Brain-Skin Connection: Stress, Inflammation and Skin Aging

ISSN: 2212-4055 (Online)
ISSN: 1871-5281 (Print)

Volume 14, 6 Issues, 2015

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Inflammation & Allergy - Drug Targets

Formerly: 'Current Drug Targets - Inflammation & Allergy

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Kurt S Zaenker
Institute of Immunology and Experimental Oncology
University Witten/Herdecke
Stockumerstraße 10
Witten, 58448

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Brain-Skin Connection: Stress, Inflammation and Skin Aging

Inflammation & Allergy - Drug Targets, 13(3): 177-190.

Author(s): Ying Chen Chen and John Lyga.

Affiliation: Clinical Project Manager Global R&D Reckitt Benckiser One Philips Parkway Montvale, NJ 07645.


The intricate relationship between stress and skin conditions has been documented since ancient times. Recent clinical observations also link psychological stress to the onset or aggravation of multiple skin diseases. However, the exact underlying mechanisms have only been studied and partially revealed in the past 20 years or so. In this review, the authors will discuss the recent discoveries in the field of “Brain-Skin Connection”, summarizing findings from the overlapping fields of psychology, endocrinology, skin neurobiology, skin inflammation, immunology, and pharmacology.


Inflammation, skin aging, stress response.

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Article Details

Volume: 13
Issue Number: 3
First Page: 177
Last Page: 190
Page Count: 14
DOI: 10.2174/1871528113666140522104422

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