Mini-Review: Recent Developments in Hydroxynitrile Lyases for Industrial Biotechnology

ISSN: 2212-4012 (Online)
ISSN: 1872-2083 (Print)


Volume 10, 3 Issues, 2016


Download PDF Flyer




Recent Patents on Biotechnology

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Nikolaos Labrou
Laboratory of Enzyme Technology, Department of Biotechnology
Agricultural University of Athens Iera Odos 75, Gr-118 55
Athens
Greece


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Mini-Review: Recent Developments in Hydroxynitrile Lyases for Industrial Biotechnology



Recent Patents on Biotechnology, 7(3): 197-206.

Author(s): Elisa Lanfranchi, Kerstin Steiner, Anton Glieder, Ivan Hajnal, Roger A. Sheldon, Sander van Pelt and Margit Winkler.

Affiliation: ACIB GmbH (Austrian Centre of Industrial Biotechnology GmbH), Petersgasse 14/III, A-8010 Graz, Austria.

Abstract

Hydroxynitrile lyases (HNLs) catalyze the cleavage as well as the formation of cyanohydrins. The latter reaction is valuable for the stereoselective C-C bond formation by condensation of HCN with carbonyl compounds. The resulting cyanohydrins serve as versatile building blocks for a broad range of chemical and enzymatic follow-up reactions. A significant number of (R)- and (S)-selective HNLs are known today and the number is still increasing. HNLs not only exhibit varying substrate scope but also differ in sequence and structure. Tailor-made enzymes for large-scale manufacturing of cyanohydrins with improved yield and enantiomeric excess are very interesting targets, which is reflected in a solid number of patents. This review will complement and extend our recent review with a strong focus on applications of HNLs for the synthesis of highly functionalized, chiral compounds with newest literature, recent and current patent literature.

Keywords:

Asymmetric synthesis, biocatalysis, biotransformation, cascade reactions, C-C coupling, chiral building blocks, cyanogenesis, cyanohydrin, enantioselectivity, enzyme engineering, HNL, hydrocyanic acid, hydroxynitrile lyase, industrial process, mandelonitrile lyase, plant enzymes, oxynitrilase, stereoselective.



Purchase Online Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 7
Issue Number: 3
First Page: 197
Last Page: 206
Page Count: 10
DOI: 10.2174/18722083113076660010
Advertisement
Global Biotechnology Congress 2016Drug Discovery and Therapy World Congress 2016

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science