Ubiquitin Carboxyl Hydrolase L1 Significance for Human Diseases

ISSN: 1875-5305 (Online)
ISSN: 0929-8665 (Print)


Volume 21, 12 Issues, 2014


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Protein & Peptide Letters

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Ubiquitin Carboxyl Hydrolase L1 Significance for Human Diseases

Author(s): Dang Ngoc Anh Suong, Dang Thi Phuong Thao, Yamaguchi Masamitsu and Tran Linh Thuoc

Affiliation: Department of Molecular and Environmental Biotechnology, University of Science, Vietnam National University in Ho Chi Minh City, Vietnam; Department of Applied Biology, Insect Biomedical Research Center, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.

Abstract

Ubiquitin carboxyl hydrolase L1 (UCH-L1) is an abundant multifunctional neuron protein. It plays an important role in maintaining the ubiquitin proteasome system (UPS), vital for recognizing and degrading dysfunctional proteins in organisms. In recent decades, UCH-L1 has been implicated in the pathogenesis of many diseases, including neurodegenerative disorders, cancer and diabetes. However, the mechanisms of UCH-L1 involvement have yet to be revealed in detail. Since UCH-L1 contributes many different functions to cell metabolism, its role and regulation might be more complex than previously thought and it has become a research target in many laboratories. In this review, we summarize recent findings related to the actions of UCH-L1 in several human diseases.

Keywords: Cancer, diabetes type-2, Parkinson’s disease, ubiquitination, UCH-L1, Ubiquitin proteasome system.

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Article Details

Volume: 21
Issue Number: 7
First Page: 624
Last Page: 630
Page Count: 7
DOI: 10.2174/0929866521666140403125959
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