Cow’s Milk Allergenicity

ISSN: 2212-3873 (Online)
ISSN: 1871-5303 (Print)

Volume 15, 4 Issues, 2015

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Endocrine, Metabolic & Immune Disorders - Drug Targets

Formerly: Current Drug Targets - Immune, Endocrine & Metabolic Disorders

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Emilio Jirillo
Universitá degli Studi di Bari
Dipartimento di Clinica Medica
Immunologia e Malattie Infettive
Sezione di Microbiologia e Immunologia
Piazza Giulio Cesare-Policlinico

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Cow’s Milk Allergenicity

Endocrine, Metabolic & Immune Disorders - Drug Targets, 14(1): 16-26.

Author(s): Sophia Tsabouri, Kostas Douros and Kostas N Priftis.

Affiliation: Child Health Department, University of Ioannina Medical School, Ioannina, Greece.


In this review, clinical and epidemiological aspects of milk allergy along with current data on the structure and function of the main cow's milk allergens, are presented. Milk allergy is the most frequent food allergy in childhood. One of the reasons why allergy to cow’s milk shows its highest prevalence in children is its early introduction into the diets of infants when breast feeding is not possible. The major allergens are caseins, a-lactalbumin and β-lactoglobulin, but allergies to other minor proteins (immunoglobulins, bovine serum albumin) have also been reported. Milk allergenicity can be reduced by various processing methods (mainly hydrolysis), and processed formulas based on cow’s milk can often be safely introduced to children allergic to milk proteins.

Cross reactivity has been described between different mammalian milks and between milk and meat or animal dander.


Cow’s milk allergenicity, cow’s milk composition, cow’s milk cross-reactivity, distribution of milk allergens, structure of milk allergens, stability of milk allergens.

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Article Details

Volume: 14
Issue Number: 1
First Page: 16
Last Page: 26
Page Count: 11
DOI: 10.2174/1871530314666140121144224

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