Islet Purification for Clinical islet Transplantation

ISSN: 2211-5439 (Online)
ISSN: 2211-5420 (Print)


Volume 3, 2 Issues, 2014


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Current Tissue Engineering

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Editor-in-Chief:
Herman S. Cheung
Department of Biomedical Engineering
University of Miami
Miami, FL 33101
USA


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Islet Purification for Clinical islet Transplantation

Author(s): Hirofumi Noguchi

Affiliation: Department of Surgery, Chiba-East National Hospital, National Hospital Organization, Chiba 260-8712, Japan.

Abstract

In clinical islet transplantation, islet purification reduces the amount of tissues to be transplanted by removing the acinar tissue, therefore minimizing the risks associated with intraportal infusion. On the other hand, the purification procedure may result in decreased numbers of islets recovered from digested tissue and may be traumatic for the islets. Ficoll-based density gradients are widely used in islet purification in clinical trials. Recently, purification with iodixanol was reported in an islet transplantation series with successful clinical outcomes. This review describes current advances in islet purification for clinical islet transplantation.

Keywords: islet transplantation, islet isolation, regular purification, supplemental purification, osmolality, density

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Article Details

Volume: 2
First Page: 1
Last Page: 5
Page Count: 5
DOI: 10.2174/2211542002666131230234825
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