Centenarian Offspring: a model for Understanding Longevity

ISSN: 1875-6212 (Online)
ISSN: 1570-1611 (Print)


Volume 12, 6 Issues, 2014


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Editor-in-Chief:
Dimitri P. Mikhailidis
Academic Head, Deptartment of Clinical Biochemistry
Royal Free Hospital Campus
University College London Medical School
University College London (UCL)
Pond Street
London, NW3 2QG
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Centenarian Offspring: a model for Understanding Longevity

Author(s): Carmela Rita Balistreri, Giulia Accardi, Silvio Buffa, Matteo Bulati, Adriana Martorana, Giuseppina Candore, Giuseppina Colonna-Romano, Domenico Lio and Calogero Caruso

Affiliation: Gruppo di Studio sull'Immunosenescenza Dipartimento di Biopatologia e di Biotecnologie Mediche e Forensi Corso Tukory 211 90134 Palermo – Italy

Abstract

A main objective of current medical research is the improving of life quality of elderly people as priority of the continuous increase of ageing population. This phenomenon implies several medical, economic and social problems because of dramatic increase in number of not autonomous individuals affected by various pathologies. Accordingly, the research interest is focused on understanding the biological mechanisms involved in determining the positive ageing phenotype, i.e. the centenarian phenotype. In achieving this goal the choice of an appropriate study models is fundamental. Centenarians have been used as an optimal model for successful ageing. However, it is characterized by several limitations, i.e. the selection of appropriate controls for centenarians and the use itself of the centenarians as a suitable model for healthy ageing. Thus, the interest has been centered on centenarian offspring, healthy elderly people. They may represent a model for understanding exceptional longevity for the following reasons: to exhibit a protective genetic background, cardiovascular and immunological profile as well as a reduced rate of cognitive decline than age-matched people without centenarian relatives. Several of these aspects are summarized in this review based on the literature and the results of our studies


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Article Details

Volume: 11
First Page: 1
Page Count: 1
DOI: 10.2174/1570161111666131219113544
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