From Nature to Market: Examples of Natural Products that Became Drugs

ISSN: 2212-4012 (Online)
ISSN: 1872-2083 (Print)


Volume 10, 3 Issues, 2016


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Recent Patents on Biotechnology

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Editor-in-Chief:
Nikolaos Labrou
Laboratory of Enzyme Technology, Department of Biotechnology
Agricultural University of Athens Iera Odos 75, Gr-118 55
Athens
Greece


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From Nature to Market: Examples of Natural Products that Became Drugs



Recent Patents on Biotechnology, 8(1): 76-88.

Author(s): Angelo de Fatima, Bruna Silva Terra, Cleiton Moreira da Silva, Daniel Leite da Silva, Debora Pereira Araujo, Leonardo da Silva Neto and Roney Anderson Nascimento de Aquino.

Affiliation: Grupo de Estudos em Química Organica e Biologica (GEQOB), Departamento de Quimica, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.

Abstract

Nature is an irrefutable source of inspiration for the modern man in many aspects. The observation and understanding of nature have allowed the development of new materials, new sources of energies, new drugs etc. Specifically, natural products provide a great contribution to the development of new agents for the treatment of infections and antitumor agents. However, obtaining natural products directly from animals, fungi, bacteria, plants etc has been considered not enough to attend the high demand by pharmaceutical industries. In this regard, various strategies based on biotechnological processes or synthetic approaches have been developed. In this scenario the total synthesis can be undoubtedly a useful and powerful tool for obtaining higher amounts of natural products and/or structural modifications thereof. Herein, we emphasize successful examples of total synthesis of galanthamine, morphine, paclitaxel and podophyllotoxin - natural products approved as pharmaceuticals.

Keywords:

Drugs, galanthamine, morphine, natural products, paclitaxel, podophyllotoxin.



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Article Details

Volume: 8
Issue Number: 1
First Page: 76
Last Page: 88
Page Count: 13
DOI: 10.2174/1872208307666131220163108
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