Euthyroid Depression: The Role of Thyroid Hormone

ISSN: 2212-3334 (Online)
ISSN: 1872-2148 (Print)

Volume 11, 2 Issues, 2017

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Recent Patents on Endocrine Metabolic & Immune Drug Discovery

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Euthyroid Depression: The Role of Thyroid Hormone

Recent Patents on Endocrine Metabolic & Immune Drug Discovery, 8(1): 38-41.

Author(s): Sanjay Kalra and Yatan Pal Singh Balhara.

Affiliation: National Drug Dependence Treatment Centre (NDDTC), WHO Collaborating Centre on Substance Abuse, Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India.


Thyroid dysfunction and psychiatric disorders share a bidirectional relation. Thyroid hormones have been found to affect the central nervous system both structurally and functionally. Conventional antidepressant drug therapy is characterized by a delayed and at times suboptimal response. Various strategies have been devised in order to circumvent this limitation. L- Thyroxine has been used as both acceleration therapy and augmentation therapy as adjuvant therapy with antidepressants. The hormone has also been used as monotherapy, both in prevention and management of depression. The potential use of thyroid hormone as an adjunct therapy in management of euthyroid depression and relevant patents has been discussed.


Antidepressant, depression, endocrinology, psychiatry, thyroid, thyroxine.

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Article Details

Volume: 8
Issue Number: 1
First Page: 38
Last Page: 41
Page Count: 4
DOI: 10.2174/1872214807666131229130540

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