Recent Development in Asymmetric Synthesis of Homo-allylic Amines Catalyzed by Small Organic Molecules

ISSN: 1875-6298 (Online)
ISSN: 1570-193X (Print)

Volume 13, 6 Issues, 2016

Download PDF Flyer

Mini-Reviews in Organic Chemistry

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Roberto Paolesse
University of Rome

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 1.042
5 - Year: 1.548

Recent Development in Asymmetric Synthesis of Homo-allylic Amines Catalyzed by Small Organic Molecules

Mini-Reviews in Organic Chemistry, 11(4): 508-516.

Author(s): Quanxuan Zhang, Changning Wang and Wenjun Zhao.

Affiliation: Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA.


Chiral homo-allylic amines have been recognized in biologically active natural products and synthetic medicinal compounds. The most significant aspect of chiral homo-allylic amines relies on their synthetic versatility as chiral building blocks for the construction of a broad range of multi-functional organic compounds. A measure of the value of chiral homoallylic amines in organic synthesis is the large volume of work that has been devoted to their construction. Of the known asymmetric methods for their synthesis, the most popular method involves the formation of an imine followed by asymmetric allylation of the imine with reactive allylmetal reagents. An alternative approach is the metal-free asymmetric synthesis of chiral homo-allylic amines catalyzed by small organic molecules, which will be discussed in details in this review.


Allylation of imines, aminoallylation of aldehydes, Brønsted acid catalysis, Homo-allylic amines, organoboronate reagents.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 11
Issue Number: 4
First Page: 508
Last Page: 516
Page Count: 9
DOI: 10.2174/1570193X11999140327113509
Global Biotechnology Congress 2016Drug Discovery and Therapy World Congress 2016

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science