Cognitive Function and Quality of Life in Mild Thyroid Hormone Deficiency

ISSN: 2212-3334 (Online)
ISSN: 1872-2148 (Print)

Volume 11, 2 Issues, 2017

Download PDF Flyer

Recent Patents on Endocrine, Metabolic & Immune Drug Discovery

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Cognitive Function and Quality of Life in Mild Thyroid Hormone Deficiency

Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, 8(2): 124-134.

Author(s): Sara Tognini, Giuseppe Pasqualetti, Valeria Calsolaro, Antonio Polini and Fabio Monzani.

Affiliation: Geriatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Via Paradisa, 56100- Pisa , Italy.


Subclinical hypothyroidism (sHT) is very common in general population, especially in women and older people. sHT individuals may experience symptoms that resemble those observed in overt hypothyroidism, resulting in impaired quality of life (QOL). Asymptomatic patients may suffer a reduction in perceived health status due to the awareness of disease. Cognitive function represents one of the most important domains of the QOL questionnaires. Given the intrinsic relationship between cognitive status and QOL it is worth to address these topics together, in a systematic review of the literature. Thus, we reviewed the English scientific literature available on National Library of Medicine ( sine 1980 regarding hypothyroidism, sHT, elderly, L-thyroxine (LT4) therapy, QOL, cognition, brain. We supplemented the search with records from personal files, textbooks, and relevant articles. The possible link, at molecular level, between cognition and thyroid failure was also assessed. Conflicting results on the association between sHT and cognitive and health related QOL impairment are still present, although the most recent, naturalistic studies did not find any significant relationship. Interestingly, a reduction in health related QOL is frequently reported in patients with thyroid autoimmune diseases regardless of thyroid dysfunction. We also report most significant patents on the topic.


Cognition, elderly, hypothyroidism, quality of life, subclinical hypothyroidism, thyroiditis.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 8
Issue Number: 2
First Page: 124
Last Page: 134
Page Count: 11
DOI: 10.2174/1872214808666140723111533
Price: $100

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science