manickavasagam Sundar.


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Garlic for Cardiovascular Disease: Prevention or Treatment?


Feras Q. Alali, Tamam El-Elimat, Lila Khalid, Reema Hudaib, Tuqa Saleh Al-Shehabi and Ali H Eid.


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Spices: Therapeutic Potential In Cardiovascular Health


Subha Rastogi, Madan Mohan Pandey and AKS Rawat.


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The Role of Biologically Active Ingredients from Chinese Herbal Medicines in the Regulation of Autophagy in Treating Cardiovascular Diseases and Other Chronic Diseases


Jie Li, Yonghong Gao, Xiaomeng Ren, Yanda Li, Lijun Wu, Xinyu Yang, Jie Wang, Hongcai Shang, Xingjiang Xiong and Yanwei Xing.


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Pomegranate Consumption and Blood Pressure: A Review


Sedigheh Asgary, Mahtab Keshvari, Amirhossein Sahebkar and Nizal Sarrafzadegan.


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Convenient, Traditional and Alternative Therapies for Cardiovascular Disorders


Mohammad M. Zarshenas, Arman Zargaran and Michael Blaschke.


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Adonis sp., Convallaria sp., Strophanthus sp., Thevetia sp., and Leonurus sp. - Cardiotonic plants with known traditional use and a few preclinical and clinical studies


Ilkay Erdogan Orhan, Alper Gokbulut and F Sezer Senol.


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Is There a Role for Curcumin Supplementation in the Treatment of Non-Alcoholic Fatty Liver Disease? The Data Suggest Yes


Narges Amel Zabihi, Matteo Pirro, Thomas P. Johnston and Amirhossein Sahebkar.


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A Review on the Pharmacology and Toxicology of Steviol Glycosides Extracted from Stevia rebaudiana


Amir Abbas Momtazi-Borojeni, Seyed-Alireza Esmaeili, Elham Abdollahi and Amirhossein Sahebkar.


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Epigenetically active drugs inhibiting DNA methylation and histone deacetylation


Dimitry A. Chistiakov, Veronika A. Myasoedova, Alexander N. Orekhov and Yuri V Bobryshev.


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Mutations of Mitochondrial DNA in Chronic Non-Inflammatory Diseases: Target Candidates for Treatment


Elena V. Galitsyna, Margarita A. Sazonova, Tatiana P. Shkurat, Natalya A. Demakova, Alexsandra A. Melnichenko, Vasily V. Sinyov, Anastasia I. Ryzhkova, Konstantin Y. Mitrofanov, Andrey V. Zhelankin, Igor A. Sobenin and Alexander N Orekhov.


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Medicinal plants for the treatment of asthma: A Traditional Persian Medicine perspective


Behjat Javadi, Amirhossein Sahebkar and Seyed Ahmad Emami.


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Sulfur Mustard-Induced Ocular Injuries: Update on Mechanisms and Management


Yunes Panahi, Danial Roshandel, Mohammad Mehdi Sadoughi, Mostafa Ghanei and Amirhossein Sahebkar.


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Ginseng in Dermatology: A Review


Sarvenaz Sabouri-Rad, Sara Sabouri-Rad, Amirhossein Sahebkar and Zahra Tayarani-Najaran.


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Phytochemicals Against Advanced Glycation End Products (AGEs) and the Receptor System


Sho-ichi Yamagishi, Takanori Matsui, Yuji Ishibashi, Fumiyuki Isami, Yumi Abe, Tatsuya Sakaguchi and Yuichiro Higashimoto.


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Sialidases: Therapeutic And Antiatherogenic Potential


VN Sukhorukov, VP Karagodin, ER Zakiev and AN Orekhov.


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Cellular and Molecular Mechanisms of Diuretic Plants: An Overview


Francislaine Aparecida Lívero, Jacqueline Vergutz Menetrier,