Islet Purification for Clinical Islet Transplantation

ISSN: 2211-5439 (Online)
ISSN: 2211-5420 (Print)

Volume 4, 2 Issues, 2015

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Current Tissue Engineering

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Herman S. Cheung
Department of Biomedical Engineering
University of Miami
Miami, FL 33101

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Islet Purification for Clinical Islet Transplantation

Current Tissue Engineering, 3(1): 34-38.

Author(s): Hirofumi Noguchi.

Affiliation: Department of Surgery, Chiba-East National Hospital, National Hospital Organization, 673 Nitonacho, Chuo-ku, Chiba 260-8712, Japan.


In clinical islet transplantation, islet purification reduces the amount of tissues to be transplanted by removing the acinar tissue, therefore minimizing the risks associated with intraportal infusion. On the other hand, the purification procedure may result in decreased numbers of islets recovered from digested tissue and may be traumatic for the islets. Ficoll- based density gradients are widely used in islet purification in clinical trials. Recently, purification with iodixanol was reported in an islet transplantation series with successful clinical outcomes. This review describes current advances in islet purification for clinical islet transplantation.


Density, islet isolation, islet transplantation, osmolality, regular purification, supplemental purification.

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Article Details

Volume: 3
Issue Number: 1
First Page: 34
Last Page: 38
Page Count: 5
DOI: 10.2174/2211542002666131230234825

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