Soy- and Rice-Based Formula and Infant Allergic to Cow's Milk

ISSN: 2212-3873 (Online)
ISSN: 1871-5303 (Print)

Volume 15, 4 Issues, 2015

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Endocrine, Metabolic & Immune Disorders - Drug Targets

Formerly: Current Drug Targets - Immune, Endocrine & Metabolic Disorders

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Emilio Jirillo
Universitá degli Studi di Bari
Dipartimento di Clinica Medica
Immunologia e Malattie Infettive
Sezione di Microbiologia e Immunologia
Piazza Giulio Cesare-Policlinico

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Soy- and Rice-Based Formula and Infant Allergic to Cow's Milk

Endocrine, Metabolic & Immune Disorders - Drug Targets, 14(1): 38-46.

Author(s): Flora Tzifi, Vasilis Grammeniatis and Marios Papadopoulos.

Affiliation: 3rd Department of Pediatrics, University of Athens, “Attikon Hospital”, Rimini Str 1, Haidari, P. C. 12462, Athens, Greece.


Soy milk formula has limited medical indications for infants feeding, although in several parts of the world it has been used as a source of nutrition in a large number of children. It used to be the main alternative feeding for infants allergic to cow’s milk who did not breastfeed before the introduction of extensively hydrolyzed formulas. Although there is a debate, the fact that some children are allergic to soy or some children with cow’s milk allergy can present with concomitant soy allergy, restricted the use of soy formulas for treatment of infants allergic to cow’s milk. Other grainbased formulas like the rice-based ones are promising in infants with cow’s milk allergy. Grain-based formulas could be an alternative and cheaper way of nutrition for infants allergic to cow’s milk than extensively hydrolyzed formulas. Further large scale longitudinal clinical studies are required to clarify the safety of soy and other grain-based formulas for treatment of cow’s milk allergy.


Children, cow’s milk allergy, rice allergenicity, rice formulas, soy allergenicity, soy formulas.

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Article Details

Volume: 14
Issue Number: 1
First Page: 38
Last Page: 46
Page Count: 9
DOI: 10.2174/1871530314666140121144604

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