Antisense Oligonucleotides in the Treatment of Cerebral Gliomas. Review of Concerning Patents

ISSN: 2212-3954 (Online)
ISSN: 1574-8898 (Print)

Volume 10, 2 Issues, 2015

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Vincenzo Di Marzo
Istituto di Chimica Biomolecolare (I.C.B.)
Consiglio Nazionale delle Ricerche (C.N.R.)
Via Campi Flegrei 34
Pozzuoli, Napoli 80078

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Antisense Oligonucleotides in the Treatment of Cerebral Gliomas. Review of Concerning Patents

Author(s): Gerardo Caruso and Maria Caffo

Affiliation: Neurosurgical Clinic, Department of Neuroscience, A.O.U. Policlinico “G. Martino”, via Consolare Valeria, 1, 98125 Messina, Italy.


Gliomas are the most common and malignant primary brain tumors in the adult population. Despite the intensive research on cancer pathology, real mechanisms concerning glioma progression are not completely understood. The prognosis in patients affected by malignant gliomas is still very unfavorable. Recent genomic analyses have revealed patterns of molecular changes within tumor subclasses that harbor distinct underlying biology, clinical prognosis, and pathogenic routes. So, novel treatments will have to be able to interfere at different molecular levels in gliomagenesis minimizing the toxicity. In particular, antisense oligonucleotides are able to inhibit expression of specific genes by interfering with transcription or, more usually, with translation.

In this review, we will focus on mechanisms of antisense oligonucleotides reporting clinical and experimental studies. We will also report a large number of patents which adopt the antisense oligonucleotides as potential therapeutic approach in gliomas treatment.

Keywords: Angiogenesis, antisense oligonucleotides, apoptosis, gliomas.

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Article Details

Volume: 9
Issue Number: 1
First Page: 2
Last Page: 12
Page Count: 11
DOI: 10.2174/1574889809666140307113439

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