Pyrroles and Fused Pyrroles: Synthesis and Therapeutic Activities
Mohamed MS and Fathallah SSAffiliation:
Helwan University, Faculty of Pharmacy, Department of Pharmaceutical Organic Chemistry, Ein-Helwan, Cairo, Egypt.
AbstractFor several decades, interest in pyrrole derivatives increases due to their pharmaceutical importance, such as antimicrobial, anti-inflammatory, analgesic, anti-tumor, anti-epileptic, anti-viral, anti-hypertensive, and anti-diabetic agents. These huge therapeutic applications have motivated new efforts in searching for novel derivatives with improved biological activity and diverse applications in pharmaceutical industry. Motivated by the importance of this system, and in continuation of our research efforts, we have tried to highlight aspects reported on the chemistry and biological activity of pyrrole and its fused derivatives during the past years (till 2012).
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