NMR Structure/Function Relationships of Peptides Corresponding to the C1B1 Region of PKCγ
Jason Lauer, Debarshi Banerjee, Denton Shanks, Huaien Dai, Yu-Xi Gong, Om Prakash and Dolores TakemotoAffiliation:
Department of Biochemistry, Chalmers Hall, Kansas State University, Manhattan, KS, 66506, USA.
Abstract The region (101-112) of C1B domain in PKCγ plays a crucial role in the activation of the enzyme and subsequent gap junction inhibition. Substitution studies on peptides correlating to the C1B region show that a flexible structure and ability to be phosphorylated on serine 109 are critical for this purpose.
Protein kinase C gamma, C1B domain, NMR, Structure function relationship, Serine 109
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