The Emerging Role of NRAS Mutations in Colorectal Cancer Patients Selected for Anti-EGFR Therapies

ISSN: 1876-1038 (Online)
ISSN: 1574-8871 (Print)

Volume 12, 4 Issues, 2017

Download PDF Flyer

Reviews on Recent Clinical Trials

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Ludovico Abenavoli
University Magna Graecia

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

The Emerging Role of NRAS Mutations in Colorectal Cancer Patients Selected for Anti-EGFR Therapies

Reviews on Recent Clinical Trials, 9(1): 8-12.

Author(s): Fausto Meriggi, William Vermi, Paola Bertocchi and Alberto Zaniboni.

Affiliation: Medical Oncology Department, Fondazione Poliambulanza via Bissolati 57, 25124 Brescia, Italy.


Colorectal cancer (CRC) is one of the most common cancers worldwide. Despite the improvement in overall survival (OS) due to new treatments and targeted therapies alone or in combination with chemotherapy up-to–date, little is known about cellular mechanisms, both of primary and acquired resistance of CRC to anti-Epidermal Growth Factor Receptor (EGFR) antibodies. EGFR is characterized by tyrosine kinase activity and occupies a key-role in the control of cellular transduction pathways. Its activation triggers both the RAS-RAF and PIK3CA pathways and is required to promote cell growth, differentiation, proliferation, and invasion. Cetuximab and panitumumab are both monoclonal antibodies (MoAbs) directed against the extracellular domain of EGFR, thus leading to inhibition of the downstream signaling pathways. Mutations in oncogene Kirsten-RAS (KRAS) are frequently associated with resistance to anti-EGFR therapy. However, a significant number of KRAS wild-type (WT) tumors fail to obtain disease control with anti-EGFR agents. Therefore, additional biomarkers of response/resistance to these drugs such as BRAF, NRAS, PIK3CA and PTEN have been investigated. This review will point attention on Neuroblastoma-RAS (NRAS) status in metastatic CRC (mCRC) patients (pts) selected for anti-EGFR therapy.


Colorectal cancer, epidermal growth factor receptor, mutations, KRAS, NRAS, anti-EGFR, monoclonal antibodies, cetuximab, panitumumab.

Download Free Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 9
Issue Number: 1
First Page: 8
Last Page: 12
Page Count: 5
DOI: 10.2174/1568026614666140423121525

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science