Biomarkers and Osteosarcoma and IGF

ISSN: 2210-3104 (Online)
ISSN: 2210-3090 (Print)


Volume 4, 3 Issues, 2014


Download PDF Flyer




Recent Patents on Biomarkers

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Biomarkers and Osteosarcoma and IGF

Author(s): Simmi Kharb

Affiliation: Department of Biochemistry, Pt. B.D.S.PGIMS, Rohtak, Haryana, India; #1396,Sector-1, Rohtak.

Abstract

Bone and soft-tissue sarcomas tend to present in young adults. A wide variety of serological markers have been associated with osteosarcoma. Tumor markers involved in angiogenesis, cell adhesion, apoptosis, and the cell cycle have been shown to play an important role in osteosarcoma growth, differentiation, and metastasis. However, there are no universal and specific serum tumor markers for early diagnosis of osteosarcoma and primary screening in risk groups. There is strong empirical evidence that the IGF signal transduction pathway may be important in osteosarcoma. Several patents of IGF and molecular biomarkers/panels in osteosarcoma have been reported. The tissue/serum biomarker panels using high-throughput technology molecular signatures will have a role in early detection of the disease and noninvasive testing.

Keywords: Biomarkers, IGF-1, osteosarcoma, patents, tumor markers.

Purchase Online Rights and Permissions

  
  



Article Details

Volume: 3
Issue Number: 3
First Page: 188
Last Page: 195
Page Count: 8
DOI: 10.2174/22103090113036660012
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science