P2 Receptors in Renal Autoregulation

ISSN: 1875-6212 (Online)
ISSN: 1570-1611 (Print)


Volume 12, 6 Issues, 2014


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Editor-in-Chief:
Dimitri P. Mikhailidis
Academic Head, Deptartment of Clinical Biochemistry
Royal Free Hospital Campus
University College London Medical School
University College London (UCL)
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P2 Receptors in Renal Autoregulation

Author(s): Zhengrong Guan, Robert C. Fellner, Justin Van Beusecum and Edward W. Inscho

Affiliation: Department of Physiology, Medical College of Georgia, Georgia Regents University, 1120 15th Street, Augusta, Georgia 30912-3000.

Abstract

Autoregulation of renal blood flow and glomerular filtration rate is an essential function of the renal microcirculation. While the existence of this phenomenon has been known for many years, the exact mechanisms that underlie this regulatory system remain poorly understood. The work of many investigators has provided insights into many aspects of the autoregulatory mechanism, but many critical components remain elusive. This review is intended to update the reader on the role of P2 purinoceptors as a postulated mechanism responsible for renal autoregulatory resistance adjustments. It will summarize recent advances in normal function and it will touch on more recent ideas regarding autoregulatory insufficiency in hypertension and inflammation. Current thoughts on the nature of the mechanosensor responsible for myogenic behavior will be also be discussed as well as current thoughts on the mechanisms involved in ATP release to the extracellular fluid space.

Keywords: ATP, adenosine, afferent arterioles, P2 receptors, connexins, myogenic behavior, tubuloglomerular feedback.

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Article Details

Volume: 12
Issue Number: 6
First Page: 818
Last Page: 828
Page Count: 11
DOI: 10.2174/15701611113116660152
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