Mortality from Herpes Simplex Virus (HSV) Infection in Australian Children, 1999-2011 Using National Datasets

ISSN: 2212-3989 (Online)
ISSN: 1871-5265 (Print)

Volume 15, 3 Issues, 2015

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Infectious Disorders - Drug Targets

Formerly: Current Drug Targets - Infectious Disorders

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Jean-Marc Sabatier
Laboratoire ERT 62 'Ingénierie des peptides à visée thérapeutique'
Université de la Méditerranée
Faculté de Médecine Nord
Boulevard Pierre Dramard
13916 - MARSEILLE, Cedex 20

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Mortality from Herpes Simplex Virus (HSV) Infection in Australian Children, 1999-2011 Using National Datasets

Author(s): Gulam Khandaker, Camille Raynes-Greenow, Hayley Smithers-Sheedy, Robert Booy, Robert Menzies and Cheryl Jones

Affiliation: Centre for Perinatal Infection Research, The Children’s Hospital at Westmead, Cnr Hawkesbury Rd and Hainsworth St, Locked Bag 4001, Westmead, NSW 2145, Australia.


Background: This study examines national childhood HSV mortality data in Australia from 1999-2011. This information is important to better understand the disease burden of HSV in early life and to formulate public health interventions. Methods: Retrospective analysis of Australian Bureau of Statistics (ABS) national mortality data from 1999- 2011 in children aged <15 years who died with specific ICD-10 codes for HSV infection listed as an underlying or contributing cause. Results: Twenty nine HSV-associated deaths in children aged <15 years from 1999-2011 were identified (0.05 per 100,000 children; 95% CI 0.04-0.06), 16 in the first month of life (0.45 per 100,000 live births; 95% CI 0.23- 0.67). Among those, 20 were males and 9 were females (p=0.04). The majority of deaths (69%) occurred in infants aged <12 months and most in infants aged <1 month (55%). HSV-associated death in infants aged < 1 month of age accounted for 0.15% of all neonatal deaths for 1999-2011 in Australia. A downward trend in HSV-associated neonatal mortality was observed between 1999 and 2011 (p=0.52). During the study period, mortality from HSV infections in Australian children resulted in an estimated 2,275 age-adjusted years of potential life lost. Conclusions: This data confirms reported findings from active surveillance of a downward trend in mortality rate from HSV infection in infants aged < 1 month in Australia over this period. Ongoing surveillance is required to confirm this observation.

Keywords: Children, Herpes simplex virus (HSV), mortality, neonate.

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Article Details

Volume: 14
Issue Number: 2
First Page: 89
Last Page: 92
Page Count: 4
DOI: 10.2174/1871526514666140714084934

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