Anionic Linear Globular Dendrimer-G2-Ciprofloxacin Nano-Conjugate: Novel Agent against Wilson Disease Cell Model
Narges Karimi, Mohammad Reza Aghasadeghi, Parichehr Yaghmaei, Hadi Fathi Moghaddam, Nasser Nassiri-Koopaei, Hamid Moloudian, Saleh Najafi, Seyed Ataaollah Shandiz and Mehdi Shafiee ArdestaniAffiliation:
Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
AbstractInherited defect of the gene ATP7B causes malexcretion of copper in the bile and leads to several complications that need treatment to deplete it from organs. Current therapy of Wilson disease, D-penicillamine has very serious side effects and drug with optimum therapeutic effects and minimum side effects is of importance. In the present study ciprofloxacin was conjugated with an anionic globular dendrimer to lower the intracellular copper concentration. The results showed its efficacy and safety to certain levels. Based on the results, ciprofloxacin-anionic linear globular dendrimer conjugate can be a useful option to reduce intracellular copper concentration and an investigational therapeutic agent in Wilson disease.
Copper, Dendrimer-ciprofloxacin nano-particle, Fluoroquinolone, Metal ions, Wilson disease.
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