Synthesis of Cyclopentadienones using Multicomponent Reactions of Primary Amines and Electron Deficient Acetylenic Compounds with Triphenylphosphine in Water
Letters in Organic Chemistry,
Volume 11 (E-pub ahead of print)Author(s): Samereh Seyfi
, Faramarz Rostami-Charati
, Zinatossadat Hossaini
and Mohammad R Zardoost
Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.
AbstractA water-accelerated multicomponent synthesis of organic target molecules has been used as a key method for the preparation of cyclopentadiene derivatives. The three-component condensation reactions of primary amines with alkyl propiolates in the presence of triphenylphosphine in water at 80 °C are developed as efficient and clean green synthetic procedures for the high-yielding preparation of 4-oxo-2,5-cyclopentadiene-1,2-dicarboxylate derivatives.
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