Smart Delivery and Controlled Drug Release with Gold Nanoparticles: New Frontiers in Nanomedicine

ISSN: 1877-9131 (Online)
ISSN: 1877-9123 (Print)


Volume 4, 2 Issues, 2014


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Editor-in-Chief:
Victor Manuel Castano Meneses
Center of Applied Physics and Advanced Technology
National Autonomous University of Mexico
Juriquilla Campus
Queretaro
México


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Smart Delivery and Controlled Drug Release with Gold Nanoparticles: New Frontiers in Nanomedicine

Author(s): Valerio Voliani, Giovanni Signore, Riccardo Nifosi, Fernanda Ricci, Stefano Luin and Fabio Beltram

Affiliation: Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, I-56127 Pisa, Italy.

Abstract

Discoveries in the field of nanotechnology are triggering a revolution in medicine, by providing a profusion of potential and actual applications of nanosized objects in the diagnosis and treatment of several diseases. This trend is also evident in the increasing number of patents recorded annually. In particular, nanoparticles able to find a target and release their payload upon a specific stimulus are highly attractive for the diagnostics and therapeutics, for example, of cancer and gene diseases. In this view, gold nanoparticles (AuNPs) stood out as suitable platforms for the development of efficient delivery and release systems. AuNPs are biocompatible, and can be easily synthesized and functionalized. The capability of tuning their size and geometry allows manipulating their optical and physical properties. Engineering their coating controls the stability, targeting and release features. In this review several patents concerning release strategies based on gold nanostructures are reported, together with a discussion about their operating processes and their mutual advantages and disadvantages.

Keywords: Biocompatibility, controlled release, drug delivery, gold nanoparticles, nanomedicine, photochemistry

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Article Details

Volume: 2
Issue Number: 1
First Page: 34
Last Page: 44
Page Count: 11
DOI: 10.2174/1877912311202010034
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