Effect of Botanicals on Inflammation and Skin Aging: Analyzing the Evidence

ISSN: 2212-4055 (Online)
ISSN: 1871-5281 (Print)

Volume 14, 6 Issues, 2015

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Inflammation & Allergy - Drug Targets

Formerly: 'Current Drug Targets - Inflammation & Allergy

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Kurt S Zaenker
Institute of Immunology and Experimental Oncology
University Witten/Herdecke
Stockumerstraße 10
Witten, 58448

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Effect of Botanicals on Inflammation and Skin Aging: Analyzing the Evidence

Inflammation & Allergy - Drug Targets, 13(3): 168-176.

Author(s): Amanda Suggs, Patricia Oyetakin-White and Elma D Baron.

Affiliation: Department of Dermatology, University Hospitals Case Medical Center 11100 Euclid Avenue, Lakeside 3500, Mailstop 5028, Cleveland, OH 44106-5028, USA.


The skin and its immune system manifest a decline in physiologic function as it undergoes aging. External insults such as ultraviolet light exposure cause inflammation, which may enhance skin aging even further leading to cancer and signs of photoaging. There is a potential role for botanicals as an adjunct modality in the prevention of skin aging. Numerous over-the-counter anti-aging products are commercially available, many of which boast unverified claims to reduce stress, inflammation and correct signs of aging. In this article we reviewed the scientific literature for data on frequently published “anti-inflammaging” additives such as vitamins A, C and E and green tea. We also analyzed the evidence available on five promising ingredients commonly found in anti-aging products, namely, argan oil, rosemary, pomegranate, Coenzyme Q10, and Coffeeberry. Though there may be an increasing amount of scientific data on a few of these novel botanicals, in general, there remains a lack of clinical data to support the anti-aging claims made.


Argan oil, coenzyme Q10, coffeeberry, green tea, pomegranate extract, rosemary extract, vitamin A, vitamin C.

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Article Details

Volume: 13
Issue Number: 3
First Page: 168
Last Page: 176
Page Count: 9
DOI: 10.2174/1871528113666140526163052

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