Irradiation Toxicity and Inflammatory Bowel Diseases (IBD): Review

ISSN: 1876-1038 (Online)
ISSN: 1574-8871 (Print)

Volume 10, 4 Issues, 2015

Download PDF Flyer

Reviews on Recent Clinical Trials

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Alberto Zaniboni
Oncologia Medica, Fondazione Poliambulanza

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Irradiation Toxicity and Inflammatory Bowel Diseases (IBD): Review

Reviews on Recent Clinical Trials, 9(1): 31-36.

Author(s): Tolia Maria, Zygogianni Anna, Kouvaris John R., Tsoukalas Nikolaos, Kokakis Ioannis, Kyrgias George, Mystakidou Kyriaki and Kouloulias Vasileios.

Affiliation: 76 Vassilissis Sofias Avenue, 115 28, Athens, Greece.


Background/Aim: The evaluation of radiotherapy toxicity in oncologic IBD patients. Defining the optimal patient and treatment factors that would be able to reduce the risk to organs.

Materials and Methods: A review of all published radiotherapy trials was performed to identify the clinical and treatment factors of inflammatory bowel disease’s patients treated for different solid tumors.

Results: Overall, acute (Grade ≥ 3) gastrointestinal complications attributable to RT ranged between 20-21% of the treated patients. A late Grade ≥ 3 gastrointestinal toxicity was developed in a range between 8-29%.

Conclusion: A special attention should be given to the description of IBD location, activity status, concurrent chemotherapy, irradiation dose and technique, in order to minimize post-irradiation morbidity. It is not easy to distinguish late morbidity attributable to radiotherapy due to the IBD itself.


Inflammatory bowel diseases, radiotherapy, toxicity.

Download Free Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 9
Issue Number: 1
First Page: 31
Last Page: 36
Page Count: 6
DOI: 10.2174/1574887109666140423123845

Related Journals

Webmaster Contact: Copyright © 2015 Bentham Science