E-Pub Articles Ahead of Print ::: Current Pharmaceutical Design

ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)


Volume 21, 42 Issues, 2015


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Current Pharmaceutical Design

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E-Pub Articles Ahead of Print

Therapeutic Effect of Ghrelin in the Course of Ischemia/Reperfusion-induced Acute Pancreatitis
J Bukowczan, Z Warzecha, P Ceranowicz, B Kusnierz-Cabala, R Tomaszewska and A Dembinski
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3D Printing Technology Over a Drug Delivery for Tissue Engineering
Jin Woo Lee and Dong-Woo Cho
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Material Couture for Wound Healing and Regeneration: an Overview
Indu Pal Kaur, Simarjot Kaur Sandhu, Parneet Kaur Deol, Gaurav Sharma, Monika Yadav and Mandeep Singh
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Reconstituted High Density Lipoprotein-Based Nanoparticles: an Overview of Applications in Regenerative Medicine, Preparation, Evaluation and Future Trends
Xiaoyi Wang, Jianping Zhou and Wei Wang
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DSPE-PEG: A Distinctive Component in Drug Delivery System
Jing Che, Chukwunweike I. Okeke, Zhong-Bo Hu and Jing Xu
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Bioactive Hydrogel Scaffolds - Advances in Cartilage Regeneration through Controlled Drug Delivery"
Roberta Censi, Alessandra Dubbini and Pietro Matricardi
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Strategies for Recruitment of Stem Cells to Treat Myocardial Infarction
Muhammad Shafiq, Sang-Hoon Lee, Youngmeex Jung and Soo Hyun Kim
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Multifunctional Therapeutic Delivery Strategiesfor Effective Neuro-Regeneration following Traumatic Spinal Cord Injury
Pradeep Kumar, Yahya E. Choonara and Viness Pillay
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Systemic Drug Delivery Systems for Bone Tissue Regeneration– A Mini Review
Wang Xinluan, Lai Yuxiao, N g HueiLengHelena, Yang Zhijun and Qin Ling
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2D, 3D and 4D Active Compound Delivery in Tissue Engineering and Regenerative Medicine
Nicolas Hanauer, Pierre Luc Latreille, Shaker Alsharif and Xavier Banquy
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3D Biomimetic Models for Drug Delivery and Regenerative Medicine
Yufan Xu and Xiaohong Wang
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Controlled Release of Growth Factors for Regenerative Medicine
Libiao Liu, Xinwei Zhou, Yufan Xu, Weiming Zhang, Cheng-Hsien Liu and Xiaohong Wang
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Application of Molecular Imaging Technologies in Antitumor Drug Development and Therapy
Yan Lin, Zhi-Yi Chen, Feng Yang, Jin-Shan Zhang, Yi-Xiang Wang, Jin-Bing Liu, Jian-Yi Liao, Yang-Ying Liao, Qiu-Lan Zhou, Bing-Cheng Li and Hui-Ying Liang
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Sarcosine-Based Glycine Transporter Type-1 (GlyT-1) Inhibitors Containing Pyridazine Moiety: A Further Search for Drugs with Potential to Influence Schizophrenia Negative Symptoms
Laszlo G. Harsing, Julia Timar, Geza Szabo, Szabolcs Udvari, Katalin M. Nagy, Bernadett Marko, Gabriella Zsilla, Andrea Czompa, Pal Tapolcsanyi, Akos Kocsis and Peter Matyus
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Applications of Important Polysaccharides in Drug Delivery
Gangliang Huang, Xinya Mei, Feng Xiao, Xin Chen, Qilin Tang and Daquan Peng
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Early Life Stress in Depressive Patients: Role of Glucocorticoid and Mineralocorticoid Receptors and of Hypothalamic-Pituitary-Adrenal Axis Activity
Mario Francisco Juruena, Cristiane Von Werne Baes, Itiana Castro Menezes and Frederico Guilherme Graeff
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Early-Life Stress and Psychiatric Disorders: Epidemiology, Neurobiology and Innovative Pharmacological Targets
A Ventriglio, A Gentile, R J Baldessarini and A Bellomo
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Cerebral White Matter Injuries Following a Hypoxic/Ischemic Insult During the Neonatal Period: Pathophysiology, Prognostic Factors, and Future Strategy of Treatment Approach. A Minireview
Christian Zammit, Richard Muscat, Gabriele Sani, Cristoforo Pomara and Mario Valentino
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Early Life and Oxidative Stress in Psychiatric Disorders: What can we Learn from Animal Models?
Emanuela Mhillaj, Maria Grazia Morgese and Luigia Trabace
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Drugs of Abuse in Pregnancy, Poor Neonatal Development, and Future Neurodegeneration. Is Oxidative Stress the Culprit?
Margherita Neri, Stefania Bello and Emanuela Turillazzi
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Childhood Maltreatment and Stress-Related Psychopathology: the Epigenetic Memory Hypothesis
Pierre-Eric Lutz, Daniel Almeida and Gustavo Turecki
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The Long-Term Impact of Early Adversities on Psychiatric Disorders: Focus on Neuronal Plasticity
Alessia Luoni, Juliet Richetto, Giorgio Racagni and Raffaella Molteni
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Impact Of Early Life Stress On The Pathogenesis Of Mental Disorders: Relation To Brain Oxidative Stress
Stefania Schiavone, Marilena Colaianna and Logos Curtis
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Epithelial-Mesenchymal Plasticity of Breast Cancer Stem Cells: Implications for Metastasis and Therapeutic Resistance
Ming Luo, Michael Brooks and Max S. Wicha
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Cancer/Testis Antigens Trigger Epithelial-Mesenchymal Transition and Genesis of Cancer Stem-Like Cells
Ping Yang, Zihe Huo, Huaidong Liao and Quanseng Zhou
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Evaluation of the in vivo Safety Profiles of Rictor Inhibition Using a Zebrafish Model
Yang Cao, Lijun Jiang, Lei Zhao, Xiaoxi Zhou, Na Wang, Peilin Zhang, Yuting Tang and Jianfeng Zhou
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CXCR4 and CXCL12 Expression in Rectal Tumors of Stage IV Patients Before and After Local Radiotherapy and Systemic Neoadjuvant Treatment
Karin Tamas, Urszula M. Domanska, Tonnis H. van Dijk, Hetty Timmer-Bosscha, Klaas Havenga, Arend Karrenbeld, Wim J. Sluiter, Jannet C. Beukema, Marcel A.T.M. van Vugt, Elisabeth G.E. de Vries, Geke A.P. Hospers and Annemiek M.E. Walenkamp
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Phenylbutyric Acid: Simple Structure – Multiple Effects
Magdalena Kusaczuk, Marek Bartoszewicz and Marzanna Cechowska-Pasko
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25OH-Vitamin D3 Levels in Obesity and Metabolic Syndrome—Unaltered in Young and not Correlated to Carotid IMT in all Ages
Harald Mangge, Sieglinde Zelzer, Andreas Meinitzer, Ingeborg Stelzer, Wolfgang J Schnedl, Daniel Weghuber, Dietmar Fuchs, Teodor T Postolache, Elmar Aigner, Christian Datz and Eva Z Reininghaus
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Novel kynurenic Acid Analogues in the Treatment of Migraine and Neurodegenerative Disorders: Preclinical Studies and Pharmaceutical Design
János Tajti, Zsófia Majláth, Délia Szok, Anett Csáti, József Toldi, Ferenc Fülöp and László Vécsei
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Editorial: Impact of Early Life Stress on Psychiatric Disorders: Searching New Biomarkers and Innovative Pharmacological Targets
Luigia Trabace
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Microrna-21: A Central Regulator of Fibrotic Diseases Via Various Targets
Ying Huang, Yong He and Jun Li
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Treatment of Leishmaniasis: A Review and Assessment of Recent Research
Ehab Kotb Elmahallawy and Ahmad Agil
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Influence of Bariatric Surgery on the Expression of Nesfatin-1 in Rats with Type 2 Diabetes Mellitus
Zefeng Xia, Geng Wang, Huiqing Li, Chaojie Hu, Qingbo Wang, Anshu Li, Anshu Li, Ende Zhao, Xiaoming Shuai, Jiliang Wang, Kailin Cai, Kaixiong Tao and Guobin Wang
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Pancreatic Cancer Metastasis: Are we being Pre-EMTed?
Srustidhar Das and Surinder K. Batra
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The Epithelial-Mesenchymal Transition and Cancer Stem Cells: Functional and Mechanistic Links
Xiangqiang Liu and Daiming Fan
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Glioblastoma Multiforme Formation and EMT: Role of FoxM1 Transcription Factor
Zhongyong Wang, Sicong Zhang, Timothy L Siu and Suyun Huang
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Role of Epithelial Mesenchymal Transition in Prostate Tumorigenesis
Mohammad Imran Khan, Abid Hamid, Vaqar Mustafa Adhami, Rahul K Lall and Hasan Mukhtar
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The Functions of F-Box Proteins in Regulating the Epithelial to Mesenchymal Transition
Jingna Su, Xuyuan Yin, Xiuxiao Zhou, Wenyi Wei and Zhiwei Wang
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Epigenetic Regulation of Epithelial-Mesenchymal Transition by Hypoxia in Cancer: Targets and Therapy
Jian-Qiu Wang and Kou-Juey Wu
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Twist-BRD4 Complex: Potential Drug Target for Basal-like Breast Cancer
Jian Shi, Jingying Cao and Binhua P. Zhou
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Vitamin D Receptor Signaling and Pancreatic Cancer Cell EMT
Zhiwei Li, Junli Guo, Keping Xie and Shaojiang Zheng
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Double point modified analogs of vitamin D as potent activators of vitamin D receptor
Sharmin Nadkarni, Michał Chodyński, Aoife Corcoran, Ewa Marcinkowsk, Geoffrey Brown and Andrzej Kutner
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Five Common Functional Polymorphisms in microRNAs (rs2910164, rs2292832, rs11614913, rs3746444, rs895819) and the Susceptibility to Breast Cancer: Evidence from 8361 Cancer Cases and 8504 Controls
Zhi-Jun Dai, Yong-Ping Shao, Xi-Jing Wang, Dan Xu, Hua-Feng Kang, Hong-Tao Ren, Wei-Li Min, Shuai Lin, Meng Wang and Zhang-Jun Song
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Editorial: Targeting Epithelial-to-Mesenchymal Transition for Cancer Therapy
Zhiwei Wang
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Chemistry and Pharmacology of Angiotensin-Converting Enzyme Inhibitors
Miłosz Regulski, Katarzyna Regulska, Beata J. Stanisz, Marek Murias, Paulina Gieremek, Anna Wzgarda and Bartłomiej Niżnik
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Infection-Associated Biomarkers Of Inflammation Inatherosclerosis
Emil Kozarov, Kurt Huber and Johann Wojta
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Safety and Efficacy of Intracoronary Human Umbilical Cord-Derived Mesenchymal Stem Cell Treatment for Very Old Patients with Coronary Chronic Total Occlusion
Xia Li, You-dong Hu, Yan Guo, Ying Chen, Dian-xuan Guo, Hua-lan Zhou, Feng-lin Zhang and Qing-na Zhao
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Serotonergic System and Its Role in Epilepsy and Neuropathic Pain Treatment: a Review Based on Receptor Ligands
Katarzyna Pańczyk, Sylwia Gołda, Anna Waszkielewicz, Dorota Żelaszczyk, Agnieszka Gunia-Krzyżak and Henryk Marona
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Design of Small Molecules Targeting I-BAR Proteins
Meng Cao, Weiwei Chang, Ming Zheng, Li Xie, Yu Zhang, Jin Cai, Junqing Chen, Xi Zhan, Min Ji and Ning Gu
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Selective Inhibitors of Zinc-Dependent Histone Deacetylases. Therapeutic Targets Relevant to Cancer
Jakub Kollar and Vladimir Frecer
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2014 Update Of Erectile Dysfunction Management Following Radical Prostatectomy: From Basic Research To Clinical Management
Serap Gur, Suresh C. Sikka, Philip J. Kadowitz, Jonathan Silberstein and Wayne JG Hellstrom
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Nano-Sized Platforms for Vaginal Drug Delivery
Mazen El-Hammadi and José L. Arias
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Polo-Like Kinase 1 as a Potential Therapeutic Target for Osteosarcoma
Li Cheng, Chongchong Wang and Juehua Jing
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Current and Experimental Pharmacological Approaches in Neonatal Hypoxic- Ischemic Encephalopathy
Teresa Zalewska, Joanna Jaworska and Malgorzata Ziemka-Nalecz
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The Cell-type Specificity and Endosomal Escape of Cell-Penetrating Peptides
Jing Feng and Liling Tang
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The Molecular Mechanisms of TRAIL Resistance in Cancer Cells: Help in Designing New Drugs
Feng Wang, Junsheng Lin and Ruian Xu
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The Role of White Matter Abnormalities in Treatment-Resistant Depression: a Systematic Review
Gianluca Serafini, Maurizio Pompili, Stefan Borgwardt, Enrico Giuffra, Oliver Howes, Paolo Girardi and Mario Amore
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Strategies for Skeletal Muscle Targeting in Drug Discovery
David C. Ebner, Peter Bialek, Ayman F. El-Kattan, Catherine M. Ambler and Meihua Tu
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Editorial: Mitochondrial Biogenesis: Pharmacological Approaches
Teresa Valero
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Mechanisms of Inflammatory Response and Organ Dysfunction: Organ-Protective Strategy by Anesthetics
Noboru Hatakeyama and Naoyuki Matsuda
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VEGF and Colon Cancer Growth Beyond Angiogenesis: Does VEGF Directly Mediate Colon Cancer Growth Via a Non-angiogenic Mechanism?
Amrita Ahluwalia, Michael K. Jones, Tamara Matysiak-Budnik and Andrzej S. Tarnawski
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The Impact of Computational Structure-Based Methods on Drug Discovery
Charles H. Reynolds
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Human Use of Leucoselect® Phytosome® with Special Reference to Inflammatoryallergic Pathologies in Frail Elderly Patients
Thea Magrone, Vittorio Pugliese, Sergio Fontana and Emilio Jirillo
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Anti-miRNA-23a Oligonucleotide Suppresses Glioma Cells Growth by Targeting Apoptotic Protease Activating Factor-1
Shizhong Lian, Ruyi Shi, Tao Bai, Yang Liu, Wang Miao, Hongqin Wang, Xiaodong Liu and Yimin Fan
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Editorial: The SNAP-tag Technology – A Versatile Tool with many Applications
Stefan Barth
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Gender Based Differences in Stress-induced Gastric Ulcer Formation and its Regulation by Nitric Oxide (NO): An Experimental Study
Kavita Gulati, Ayanabha Chakraborti and Arunabha Ray
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Differential Influences of Gastric Bypass and Sleeve Gastrectomy on Plasma Nesfatin-1 and Obestatin Levels in Patients with Type 2 Diabetes Mellitus
Wei-Jei Lee, Chih-Yen Chen, Kong-Han Ser, Keong Chong, Shu-Chun Chen, Pui-Ching Lee, You-Di Liao and Shou-Dong Lee
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Probiotics for the Prevention and Treatment of Allergies, with an Emphasis on Mode of Delivery and Mechanism of Action
Satya Prakash, Catherine Tomaro-Duchesneau, Shyamali Saha, Laetitia Rodes, Imen Kahouli and Meenakshi Malhotra
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Consumption of Mixed Fruit-juice Drink and Vitamin C Reduces Postprandial Stress Induced by a High Fat Meal in Healthy Overweight Subjects
Ilaria Peluso, Debora V. Villano, Susan A. Roberts, Eleonora Cesqui, Anna Raguzzini, Gina Borges, Alan Crozier, Giovina Catasta, Elisabetta Toti and Mauro Serafini
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Immunomodulating and Anti-allergic Effects of Negroamaro and Koshu Vitis vinifera Fermented Grape Marc (FGM)
Giuseppe Marzulli, Thea Magrone, Luisa Vonghia, Masahiro Kaneko, Hiroaki Takimoto, Yoshio Kumazawa and Emilio Jirillo
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Potential Use of Dietary Natural Products, Especially Polyphenols, for Improving Type-1 Allergic Symptoms
Kumazawa Y, Takimoto H, Matsumoto T and Kawaguchi K
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Omega-6 and Omega-3 Polyunsaturated Fatty Acids and Allergic Diseases in Infancy and Childhood
Elizabeth A. Miles and Philip C. Calder
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Factors Affecting Residual Platelet Aggregation in Prasugrel Treated Patients
Dimitrios Alexopoulos, Ioanna Xanthopoulou, Angelos Perperis, Argyro Siapika, Katerina Stavrou, Evropi Tsoni, Periklis Davlouros and George Hahalis
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What Fans the Fire: Insights into Mechanisms of Leptin in Metabolic Syndrome- Associated Heart Diseases
Maolong Dong and Jun Ren
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Transactivation of ErbB Receptors by Leptin in the Cardiovascular System: Mechanisms, Consequences and Target for Therapy
Jerzy Bełtowski and Anna Jazmroz-Wiśniewska
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Structural Insights into Chitinolytic Enzymes and Inhibition Mechanisms of Selective Inhibitors
Tian Liu, Lei Chen, Qiang Ma, Xu Shen and Qing Yang
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Structure-based Design of Conformationally Flexible Reverse Transcriptase Inhibitors to Combat Resistant HIV
Ge-Fei Hao, Sheng-Gang Yang and Guang-Fu Yang
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Structural Basis of Resistance to Anti-Cytochrome bc1 Complex Inhibitors: Implication for Drug Improvement
Lothar Esser, Chang-An Yu and Di Xia
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ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development
Young Hee Choi, Ai-Ming Yu and Ai-Ming Yu
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Structure-Based Drug Design to Overcome Drug Resistance: Challenges and Opportunities
Rafaela S. Ferreira1, Adriano D. Andricopulo and Adriano D. Andricopulo
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Novel Next-Generation Sequencing and Networks-Based Therapeutic Targets: Realistic and More Effective Drug Design and Discovery
Dimitrios H. Roukos, Giannis G. Baltogiannis, Christos S. Katsouras, Aris Bechlioulis, Katerina K. Naka, Charalambos Batsis, Theodore Liakakos and Lampros K. Michalis
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Endothelial Dysfunction and the Effects of TNF Inhibitors on the Endothelium in Psoriasis and Psoriatic Arthritis: A Systematic Review
Elizabeth A. Brezinski, Matthew R. Follansbee, Ehrin J. Armstrong and April W. Armstrong
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Effects of Biologic Agents and Other Disease-Modifying Antirheumatic Drugs on Cardiovascular Outcomes in Psoriasis and Psoriatic Arthritis: A Systematic Review
April W. Armstrong, Elizabeth A. Brezinski, Matthew R. Follansbee and Ehrin J. Armstrong
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Ultrasound-Based Multimodal Molecular Imaging and Functional Ultrasound Contrast Agents
Yan Lin, Zhi-Yi Chen and Feng Yang
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Long-term Etanercept Therapy Favors Weight Gain and Ameliorates Cachexia in Rheumatoid Arthritis Patients: Roles of Gut Hormones and Leptin
Chih-Yen Chen, Chang-Youh Tsai, Pui-Ching Lee and Shou-Dong Lee
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The Effect of First-in-Class Small Molecule RhoA Inhibitor, HL07, on the Phenylephrine-induced Artery Contraction
Yan Zhang, Jing Deng, Sheng Ma, Lin Xue, Jin Zhu, Wei-liang Zhu, Hua-liang Jiang, Jian Li and Li-yan Miao
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Non-Systemic Drugs: A Critical Review
Dominique Charmot
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Advancement of Targeted Ultrasound Contrast Agents and their Applications in Molecular Imaging and Targeted Therapy
Feng Yang, Zhi-Yi Chen and Yan Lin
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Atorvastatin Sensitises Vascular Smooth Muscle Cells, but not Endothelial Cells, to TNF-α-induced Cell Death
Arturo Giordano, Simona Romano, Giovanna Nappo, Stefano Messina, Michele Polimeno, Nicola Corcione, Gaetano Calì, Paolo Ferraro, Mario Monaco, Nicola Zambrano and Maria Fiammetta Romano
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Carotenoids and Cardiovascular Risk
Paola Giordano, Pietro Scicchitano, Manuela Locorotondo, Cosimo Mandurino, Gabriella Ricci, Santa Carbonara, Michele Gesualdo, Annapaola Zito, Annamaria Dachille, Paola Caputo, Roberta Riccardi, Giulia Frasso, Giuseppe Lassandro, Antonio Di Mauro and Marco Matteo Ciccone
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A Computational Study of the Oligosaccharide Binding Sites in the Lectin-Like Domain of Tumor Necrosis Factor and the TNF-derived TIP Peptide
Alexander Dulebo, Rüdiger Ettrich, Rudolf Lucas and David Kaftan
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Target-based Anti-angiogenic Therapy in Breast Cancer
Markus Wehland, Johann Bauer, Manfred Infanger and Daniela Grimm
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Preclinical Safety and Pharmacokinetic Profile of 3K3A-APC, a Novel, Modified Activated Protein C for Ischemic Stroke
Patricia D. Williams, Berislav V. Zlokovic, John H. Griffin, Kent E. Pryor and Thomas P. Davis
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