Polymeric Nanoparticles to Combat Squamous Cell Carcinomas in Patients with Dystrophic Epidermolysis Bullosa

ISSN: 1877-9131 (Online)
ISSN: 1877-9123 (Print)


Volume 4, 2 Issues, 2014


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Editor-in-Chief:
Victor Manuel Castano Meneses
Center of Applied Physics and Advanced Technology
National Autonomous University of Mexico
Juriquilla Campus
Queretaro
México


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Polymeric Nanoparticles to Combat Squamous Cell Carcinomas in Patients with Dystrophic Epidermolysis Bullosa

Author(s): Martin A.C. Manoukian, Susanne V. Ott, Jayakumar Rajadas and Mohammed Inayathullah

Affiliation: Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, 1050 Arastradero Road, Bldg A, Rm 162, Palo Alto, CA 94304, USA.

Abstract

Skin cancer is the leading cause of malignancy in the United States, with Basal Cell Carcinoma, Squamous Cell Carcinoma, and Melanoma being the three most common diagnoses, respectively. Squamous Cell Carcinoma (SCC) is a particular concern for patients suffering from Dystrophic Epidermolysis Bullosa (DEB), a disease that affects the production and function of collagen VII, a protein that forms the anchoring fibrils which bind the epidermis to the dermis. Patients with DEB suffer from chronic blistering and wounds that have impaired healing capabilities, often leading to the development of SCC and eventual mortality. Nanomedicine is playing an increasing role in the delivery of effective therapeutics to combat a wide range of diseases, including the imaging and treatment of SCC. In this review, we discuss the role of nanoparticles in the treatment of SCC with an emphasis on PLGA nanoparticles and SCCs found in patients suffering from DEB, and address recent patents that are pertinent to the development of novel nanomedical therapeutics.

Keywords: Bullosa, carcinoma, dystrophic, EGFR, epidermolysis squamous, nanomedicine, nanoparticles, p53, PLGA.

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Article Details

Volume: 4
Issue Number: 1
First Page: 15
Last Page: 24
Page Count: 10
DOI: 10.2174/1877912304666140708184013
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