Pyrroles and Fused Pyrroles: Synthesis and Therapeutic Activities

ISSN: 1875-6298 (Online)
ISSN: 1570-193X (Print)


Volume 11, 4 Issues, 2014


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Pyrroles and Fused Pyrroles: Synthesis and Therapeutic Activities

Author(s): Mosaad S. Mohamed and Samar S. Fathallah

Affiliation: Helwan University, Faculty of Pharmacy, Department of Pharmaceutical Organic Chemistry, Ein-Helwan, Cairo, Egypt.

Abstract

For several decades, interest in pyrrole derivatives increased due to their pharmaceutical importance, such as antimicrobial, anti-inflammatory, analgesic, anti-tumor, anti-epileptic, anti-viral, anti-hypertensive, and anti-diabetic agents. These huge therapeutic applications have motivated new efforts in searching for novel derivatives with improved biological activity and diverse applications in pharmaceutical industry. Motivated by the importance of this system, and in continuation of our research efforts, we have tried to highlight aspects reported on the chemistry and biological activity of pyrrole and its fused derivatives during the past years (till 2012).

Keywords: Pyrrole, fused pyrrole, pyrrolopyrimidine, synthesis, biological activities and drugs.

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Article Details

Volume: 11
Issue Number: 4
First Page: 477
Last Page: 507
Page Count: 31
DOI: 10.2174/1570193X113106660018
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