Impaired Renal Autoregulation in Susceptible Models of Renal Disease

ISSN: 1875-6212 (Online)
ISSN: 1570-1611 (Print)


Volume 12, 6 Issues, 2014


Download PDF Flyer




Current Vascular Pharmacology

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 27th of 65 in Peripheral Vascular Disease
  • 84th of 254 in Pharmacology & Pharmacy

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Dimitri P. Mikhailidis
Academic Head, Deptartment of Clinical Biochemistry
Royal Free Hospital Campus
University College London Medical School
University College London (UCL)
Pond Street
London, NW3 2QG
UK


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 2.908
5 - Year: 2.765

Impaired Renal Autoregulation in Susceptible Models of Renal Disease

Author(s): Sydney Murphy and Jan Michael Williams

Affiliation: Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216.

Abstract

One of the major functions of the kidney is to maintain constant renal blood flow and glomerular filtration rate in response to increases in renal perfusion pressure. This phenomenon is referred to autoregulation and involves two independent mechanisms: tubular glomerular feedback and myogenic response. The latter, the renal myogenic response, involves constriction of the preglomerular vasculature to increases in transmural pressure. Over the last three decades, there has been substantial evidence that demonstrates that the myogenic response plays an important role in protecting the kidney from hypertension-induced renal injury. Furthermore, impairment of the renal myogenic response allows the transmission of systemic pressures to the glomerular capillaries leading to the development of glomerular injury and progressive proteinuria during hypertension. This review article discusses the role of the myogenic response in the pathogenesis of renal disease in various genetic and experimental rodent models that develop hypertension-induced renal injury

Keywords: Autoregulation, glomerulosclerosis, glomerular capillary pressure, renal blood flow

Purchase Online Order Reprints Order Eprints Rights and Permissions

  
  



Article Details

Volume: 11
First Page: 1
Last Page: 8
Page Count: 8
DOI: 10.2174/15701611113116660148
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science