Cytokines Polymorphism and mRNA Expression as Biomarkers in HCV Treatment Response

ISSN: 2210-3104 (Online)
ISSN: 2210-3090 (Print)

Volume 6, 2 Issues, 2016

Download PDF Flyer

Recent Patents on Biomarkers

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Cytokines Polymorphism and mRNA Expression as Biomarkers in HCV Treatment Response

Recent Patents on Biomarkers, 4(1): 11-20.

Author(s): Fadia M. Attia, Maha M. Enany, Mai H. Saleh, Heba-t-Allah H. Nashaat and Nahaat M Soliman.

Affiliation: Faculty of Medicine, Clinical Pathology Department, Suez Canal University Hospital, El-Daerie Street, Ismailia, Egypt.


Background: Hepatitis C virus is a serious global health problem affecting more than 170 million patients who are at risk of developing liver cirrhosis and/or hepatocellular carcinoma. Egypt has the highest prevalence of HCV (genotype 4) as about 14.7% of Egyptian populations are positive for HCV antibodies. Aim: To review recent data and patents concerning cytokine polymorphism that affect the likelihood of achieving SVR and can be used as biomarkers for predicting the treatment response to overcome the unnecessary cost, time, and side effects of antiviral therapy for nonresponders. Methods: Data were pooled from 36 studies carried out internationally in which patients with chronic HCV receiving PEG IFN/RBV therapy were evaluated regarding cytokine polymorphism and/or its mRNA expression profile in relation to therapy response. Results and Conclusions: Studies to date have shown that cytokine gene polymorphism plays an important role in the natural clearance of HCV. Most of polymorphisms are in cytokine gene regulatory regions and are consequently involved directly in controlling the transcription rates. Type 1-like cytokines, such as IL-1β, IL-2, IL-6, IL-18, TNF-α, and IFN-γ were up-regulated in chronic HCV infection. The poor response was found to be associated with high producing genotype of IL-10, up-regulation of IL-28B and most of IGS genes, and associated with downregulation of TGF- β, IFN-γ. Good response was noticed to be associated with high level IL-6, IL-8, and certain genotypes of IL-6, IL-12, IFN-γ, TNF-α IFN λ4 and IFN λ3.


Antiviral therapy, cytokines, HCV, interleukins, ISG, polymorphism.

Download Free Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 4
Issue Number: 1
First Page: 11
Last Page: 20
Page Count: 10
DOI: 10.2174/2210309004666140113200407
Global Biotechnology Congress 2016Drug Discovery and Therapy World Congress 2016

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science