Novel Urea/Thiourea Derivatives of Quinazolin-4(3H)-one: Design, Synthesis, Antimicrobial and Anti-TB Study

ISSN: 1875-628X (Online)
ISSN: 1570-1808 (Print)


Volume 11, 10 Issues, 2014


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Letters in Drug Design & Discovery

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Novel Urea/Thiourea Derivatives of Quinazolin-4(3H)-one: Design, Synthesis, Antimicrobial and Anti-TB Study

Author(s): Dhruvin R. Shah, Rahul P. Modh, Dhara V. Desai and Kishor H. Chikhalia

Affiliation: Department of Chemistry, School of Sciences, Gujarat University, Ahmedabed-380009, Gujarat, India.

Abstract

In an attempt to control multidrug resistant dilemma, a library of quinazolinone based on two novel series was rationalized and synthesized with simple and efficient etiquette. A number of compounds encompass ethyl thioureidic backbone, structurally related to PETT (Phenyl Ethyl Thiazolyl Thiourea) congeners. All the final synthesized compounds were characterized by IR, 1H NMR, 13C NMR, mass and elemental analysis. The newly synthesized compounds were studied for efficacy against several bacteria (Staphylococcus Aureus, Bacillus Cereus, Escherichia Coli, Pseudomonas Aeruginosa, Klebsiella Pneumoniae, Salmonella Typhi, Proteus Vulgaris, Shigella Flexneria) and fungi (Candida Albicans, Aspergillus Niger, Aspergillus Clavatus) using the broth dilution technique. Moreover, these compounds were also screened for their in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv using the BACTEC MGIT method.

Keywords: Antimicrobial, Antimycobacterial, Minimum Inhibitory Concentration, Quinazolinone; Synthesis, Thiourea, Urea.

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Article Details

Volume: 11
Issue Number: 5
First Page: 560
Last Page: 571
Page Count: 12
DOI: 10.2174/1570180810666131122003517
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