Synthesis of Oxygenated Chalcones with Anti-Staphylococcal Activity

ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)

Volume 12, 10 Issues, 2015

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Letters in Drug Design & Discovery

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Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge

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Synthesis of Oxygenated Chalcones with Anti-Staphylococcal Activity

Letters in Drug Design & Discovery, 11(5): 525-530.

Author(s): Luciana Dalla-Vechia, Cíntia Janine Kiekow, Ivana Correa Ramos Leal, Katia Regina Netto Dos Santos, Simone Cristina Baggio Gnoatto, Hugo Verli, Rodrigo Octavio Mendonca Alves de Souza and Grace Gosmann.

Affiliation: Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, UFRGS, Av. Ipiranga, 2752, Porto Alegre, 90610-000, RS, Brazil.


Gram-positive bacteria are the most common cause of skin infection in hospitalized patients, with Staphylococcus aureus being the principal pathogen responsible for deaths. A series of poly-oxygenated chalcones was synthesized and assayed for anti-staphylococcal activity. Hydroxylated chalcones were more effective in the inhibition of microbial growth than methoxylated analogues. The compound 3’,5’,4-trihydroxychalcone is the most promising compound among those evaluated, showing a much broader antimicrobial spectrum than oxacillin and a MIC of 64 µg/ml to a multidrug- resistant hospital clinical strain of S. aureus.


Antimicrobial, Aldol condensation, Chalcone, Phenolic compound.

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Article Details

Volume: 11
Issue Number: 5
First Page: 525
Last Page: 530
Page Count: 6
DOI: 10.2174/1570180810666131125221032

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