Mechanically Activated Solid-State Synthesis of Phenylhydrazone Derivatives via High-Speed Ball Milling
Xingyi Zhu, Yuanyuan Chen, Yuhe Chen, Jue Wang and Weike SuAffiliation:
Key Laboratory of Pharmaceutical Engineering (Ministry of Education), Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P.R. China.
AbstractA series of phenylhydrazone derivatives was synthesized from arenediazonium tetrafluoroborates and active methylene compounds under high-speed ball milling. The reaction occurred in the absence of the solvent and products were obtained in good yield within short reaction times (no more than 30 min).
Ball milling, solid-state synthesis, phenylhydrazones, arenediazonium tetrafluoroborates, active methylene compounds.
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