New Chalcones Containing Nucleosides Exhibiting In Vitro Anti-cancer Activities

ISSN: 1875-6255 (Online)
ISSN: 1570-1786 (Print)


Volume 11, 10 Issues, 2014


Download PDF Flyer




Letters in Organic Chemistry

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 47th of 57 in Chemistry, Organic

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Miguel Yus
Universidad de Alicante Apdo
Alicante
Spain


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 0.667
5 - Year: 0.695

New Chalcones Containing Nucleosides Exhibiting In Vitro Anti-cancer Activities

Author(s): Luu Van Chinh, Truong Ngoc Hung, Nguyen Thi Nga, Le phong, Le Mai Huong, Tran Thi Hong Ha, Soo Un Kim and Tran Khac Vu

Affiliation: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet- Cau Giay - Ha Noi, Vietnam.

Abstract

Twenty-one new chalcones 9a-m (excluding 9e, 9j and 9l) and 10a-m (excluding 10j and 10l), containing nucleobases were synthesized from 2'-hydroxyacetophenone (1) by the reactions including chloromethylation, nucleophilic substitution with thymine and uracil, and Claisen-Schmidt reactions. These new chalcones were evaluated for in vitro cytotoxicity against five human cancer cell lines: SK-LU-1, Hep-G2, MCF7, SW480 and P388. The results showed that most of the tested chalcones exhibited inhibitory activity against five cancer cell lines except 10h, and 10i. Among the synthesized chalcones, compound 10c exhibited most potent cytotoxicity against MCF-7, SK-LU-1, SW480, HepG2 and P388 with IC50 values of 4.42, 4.81, 5.27, 3.67 and 4.11 μ g/mL, respectively.




Keywords: Chalcones, Claisen-Schmidt, cytotoxicity, 2'-hydroxyacetophenone, thymine, uracil.

Purchase Online Rights and Permissions

Article Details

Volume: 11
Issue Number: 7
First Page: 534
Last Page: 545
Page Count: 12
DOI: 10.2174/1570178611666140401221121
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science