Wound Healing Microenvironmental Cues: From Tissue Analogs to Skin Regeneration

ISSN: 2211-5439 (Online)
ISSN: 2211-5420 (Print)

Volume 6, 2 Issues, 2017

Download PDF Flyer

Current Tissue Engineering

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Herman S. Cheung
Department of Biomedical Engineering
University of Miami
Miami, FL 33101

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Wound Healing Microenvironmental Cues: From Tissue Analogs to Skin Regeneration

Current Tissue Engineering, 2(2): 145-153.

Author(s): Mariana T. Cerqueira, Rui L. Reis and Alexendra P Marques.

Affiliation: 3B’s Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909 Taipas, Guimaraes, Portugal.


Upon injury or burn, and if no intervention takes place, skin repair is the natural tissue restoration mechanism in humans. However, massive scar tissue and consequently non-functional skin is often formed.

Although skin substitutes have the longest history of application, and the highest record of tissue engineering products in the market, major limitations including deficient vascularization, low performance of cellular components and lack of adnexal appendages are still a foremost concern. Moreover, current products proved to represent replacement strategies where the major concern is the survival of the implanted substitute and wound healing, instead of promotion skin tissue regeneration.

Current state of the art, exploring stem cells potential, as well as the healing microenvironment/matrix, is indicative of skin substitute’s defective signals to induce skin regeneration. Stem cells are expected to play an active role, either by direct or indirect signaling through paracrine interactions or transdifferentiation, privileging an integrated and orchestrated remodeling rather then replacement. Nonetheless, the extracellular matrix dynamics during wound healing is also seen as a determinant factor in the presentation of cues for tissue morphogenesis, accurately leading regeneration. Thus the complex interplay between extracellular matrix, cells and growth factors, within a particular three dimensional environment, is being taken as the basis for the design of improved and more efficient skin tissue engineering strategies.


Extracellular matrix, skin regeneration, stem cells, tissue engineering, wound healing.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 2
Issue Number: 2
First Page: 145
Last Page: 153
Page Count: 9
DOI: 10.2174/2211542011302020005
Price: $58
Global Biotechnology Congress 2017Drug Discovery and Therapy World Congress 20173D Cell Culture 2017

Related Journals

Related eBooks

Webmaster Contact: urooj@benthamscience.org Copyright © 2017 Bentham Science