Substance P at the Neuro-Immune Crosstalk in the Modulation of Inflammation, Asthma and Antimicrobial Host Defense

ISSN: 2212-4055 (Online)
ISSN: 1871-5281 (Print)


Volume 13, 6 Issues, 2014


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Inflammation & Allergy - Drug Targets

Formerly: 'Current Drug Targets - Inflammation & Allergy

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Editor-in-Chief:
Kurt S Zaenker
Institute of Immunology and Experimental Oncology
University Witten/Herdecke
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Witten, 58448
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Substance P at the Neuro-Immune Crosstalk in the Modulation of Inflammation, Asthma and Antimicrobial Host Defense

Author(s): Jia Sun and Madhav Bhatia

Affiliation: (Jia Sun) at the Synergetic Innovation Center of Food Safety and Nutrition, State Key Laboratory of Food Science and Technology, and School of Food Science and Technology, Jiangnan University, Wuxi 214122, P.R. China.

Abstract

Substance P, a neuropeptide belonging to the tachykinin family is a pleiotropic peptide with specific neural activities and involved in immunomodulation and antimicrobial host defense. It has been found to modulate a variety of inflammatory processes, including acute pancreatitis, sepsis, systemic inflammatory response syndrome and asthma. Also notably, substance P shares common bio-physical and -chemical properties such as low molecular mass, cathionicity and amphipathicity with antimicrobial peptides. It is therefore suggested to take part in host defense at specialized locations.

The review aims to highlight undated understanding on substance P in inflammation, allergy and its antimicrobial activities with potential implications in infection and host defense.

Therapeutic implications of the peptide, modulators of peptide expression and receptor signalling will be highlighted in each topic. Taken together, these topics will be of significant values for future pharmaceutical investigation and application of the field.


Keywords: Antimicrobial peptides, cathelicidins, immunomodulation, substance P.

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Article Details

Volume: 13
Issue Number: 2
First Page: 112
Last Page: 120
Page Count: 9
DOI: 10.2174/1871528113666140323202419
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