Bioactive Triterpenic Acids: From Agroforestry Biomass Residues to Promising Therapeutic Tools

ISSN: 1875-6298 (Online)
ISSN: 1570-193X (Print)


Volume 11, 4 Issues, 2014


Download PDF Flyer




Mini-Reviews in Organic Chemistry

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 0.826
5 - Year: 1.725

Bioactive Triterpenic Acids: From Agroforestry Biomass Residues to Promising Therapeutic Tools

Author(s): Rui M.A. Domingues, Angela R. Guerra, M. Duarte, Carmen S.R. Freire, Carlos P. Neto, Carlos M.S. Silva and Arnando J.D. Silvestre

Affiliation: CICECO and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.

Abstract

This review aims to provide an overview of the biogenetic origin of triterpenic acids (with particular emphasis on ursolic, oleanolic and betulinic acids), on the analytical extraction and hyphenated methodologies (mainly GC-MS) used on their identification and quantification, followed by an overview of the major sources of these components, indicating their potential large scale production pathways, with especial emphasis on abundant agroforestry biomass residues. The biological activity of ursolic, oleanolic and betulinic acids is described, focusing on their antitumoral potential as modulators of growth inhibitory signals, evasion of apoptosis and angiogenesis. The future perspectives towards improved therapeutic strategies using these triterpenic acids are also herein discussed.

Keywords: Antitumoral activity, betulinic acid, biological activity, birch bark, Eucalyptus, oleanolic acid, olive, triterpenic acids, ursolic acid.

Purchase Online Order Reprints Order Eprints Rights and Permissions

  
  



Article Details

Volume: 11
Issue Number: 3
First Page: 382
Last Page: 399
Page Count: 18
DOI: 10.2174/1570193X113106660001
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science