E-Pub Articles Ahead of Print ::: Current Medicinal Chemistry

ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)


Volume 24, 42 Issues, 2017


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Current Medicinal Chemistry

This journal supports open access

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  • 10th of 59 in Chemistry & Medicinal
  • 63rd of 253 in Pharmacology & Pharmacy
  • 100th of 289 in Biochemistry & Molecular Biology

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Editor-in-Chief:
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK


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Articles Ahead of Print

Biomarkers in Aortic Valve Stenosis and their Clinical Significance in Transcatheter Aortic Valve Implantation


Konstantinos Toutouzas, Konstantinos Stathogiannis, George Latsios, Andreas Synetos, Maria Drakopoulou, Vicky Penesopoulou, Archontoula Michelongona, Eleftherios Tsiamis and Dimitris Tousoulis.


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Targeting Melatonin MT2 Receptors: A Novel Pharmacological Avenue for Inflammatory and Neuropathic Pain


Luca Posa, Danilo De Gregorio, Gabriella Gobbi and Stefano Comai.


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Targeting Kinase-activating Genetic Lesions to Improve Therapy of Pediatric Acute Lymphoblastic Leukemia


Raffaella Franca, Natasa Karas Kuzelicki, Claudio Sorio, Eleonora Toffoletti, Oksana Montecchini, Alice Poropat, Marco Rabusin, Debora Curci, Dino Paladin, Gabriele Stocco and Giuliana Decorti.


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Pro-angiogenic Molecules for Therapeutic Angiogenesis


Selvaprithiviraj Vignesh , Sankar Deepthi , Amirthalingam Sivashanmugam, Sowmya Srinivasan and Rangasamy Jayakumar.


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New-Generation, Non-SSRI Antidepressants: Therapeutic Drug Monitoring and Pharmacological Interactions. Part 1: SNRIs, SMSs, SARIs


Roberto Mandrioli, Michele Protti and Laura Mercolini.


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Expression and Single Nucleotide Polymorphism of Poly (ADPRibose) Polymerase-1 in Gastrointestinal Tumours: Clinical Involvement


Sandra María Martín-Guerreroa, Josefa Leóna, Rosa Quiles-Pereza, Laura Belmonte, David Martin-Oliva, Ángeles Ruiz-Extremera, Javier Salmerón and José Antonio Muñoz-Gámez.


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Pyrrolo[2,3-d]Pyrimidines as Kinase Inhibitors


Francesca Musumeci, Monica Sanna, Giancarlo Grossi, Chiara Brullo, Anna Fallacara and Silvia Schenone.


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The Orexinergic (Hypocretin) System and Nociception: An Update to Supraspinal Mechanisms


Ali Roohbakhsh, Mohaddeseh Sadat Alavi and Hassan Azhdari-Zarmehri.


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Clinical Uses of Melatonin in Neurological Diseases and Mental and Behavioural Disorders


Emilio J. Sánchez-Barceló, Noemi R. Revilla, María D. Mediavilla , Carmen Martínez-Cué and Russel J Reiter.


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Hydroxypyridinone Derivatives: A Fascinating Class of Chelators with Therapeutic Applications - An Update


Sílvia Chaves, Luca Piemontese, Asha Hiremathad and Maria Amélia Santos.


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Biomarkers Associated with Bleeding Risk in the Setting of Atrial Fibrillation


Skevos Sideris, Stefanos Archontakis, George Latsios, George Lazaros, Konstantinos Toutouzas, Eleftherios Tsiamis, Manolis Vavuranakis, Charalampos Vlachopoulos, Konstantinos Gatzoulis, Konstantinos Tsioufis and Dimitris Tousoulis.


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Biomarkers Associated with Stroke Risk in Atrial Fibrillation


Adam Ioannou, Nikolaos Papageorgiou, Debbie Falconer, Onkar Rehal, Emma Sewart, Effimia Zacharia, Konstantinos Toutouzas, Charalampos Vlachopoulos, Gerasimos Siasos, Constantinos Tsioufis and Dimitris Tousoulis.


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Combining Drug and Psychological Treatments for Obsessive- Compulsive Disorder: What is the Evidence, When and for Whom


Umberto Albert, Gabriele Di Salvo, Francesca Solia, Gianluca Rosso and Giuseppe Maina.


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Immunotherapeutic Interleukin-6 or Interleukin-6 Receptor Blockade in Cancer: Challenges and Opportunities


Nirmala C. Kampan, Sue D. Xiang, Orla M McNally, Andrew N. Stephens, Michael A. Quinn and Magdalena Plebanski.


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Migraine, Neurogenic Inflammation, Drug Development - Pharmacochemical Aspects


Melinda Lukács, János Tajti, Ferenc Fülöp, József Toldi, Lars Edvinsson and László Vécsei.


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New Tracers and New Perspectives for Molecular Imaging in Lewy Body Diseases


Matteo Bauckneht, Dario Arnaldi, Flavio Nobili, Dag Aarsland and Silvia Morbelli.


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Impact of Red Wine Consumption on Cardiovascular Health


Luca Liberale, Aldo Bonaventura, Fabrizio Montecucco, Franco Dallegri and Federico Carbone.


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Na+,K+-ATPase as a Target for Treatment of Tissue Fibrosis


Sergei N. Orlov, Jenifer La, Larisa V. Smolyaninova and Nickolai O Dulin.


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Update on the Molecular Mechanisms Underlying the Effect of Cholecystokinin and Cholecystokinin-1 Receptor on the Formation of Cholesterol Gallstones


Helen H. Wang, Piero Portincasa and David Q-H Wang.


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Defensive and Offensive Cross-Reactive Antibodies Elicited by Pathogens: The Good, the Bad and the Ugly


Daria Augustyniak, Grażyna Majkowska-Skrobek, Justyna Roszkowiak and Agata Dorotkiewicz-Jach.


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Biomarkers for Diagnosing and Staging of Fabry Disease


Johannes Krämer and Frank Weidemann.


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Small Molecule Inhibitors of Hepatitis B Virus Nucleocapsid Assembly: A New Approach to Treat Chronic HBV Infection


Li Yang and Mengji Lu.


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Glioblastoma Multiforme, Diagnosis and Treatment; Recent Literature Review


Ron Batash , Noam Asna , Pamela Schaffer, Nicole Francis and Moshe Schaffer.


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Cyclic Dipeptides: Secondary Metabolites Isolated from Different Microorganisms with Diverse Biological Activities


Aurelio Ortiz and Estibaliz Sansinenea.


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Supervised Machine Learning Methods Applied to Predict Ligand- Binding Affinity


Gabriela Sehnem Heck , Val Oliveira Pintro, Richard Rene Pereira, Mauricio Boff de Ávila, Nayara Maria Bernhardt Levin and Walter Filgueira de Azevedo.


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Modulating Mitophagy in Mitochondrial Disease


Eszter Dombi, Heather Mortiboys and Joanna Poulton.


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Role of Anti-PCSK9 Antibodies in the Treatment of Patients with Statin Intolerance


Julia Schreml and Ioanna Gouni-Berthold.


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The Role of Mitochondrial Dysfunction in the Progression of Alzheimer’s Disease


Claus Desler, Meryl S. Lillenes, Tone Tønjum and Lene Juel Rasmussen.


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APOC-III Antisense Oligonucleotides: A New Option for the Treatment of Hypertriglyceridemia


Joel Schmitz and Ioanna Gouni-Berthold.


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Therapeutic Proteins for Treatment of Corneal Epithelial Defects


Evgeni Yu. Zernii, Viktoriia E. Baksheeva, Elena V. Yani, Pavel P. Philippov and Ivan I Senin.


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Fatty Acids and Effects on In Vitro and In Vivo Models of Liver Steatosis


Laura Vergani.


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Promising Treatments for Obsessive-Compulsive Disorder: A Call for Additional Research


Lorrin M. Koran and Elias Aboujaoude.


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Microneedle Patches as Drugs and Vaccine Delivery Platform


Junwei Li , Mingtao Zeng , Hu Shan and Chunyi Tong.


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Synthesis and Biological Activity of Unnatural Enediynes


Roberto Romeo, Salvatore V. Giofrè and Maria A Chiacchio.


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Effect of Metformin and Statin Use on Survival in Pancreatic Cancer Patients: a Systematic Literature Review and Meta-analysis


Jian Yu E, Judith M. Graber, Shou-En Lu, Yong Lin, Grace Lu-Yao and Xiang-Lin Tan.


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A Systematic Analysis of Physicochemical and ADME Properties of All Small Molecule Kinase Inhibitors Approved by US FDA from January 2001 to October 2015


Zhihong O’Brien and Mehran F Moghaddam.


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Targeting Malassezia species for Novel Synthetic and Natural Antidandruff Agents


Letizia Angiolella, Simone Carradori, Cristina Maccallini, Gustavo Giusiano and Claudiu T Supuran.


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The Role of Diet in the Pathogenesis of Cholesterol Gallstones


Agostino Di Ciaula, Gabriella Garruti, Gema Frühbeck, Maria De Angelis, Ornella De Bari, David Q.-H. Wang, Frank Lammert and Piero Portincasa.


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Food and Gastroesophageal Reflux Disease


Teodora Surdea-Blaga, Dana E. Negrutiu, Mariana Palage and Dan L Dumitrascu.


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Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease


José Teixeira, Daniel Chavarria, Fernanda Borges, Lech Wojtczak, Mariusz R. Wieckowsk, Anieszka Karkucińska-Wieckowska and Paulo J Oliveira.


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A Mini-Review on Thalidomide: Chemistry, Mechanisms of Action, Therapeutic Potential and Anti-Angiogenic Properties in Multiple Myeloma


Annalisa Mercurio , Giulia Adriani , Alessia Catalano , Alessia Carocci , Luigia Rao , Giovanni Lentini , Maria Maddalena Cavalluzzi , Carlo Franchini , Angelo Vacca and Filomena Corbo.


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Lectin-Carbohydrate Interactions: Implications for the Development of New Anticancer Agents


Evellyne de Oliveira Figueirôa, Cassia Regina Albuquerque da Cunha, Priscilla B.S. Albuquerque , Raiana Apolinário de Paula , Mary Ângela Aranda-Souza , Matheus Alves da Silva, Adrielle Zagmignan, Maria G. Carneiro-da-Cunha , Luís Cláudio Nascimento da Silva and Maria Tereza dos Santos Correia.


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Soluble Guanylate Cyclase: A New Therapeutic Target for Fibrotic Diseases


Liqing Hu, Zeyu Wang, Rui Yi , Honghong Yi , Sijia Xiao, Zhuo Chen , Gaoyun Hu and Qianbin Li.


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Update on Cardiovascular Effects of Older and Newer Anti-diabetic Medications


Ioanna Eleftheriadou, Pinelopi Grigoropoulou, Evangelos Liberopoulos, Stavros Liatis, Alexandros Kokkinos and Nikolaos Tentolouris.


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Exploitation of Novel Molecular Targets to treat Idiopathic Pulmonary Fibrosis: A Drug Discovery Perspective


Bhuvaneshwar Vaidya , Ruaab Patel , Aaron Muth and Vivek Gupta.


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Phosphodiesterase 4 Inhibitors in Immune-mediated Diseases: Mode of Action, Clinical Applications, Current and Future Perspectives


Lazaros I. Sakkas, Athanasios Mavropoulos and Dimitrios P Bogdanos.


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Recent Advances in Antibody-Drug Conjugates for Breast Cancer Treatment


Shanshan Deng, Zongtao Lin and Wei Li.


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Mycosporine-Like Amino Acids for Skin Photoprotection


Karl P Lawrence, Paul F Long and Antony R Young.


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Neurotoxicity of Insecticides


Julien Cassereau, Marc Ferré, Arnaud Chevrollier, Philippe Codron, Christophe Verny, Chadi Homedan, Guy Lenaers, Vincent Procaccio, Pascale May-Panloup and Pascal Reynier.


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Diet After Cholecystectomy


Donato F. Altomare, Maria T. Rotelli and Nicola Palasciano.


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The Food-Gut Human Axis: The Effects of Diet on Gut Microbiota and Metabolome


Maria De Angelis, Gabriella Garruti, Fabio Minervini, Leonilde Bonfrate, Piero Portincasa and Marco Gobbetti.


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Lanthanum Carbonate - A New Phosphate Binding Drug in Advanced Renal Failure


Jan Aaseth and Anne-Lise Bjørke-Monsen.


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New Diagnostic and Therapeutic Aspects of Pancreatic Ductal Adenocarcinoma


Harald Mangge , Tobias Niedrist, Wilfried Renner , Stefan Lyer , Christoph Alexiou and Johannes Haybaeck.


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Treatment and Response to Statins: Gender-related Differences


V. Raparelli, G. Pannitteri, T. Todisco , F. Toriello, L. Napoleone , R. Manfredini and S Basili.


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An Overview on Screening Methods for Lysine Specific Demethylase 1 (LSD1) Inhibitors


Yi-Chao Zheng, Jiao Chang, Ting Zhang , Feng-Zhi Suo , Xiao-Bing Chen, Ying Liu , Bing Zhao, Bin Yu and Hong-Min Liu.


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Diet and Contaminants: Driving the Rise to Obesity Epidemics?


Agostino Di Ciaula and Piero Portincasa.


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Tungsten or Wolfram: Friend or Foe?


Maria Antonietta Zoroddu, Serenella Medici, Massimiliano Peana, Valeria Marina Nurchi, Joanna I. Lachowicz and Max Costa.


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The Woman’s Heart: Insights into New Potential Targeted Therapy


Daniele Gianfrilli, Ricardo Pofi, Tiziana Feola, Andrea Lenzi and Elisa Giannetta.


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Metabolomics of Healthy Berry Fruits


Gilda D`Urso, Sonia Piacente, Cosimo Pizza and Paola Montoro.


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Antitubercular Marine Natural Products


Lishu Wang, Jungfeng Wang, Juan Liu and Yonghong Liu.


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Antimicrobial Polymers: Mimicking Amino Acid Functionality, Sequence Control and Three-dimensional Structure of Host-defense Peptides


Matthias Hartlieb, Elizabeth G. L. Williams, Agnès Kuroki, Sébastien Perrier and Katherine E S Locock.


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Advances in Chemistry and Pharmacology of Triterpenoid Synthetic Dimers


Barbara Bednarczyk-Cwynar and Andrzej Günther.


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Vitamin D, Autoimmunity and Gender


Clara Crescioli and Salvatore Minisola.


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Cyclodextrins based Electrochemical Sensors for Biomedical and Pharmaceutical Analysis


Joanna Lenik.


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Diet and Cardiovascular Disease: Effects of Foods and Nutrients in Classical and Emerging Cardiovascular Risk Factors


Lina Badimon, Patricia Chagas and Gemma Chiva-Blanch.


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Depleted Uranium and Human Health


Armando Faa, Clara Gerosa, Daniela Fanni, Giuseppe Floris, Peter Van Eyken, Joanna Izabela Lachowicz and Valeria Marina Nurchi.


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New Directions in the Use of Brain Stimulation Interventions in Patients with Obsessive-Compulsive Disorder


Bernardo Dell’Osso , Laura Cremaschi , Lucio Oldani and Altamura Alfredo Carlo.


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Multicyclic Peptides as Scaffolds for the Development of Tumor Targeting Agents


Anastasia Loktev, Uwe Haberkorn and Walter Mier.


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Major Developments in the Design of Inhibitors Along the Kynurenine Pathway


Kelly R. Jacobs, Gloria Castellano Gonzalez , Gilles J. Guillemin and David B Lovejoy.


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Targeting NPY, CRF/UCNs and NPS Neuropeptide Systems to Treat Alcohol Use Disorder (AUD)


Francisco David Rodriguez and Rafael Coveñas.


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Catestain: A Master Regulator of Cardiovascular Functions


Sushil K. Mahata, Malapaka Kiranmayi and Nitish R Mahapatra.


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Gold - Old Drug with New Potentials


Gavino Faa, Clara Gerosa, Daniela Fanni, Joanna I. Lachowicz and Valeria M Nurchi.


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Structure, Roles and Inhibitors of a Mitotic Protein Kinase Haspin


Katrin Kestav, Asko Uri and Darja Lavogina.


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Incretins and Lipid Metabolism


Vasilis Tsimihodimos and Moses S Elisaf.


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The Pharmacological Mechanisms and Therapeutic Activities of Hydroxychloroquine in Rheumatic and Related Diseases


Changfeng Hu, Lu Lu, Jie-Ping Wan and Chengping Wen.


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Biotechnological Approaches for Production of Anti-Cancerous Compounds Resveratrol, Podophyllotoxin and Zerumbone


Krishnadas Nandagopal, Mihir Halder, Biswabhusan Dash, Sanghamitra Nayak and Sumita Jha.


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The Impact of IL-17 in Atherosclerosis


Xinjie Lu.


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Phage Life Cycles Behind Bacterial Biodiversity


Tomasz Olszak, Agnieszka Latka, Bartosz Roszniowski, Miguel Angel Valvano and Zuzanna Drulis-Kawa.


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Immune Checkpoint Inhibitors and Cardiac Toxicity: An Emerging Issue


Gilda Varricchi, Giancarlo Marone, Valentina Mercurio, Domenico Bonaduce, Maria Rosaria Galdiero and Carlo G Tocchetti.


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Serotonin Receptor Binding Characteristics of Geissoschizine Methyl Ether, an Indole Alkaloid in Uncaria Hook


Yasushi Ikarashi, Kyoji Sekiguchi and Kazushige Mizoguchi.


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Targeting Heparan Sulfate Proteoglycans and their Modifying Enzymes to Enhance Anticancer Chemotherapy Efficacy and Overcome Drug Resistance


Cinzia Lanzi, Nadia Zaffaroni and Giuliana Cassinelli.


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Metaflammation: Tissue-Specific Alterations of the NLRP3 Inflammasome Platform in Metabolic Syndrome


Raffaella Mastrocola, Manuela Aragno, Giuseppe Alloatti, Massimo Collino, Claudia Penna and Pasquale Pagliaro.


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Recent Findings on the Application of Toll-like Receptors Agonists in Cancer Therapy


Martina Mikulandra, Jasminka Pavelic and Tanja Matijevic Glavan.


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Biosimilars for the Management of Inflammatory Bowel Diseases: Economic Considerations


Laszlo Gulacsi, Marta Pentek, Fanni Rencz, Valentin Brodszky, Petra Baji, Zsuzsanna Vegh, Krisztina B Gecse, Silvio Danese, Laurent Peyrin- Biroulet and Peter L Lakatos.


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Peptide-Drug Conjugate: A Novel Drug Design Approach


Liang Ma , Chao Wang, Zihao He , Biao Cheng , Ling Zheng and Kun Huang.


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Discovery of Hedgehog Antagonists for Cancer Therapy


Harleen Khatra, Chandra Bose and Surajit Sinha.


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Natural Products from Deep-Sea-Derived Fungi ̶ A New Source of Novel Bioactive Compounds?


Georgios Daletos, Weaam Ebrahim, Elena Ancheeva, Mona El-Neketi, Weiguo Song, Wenhan Lin and Peter Proksch.


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Lactate Dehydrogenase Inhibition: Biochemical Relevance and Therapeutical Potential


Giuseppina Laganà, Davide Barreca, Antonella Calderaro and Ersilia Bellocco.


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Epigenetic Modulation Using Small Molecules - Targeting Histone Acetyltransferases in Disease


André Richters and Angela N Koehler.


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Targeting Cancer Stem Cells for Chemoprevention of Pancreatic Cancer


Dharmalingam Subramaniam, Gaurav Kaushik, Prasad Dandawate and Shrikant Anant.


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Mitochondria-targeted Antioxidants as a Prospective Therapeutic Strategy for Multiple Sclerosis


Elena K. Fetisova, Boris V. Chernyak, Galina A. Korshunova, Maria S. Muntyan and Vladimir P Skulachev.


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Regulatory Role of G Protein-coupled Receptors in Pancreatic Cancer Development and Progression


Hildegard M Schuller.


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Molecular Players in Tuberculosis Drug Development: Another Break in the Cell Wall


Flavia Squeglia, Maria Romano, Alessia Ruggiero and Rita Berisio.


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In Vitro Skin Models for the Evaluation of Sunscreen-Based Skin Photoprotection: Molecular Methodologies and Opportunities


Claire Marionnet and Françoise Bernerd.


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Update on Interventions in Prevention and Treatment of Pediatric Asthma


Marcello Lanari, Paolo Bottau and Elisabetta Calamelli.


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The Role of Universal Stress Proteins in Bacterial Infections


Andrew O`Connor and Siobhán McClean.


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Gut-brain Axis: Role of Lipids in the Regulation of Inflammation, Pain and CNS Diseases


Roberto Russo, Claudia Cristiano, Carmen Avagliano, Carmen De Caro, Giovanna La Rana, Giuseppina Mattace Raso, Roberto Berni Canani, Rosaria Meli and Antonio Calignano.


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Small-molecule Modulation of HDAC6 Activity: The Propitious Therapeutic Strategy to Vanquish Neurodegenerative Disorders


Shabir Ahmad Ganai.


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Modes of Action, Resistance and Toxicity of Insecticides Targeting Nicotinic Acetylcholine Receptors


Makoto Ihara, Steven D. Buckingham, Kazuhiko Matsuda and David B Sattelle.


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Mitogen-activated Protein Kinase (MAPK) Interacting Kinases 1 and 2 (MNK1 and MNK2) as Targets for Cancer Therapy: Recent Progress in the Development of MNK Inhibitors


Agnieszka Dreas, Maciej Mikulski, Mariusz Milik, Charles-Henry Fabritius, Krzysztof Brzózka and Tomasz Rzymski.


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Defense Against Pathogens: Structural Insights into the Mechanism of Chitin Induced Activation of Innate Immunity


Flavia Squeglia, Rita Berisio, Naoto Shibuya and Hanae Kaku.


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Pathobiology and Therapeutic Implications of Tumor Acidosis


Jenny Viklund, Sofia Avnet and Angelo De Milito.


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Late-life depression and Alzheimer disease: a potential synergy of the underlying mechanisms


Jerzy Leszek, Elżbieta Trypka, Euphrosyni Koutsourak, Dimitrios Michmizos, V V Tarasov, Ghulam Md Ashraf and Gjumrakch Aliev.


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Update on Recent Developments in Small Molecular HIV-1 RNase H Inhibitors (2013-2016): Opportunities and Challenges


Xueshun Wang, Ping Gao, Luis Menéndez-Arias, Xinyong Liu and Peng Zhan.


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Molecular Mechanism of Action and Selectivity of Sodium Channel Blocker Insecticides


Kristopher Silver, Ke Dong and Boris S Zhorov.


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Drug Delivery Nanoparticles in Treating Chemoresistant Tumor Cells


Giuseppina Barrera, Martina Daga, Benedetta Ferrara, Chiara Dianzani, Stefania Pizzimenti, Monica Argenziano, Roberta Cavalli and Francesco Trotta.


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Therapeutic Potential of Caffeic Acid Phenethyl Ester (CAPE) in Diabetes


Valeria Pittala, Loredana Salerno, Giuseppe Romeo, Rosaria Acquaviva, Claudia Di Giacomo and Valeria Sorrenti.


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Recent Insights into the Development of Preclinical Trastuzumab- Resistant HER2+ Breast Cancer Models


Paula González-Alonso, Ion Cristóbal, Sandra Zazo, Ester Martín-Aparicio, Cristina Chamizo, Juan Madoz-Gúrpide, Ana Rovira, Pilar Eroles, Ana Lluch, Joan Albanell and Federico Rojo.


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Sex Differences in Alcohol Use Disorder


Roberta Agabio, Claudia Pisanu, Gian Luigi Gessa and Flavia Franconi.


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Comparison of Clinical Outcomes Between Genders Following Antihypertensive Therapy: A Meta-Analysis


Paolo Giorgini, Amirhossein Sahebkar, Valeria Raparelli, Cosimo Andrea Stamerra, Marco Petrarca, Davide Grassi, Claudio Ferri and Paolo Di Giosia.


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Structure-activity Relationship Studies of New Marine Anticancer Agents and their Synthetic Analogues


Sergey N. Fedorov, Valentin A. Stonik, Friedemann Honecker and Sergey Dyshlovoy.


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Alzheimer's Disease: A Review from the Pathophysiology to Diagnosis, New Perspectives for Pharmacological Treatment


Leide Caroline dos Santos Picanço, Priscilla Farias Ozela, Maiara de Fátima de Brito Brito, Abraão Alves Pinheiro, Elias Carvalho Padilha, Francinaldo Sarges Braga, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos, Joaquín María Campos Rosa and Lorane Izabel da Silva Hage-Melim.


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Microwave Assisted Synthesis of Biorelevant Benzazoles


Kapileswar Seth, Priyank Purohit and Asit K Chakraborti.


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A Focused Review of Gender Differences in Antithrombotic Therapy


Andrea Salzano, Pablo Demelo-Rodriguez, Alberto Maria Marra and Marco Proietti.


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Snake Venom Peptides and Low Mass Proteins: Molecular Tools and Therapeutic Agents


J.R. Almeida L.M. Resende, R. K. Watanabe, V.C. Corassola, S. Huancahuire-Vega, C. A. da S. Caldeira, A. Coutinho-Neto, A. M. Soares, N. Vale, P. A. de C. Gomes, S. Marangoni, L. de A. Calderon and S L Da Silva.


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Polymeric Biomaterial and Lipid Based Nanoparticles for Oral Drug Delivery


Fahima Dilnawaz.


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Leveraging Structural Diversity and Allosteric Regulatory Mechanisms of Protein Kinases in the Discovery of Small Molecule Inhibitors


Gennady M Verkhivker.


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Nanoparticle Based Delivery of Protease Inhibitors to Cancer Cells


Mateja Prunk and Janko Kos.


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Sex Impact on Biomarkers, Pharmacokinetics and Pharmacodynamics


Flavia Franconi and Ilaria Campesi.


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Gender Differences in Cancer-Associated Venous Thromboembolism


Silvia Riondino, Fiorella Guadagni, Vincenzo Formica, Patrizia Ferroni and Mario Roselli.


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Efficacy, Safety and Immunogenicity of Biosimilars in Inflammatory Bowel Diseases: A Systematic Review


Laura Martelli and Laurent Peyrin-Biroulet.


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Ellagitannins, gallotannins and their metabolites- the contribution to the anti-inflammatory effect of food products and medicinal plants


Anna K. Kiss and Jakub Piwowarski.


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Phytochemical and pharmacological activity profile of Crataegus oxyacantha L. (hawthorn) - A cardiotonic herb


Ilkay Erdogan Orhan.


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Quercetin is a useful medicinal compound showing various actions including control of blood pressure, neurite elongation and epithelial ion transport


Yoshinori Marunaka, Naomi Niisato, Hiroaki Miyazaki, Ken-­Ichi Nakajima, Akiyuki Taruno, Hongxin Sun, Rie Marunaka, Motoki Okui, Toshiro Yamamoto, Narisato Kanamura, Haruka Kogiso, Yukiko Ikeuchi, Makiko Kashio, Shigekuni Hosogi and Takashi Nakahari.


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Cocoa polyphenols: Chemistry, bioavailability and effects on cardiovascular performance


Chiara Fanali, Laura Dugo, Giusy Tripodo and Luca Santi.


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Beyond Photodynamic Therapy: Light-Activated Cancer Chemotherapy


Wiktor Szymanski and Friederike Reeßing.


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Expediting the Design, Discovery, and Development of Anticancer Drugs using Computational Approaches


Sun Choi, Stephani Joy Y. Macalino, Minghua Cui and Shaherin Basith.


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The metabolite Trimethylamine‐N‐oxide is an emergent biomarker of human health


Jyoti Chhibber-Goel, Varsha Singhal, Neeraj Parakh, Balram Bhargava and Amit Sharma.


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Oncogene Expression Modulation in Cancer Cell Lines by DNA G-Quadruplex-Interactive Small Molecules


Alexandra Paulo and Ana Paula Francisco.


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New Therapeutic Property of Dimebon as a Neuroprotective Agent


Aleksey Ustyugov, Elena Shevtsova, George E. Barreto, Ghulam Md. Ashraf, Sergey O. Bachurin and Gjumrakch Aliev.


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Updates on Managing Type 2 Diabetes Mellitus with Natural Products: Towards Antidiabetic Drug Development


Fahmida Alam, Md Asiful Islam, M A Kamal and Siew Hua Gan.


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Microwave-assisted Formation of Organic Disulfides of Biochemical Significance


Debasish Sengupta, Babli Roy and Basudeb Basu.


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Editorial: Mechanisms and Therapeutic Strategies for Major Neurological Disorders: Current Advances and Future Perspectives


Weihai Ying.





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