Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)- 1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model

ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)


Volume 11, 10 Issues, 2014


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Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)- 1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model

Author(s): Alla V. Pavlova, Irina V. Il'ina, Ekaterina A. Morozova, Dina V. Korchagina, Svetlana Yu. Kurbakova, Irina V. Sorokina, Tatyana G. Tolstikova, Konstantin P. Volcho and Nariman F. Salakhutdinov

Affiliation: N.N.Vorozhtsov Novosibirsk Institute of Organic Chemistry, Lavrentiev av., 9, 630090 Novosibirsk, Russian Federation.

Abstract

Studies of the neuroprotective activity of a series of monoterpene-derived compounds on the MPTP mice model showed that 4-[(3aR,7aS)-1,3,3a,4,5,7a-hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol 15 possessed a considerable neuroprotective activity. Compound 15 was synthesized by one-stage reaction of (+)-2-carene with vanillin. It has low acute toxicity and significantly decreased the development of catalepsy evoked by haloperidol in rats.

Keywords: Neuroprotection, Parkinson disease, MPTP, Mice, Monoterpene, Carene, Vanillin.

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Article Details

Volume: 11
Issue Number: 5
First Page: 611
Last Page: 617
Page Count: 7
DOI: 10.2174/1570180811666131210000316
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