E-Pub Articles Ahead of Print ::: Current Pharmaceutical Design

ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 20, 42 Issues, 2014


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Current Pharmaceutical Design

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  • 62nd of 254 in Pharmacology & Pharmacy

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E-Pub Articles Ahead of Print

Best Practice for Atrial Fibrillation Patient Education
Deirdre A. Lane, Rachel V. Barker and Gregory Y. H. Lip
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Clinical Applications of Choline PET/CT in Brain Tumors
Elisabetta Giovannini, Patrizia Lazzeri, Amelia Milano, Maria Chiara Gaeta and Andrea Ciarmiello
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Molecular Mechanisms Involved in the Control of Neurohypophyseal Hormones Secretion
M Iovino, E Guastamacchia, V A Giagulli, B Licchelli, E Iovino and V Triggiani
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Editorial: ‘Lone’ atrial fibrillation: No longer lone or even alone
Tatjana S. Potpara and Gregory Y.H. Lip
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Bacteriophages and their Enzymes in Biofilm Control
Benjamin K. Chan and Stephen T. Abedon
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Nitric Oxide: a Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases
Nicolas Barraud, Michael J. Kelso, Scott A. Rice and Staffan Kjelleberg
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Quorum Sensing and Biofilms in the Pathogen, Streptococcus Pneumoniae
Joana Galante, Alfred C-Y Ho, Sarah Tingey and Bambos M Charalambous
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Quorum Sensing Inhibitors as Anti-Biofilm Agents
Gilles Brackman and Tom Coenye
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Strategies for Antimicrobial Drug Delivery to Biofilm
Claire Martin, Wan Li Low, Abhishek Gupta, Mohd Cairul, Iqbal Mohd Amin, Iza Radecka, Stephen T. Britland, Prem Raj and Ken MA Kenward
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Current and Future Approaches to the Prevention and Treatment of Staphylococcal Medical Device-Related Infections
S Hogan, N T Stevens, H Humphreys, J P O’Gara and E. O’Neill
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Potential Application of Antimicrobial Peptides in the Treatment of Bacterial Biofilm Infections
Nikola Strempel, Janine Strehmel and Joerg Overhage
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Targeting Cyclic di-GMP Signalling: a Strategy to Control Biofilm Formation?
Delphine L. Caly, Domenico Bellini, Martin A. Walsh, J Maxwell Dow and Robert P. Ryan
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Phosphodiesterase Inhibitors as a Target for Cognition Enhancement in Aging and Alzheimer’s Disease: A Translational Overview
P.R.A. Heckman, C. Wouters and J. Prickaerts
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The Roles of Phosphodiesterase 2 in the Central Nervous and Peripheral Systems
Chong Zhang, Yingcong Yu, Lina Ruan, Chuang Wang, Jianchun Pan, Jonathan Klabnik, Lindsay Lueptow, Han-Ting Zhang, James M. O’Donnell and Ying Xu
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Editorial: Emerging Concepts in Management of Bacterial Biofilm Infections
Brendan Gilmore
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Role of synovial fibroblasts in rheumatoid arthritis
S Lefèvre, FMP Meier, E Neumann and U Muller-Ladner
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Role of T lymphocytes in the development of rheumatoid arthritis. Implications for treatment.
Erik Lubberts
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Biomarkers for radiographic progression in rheumatoid arthritis
A. Krabben, T.W.J. Huizinga and A.H.M. van der Helm-van Mil
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Biomarkers predicting a need for intensive treatment in patients with early arthritis
I. Gonzalez-Alvaro, A. Mª. Ortiz, I. V. Seoane, R. García-Vicuna, C. Martínez and R. P. Gomariz
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Rheumatoid Arthritis: Genetic Variants as Biomarkers of Cardiovascular Disease
Luis Rodriguez-Rodriguez, Raquel Lopez-Mejias, Benjamín Fernandez-Gutiérrez, Alejandro Balsa, Miguel A. González-Gay and Javier Martín
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Laboratory biomarkers for guiding therapy with methotrexate in rheumatoid arthritis
Carlos Abud-Mendoza, Marco U. Martínez-Martínez, Adriana Monsiváis-Urenda and Roberto González-Amaro
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Response to rituximab: has the original hypothesis been confirmed?
Geraldine Cambridge and Inmaculada De La Torre
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Predictors of Response to TNF Antagonists
Eva Salgado, Jose Ramon Maneiro and Juan J. Gomez-Reino
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Predicting toxicity: biomarkers and the value of the patient’s opinion
MJ Garcia de Yebenes, E Loza and L Carmona
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Are patient self-report questionnaires as “scientific” as biomarkers in “treat-to-target” and prognosis in rheumatoid arthritis?
Theodore Pincus and Isabel Castrejón
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Psychological factors associated with response to treatment in rheumatoid arthritis
Santiago T, Geenen R, Jacobs WG and Da Silva JAP
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Genetic Signatures in the Treatment of Stroke
Anjana Munshia and Vandana Sharma
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Phosphodiesterase Inhibitors as Therapeutics for Traumatic Brain Injury
David J. Titus, Anthony A. Oliva, Nicole M. Wilson and and Coleen M. Atkins
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‘Phosphodiesterases as therapeutic targets for Huntington’s disease.’
Francesca R. Fusco and Carmela Giampà
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Phosphodiesterase-4 modulation as a potential therapeutic for cognitive loss in pathological and non-pathological aging: Possibilities and Pitfalls
Rolf T. Hansen III and Han-Ting Zhang
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Role of Phosphodiesterase 4-mediated cyclic AMP signaling in pharmacotherapy for substance dependence
Rui-Ting Wen, Wan-Yu Feng, Jian-Hui Liang and Han-Ting Zhang
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‘Emerging Biology of PDE10A’
Lindsay S. Wilson and Nicholas J. Brandon
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Does Phosphodiesterase 11A (PDE11A) Hold Promise as a Future Therapeutic Target?
Michy P. Kelly
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Phosphodiesterase: An Interface Connecting Cognitive Deficits to Neuropsychiatric and Neurodegenerative Diseases
Zhen-Zhen Wang, Yi Zhang, Han-Ting Zhang and Yun-Feng Li
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Telomere-Dependent Genomic Integrity: Evolution of the Fusion-Bridge-Breakage Cycle Concept
Purificación Feijoo, Daniel Domínguez, Laura Tusell and Anna Genescà
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Telomere Recombination and the ALT Pathway: a Therapeutic Perspective for Cancer
Irena Draskovic and Arturo Londono-Vallejo
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Telomerase Modulation in Therapeutic Approach
Aleksandra Romaniuk, Przemysław Kopczynski, Krzysztof Książek and Błażej Rubiś
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Telomeric G-Quadruplex Architecture and Interactions with Potential Drugs
Claudia Sissi and Manlio Palumbo
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Extra-telomeric Functions of Human Telomerase: Cancer, Mitochondria and Oxidative Stress
G. Saretzki
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MicroRNA-dependent Regulation of Telomere Maintenance Mechanisms: a Field as Much Unexplored as Potentially Promising
Francesca Santambrogio, Paolo Gandellini, Graziella Cimino-Reale, Nadia Zaffaroni and Marco Folini
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Conventional Anticancer Therapeutics and Telomere Maintenance Mechanisms
Orit Uziel and Meir Lahav
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Oligonucleotides and G-quadruplex Stabilizers: Targeting Telomeres and Telomerase in Cancer Therapy
Zachary Crees, Jennifer Girard, Zechary Rios, Gregory M. Botting, Kymberly Harrington, Caleb Shearrow, Luke Wojdyla, Amanda L. Stone, Srijayaprakash B. Uppada, Joseph T. Devito and Neelu Puri
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Tankyrases: Structure, Function and Therapeutic Implications in Cancer
Teemu Haikarainen, Stefan Krauss and Lari Lehtio
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Telomere Maintenance Mechanisms in Cancer: Clinical Implications
Roger R. Reddel
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Editorial: Targeting Telomere Maintenance Mechanisms in Cancer Therapy
M. Folini
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Dyslipidaemia Related to Insulin Resistance and Cardiovascular Disease in South Asian and West African Populations
Mfon Ewang-Emukowhate, Dilinika Perera and Anthony S. Wierzbicki
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Combination of Statin plus Renin Angiotensin System Inhibition for the Prevention or the Treatment of Atherosclerotic Cardiovascular Disease
Vasilios G. Athyros, Niki Katsiki, Asterios Karagiannis and Dimitri P Mikhailidis
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Hypertriglyceridaemia, Postprandial Lipaemia And Non-Hdl Cholesterol
Claudia Stefanutti, Giancarlo Labbadia and Vasilios G. Athyros
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Apolipoprotein B and Apolipopotein A-I in Vascular Risk Prediction – a Review
C Schmidt and G Bergström
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HDL Genetic Defects
Devaki R Nair, Arun Nair and Anjly Jain
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Familial Hypercholesterolemia: Etiology, Diagnosis and New Treatment Options
Ioanna Gouni-Berthold and Heiner K. Berthold
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Alcohol and the Cardiovascular System: a Double-Edged Sword
Niki Katsiki, Konstantinos Tziomalos and Dimitri P Mikhailidis
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LDL and HDL Subfractions, Dysfunctional HDL: Treatment Options
Antonio García Ríos, Dragana Nikolic, Pablo Perez-Martinez, Jose Lopez-Miranda, Manfredi Rizzo and Ron C. Hoogeveen
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Hypolipidaemic Drug Treatment: Yesterday is Not Gone Yet, Today is Challenging and Tomorrow is Coming Soon; let us Combine them all
Vasilios G. Athyros, Konstantinos Tziomalos, Asterios Karagiannis and Dimitri P. Mikhailidis
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Halting arterial aging in Patients with Cardiovascular Disease: Hypolipidemic and Antihypertensive Therapy
Vasilios Papademetriou, Niki Katsiki, Michael Doumas and Charles Faselis
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Statin Treatment Non-adherence and Discontinuation: Clinical Implications and Potential Solutions
Kim Phan, Yessica-Haydee Gomez, Laura Elbaz and Stella S. Daskalopoulou
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Medications not Intended for Treatment of Dyslipidemias and with a Variable Effect on Lipids
Thomas F Whayne and Debabrata Mukherjee
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Pathophysiological Role and Clinical Significance of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Bound to LDL and HDL
Constantinos C. Tellis and Alexandros D. Tselepis
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Effects of Lipid-Lowering Agents on Inflammation, Haemostasis and Blood Pressure
Konstantinos Tziomalos, Asterios Karagiannis and Vasilios G. Athyros
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Editorial : Novel Data on the Pathogenesis of Atherosclerosis, Treatment Targets, and New Therapeutic Interventions in Lipid-Related Cardiovascular Risk Factors
Vasilios G. Athyros, Konstantinos Tziomalos, Niki Katsiki and Dimitri P. Mikhailidis
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Editorial: Mitochondrial Biogenesis: Pharmacological Approaches
Teresa Valero
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Mechanisms of Inflammatory Response and Organ Dysfunction: Organ-Protective Strategy by Anesthetics
Noboru Hatakeyama and Naoyuki Matsuda
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VEGF and Colon Cancer Growth Beyond Angiogenesis: Does VEGF Directly Mediate Colon Cancer Growth Via a Non-angiogenic Mechanism?
Amrita Ahluwalia, Michael K. Jones, Tamara Matysiak-Budnik and Andrzej S. Tarnawski
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Supplementation of Creatine and Ribose Prevents Apoptosis and Right Ventricle Hypertrophy in Hypoxic Hearts
Anna Caretti, Paola Bianciardi, Marina Marini, Provvidenza M. Abruzzo, Alessandra Bolotta, Carlo Terruzzi, Franco Lucchina and Michele Samaja
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The Impact of Computational Structure-Based Methods on Drug Discovery
Charles H. Reynolds
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Human Use of Leucoselect® Phytosome® with Special Reference to Inflammatoryallergic Pathologies in Frail Elderly Patients
Thea Magrone, Vittorio Pugliese, Sergio Fontana and Emilio Jirillo
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Anti-miRNA-23a Oligonucleotide Suppresses Glioma Cells Growth by Targeting Apoptotic Protease Activating Factor-1
Shizhong Lian, Ruyi Shi, Tao Bai, Yang Liu, Wang Miao, Hongqin Wang, Xiaodong Liu and Yimin Fan
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Editorial: The SNAP-tag Technology – A Versatile Tool with many Applications
Stefan Barth
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Gender Based Differences in Stress-induced Gastric Ulcer Formation and its Regulation by Nitric Oxide (NO): An Experimental Study
Kavita Gulati, Ayanabha Chakraborti and Arunabha Ray
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Differential Influences of Gastric Bypass and Sleeve Gastrectomy on Plasma Nesfatin-1 and Obestatin Levels in Patients with Type 2 Diabetes Mellitus
Wei-Jei Lee, Chih-Yen Chen, Kong-Han Ser, Keong Chong, Shu-Chun Chen, Pui-Ching Lee, You-Di Liao and Shou-Dong Lee
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Probiotics for the Prevention and Treatment of Allergies, with an Emphasis on Mode of Delivery and Mechanism of Action
Satya Prakash, Catherine Tomaro-Duchesneau, Shyamali Saha, Laetitia Rodes, Imen Kahouli and Meenakshi Malhotra
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Consumption of Mixed Fruit-juice Drink and Vitamin C Reduces Postprandial Stress Induced by a High Fat Meal in Healthy Overweight Subjects
Ilaria Peluso, Debora V. Villano, Susan A. Roberts, Eleonora Cesqui, Anna Raguzzini, Gina Borges, Alan Crozier, Giovina Catasta, Elisabetta Toti and Mauro Serafini
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Immunomodulating and Anti-allergic Effects of Negroamaro and Koshu Vitis vinifera Fermented Grape Marc (FGM)
Giuseppe Marzulli, Thea Magrone, Luisa Vonghia, Masahiro Kaneko, Hiroaki Takimoto, Yoshio Kumazawa and Emilio Jirillo
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Potential Use of Dietary Natural Products, Especially Polyphenols, for Improving Type-1 Allergic Symptoms
Kumazawa Y, Takimoto H, Matsumoto T and Kawaguchi K
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Omega-6 and Omega-3 Polyunsaturated Fatty Acids and Allergic Diseases in Infancy and Childhood
Elizabeth A. Miles and Philip C. Calder
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Factors Affecting Residual Platelet Aggregation in Prasugrel Treated Patients
Dimitrios Alexopoulos, Ioanna Xanthopoulou, Angelos Perperis, Argyro Siapika, Katerina Stavrou, Evropi Tsoni, Periklis Davlouros and George Hahalis
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What Fans the Fire: Insights into Mechanisms of Leptin in Metabolic Syndrome- Associated Heart Diseases
Maolong Dong and Jun Ren
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Transactivation of ErbB Receptors by Leptin in the Cardiovascular System: Mechanisms, Consequences and Target for Therapy
Jerzy Bełtowski and Anna Jazmroz-Wiśniewska
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Structural Insights into Chitinolytic Enzymes and Inhibition Mechanisms of Selective Inhibitors
Tian Liu, Lei Chen, Qiang Ma, Xu Shen and Qing Yang
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Structure-based Design of Conformationally Flexible Reverse Transcriptase Inhibitors to Combat Resistant HIV
Ge-Fei Hao, Sheng-Gang Yang and Guang-Fu Yang
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Structural Basis of Resistance to Anti-Cytochrome bc1 Complex Inhibitors: Implication for Drug Improvement
Lothar Esser, Chang-An Yu and Di Xia
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ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development
Young Hee Choi, Ai-Ming Yu and Ai-Ming Yu
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Structure-Based Drug Design to Overcome Drug Resistance: Challenges and Opportunities
Rafaela S. Ferreira1, Adriano D. Andricopulo and Adriano D. Andricopulo
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Novel Next-Generation Sequencing and Networks-Based Therapeutic Targets: Realistic and More Effective Drug Design and Discovery
Dimitrios H. Roukos, Giannis G. Baltogiannis, Christos S. Katsouras, Aris Bechlioulis, Katerina K. Naka, Charalambos Batsis, Theodore Liakakos and Lampros K. Michalis
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Endothelial Dysfunction and the Effects of TNF Inhibitors on the Endothelium in Psoriasis and Psoriatic Arthritis: A Systematic Review
Elizabeth A. Brezinski, Matthew R. Follansbee, Ehrin J. Armstrong and April W. Armstrong
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Effects of Biologic Agents and Other Disease-Modifying Antirheumatic Drugs on Cardiovascular Outcomes in Psoriasis and Psoriatic Arthritis: A Systematic Review
April W. Armstrong, Elizabeth A. Brezinski, Matthew R. Follansbee and Ehrin J. Armstrong
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Ultrasound-Based Multimodal Molecular Imaging and Functional Ultrasound Contrast Agents
Yan Lin, Zhi-Yi Chen and Feng Yang
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Long-term Etanercept Therapy Favors Weight Gain and Ameliorates Cachexia in Rheumatoid Arthritis Patients: Roles of Gut Hormones and Leptin
Chih-Yen Chen, Chang-Youh Tsai, Pui-Ching Lee and Shou-Dong Lee
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The Effect of First-in-Class Small Molecule RhoA Inhibitor, HL07, on the Phenylephrine-induced Artery Contraction
Yan Zhang, Jing Deng, Sheng Ma, Lin Xue, Jin Zhu, Wei-liang Zhu, Hua-liang Jiang, Jian Li and Li-yan Miao
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Non-Systemic Drugs: A Critical Review
Dominique Charmot
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Advancement of Targeted Ultrasound Contrast Agents and their Applications in Molecular Imaging and Targeted Therapy
Feng Yang, Zhi-Yi Chen and Yan Lin
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Atorvastatin Sensitises Vascular Smooth Muscle Cells, but not Endothelial Cells, to TNF-α-induced Cell Death
Arturo Giordano, Simona Romano, Giovanna Nappo, Stefano Messina, Michele Polimeno, Nicola Corcione, Gaetano Calì, Paolo Ferraro, Mario Monaco, Nicola Zambrano and Maria Fiammetta Romano
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Carotenoids and Cardiovascular Risk
Paola Giordano, Pietro Scicchitano, Manuela Locorotondo, Cosimo Mandurino, Gabriella Ricci, Santa Carbonara, Michele Gesualdo, Annapaola Zito, Annamaria Dachille, Paola Caputo, Roberta Riccardi, Giulia Frasso, Giuseppe Lassandro, Antonio Di Mauro and Marco Matteo Ciccone
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A Computational Study of the Oligosaccharide Binding Sites in the Lectin-Like Domain of Tumor Necrosis Factor and the TNF-derived TIP Peptide
Alexander Dulebo, Rüdiger Ettrich, Rudolf Lucas and David Kaftan
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Target-based Anti-angiogenic Therapy in Breast Cancer
Markus Wehland, Johann Bauer, Manfred Infanger and Daniela Grimm
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Preclinical Safety and Pharmacokinetic Profile of 3K3A-APC, a Novel, Modified Activated Protein C for Ischemic Stroke
Patricia D. Williams, Berislav V. Zlokovic, John H. Griffin, Kent E. Pryor and Thomas P. Davis
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