Microwave-Assisted Synthesis of Benzo-fused Seven-membered Azaheterocycles

ISSN: 1875-6298 (Online)
ISSN: 1570-193X (Print)


Volume 11, 4 Issues, 2014


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Microwave-Assisted Synthesis of Benzo-fused Seven-membered Azaheterocycles

Author(s): Rajeev Sakhuja, Kiran Bajaj, S. M. Abdul Shakoor and Anil Kumar

Affiliation: Department of Chemistry, Birla Institute of Technology and Science, Pilani 333 031, Rajasthan, India.

Abstract

The use of microwave energy in chemical reactions has revolutionized the field of heterocyclic chemistry in the past two decades. Synergy of microwave methodology with reactions performed on support media and/or in the absence of solvent constitutes an environmentally clean technique, that offers tremendous advantages such as clean chemistry, reduction in reaction times, improved yields, and applicability to wide range of reactions, safety and tremendous scope for automation over the traditional heating. The benzoannulated azaheterocycles display an impressive repertoire of biological activities. The present review will provide an in-depth view of microwave-assisted synthetic methodologies of benzo-fused seven-membered azaheterocycles such as benzodiazepines, benzothiazepines and benzoxazepines.

Keywords: Benzodiazepines, benzothiazepines, benzoxazepines, microwave.

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Article Details

Volume: 11
Issue Number: 1
First Page: 55
Last Page: 72
Page Count: 18
DOI: 10.2174/1570193X1101140402101513
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