Patents and Heart Valve Surgery - II: Tissue Valves
Faisal H. Cheema, Alexander P. Kossar, Atiq Rehman, Fahad Younas and Gianluca PolvaniAffiliation:
Director, Clinical Research and Innovations, Assistant Professor of Surgery, Division of Cardiac Surgery, Department of Surgery, University of Maryland School of Medicine, 110 S Paca Street, 7th
Floor, Baltimore, MD, 21201, USA & Laboratorio di Ingegneria Tissutale Cardiovascolare, Centro Cardiologico Monzino - IRCCS, via PAREA 4, 20138, Milan, Italy.
AbstractValvular heart disease affects millions of Americans yearly and currently requires surgical intervention to repair or replace the defective valves. Through a close-knit collaboration between physicians, scientists and biomedical engineers, a vast degree of research and development has been aimed towards the optimization of prosthetic heart valves. Although various methods have made fantastic strides in producing durable prostheses, the therapeutic efficacy of prosthetic valves is inherently limited by a dependency upon lifelong anticoagulant regimens for recipients - a difficult challenge for many in clinical setting. Thus, biological tissue valves have been developed to circumvent vascular and immunemediated complications by incorporating biological materials to mimic native valves while still maintaining a necessary level of structural integrity. Over the past decade, a multitude of patents pertaining to the refinement of designs as well as the advancement in methodologies and technologies associated with biological tissue valves have been issued. This review seeks to chronicle and characterize such patents in an effort to track the past, present, and future progress as well as project the trajectory of tissue valves in the years to come.
Valvular heart disease, tissue heart valve, bioprosthetic valves, patents, cardiac surgery.
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