NMR Structure/Function Relationships of Peptides Corresponding to the C1B1 Region of PKCγ

ISSN: 1875-5305 (Online)
ISSN: 0929-8665 (Print)


Volume 21, 12 Issues, 2014


Download PDF Flyer




Protein & Peptide Letters

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Prof. Ben M. Dunn
Department of Biochemistry and Molecular Biology
University of Florida
College of Medicine
P.O. Box 100245
Gainesville, FL
USA
Email: bdunn@ufl.edu

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 1.735
5 - Year: 1.493

NMR Structure/Function Relationships of Peptides Corresponding to the C1B1 Region of PKCγ

Author(s): Jason Lauer, Debarshi Banerjee, Denton Shanks, Huaien Dai, Yu-Xi Gong, Om Prakash and Dolores Takemoto

Affiliation: Department of Biochemistry, Chalmers Hall, Kansas State University, Manhattan, KS, 66506, USA.

Abstract

The region (101-112) of C1B domain in PKCγ plays a crucial role in the activation of the enzyme and subsequent gap junction inhibition. Substitution studies on peptides correlating to the C1B region show that a flexible structure and ability to be phosphorylated on serine 109 are critical for this purpose.

Keywords: Protein kinase C gamma, C1B domain, NMR, Structure function relationship, Serine 109

Download Free Rights and Permissions

  
  



Article Details

Volume: 17
Issue Number: 1
First Page: 1
Last Page: 10
Page Count: 10
DOI: 10.2174/092986610789909485
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science