Synthesis and Antibacterial Activity of a Novel Class of Benzylidenrhodanine Based Furan Derivatives

ISSN: 1875-6255 (Online)
ISSN: 1570-1786 (Print)


Volume 11, 10 Issues, 2014


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Letters in Organic Chemistry

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Universidad de Alicante Apdo
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Synthesis and Antibacterial Activity of a Novel Class of Benzylidenrhodanine Based Furan Derivatives

Author(s): Robabeh Baharfar, Sahar Peiman and Mojtaba Mohseni

Affiliation: Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.

Abstract

A simple synthesis of novel benzylidenrhodanine based Furan derivatives was described from 5-arylidene 3- carboxymethylrhodanine derivatives via multi-component reactions. The reactive 1:1 intermediate produced from the reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates was trapped at room temperature by 5-arylidene 3- carboxymethylrhodanine derivatives to yield polyfunctionalized furan rings in fairly good yields. The products have been analyzed for antibacterial activity against Gram positive and Gram negative bacteria. The results indicated that the synthesized compounds are effective against bacterial growth retardation activity to some extent and their effectiveness is higher for Staphylococcusaureus.




Keywords: Antibacterial activity, Benzylidenrhodanine, Dialkyl acetylenedicarboxylates, tert-butyl isocyanide.

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Article Details

Volume: 11
Issue Number: 6
First Page: 393
Last Page: 397
Page Count: 5
DOI: 10.2174/1570178611666140218004601
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