Oral Solid Self-Emulsifying Formulations: A Patent Review

ISSN: 2212-4039 (Online)
ISSN: 1872-2113 (Print)


Volume 8, 3 Issues, 2014


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Editor-in-Chief:
Mark A. Babizhayev
Innovative Vision Products, Inc
County of New Castle, Delaware
USA


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Oral Solid Self-Emulsifying Formulations: A Patent Review

Author(s): Bapurao Tarate, Rahul Chavan and Arvind K. Bansal

Affiliation: Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar (Mohali), Punjab-160 062, India.

Abstract

Self-emulsifying compositions are lipidic drug delivery systems that provide a number of delivery advantages. A variety of excipients are available for designing of these drug delivery systems. These systems can be classified as Type I, II, III, and IV, and alternatively as solid, semi-solid, and liquid. Till date many patents have been published on selfemulsifying compositions, and a few commercial products have also been launched. The purpose of this review is to have insights into the patent literature capturing the developments in the area of oral solid self-emulsifying formulations. Though the main emphasis is on developments in solid self-emulsifying formulations, an overview of different manufacturing techniques has also been provided. These formulations can be grouped as conventional, granules, pellets, tablets, supersaturable, controlled release, eutectic-based, and positively charged. The components of self-emulsifying formulations described in this review are not limited only to oils, surfactants, and cosurfactants but also include binders, polymers, diluents, alkalinizing agents, stabilizing agents, preservatives, and viscosity adjusting agents. The inventions highlighted in this article provide useful guidelines for enhancement of oral bioavailability of drugs through this drug delivery platform.

Keywords: Absorption, bioavailability, lipid based drug delivery, oils, solidification techniques, solid self-emulsifying formulations, solubility, stability, surfactants.

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Article Details

Volume: 8
Issue Number: 2
First Page: 126
Last Page: 143
Page Count: 18
DOI: 10.2174/1872211308666140313145836
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