E-Pub Articles Ahead of Print ::: Current Pharmaceutical Design

ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 22, 46 Issues, 2016


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Current Pharmaceutical Design

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  • 73rd of 253 in Pharmacology & Pharmacy

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Editor-in-Chief:
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E-Pub Articles Ahead of Print

Therapeutic Suppression of Nonsense Mutation: An Emerging Target in Multiple Diseases and Thrombotic Disorders


Md. Asiful Islam, Fahmida Alam, Mohammad Amjad Kamal, Siew Hua Gan, Kah Keng Wong and Teguh Haryo Sasongko.


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PI3K/Akt/mTOR Intracellular Pathway and Breast Cancer: Factors, Mechanism and Regulation


Var Ruchi Sharma, Girish Kumar Gupta, A.K. Sharma, Navneet Batra, Daljit K. Sharma, Amit Joshi and Anil K Sharma.


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Gymnema sylvestre for Diabetes: From Traditional Herb to Future’s Therapeutic


Pragya Tiwari, Khurshid Ahmad and Mohammad Hassan Baig.


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The Underestimated Role of Mechanical Stimuli in Brain Diseases and the Related In Vitro Models


Tingwang Guo, Peng Ren, Shilei Hao and Bochu Wang.


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A Review on Injury Mechanism of Intracerebral Hemorrhage in Vehicle Accidents


Fan Li, Honggeng Li, Zhi Xiao, Ronggui Lu, Zhiteng Zhang, Haiyun Zhu and Lihai Ren.


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Injectable Drug-Loaded Nanocarriers for Lung Cancer Treatments


Huang-Ping Yu, Ibrahim A. Aljuffali and Jia-You Fang.


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Epidemiology, Prognosis and Prevention of Non-Traumatic Intracerebral Hemorrhage


Christian Weimar and Julian Kleine-Borgmann.


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Targeting Vascular Neural Network in Intracerebral Hemorrhage


Yi Yin, Hongfei Ge, John H. Zhang and Hua Feng.


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Brain Drug Delivery Systems for the Stroke Intervention and Recovery


Tiantian Luo, Ju Wang, Shilei Hao, Tingwang Guo, Peng Ren, Zhongjun Cheng, Feiyan Gao, Yuhua Gong and Bochu Wang.


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From PK/PD to QSP: Understanding the Dynamic Effect of Cholesterol-Lowering Drugs on Atherosclerosis Progression and Stratified Medicine


Cesar Pichardo-Almarza and Vanessa Diaz-Zuccarini.


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Therapeutic Potential of Drugs Targeting Pathophysiology of Intracerebral Hemorrhage: From Animal Models to Clinical Applications


Kuo-Hsing Liao, Chih-Wei Sung, Ya-Ni Huang, Wei-Jiun Li, Po-Chuan Yu and Jia-Yi Wang.


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Liposomes For Pulmonary Drug Delivery: The role of Formulation and Inhalation Device Design


Abdelbary Elhissi.


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Targeting the Nrf2-Heme Oxygenase-1 Axis after Intracerebral Hemorrhage


Jing Chen-Roetling and Raymond F Regan.


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Amorphous and Crystalline Particulates: Challenges and Perspectives in Drug Delivery


Hisham Al-Obaidi, Mridul Majumder and Fiza Bari.


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Cellular Tests for the Evaluation of Drug Hypersensitivity


Adriana Ariza, Maria I. Montañez, Tahia D. Fernández, James R. Perkins and C Mayorga.


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Cell-Free Circulating Epigenomic Signatures: Non-Invasive Biomarker for Cardiovascular and Other Age-Related Chronic Diseases


Arpit Bhargava, Naveen Kumar Khare, Neha Bunkar, Koel Chaudhury, Kailash Chand Pandey, Subodh Kumar Jain and Pradyumna Kumar Mishra.


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Polymer Nanoparticles as Smart Carriers for the Enhanced Release of Therapeutic Agents to the CNS


Mariacristina Gagliardi and Claudia Borri.


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Separation of Biologically Active Compounds by Membrane Operations


Xiaoying Zhu and Renbi Bai.


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HDL-Targeting Therapeutics: Past, Present and Future


Emile Zakiev, Ma Feng, Vasily Sukhorukov and Anatol Kontush.


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Exploring the Role of Nanoparticles in Amphotericin B Delivery


Soraia Zaioncz, Najeh Maissar Khalil and Rubiana Mara Mainardes.


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Evaluation of the Performance of an Ophthalmic Thermosensitive Hydrogel Containing Combination of Suramin and Bevacizumab


Daniela Alejandra Quinteros, Emiliano Sebastián López, Juan Lucio Silva Couto, Belkys Angélica Maletto, Daniel Alberto Allemandi, Santiago Daniel Palma and Juan Eduardo Gallo.


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Determining Effective Diabetic Care; A Multicentre - Longitudinal Interventional Study


Syed Wasif Gillani.


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Enkephalin-Fentanyl Multifunctional Opioids as Potential Neuroprotectants for Ischemic Stroke Treatment


Mohammad R. Islam, Li Yang, Yeon Sun Lee, Victor J. Hruby, Vardan T. Karamyan and Thomas J Abbruscato.


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Gradually Expanding Scope for Biowaivers: An Overview


Vikrant Saluja, Amanpreet Singh and Adnan Mohammed Algradi.


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Editorial: Discovery and Validation of Drug Targets Through Human Genetics and Epigenetics


Karmen Stankov.


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María José Torres.


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Editorial: Towards the Integration of Quantitative and Systems Pharmacology into Drug Discovery: a Systems Level Understanding of Therapeutic and Toxic Effects of Drugs


Violeta I Pérez Nueno.


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Mesoporous Silica Molecular Sieve Based Nanocarriers: Transpiring Drug Dissolution Research


Satyanarayan Pattnaik and Kamla Pathak.


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Transferrin-Conjugated Nanocarriers as Active-Targeted Drug Delivery Platforms for Cancer Therapy


Daniele R. Nogueira-Librelotto, Cristiane F. Codevilla, Ammad Farooqi and Clarice M B Rolim.


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Stimuli-Responsive Capsule Membranes for Controlled Release in Pharmaceutical Applications


Zhuang Liu, Xiao-Jie Ju, Wei Wang, Rui Xie, Lu Jiang, Qianming Chen, Yan-Qiong Zhang, Jiang-Feng Wu and Liang-Yin Chu.


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Biohybrid Membrane Systems And Bioreactors As Tools For In Vitro Drug Testing


Simona Salerno and Loredana De Bartolo.


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Membrane-based Technologies in the Pharmaceutical Industry and Continuous Production of Polymer-coated Crystals/Particles


Dengyue Chen, Kamalesh K. Sirkar, Chi Jin, Dhananjay Singh and Robert Pfeffer.


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Molecularly Engineered Polymer-Based Systems in Drug Delivery and Regenerative Medicine


Susanna Piluso, Al Halifa Soultan and Jennifer Patterson.


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Concentration and Fractionation of Polyphenols by Membrane Operations


Bartosz Tylkowski, Martyna Nowak, Irene Tsibranska, Anna Trojanowska, Łukasz Marciniak, Ricard Garcia Valls, Tania Gumi, Marta Giamberini and Renata Jastrząb.


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Estradiol Uptake in a Combined Magnetic Ion Exchange - Ultrafiltration (MIEX-UF) Process During Water Treatment


Alessandra Imbrogno, Jennifer Biscarat and Andrea Iris Schäfer.


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Circulating microRNAs as Potential Diagnostic, Prognostic and Therapeutic Targets in Pancreatic Cancer


Safieh Ebrahimi, Faezeh Ghasemi, Seyed Mahdi Hassanian, Soodabeh Shahidsales, Ramin Mardani, Hamed Akbarzade, Seyed Mohammad Reza Parizadeh, Sharareh Gholamin, Anvar Soleimani, Majid Ghayour-Mobarhan and Amir Avan.


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Pleiotropic Effects of Simvastatin on Some Calcium Regulatory and Myofibrillar Proteins in Ischemic/Reperfused Heart: Causality of Statins Cardioprotection?


Adrian Szobi, Martin Lichy, Slavka Carnicka, Dezider Pancza, Pavel Svec, Tana Ravingerova and Adriana Adameova.


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PPAR Agonists, Atherogenic Dyslipidemia and Cardiovascular Risk


Dragana Nikolic, Giuseppa Castellino, Maciej Banach, Peter P. Toth, Ekaterina Ivanova, Alexander N. Orekhov, Giuseppe Montalto and Manfredi Rizzo.


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Medicinal Plants with Multiple Effects on Cardiovascular Diseases: A Systematic Review


Hojjat Rouhi-Boroujeni, Esfandiar Heidarian, Hamid Rouhi-Boroujeni, Fatemeh Deris and Mahmoud Rafieian-Kopaei.


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An Umbrella Review of Nuts Intake and Risk of Cardiovascualr Disease


Lukas Schwingshackl, Georg Hoffmann, Benjamin Missbach, Marta Stelmach-Mardas and Heiner Boeing.


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Complementary Role of Herbal Medicine and Exercise in Cardiovascular Disease Prevention and Management: A Review of Evidence


Sundar Kumar Veluswamy, Abraham Samuel Babu and Lakshmi Manickavasagam Sundar.


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Garlic for Cardiovascular Disease: Prevention or Treatment?


Feras Q. Alali, Tamam El-Elimat, Lila Khalid, Reema Hudaib, Tuqa Saleh Al-Shehabi and Ali H Eid.


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Effect of Sibutramine on Plasma C-Reactive Protein, Leptin and Adiponectin Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials


Antonio De Vincentis, Claudio Pedone, Umberto Vespasiani-Gentilucci, Antonio Picardi, Giuseppe Derosa, Pamela Maffioli and Amirhosssein Sahebkar.


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The Insular Cortex and Takotsubo Cardiomyopathy


Michiaki Nagai, Keigo Dote, Masaya Kato, Shota Sasaki, Noboru Oda, Eisuke Kagawa, Yoshinori Nakano, Aya Yamane, Tasuku Higashihara, Shunsuke Miyauchi, Akane Tsuchiya, Wakako Harada and Kazuomi Kario.


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Precision Medicine and a Patient-Orientated Approach: Is this the Future for Tracking Cardiovascular Disorders


Etheresia Pretorius.


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Therapeutic Interventions for Advanced Glycation-End Products and its Receptor- Mediated Cardiovascular Disease


Kailash Prasad and Shuchita Tiwari.


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Therapeutic Potential of Phytochemicals in Combination with Drugs for Cardiovascular Disorders


James Zheng Shen, Ting Long Jacky Ng and Wing Shing Ho.


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Impact of Statin Therapy on Plasma Vitamin D Levels: A Systematic Review and Meta-Analysis


Amirhossein Sahebkar, Željko Reiner, Luis E. Simental-Mendía, Gianna Ferretti, Claudia Della Corte and Valerio Nobili.


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A New Direction in Ophthalmic Development: Nanoparticle Drug Delivery Systems


Velichka Yordanova Andonova.


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Polymeric Nanomaterials as Nanomembrane Entities for Biomolecule and Drug Delivery


Airama Albisa, Laura Español, Martin Prieto and Victor Sebastian.


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The Influence of Tetracycline Inducible Targeting Rat PPARγ Gene Silencing on the Osteogenic and Adipogenic Differentiation of Bone Marrow Stromal Cells


Xiaobo Feng, Xianzhe Liu, Xianyi Cai, Tao Lin, Weihua Xu, Cao Yang, Yongwei Liu, Shuhua Yang and Dehao Fu.


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Spices: Therapeutic Potential In Cardiovascular Health


Subha Rastogi, Madan Mohan Pandey and AKS Rawat.


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The Role of Biologically Active Ingredients from Chinese Herbal Medicines in the Regulation of Autophagy in Treating Cardiovascular Diseases and Other Chronic Diseases


Jie Li, Yonghong Gao, Xiaomeng Ren, Yanda Li, Lijun Wu, Xinyu Yang, Jie Wang, Hongcai Shang, Xingjiang Xiong and Yanwei Xing.


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Pomegranate Consumption and Blood Pressure: A Review


Sedigheh Asgary, Mahtab Keshvari, Amirhossein Sahebkar and Nizal Sarrafzadegan.


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Convenient, Traditional and Alternative Therapies for Cardiovascular Disorders


Mohammad M. Zarshenas, Arman Zargaran and Michael Blaschke.


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Adonis sp., Convallaria sp., Strophanthus sp., Thevetia sp., and Leonurus sp. - Cardiotonic plants with known traditional use and a few preclinical and clinical studies


Ilkay Erdogan Orhan, Alper Gokbulut and F Sezer Senol.


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Is There a Role for Curcumin Supplementation in the Treatment of Non-Alcoholic Fatty Liver Disease? The Data Suggest Yes


Narges Amel Zabihi, Matteo Pirro, Thomas P. Johnston and Amirhossein Sahebkar.


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Current Trends in Drug Sensitivity Prediction


Isidro Cortés-Ciriano, Lewis H. Mervin and Andreas Bender.


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Desensitization for Drug Hypersensitivity to Chemotherapy and Monoclonal Antibodies


Rafael Bonamichi-Santos and Mariana Castells.


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A Review on the Pharmacology and Toxicology of Steviol Glycosides Extracted from Stevia rebaudiana


Amir Abbas Momtazi-Borojeni, Seyed-Alireza Esmaeili, Elham Abdollahi and Amirhossein Sahebkar.


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Hypersensitivity Reactions to Non-Steroidal Anti-Inflammatory Drugs


Inmaculada Doña, María Salas, James R. Perkins, Esther Barrionuevo, Francesco Gaeta, Jose A. Cornejo-García, Paloma Campo and Maria José Torres.


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Epigenetically active drugs inhibiting DNA methylation and histone deacetylation


Dimitry A. Chistiakov, Veronika A. Myasoedova, Alexander N. Orekhov and Yuri V Bobryshev.


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Mutations of Mitochondrial DNA in Chronic Non-Inflammatory Diseases: Target Candidates for Treatment


Elena V. Galitsyna, Margarita A. Sazonova, Tatiana P. Shkurat, Natalya A. Demakova, Alexsandra A. Melnichenko, Vasily V. Sinyov, Anastasia I. Ryzhkova, Konstantin Y. Mitrofanov, Andrey V. Zhelankin, Igor A. Sobenin and Alexander N Orekhov.


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Medicinal plants for the treatment of asthma: A Traditional Persian Medicine perspective


Behjat Javadi, Amirhossein Sahebkar and Seyed Ahmad Emami.


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Sulfur Mustard-Induced Ocular Injuries: Update on Mechanisms and Management


Yunes Panahi, Danial Roshandel, Mohammad Mehdi Sadoughi, Mostafa Ghanei and Amirhossein Sahebkar.


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Ginseng in Dermatology: A Review


Sarvenaz Sabouri-Rad, Sara Sabouri-Rad, Amirhossein Sahebkar and Zahra Tayarani-Najaran.


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Perspectives on Strategies Using Swellable Polymers in Solid Dispersions for Controlled Drug Release


Thao TD Tran and Phuong HL Tran.


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Phytochemicals Against Advanced Glycation End Products (AGEs) and the Receptor System


Sho-ichi Yamagishi, Takanori Matsui, Yuji Ishibashi, Fumiyuki Isami, Yumi Abe, Tatsuya Sakaguchi and Yuichiro Higashimoto.


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Propagation on Molecular Interaction Networks: Prediction of Effective Drug Combinations and Biomarkers in Cancer Treatment


Balázs Ligeti, Ottilia Menyhárt, Ingrid Petrič, Balázs Győrffy and Sándor Pongor.


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Sialidases: Therapeutic And Antiatherogenic Potential


VN Sukhorukov, VP Karagodin, ER Zakiev and AN Orekhov.


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Cellular and Molecular Mechanisms of Diuretic Plants: An Overview


Francislaine Aparecida Lívero, Jacqueline Vergutz Menetrier, Emerson Luiz Botelho Lourenço and Arquimedes Gasparotto Junior.


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Targeting obesity for the prevention of chronic cardiovascular disease through gut microbiota-herb interactions: An opportunity for traditional herbs


Feng Chen, Jun Jiang, Dan-Dan Tian, Qi Wen, Yong-Hui Li, Jun-Qing Zhang, Chen Cheng and Tengfei Wang.


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Mutations of Nuclear and Mitochondrial Genomes as Potential Targets for the Treatment of Metabolic Syndrome


Elena V. Galitsyna, Andrey V. Zhelankin, Igor A. Sobenin and Alexander N Orekhov.


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Outcomes With Dronedarone In Atrial Fibrillation: What Differences Between Real-World Practice And Trials? A Meta-Analysis And Meta-Regression Analysis


Igor Diemberger, Giulia Massaro, Maria Letizia Bacchi Reggiani, Stefano Lorenzetti, Mauro Biffi, Matteo Ziacchi, Cristian Martignani and Giuseppe Boriani.


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Bile Acids as Novel Pharmacological Agents: the Interplay between Gene Polymorphisms, Epigenetic Factors and Drug Response


Nebojša Pavlović, Bojan Stanimirov and Momir Mikov.


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The Role of Microbiota and Intestinal Permeability in the Pathophysiology of Autoimmune and Neuroimmune Processes with an Emphasis on Inflammatory Bowel Disease Type 1 Diabetes and Chronic Fatigue Syndrome


Gerwyn Morris, Michael Berk, André F. Carvalho, Javier R. Caso, Yolanda Sanz and Michael Maes.


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Adduct Formation and Context Factors in Drug Hypersensitivity: Insight from Proteomic Studies


Juan M. González-Morena, María I. Montañez, Giancarlo Aldini, Francisco J. Sánchez-Gómez and Dolores Pérez-Sala.


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Genetic Predictors of Drug Hypersensitivity


José A. Cornejo-García, Abderrahim Oussalah, Miguel Blanca, Rosa-María Guéant-Rodríguez, Cristobalina Mayorga, Julie Waton, Annick Barbaud, Francesco Gaeta, Antonino Romano and Jean-Louis Guéant.


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Mast Cell Disorders In Drug Hypersensitivity


Patrizia Bonadonna, Massimiliano Bonifacio and Roberta Zanotti.


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Severe drug hypersensitivity reactions: Clinical pattern, diagnosis, etiology and therapeutic options


Maren Paulmann and Maja Mockenhaupt.


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Systemic Allergy to Corticosteroids: Clinical features and cross reactivity


Annick Barbaud and Julie Waton.


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Bona fide targets of deregulated microRNAs in non-small cell lung cancer as tool to identify novel therapeutic targets. A review


Monica Cipollini, Stefano Landi and Federica Gemignani.


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Predictive Biomarkers for Linking Disease Pathology and Drug Effect


Bernd Mayer, Andreas Heinzel, Arno Lukas and Paul Perco.


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Casein kinase II (CK2) as a therapeutic target for hematological malignancies


Chandrika Gowda, Mansi Sachdev, Sunil Muthisami, Malika Kapadia, Lidija Petrovic-Dovat, Melanie Hartman, Yali Ding, Chunhua Song, Jonathon L. Payne, Bi-Hua Tan and Sinisa Dovat.


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Hedgehog Signaling Pathway as Genetic and Epigenetic Target in Ovarian Tumors


Sonja Levanat, Maja Sabol, Vesna Musani, Petar Ozretić and Diana Trnski.


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Targeting Signalling Pathways in Hepatocellular carcinoma


Kaja Blagotinšek and Damjana Rozman.


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Targeting Notch as a Therapeutic Approach for Human Malignancies


Platonova Natalia, Lesma Elena, Basile Andrea, Bignotto Monica, Garavelli Silvia, Palano Maria Teresa, Moschini Adriana, Neri Antonino, Colombo Michela and Chiaramonte Raffaella.


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Diagnosing β-lactam hypersensitivity


Francesco Gaeta, Maria J. Torres, Rocco Luigi Valluzzi, Cristiano Caruso, Cristobalina Mayorga and Antonino Romano.


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Immunological Mechanisms of Drug Hypersensitivity


Xiaoli Meng, Adriana Ariza, James Waddington, Kevin Park and Dean Naisbitt.


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Specific Aspects of Drug Hypersensitivity in Children


MM Bergmann and JC Caubet.


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New Advances in the Study of IgE Drug Recognition


Ángela Martín-Serrano, Nekane Barbero, José A. Agundez, Yolanda Vida, Ezequiel Pérez-Inestrosa and María I Montañez.


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Editorial: Antibody Phage Display: The Evolution of Antibody Therapeutics


Theam Soon Lim.


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Salvia Miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases


Lili Wang, Rufeng Ma, Chenyue Liu, Haixia Liu, Ruyuan Zhu, Shuzhen Guo, Minke Tang, Yu Li, Jianzhao Niu, Min Fu, Sihua Gao and Dongwei Zhang.


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A brief review of blue- and bilberries’ potential to curb cardio-metabolic perturbations: Focus on diabetes


M. Carmen Crespo and Francesco Visioli.


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Cardiovascular Toxicity of Cyclooxygenase Inhibitors and Promising Natural Substitutes


Mahmoud Bahmani, Amir Sarrafchi, Hedayatollah Shirzad, Sedigheh Asgari and Mahmoud Rafieian-Kopaei.


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Systems toxicology: Systematic Approach to Predict Toxicity


Narsis A. Kiani, Ming-Mei Shang and Jesper Tegnér.


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Genetic and Epigenetic Drug Targets in Myelodysplastic Syndromes


Karmen Stankov, Sunčica Stankov and Jasmina Katanić.


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Methods for Selecting Phage Display Antibody Libraries


Ricardo Jara-Acevedo, Paula Díez, María González-González, Rosa María Dégano, Nieves Ibarrola, Rafael Góngora, Alberto Orfao and Manuel Fuentes.


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RNF5, DAB2 and Friends: Novel Drug Targets for Cystic Fibrosis


Elvira Sondo, Emanuela Pesce, Valeria Tomati, Monica Marini and Nicoletta Pedemonte.


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Curcumin: An Effective Inhibitor of Interleukin-6


Morteza Ghandadi and Amirhossein Sahebkar.


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Predictive Modeling of Ocular Pharmacokinetics and Adverse Effects


Leo Ghemtio, Henri Xhaard, Arto Urtti and Heidi Kidron.


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Polypharmacology in Precision Oncology: Current Applications and Future Prospects


Albert A. Antolin, Paul Workman, Jordi Mestres and Bissan Al-Lazikani.


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Identification of Useful Nanobodies by Phage Display of Immune Single Domain Libraries Derived from Camelid Heavy Chain Antibodies


Ema Romão, Francisco Morales-Yánez, Yaozhong Hu, Maxine Crauwels, Pieter De Pauw, Gholamreza Ghassanzadeh Hassanzadeh, Nick Devoogdt, Chloé Ackaert, Cécile Vincke and Serge Muyldermans.


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Therapeutic Antibodies by Phage Display


Hyunbo Shim.


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Unraveling Antibody Display: Systems Biology and Personalized Medicine


Luiz Ricardo Goulart, Paula Souza Santos, Ana Paula Carneiro, Barbara Brasil Santana, Antonio C. R. Valinotto and Thaise Gonçalves Araújo.


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Immunized Antibody Libraries: Manipulating The Diverse Immune Repertoire For Antibody Discovery


Theam Soon Lim and Soo Khim Chan.


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Intestinal Dysbiosis, Gut Hyperpermeability and Bacterial Translocation: Missing Links Between Depression, Obesity and Type 2 Diabetes?


Anastasiya Slyepchenko, Michael Maes, Rodrigo Machado-Veira, George Anderson, Marco Solmi, Yolanda Sanz, Michael Berk, Cristiano A. Köhler and André F Carvalho.


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Engineered Autonomous Human Variable Domains


Johan Nilvebrant, Peter M. Tessier and Sachdev S Sidhu.


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The Synthetic Cannabinoids Phenomenon


Laurent Karila, Amine Benyamina, Lisa Blecha, Olivier Cottencin and Joël Billieux.


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In Silico Systems Pharmacology to Assess Drug's Therapeutic and Toxic Effects


Alejandro Aguayo Orozco, Karine Audouze, Søren Brunak and Olivier Taboureau.


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Modeling Polypharmacological Profiles by Affinity Fingerprinting


Ágnes Peragovics, Zoltán Simon, András Málnási-Csizmadia and Andreas Bender.


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Editorial: Revisiting Drug-DNA Interaction: Novel Molecules and Applications in Antitumor Strategies


Laura Gatti.


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Phage Display Derived IgNAR V Region Binding Domains for Therapeutic Development


Obinna C. Ubah, Caroline J. Barelle, Magdalena J. Buschhaus and Andrew J Porter.


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Organotin(IV) carboxylates as a promising potential drug candidates in the field of cancer chemotherapy


Muhammad Sirajuddin and Saqib Ali.


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Cisplatin Analogues with an Increased Interaction with DNA: Prospects for Therapy


Megan E. Hardie, Hieronimus W. Kava and Vincent Murray.


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Emerging Role of G-quadruplex DNA as Target in Anticancer Therapy


Graziella Cimino-Reale, Nadia Zaffaroni and Marco Folini.


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Genotype- or phenotype-targeting anticancer therapies? Lessons from tumor evolutionary biology


Alexandre E. Escargueil, Soizic Prado, Ambre Dezaire, Jean Clairambault, Annette K. Larsen and Daniele G Soares.


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Methods for Elucidation of DNA-Anticancer Drug Interactions and Their Applications in the Development of New Drugs


Majus Misiak, Francesco Mantegazza and Giovanni L Beretta.


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Editorial: Gut Permeability and the Microbiome: Emerging Roles in CNS Function in Health and Disease


André F. Carvalho, Michael Berk and Michael Maes.


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The Gut Microbiota and the Emergence of Autoimmunity: Relevance to Major Psychiatric Disorders


EG Severance, D Tveiten, LH Lindström, RH Yolken and KL Reichelt.


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An Updated Review of Iscoms™ and Iscomatrix™ Vaccines


Alexis Garcia and Diego Lema.


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Multiple Sclerosis, Gut Microbiota and Permeability: Role of Tryptophan Catabolites, Depression and the Driving Down of Local Melatonin


Moses Rodriguez, Bharath Wootla and George Anderson.


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The Gut-Brain Axis, Including the Microbiome, Leaky Gut and Bacterial Translocation: Mechanisms and Pathophysiological Role in Alzheimer’s Disease


Cristiano A. Köhler, Michael Maes, Anastasiya Slyepchenko, Michael Berk, Marco Solmi, Krista L. Lanctôt and André F Carvalho.


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Asthma COPD Overlap Syndrome: An Approach to A Real -World Endotype in Obstructive Lung Disease?


Maria E. Laucho-Contreras, Maria Montes de Oca and Caroline A Owen.


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Gut Permeability and Microbiota in Parkinson’s Disease: Role of Depression, Tryptophan Catabolites, Oxidative and Nitrosative Stress and Melatoninergic Pathways


George Anderson, M Seo, M Berk, AF Carvalho and M Maes.


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The Microbiota and Gut-Brain Axis: Contributions to the Immunopathogenesis of Schizophrenia


Javier R. Caso, Vicent Balanzá-Martínez, Tomás Palomo and Borja García-Bueno.


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Enteric Ecosystem Disruption in Autism Spectrum Disorder: Can the Microbiota and Macrobiota be Restored?


John Slattery, Derrick F. MacFabe, Stephen G. Kahler and Richard E Frye.


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Editorial: Immune Modulation


Juan B De Sanctis.


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Carrier Mediated Systemic Delivery of Protein and Peptide Therapeutics


Rahela Zaman, Iekhan Othman and Ezharul Hoque Chowdhury.


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A Review of Clinical Trials of Belimumab In The Management of Systemic Lupus Erythematosus


Alexis Garcia and Juan B De Sanctis.


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Editorial: Current Research on Cannabis Use Disorder


Aviv Weinstein.


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From Cannabis to Cannabidiol to Treat Epilepsy, Where Are We?


Pellegrino Lippiello, Simona Balestrini, Antonio Leo, Antonietta Coppola, Rita Citraro, Maurizio Elia, Emilio Russo and Giovambattista De Sarro.


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Subcutaneous Immunoglobulins: A Promising Alternative for Immunomodulation?


Silvia Sánchez-Ramón, Ángel L. Corbí, Águeda García Fidalgo and Ángeles Domínguez-Soto.


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Genetic Influences in Cannabis Use Disorder and Psychosis: Dopamine and Beyond


Amine Benyamina, Laurent Karila, Geneviève Lafaye and Lisa Blecha.


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A Narrative Review of Psychological Cannabis Use Treatments With And Without Pharmaceutical Adjunct


Jan Copeland, Peter Gates and Izabella Pokorski.


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New Biological Insights in the Immunomodulatory Effects of Mucosal Polybacterial Vaccines in Clinical Practice


Marta Tejera-Alhambra, Oscar Palomares, Rebeca Pérez de Diego, Ignacio Díaz-Lezcano and Silvia Sánchez-Ramón.


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Role of Salmonella Typhi Vi Antigen and Secretory Systems on Immune Response


Ermin Schadich, Petr Džubák and Marián Hajdúch.


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Allergic Asthma. A Summary from Genetic Basis, Mouse Studies, to Diagnosis and Treatment


Cynthia Kanagaratham and Danuta Radzioch.


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Understanding Tumor-Antigen Presentation in the New Era of Cancer Immunotherapy


Daniela Cerezo-Wallis and Marisol Soengas.


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Therapeutic Potential of Targeting TREM-1 in Inflammatory Diseases and Cancer


Maria Carla Bosco, Federica Raggi and Luigi Varesio.


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Cannabinoids and Psychosis


Deepak Cyril D`Souza, Rajiv Radhakrishnan, Mohamed Sherif, Jose Cortes-Briones, John Cahill, Swapnil Gupta, Patrick D. Skosnik and Mohini Ranganathan.


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Brain imaging studies on the cognitive, pharmacological and neurobiological effects of cannabis in humans: Evidence from studies of adult users


A. Weinstein, A. Livny-Ezer and A Weizman.


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Pharmacological Treatment of Cannabis-Related Disorders: A Narrative Review


David A Gorelick.


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Lipid-Based Nanocarriers for Cutaneous Leishmaniais and Buruli Ulcer Management


Sandra Simões, Manuela Carvalheiro and Maria Manuela Gaspar.


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Cannabis Epidemiology: A Selective Review


James C. Anthony, Catalina Lopez-Quintero and Omayma Alshaarawy.


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Adolescent cannabis use: What is the evidence for functional brain alteration?


V. Lorenzetti, S. Alonso-Lana, G.J. Youssef, A. Verdejo-Garcia, C. Suo, J Cousijn, M. Takagi, M. Yücel and N Solowij.


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Quinolones in the Search for New Anticancer Agents


Pedro Netto Batalha Netto Batalha, Maria Cecília Bastos Vieira de Souza, Eduardo Peña-Cabrera, David Cruz Cruz and Fernanda da Costa Santos Boechat.


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Editorial: Recent Advances in Cancer Research: Targets and New Ligands


Marcela Cristina de Moraes and Fernando de Carvalho da Silva.


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Gastric Cancer: Nanoparticles as Tools to Improve Treatment Efficacy


Ariel R. Guerrero, Felipe Oyarzún-Ampuero, Natalia Hassan, Alejandro H. Corvalán, Andrew F.G. Quest and Marcelo J Kogan.


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Determinants of Anti-Cancer Effect of Mitochondrial Electron Transport Chain Inhibitors: Bioenergetic Profile and Metabolic Flexibility of Cancer Cells


Félix A. Urra, Boris Weiss-López and Ramiro Araya-Maturana.


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Targeting the EGF/HER Ligand-Receptor System in Cancer


Azucena Esparís-Ogando, Juan Carlos Montero, Joaquín Arribas, Alberto Ocaña and Atanasio Pandiella.


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Targeted Nanosystems to Prostate Cancer


Luiz Cláudio Rodrigues Pereira da Silva, Flávia Almada do Carmo, Luiz Eurico Nasciutti, Patrícia Zancan, Plínio Cunha Sathler and Lucio Mendes Cabral.


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Latest Results for Anti-Angiogenic Drugs in Cancer Treatment


Sofie Frandsen, Sascha Kopp, Markus Wehland, Jessica Pietsch, Manfred Infanger and Daniela Grimm.


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Writers and Erasers of Histone Lysine Methylation with Clinical Applied Modulators: Promising Target for Cancer Therapy


Yi-Chao Zheng, Jin-Lian Ma, Ying Liu and Hong M Liu.


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Insulin-Like Growth Factor 2 – The Oncogene and its Accomplices


Sonja M. Kessler, Johannes Haybaeck and Alexandra K Kiemer.


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Targeting cancer cells with photoactive silica nanoparticles


Wioleta Borzęcka, Tito Trindade, Tomás Torres and João Tomé.


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Editorial: Mitochondrial and Metabolism: Novel Targets for Heart Failure


Lei Xu and Aijun Sun.


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Triggering PIK3CA mutations in PI3K/AKT/mTOR axis: Exploration of newer inhibitors and rational preventive strategies


Vivek Asati, Sanjay K. Bharti, Debarshi Kar Mahapatra, Vikas Asati and Ashok Kumar Budhwani.


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Targeting Anti-Cancer Active Compounds: Affinity-Based Chromatographic Assays


Marcela Cristina de Moraes, Carmen Lucia Cardoso, Claudia Seidl, Ruin Moaddel and Quezia Bezerra Cass.


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Strategies for Increasing the Solubility and Bioavailability of Anticancer Compounds: β-Lapachone and Other Naphthoquinones


Caroline Deckmann Nicoletti, Vitor Francisco Ferreira, Patricia Garcia Ferreira, Debora Omena Futuro and Fernando de Carvalho da Silva.


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Effects and Role of Multikinase Inhibitors in Thyroid Cancer.


Rasmus Laursen, Markus Wehland, Sascha Kopp, Jessica Pietsch, Manfred Infanger, Jirka Grosse and Daniela Grimm.


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A Case Report of IgG4-related Syndrome and Literature Review


Antonino Tuttolomondo, Irene Simonetta, Domenico Di Raimondo, Roberta Conigliaro, Francesca Corpora, Valerio Vassallo and Antonio Pinto.


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Targeting inflammatory bowel diseases by nanocarriers loaded with small and biopharmaceutical anti-inflammatory drugs


Ana Beloqui, Régis Coco and Véronique Préat.


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Editorial: Metabolic Disorders, Drug Development, Drug Design and Biomarkers


Gjumrakch Aliev, Ramon Cacabelos and V Prakash Reddy.


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Nanotechnology for Drug Delivery: Part III


Jian Zhong.


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Editorial: The Pathogenesis of Inflammation and Cancer in the Gastrointestinal Tract: From Basic Science to Translational Medicine


C.H. Cho and HY Wang.


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