Glioblastoma Stem-Like Cells – Isolation, Biology and Mechanisms of Chemotherapy Resistance

ISSN: 2212-389X (Online)
ISSN: 1574-3624 (Print)

Volume 10, 2 Issues, 2015

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Current Signal Transduction Therapy

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György Kéri
Vichem Chemie Research Ltd
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Glioblastoma Stem-Like Cells – Isolation, Biology and Mechanisms of Chemotherapy Resistance

Current Signal Transduction Therapy, 8(3): 256-267.

Author(s): Iwona Anna Ciechomska, Marta Kocyk and Bozena Kaminska.

Affiliation: Nencki Institute of Experimental Biology, 3 Pasteur Str., 02-093 Warsaw, Poland.


Malignant gliomas are common primary tumors of the central nervous system, characterized by aggressive cell proliferation, diffuse infiltration and resistance to conventional therapy. Glioblastoma (former Glioblastoma multiforme, GBM), grade IV astrocytoma, is the most aggressive tumor, with a median survival of around 14 months. New therapies against this devastating and invariably fatal disease are needed. Stem-like cell populations have been identified in a number of malignancies including glioblastoma. These rare stem cells (called also glioma-initiating cells) are believed to be responsible not only for tumor initiation and progression but also resistance to therapeutic agents and tumor recurrence. Recently, the population of cells within glioblastoma with stem-like properties has gained increasing attention as a target to refine treatment strategies. This chapter aims to summarize the recent data regarding isolation, biology and mechanisms of resistance of glioblastoma stem-like cells to therapy.


Glioblastoma, glioma-initiating cells (GIC), glioma stem cells (GSC), functional characteristics, isolation, markers, therapeutic resistance.

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Article Details

Volume: 8
Issue Number: 3
First Page: 256
Last Page: 267
Page Count: 12
DOI: 10.2174/1574362409666140206223501

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