Evidence on the Protective Role of High-Density Lipoprotein (HDL) in HIV-Infected Individuals

ISSN: 1875-6212 (Online)
ISSN: 1570-1611 (Print)


Volume 12, 6 Issues, 2014


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Current Vascular Pharmacology

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Editor-in-Chief:
Dimitri P. Mikhailidis
Academic Head, Deptartment of Clinical Biochemistry
Royal Free Hospital Campus
University College London Medical School
University College London (UCL)
Pond Street
London, NW3 2QG
UK


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Evidence on the Protective Role of High-Density Lipoprotein (HDL) in HIV-Infected Individuals

Author(s): Alexandra Calmy, Fabrizio Montecucco and Richard W. James

Affiliation: Division of Infectious Diseases, Department of Medical Specialties, Geneva University Hospital, 4 rue Gabrielle Perret Gentil, 1205 Geneva, Switzerland

Abstract

During the last decades, the improvements in the assessment and management of cardiovascular risk have been successful in the reduction of acute cardiovascular outcomes. Among different prevention and therapeutic strategies, treatments targeting HDL increase have been indicated as promising interventions from both basic research and clinical studies. Although this therapeutic approach still requires confirmatory findings from large clinical trials, emerging evidence indicates that it would be particularly useful in some patient categories characterized by accelerated atherosclerotic diseases. In this regard, HIV-infected patients (under antiretroviral treatment or not) have been recently indicated as an appropriate target population. The present review will discuss the promising role of HDL in HIV-related cardiovascular pathophysiology and update novelties from clinical studies targeting HDL increase in HIV patients

Keywords: HIV, cardiovascular risk, high-density lipoprotein

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Article Details

Volume: 11
First Page: 1
Last Page: 6
Page Count: 6
DOI: 10.2174/1570161111999131203092322
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