E-Pub Articles Ahead of Print ::: Current Medicinal Chemistry

ISSN: 1875-533X (Online)
ISSN: 0929-8673 (Print)


Volume 24, 42 Issues, 2017


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Current Medicinal Chemistry

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  • 10th of 59 in Chemistry & Medicinal
  • 63rd of 253 in Pharmacology & Pharmacy
  • 100th of 289 in Biochemistry & Molecular Biology

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Editor-in-Chief:
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK


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Articles Ahead of Print

Role of Hepcidin-25 in Chronic Kidney Disease: Anemia and Beyond


Norishi Ueda and Kazuya Takasawa.


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Mitochondria-targeted Antioxidants as a Prospective Therapeutic Strategy for Multiple Sclerosis


Elena K. Fetisova, Boris V. Chernyak, Galina A. Korshunova, Maria S. Muntyan and Vladimir P Skulachev.


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Regulatory Role of G Protein-coupled Receptors in Pancreatic Cancer Development and Progression


Hildegard M Schuller.


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Molecular Players in Tuberculosis Drug Development: Another Break in the Cell Wall


Flavia Squeglia, Maria Romano, Alessia Ruggiero and Rita Berisio.


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In Vitro Skin Models for the Evaluation of Sunscreen-Based Skin Photoprotection: Molecular Methodologies and Opportunities


Claire Marionnet and Françoise Bernerd.


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Treatment with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors to Reduce Cardiovascular Inflammation and Outcomes


Luca Liberale, Fabrizio Montecucco, Giovanni G. Camici, Franco Dallegri, Alessandra Vecchié, Federico Carbone and Aldo Bonaventura.


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Update on Interventions in Prevention and Treatment of Pediatric Asthma


Marcello Lanari, Paolo Bottau and Elisabetta Calamelli.


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Therapeutic Targeting of NLRP3 Inflammasomes by Natural Products and Pharmaceuticals: A Novel Mechanistic Approach for Inflammatory Diseases


Sadaf Jahan, Dipak Kumar, Swati Chaturvedi, Mamunur Rashid, Muhammad Wahajuddin, Yasir Akhtar Khan, Sameer N. Goyal, C. R. Patil, Rajesh Mohanraj, Sandeep Subramanya and Shreesh Ojha.


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Emerging Insight into MAPK Inhibitors and Immunotherapy in Colorectal Cancer


Massimo Pancione, Guido Giordano, Pietro Parcesepe, Luigi Cerulo, Luigi Coppola, Anais Del Curatolo, Fabiana Conciatori, Michele Milella and Almudena Porras.


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The Role of Universal Stress Proteins in Bacterial Infections


Andrew O`Connor and Siobhán McClean.


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Gut-brain Axis: Role of Lipids in the Regulation of Inflammation, Pain and CNS Diseases


Roberto Russo, Claudia Cristiano, Carmen Avagliano, Carmen De Caro, Giovanna La Rana, Giuseppina Mattace Raso, Roberto Berni Canani, Rosaria Meli and Antonio Calignano.


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Vitamin D and Cancer Stem Cells in the Gastrointestinal Tract


Ming-Xing Li, Long-Fei Li, Lin Zhang, Zan-Gang Xiao, Jing Shen, Wei Hu, Qiang Zeng and Chi-Hin Cho.


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Kynurenines and PACAP in Migraine: Medicinal Chemistry and Pathogenetic Aspects


János Tajti, Délia Szok, Gábor Nagy-Grócz, Bernadett Tuka, Anna Petrovics-Balog, József Toldi and László Vécsei.


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An Approach Towards Structure Based Antimicrobial Peptide Design for Use in Development of Transgenic Plants: A Strategy for Plant Disease Management


Humaira Ilyas, Aritreyee Datta and Anirban Bhunia.


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Recent Advances in Targeted Therapy for Glioma


Lin Lin, Jinquan Cai and Chuanlu Jiang.


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Role of Oxidative Stress in Renal Transplantation: Bases for an n-3 PUFA Strategy against Delayed Graft Function


Camilo G. Sotomayor, Ignacio Cortés, Juan Guillermo Gormaz, Sergio Vera, Matías Libuy, Nicolás Valls and Ramón Rodrigo.


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Small-molecule Modulation of HDAC6 Activity: The Propitious Therapeutic Strategy to Vanquish Neurodegenerative Disorders


Shabir Ahmad Ganai.


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Neurotoxicity Associated With Platinum-Based Anti-Cancer Agents: What are the Implications of Copper Transporters?


Vanesa Stojanovska, Rachel McQuade, Emma Rybalka and Kulmira Nurgali.


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Lipoprotein (a) Management: Lifestyle and Hormones


Antonio Garcia-Rios, Ana Leon-Acuña, Jose Lopez-Miranda and Pablo Perez-Martinez.


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Lipoprotein (a) Evolution: Possible Benefits and Harm. Genetic and Non-Genetic Factors Influencing its Plasma Levels


Peggy M. Kostakou, George Hatzigeorgiou, Vana Kolovou, Sophie Mavrogeni and Genovefa D Kolovou.


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Colorectal Cancer Chemotherapy: The Evolution of Treatment and New Approaches


Rachel M McQuade, Vanesa Stojanovska, Joel C Bornstein and Kulmira Nurgali.


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Application of Organic Monolithic Materials to Enantioseparation in Capillary Separation Techniques


Enrique Javier Carrasco-Correa, Ernesto Francisco Simó-Alfonso, Guillermo Ramis-Ramos and Jose Manuel Herero-Martinez.


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Modes of Action, Resistance and Toxicity of Insecticides Targeting Nicotinic Acetylcholine Receptors


Makoto Ihara, Steven D. Buckingham, Kazuhiko Matsuda and David B Sattelle.


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DNA Damage-inducing Compounds: Unraveling their Pleiotropic Effects Using High Throughput Sequencing


Sebastian Müller.


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Mitogen-activated Protein Kinase (MAPK) Interacting Kinases 1 and 2 (MNK1 and MNK2) as Targets for Cancer Therapy: Recent Progress in the Development of MNK Inhibitors


Agnieszka Dreas, Maciej Mikulski, Mariusz Milik, Charles-Henry Fabritius, Krzysztof Brzózka and Tomasz Rzymski.


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Displacement of Drugs from Human Serum Albumin: From Molecular Interactions to Clinical Significance


Hrvoje Rimac, Željko Debeljak, Mirza Bojić and Larisa Miller.


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Secondary Metabolites from Cissampelos, A Possible Source for New Leads with Anti-Inflammatory Activity


Mateus Feitosa Alves, Marcus Tullius Scotti, Luciana Scotti, Francisco Jaime Bezerra Mendonça Junior, José Maria Barbosa Filho, Sílvia Adelaide Linhares de Melo, Sócrates Golzio dos Santos and Margareth de Fátima Formiga Melo Diniz.


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Defense Against Pathogens: Structural Insights into the Mechanism of Chitin Induced Activation of Innate Immunity


Flavia Squeglia, Rita Berisio, Naoto Shibuya and Hanae Kaku.


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Prediction of Chemical Multi-target Profiles and Adverse Outcomes with Systems Toxicology


Henri Wathieu, Abiola Ojo and Sivanesan Dakshanamurthy.


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Action and Function of Vitamin D in Digestive Tract Physiology and Pathology


Maikel P. Peppelenbosch, Gwenny M. Fuhler, Auke Pieter Verhaar and Luc JW Van Der Laan.


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Epratuzumab and Blinatumomab as Therapeutic Antibodies for Treatment of Pediatric Acute Lymphoblastic Leukemia: Current Status and Future Perspectives


Raffaella Franca, Diego Favretto, Marilena Granzotto, Giuliana Decorti, Marco Rabusin and Gabriele Stocco.


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Farnesoid-X Receptor (FXR) as a Promising Pharmaceutical Target in Atherosclerosis


Demetrios Moris, Constantinos Giaginis, Gerasimos Tsourouflis and Stamatios Theocharis.


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Fc-fusion Proteins in Therapy: An Updated View


Reza Jafari, Naime Majidi Zolbanin, Houshang Rafatpanah, Jafar Majidi and Tohid Kazemi.


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Lipoprotein (a) and Cardiovascular Risk: The Show Must go on


Niki Katsiki, Khalid Al-Rasadi and Dimitri P Mikhailidis.


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DNA-Damaging Anticancer Drugs – A Perspective for DNA Repair- Oriented Therapy


Janusz Blasiak.


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Kinase Inhibitors in Multitargeted Cancer Therapy


Carla Gentile, Annamaria Martorana, Antonino Lauria and Riccardo Bonsignore.


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Pathobiology and Therapeutic Implications of Tumor Acidosis


Jenny Viklund, Sofia Avnet and Angelo De Milito.


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Late-life depression and Alzheimer disease: a potential synergy of the underlying mechanisms


Jerzy Leszek, Elżbieta Trypka, Euphrosyni Koutsourak, Dimitrios Michmizos, V V Tarasov, Ghulam Md Ashraf and Gjumrakch Aliev.


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Update on Recent Developments in Small Molecular HIV-1 RNase H Inhibitors (2013-2016): Opportunities and Challenges


Xueshun Wang, Ping Gao, Luis Menéndez-Arias, Xinyong Liu and Peng Zhan.


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Tofacitinib, an Oral Janus Kinase Inhibitor: Perspectives in Dermatology


Kresimir Kostovic, Sandra Jerkovic Gulin, Zrinka Bukvic Mokos and Romana Ceovic.


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Lipoprotein(a) Management: Pharmacological and Apheretic Treatment


Ruth Hanssen and Ioanna Gouni-Berthold.


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Molecular Mechanism of Action and Selectivity of Sodium Channel Blocker Insecticides


Kristopher Silver, Ke Dong and Boris S Zhorov.


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PDE7-Selective and Dual Inhibitors: Advances in Chemical and Biological Research


Agnieszka Jankowska, Artur Świerczek, Grażyna Chłoń-Rzepa, Maciej Pawłowski and Elżbieta Wyska.


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Topoisomerases and Anthracyclines: Recent Advances and Perspectives in Anticancer Therapy and Prevention of Cardiotoxicity


Alvaro Mordente, Elisabetta Meucci, Giuseppe Ettore Martorana, Daniela Tavian and Andrea Silvestrini.


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Combination Platinum-based and DNA Damage Response-targeting Cancer Therapy: Evolution and Future Directions


Spyridon P. Basourakos, Likun Li, Ana M. Aparicio, Paul G. Corn, Jeri Kim and Timothy C Thompson.


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A Brief Review of Drug Discovery Research for Human African Trypanosomiasis


Danica R. Cullen and Mauro Mocerino.


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Drug Delivery Nanoparticles in Treating Chemoresistant Tumor Cells


Giuseppina Barrera, Martina Daga, Benedetta Ferrara, Chiara Dianzani, Stefania Pizzimenti, Monica Argenziano, Roberta Cavalli and Francesco Trotta.


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Balancing Antioxidant, Hypolipidemic and Anti-inflammatory Activity in a Single Agent: A Rational Therapeutic Approach against Atherosclerosis


Alexios N. Matralis, Eugenia-Ismini Bavavea, Sandra Incerpi, Jens Z. Pedersen and Angeliki P Kourounakis.


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Therapeutic Potential of Caffeic Acid Phenethyl Ester (CAPE) in Diabetes


Valeria Pittala, Loredana Salerno, Giuseppe Romeo, Rosaria Acquaviva, Claudia Di Giacomo and Valeria Sorrenti.


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MRP1-dependent Collateral Sensitivity of Multidrug-resistant Cancer Cells: Identifying Selective Modulators Inducing Cellular Glutathione Depletion


Doriane Lorendeau, Lauriane Dury, Rachad Nasr, Ahcène Boumendjel, Elisabetta Teodori, Michael Gütschow, Pierre Falson, Attilio Di Pietro and Hélène Baubichon-Cortay.


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Ketogenic Diet and Other Dietary Intervention Strategies in the Treatment of Cancer


Matteo Vergati, Eriseld Krasniqi, Girolamo Del Monte, Silvia Riondino, Doriana Vallone, Fiorella Guadagni, Patrizia Ferroni and Mario Roselli.


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Recent Insights into the Development of Preclinical Trastuzumab- Resistant HER2+ Breast Cancer Models


Paula González-Alonso, Ion Cristóbal, Sandra Zazo, Ester Martín-Aparicio, Cristina Chamizo, Juan Madoz-Gúrpide, Ana Rovira, Pilar Eroles, Ana Lluch, Joan Albanell and Federico Rojo.


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Current Strategies in the Modification of PLGA–based Gene Delivery System


Mohammad Ramezani, Mahboubeh Ebrahimian and Maryam Hashemi.


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Trypanothione Reductase and Superoxide Dismutase as Current Drug Targets for Trypanosoma cruzi: An Overview of Compounds with Activity against Chagas Disease


Iván Beltrán-Hortelano, Silvia Pérez-Silanes and Silvia Galiano.


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Vitamin D/VDR, Probiotics, and Gastrointestinal Diseases


Mei Shang and Jun Sun.


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Sex Differences in Alcohol Use Disorder


Roberta Agabio, Claudia Pisanu, Gian Luigi Gessa and Flavia Franconi.


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Vitamin D and the Epigenetic Machinery in Colon Cancer


Meiyan Sun and Bin Guo.


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Eryptosis: Ally or Enemy


Marilena Briglia, Maria Antonia Rossi and Caterina Faggio.


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Novel Antibacterial Compounds and their Drug Targets - Successes and Challenges


Agnieszka A. Kaczor, Andrzej Polski, Karolina Sobótka-Polska, Anna Pachuta-Stec, Magdalena Makarska-Bialokoz and Monika Pitucha.


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Control of Inflammatory Bowel Disease and Colorectal Cancer by Synthetic Vitamin D Receptor Ligands


Ichiro Takada and Makoto Makishima.


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New Insights into Vitamin D and Autophagy in Inflammatory Bowel Diseases


Hyun-Woo Suh, Jin Kyung Kim, Tae Sung Kim and Eun-Kyeong Jo.


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Comparison of Clinical Outcomes Between Genders Following Antihypertensive Therapy: A Meta-Analysis


Paolo Giorgini, Amirhossein Sahebkar, Valeria Raparelli, Cosimo Andrea Stamerra, Marco Petrarca, Davide Grassi, Claudio Ferri and Paolo Di Giosia.


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Possible Molecular Mechanisms by Which Vitamin D Prevents Inflammatory Bowel Disease and Colitis-Associated Colorectal Cancer


Zijian Luan, Yiming Ma, Yu Xin, Jiaming Qian and Hongying Wang.


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Structure-activity Relationship Studies of New Marine Anticancer Agents and their Synthetic Analogues


Sergey N. Fedorov, Valentin A. Stonik, Friedemann Honecker and Sergey Dyshlovoy.


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Treatment and Response to Statins: Gender-related Differences


Valeria Raparelli, Gaetano Pannitteri, Tommaso Todisco, Filippo Toriello, Laura Napoleone, Roberto Manfredini and Stefania Basili.


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Scutellarin Attenuates Microglia-Mediated Neuroinflammation and Promotes Astrogliosis in Cerebral Ischemia - A Therapeutic Consideration


Chun-Yun Wu, Ming Fang, Aparna Karthikeyan, Yun Yuan and Eng-Ang Ling.


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Human Serum Albumin as Chiral Selector in Enantioselective High- Performance Liquid Chromatography


Carlo Bertucci and Daniele Tedesco.


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Oxidative Stress & FoxO Transcription Factors in Cardiovascular Aging


Juewon Kim, Si Young Cho, Donghyun Cho, Su Hwan Kim, Dae Bang Seo and Song Seok Shin.


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Alzheimer's Disease: A Review from the Pathophysiology to Diagnosis, New Perspectives for Pharmacological Treatment


Leide Caroline dos Santos Picanço, Priscilla Farias Ozela, Maiara de Fátima de Brito Brito, Abraão Alves Pinheiro, Elias Carvalho Padilha, Francinaldo Sarges Braga, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos, Joaquín María Campos Rosa and Lorane Izabel da Silva Hage-Melim.


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Visual Sexual Stimulation and Erection, a Brief Review with New fMRI Data


Sharon L Wu, Maggie SM Chow, YL Jiang, Jingjin Yang, Hao Zhou and David T Yew.


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Human Host Defense Peptides – Role in Maintaining Human Homeostasis and Pathological Processes


Malgorzata Anna Dawgul, Katarzyna Ewa Greber, Wieslaw Sawicki and Wojciech Kamysz.


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Enantiomeric Resolution of (RS)-Naproxen and Application of (S)- Naproxen in the Direct and Indirect Enantioseparation of Racemic Compounds by Liquid Chromatography: A Review


Sonika Batra and Ravi Bhushan.


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Topoisomerase II Inhibitors and Poisons, and the Influence of Cell Cycle Checkpoints


Nicholas D`Arcy and Brian Gabrielli.


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Microwave Assisted Synthesis of Biorelevant Benzazoles


Kapileswar Seth, Priyank Purohit and Asit K Chakraborti.


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A Focused Review of Gender Differences in Antithrombotic Therapy


Andrea Salzano, Pablo Demelo-Rodriguez, Alberto Maria Marra and Marco Proietti.


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Snake Venom Peptides and Low Mass Proteins: Molecular Tools and Therapeutic Agents


J.R. Almeida L.M. Resende, R. K. Watanabe, V.C. Corassola, S. Huancahuire-Vega, C. A. da S. Caldeira, A. Coutinho-Neto, A. M. Soares, N. Vale, P. A. de C. Gomes, S. Marangoni, L. de A. Calderon and S L Da Silva.


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Polymeric Biomaterial and Lipid Based Nanoparticles for Oral Drug Delivery


Fahima Dilnawaz.


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Leveraging Structural Diversity and Allosteric Regulatory Mechanisms of Protein Kinases in the Discovery of Small Molecule Inhibitors


Gennady M Verkhivker.


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Interplay of Immunity and Vitamin D: Interactions and Implications with Current IBD Therapy


Joe Abdo, Vikrant Rai and Devendra Agrawal.


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Plant Pathogenesis-Related Proteins PR-10 and PR-14 as Components of Innate Immunity System and Ubiquitous Allergens


Ekaterina I. Finkina, Daria N. Melnikova, Ivan V. Bogdanov and Tatiana V Ovchinnikova.


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Nanoparticle Based Delivery of Protease Inhibitors to Cancer Cells


Mateja Prunk and Janko Kos.


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Sex Impact on Biomarkers, Pharmacokinetics and Pharmacodynamics


Flavia Franconi and Ilaria Campesi.


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Gender Differences in Cancer-Associated Venous Thromboembolism


Silvia Riondino, Fiorella Guadagni, Vincenzo Formica, Patrizia Ferroni and Mario Roselli.


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Efficacy, Safety and Immunogenicity of Biosimilars in Inflammatory Bowel Diseases: A Systematic Review


Laura Martelli and Laurent Peyrin-Biroulet.


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Cyclic Oligosaccharide Based Chiral Stationary Phases Applicable to Drug Purity Control: A Review


Květa Kalíková, Tereza Šlechtová and Eva Tesařová.


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Ellagitannins, gallotannins and their metabolites- the contribution to the anti-inflammatory effect of food products and medicinal plants


Anna K. Kiss and Jakub Piwowarski.


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Phytochemical and pharmacological activity profile of Crataegus oxyacantha L. (hawthorn) - A cardiotonic herb


Ilkay Erdogan Orhan.


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Quercetin is a useful medicinal compound showing various actions including control of blood pressure, neurite elongation and epithelial ion transport


Yoshinori Marunaka, Naomi Niisato, Hiroaki Miyazaki, Ken-­Ichi Nakajima, Akiyuki Taruno, Hongxin Sun, Rie Marunaka, Motoki Okui, Toshiro Yamamoto, Narisato Kanamura, Haruka Kogiso, Yukiko Ikeuchi, Makiko Kashio, Shigekuni Hosogi and Takashi Nakahari.


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Cocoa polyphenols: Chemistry, bioavailability and effects on cardiovascular performance


Chiara Fanali, Laura Dugo, Giusy Tripodo and Luca Santi.


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Laboratory-Scale Preparative Enantioseparations of Pharmaceutically Relevant Compounds on Commercially Available Chiral Stationary Phases for HPLC


Roccaldo Sardella, Benedetto Natalini, Federica Ianni, Maura Marinozzi and Antonio Macchiarulo.


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Beyond Photodynamic Therapy: Light-Activated Cancer Chemotherapy


Wiktor Szymanski and Friederike Reeßing.


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Expediting the Design, Discovery, and Development of Anticancer Drugs using Computational Approaches


Sun Choi, Stephani Joy Y. Macalino, Minghua Cui and Shaherin Basith.


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The metabolite Trimethylamine‐N‐oxide is an emergent biomarker of human health


Jyoti Chhibber-Goel, Varsha Singhal, Neeraj Parakh, Balram Bhargava and Amit Sharma.


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Oncogene Expression Modulation in Cancer Cell Lines by DNA G-Quadruplex-Interactive Small Molecules


Alexandra Paulo and Ana Paula Francisco.


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New Therapeutic Property of Dimebon as a Neuroprotective Agent


Aleksey Ustyugov, Elena Shevtsova, George E. Barreto, Ghulam Md. Ashraf, Sergey O. Bachurin and Gjumrakch Aliev.


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Chiral Ligand-Exchange Chromatography of Pharmaceutical Compounds on Dinamically Coated (Home-Made) Stationary Phases


Maurizio Remelli.


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Updates on Managing Type 2 Diabetes Mellitus with Natural Products: Towards Antidiabetic Drug Development


Fahmida Alam, Md Asiful Islam, M A Kamal and Siew Hua Gan.


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Microwave-assisted Formation of Organic Disulfides of Biochemical Significance


Debasish Sengupta, Babli Roy and Basudeb Basu.


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Natural AMPK Activators: An Alternative Approach for the Treatment and Management of Metabolic Syndrome


Hitender Sharma and Sunil Kumar.


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Editorial: Mechanisms and Therapeutic Strategies for Major Neurological Disorders: Current Advances and Future Perspectives


Weihai Ying.





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