Synthesis of Pyrimidine Derivatives from Three-component Reaction of Malononitrile, Aldehydes and Thiourea/Urea in the Presence of High Surface Area and Nanosized MgO as a Highly Effective Heterogeneous Base Catalyst

ISSN: 1875-6255 (Online)
ISSN: 1570-1786 (Print)


Volume 11, 10 Issues, 2014


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Letters in Organic Chemistry

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Miguel Yus
Universidad de Alicante Apdo
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Synthesis of Pyrimidine Derivatives from Three-component Reaction of Malononitrile, Aldehydes and Thiourea/Urea in the Presence of High Surface Area and Nanosized MgO as a Highly Effective Heterogeneous Base Catalyst

Author(s): Zahra Hassani

Affiliation: Department of New Materials, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.

Abstract

The three-component reaction of malononitrile, aldehydes and thiourea/urea, is applied to the formation of pyrimidine derivatives. The reaction occurs at best in EtOH at reflux, in the presence of high surface area and nanosized MgO. This methodology is more convenient to compare with alternative ways because it needs shorter reaction times, allows straightforward product isolation, and provides higher yields.




Keywords: High surface area, nanosized MgO, Pyrimidine derivatives, Three-component reaction.

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Article Details

Volume: 11
Issue Number: 7
First Page: 546
Last Page: 549
Page Count: 4
DOI: 10.2174/1570178611666140313005406
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