Synthesis of Oxygenated Chalcones with Anti-Staphylococcal Activity
Letters in Drug Design & Discovery,
Luciana Dalla-Vechia, Cíntia Janine Kiekow, Ivana Correa Ramos Leal, Katia Regina Netto Dos Santos, Simone Cristina Baggio Gnoatto, Hugo Verli, Rodrigo Octavio Mendonca Alves de Souza and Grace GosmannAffiliation:
Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, UFRGS, Av. Ipiranga, 2752, Porto Alegre, 90610-000, RS, Brazil.
AbstractGram-positive bacteria are the most common cause of skin infection in hospitalized patients, with Staphylococcus aureus being the principal pathogen responsible for deaths. A series of poly-oxygenated chalcones was synthesized and assayed for anti-staphylococcal activity. Hydroxylated chalcones were more effective in the inhibition of microbial growth than methoxylated analogues. The compound 3’,5’,4-trihydroxychalcone is the most promising compound among those evaluated, showing a much broader antimicrobial spectrum than oxacillin and a MIC of 64 µg/ml to a multidrug- resistant hospital clinical strain of S. aureus.
Antimicrobial, Aldol condensation, Chalcone, Phenolic compound.
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