Aqua Mediated One-Pot Synthesis of 2-Amino-tetrahydrobenzo[b]pyran Derivatives Catalyzed by Mg(NO<sub>3</sub>)<sub>2</sub>•6H<sub>2</sub>O

ISSN: 1875-6255 (Online)
ISSN: 1570-1786 (Print)

Volume 14, 10 Issues, 2017

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Letters in Organic Chemistry

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Miguel Yus
Universidad de Alicante Apdo

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Aqua Mediated One-Pot Synthesis of 2-Amino-tetrahydrobenzo[b]pyran Derivatives Catalyzed by Mg(NO3)2•6H2O

Letters in Organic Chemistry, 11(7): 475-479.

Author(s): Boudjemaa Boumoud, Amina Debbache, Taoues Boumoud, Raouf Boulcina and Abdelmadjid Debache.

Affiliation: Laboratoire de Synthese de Molecules d' Interets Biologiques, Departement de Chimie, Faculte des Sciences Exactes, Universite Constantine 1, 25000 Constantine, Algerie.


We describe herein a clean and efficient one-pot synthesis of 4H-benzo[b]pyran derivatives using dimedone, active methylene nitriles and aryl aldehyde via Knoevenagel condensation followed by Michael addition in the presence of Mg(NO3)2•6H2O as catalyst and water as a green solvent. The advantages of this method lie in its simplicity, low catalyst loading, cost effectiveness and easy handling. The present method also allows us to synthesize highly functionalized tetrahydrobenzo[b]pyran derivatives from simple and readily available starting materials.


Mg(NO<sub>3</sub>)<sub>2</sub>•6H<sub>2</sub>O, multi-component reaction, 4H-benzo[b]pyran, active methylene nitrile, aqua mediated, dimedone.

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Article Details

Volume: 11
Issue Number: 7
First Page: 475
Last Page: 479
Page Count: 5
DOI: 10.2174/1570178611666140401221534
Price: $58

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